SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/03/2004
Date Updated: 09/02/2002
Version 1.3
Section 1 - Product and Company Information
Product Name CHROMIUM(VI) OXIDE, 99.9%
Product Number 232653
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
CHROMIUM (VI) OXIDE 1333-82-0 Yes
Formula CrO3
Synonyms Anhydride chromique (French) * Anidride cromica
(Italian) * Chrome (trioxyde de) (French) *
Chromia (CrO3) * Chromic anhydride * Chromium
oxide (Cr4O12) * Chromium trioxide * Chromium(6+)
trioxide * Chromium(VI) oxide *
Chromsaeureanhydrid (German) * Chromtrioxid
(German) * Chroomtrioxyde (Dutch) *
Chroomzuuranhydride (Dutch) * Cromo(triossido di)
(Italian) * Monochromium trioxide * Puratronic
chromium trioxide
RTECS Number: GB6650000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Oxidizing. Toxic.
May cause cancer by inhalation. Contact with combustible material
may cause fire. Toxic if swallowed. Causes severe burns. Very
toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
Target organ(s): Lungs. Kidneys.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 0
REACTIVITY: 3
SPECIAL HAZARD(S): Oxidizer
NFPA RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 3
SPECIAL HAZARD(S): Oxidizer
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam. Use water spray to cool fire-exposed containers.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Contact with other material may cause fire. May accelerate
combustion.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
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HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Keep away from combustible
materials, heat, sparks, and open flame.
SPECIAL REQUIREMENTS
Hygroscopic.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Remove and wash contaminated
clothing promptly. Discard contaminated shoes.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 0.05 MG(CR)/M3
USA MSHA Standard-air TWA 0.5 MG(CR)/M3
USA OSHA. PEL CL 0.1 MG(CRO3)/M3
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 0.001 MG(CR)/M3
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: Violet
Form: Fine crystals
Property Value At Temperature or Pressure
Molecular Weight 99.99 AMU
pH N/A
BP/BP Range N/A
MP/MP Range 196 掳C
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density 2.7 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
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Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Conditions of Instability: Chromium(VI) oxide produces
incandescence when mixed with: As; ammonia; hydrogen sulfide;
phosphorus; potassium; sodium; and selenium. Mixtures of
chromium(VI) oxide and DMF can explode violently. Chromium(VI)
oxide decomposes at 250掳C to chromium(III) oxide and oxygen
Conditions to Avoid: Heat. Protect from moisture.
Materials to Avoid: Phosphorus, Organic materials, Finely powdered
metals.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Nature of decomposition products
not known.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes burns.
Inhalation: Material is extremely destructive to the tissue of
the mucous membranes and upper respiratory tract. May be harmful
if inhaled.
Ingestion: Toxic if swallowed.
SENSITIZATION
Sensitization: May cause allergic respiratory and skin reactions
TARGET ORGAN(S) OR SYSTEM(S)
Kidneys. Lungs. Liver. Nerves.
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting.
TOXICITY DATA
Skin
Rabbit
20 < C > 200 MG/KG
LD50
Inhalation
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Rat
21.7 mg/m3
LC50
Oral
Rat
80 mg/kg
LD50
Remarks: Lungs, Thorax, or Respiration:Cyanosis.
Gastrointestinal:Hypermotility, diarrhea. Skin and Appendages:
Other: Hair.
Intraperitoneal
Rat
58400 UG/KG
LD50
Intravenous
Rat
9260 UG/KG
LD50
Oral
Mouse
127 mg/kg
LD50
Intraperitoneal
Mouse
14 MG/KG
LD50
Intravenous
Mouse
17100 UG/KG
LD50
CHRONIC EXPOSURE - CARCINOGEN
Result: This is or contains a component that has been reported
to be carcinogenic based on its IARC, OSHA, ACGIH, NTP, or EPA
classification.
Species: Human
Route of Application: Inhalation
Dose: 110 UG/M3
Exposure Time: 3Y-
Frequency: C
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors.
Lungs, Thorax, or Respiration:Tumors.
Species: Rat
Route of Application: Implant
Dose: 125 MG/KG
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Tumorigenic:Tumors at site or application.
Species: Mouse
Route of Application: Inhalation
Dose: 3480 UG/M3
Exposure Time: 2H/1Y-
Frequency: I
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Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Olfaction:Tumors.
IARC CARCINOGEN LIST
Rating: Group 1
NTP CARCINOGEN LIST
Rating: Known to be carcinogenic.
ACGIH CARCINOGEN LIST
Rating: A1
CHRONIC EXPOSURE - TERATOGEN
Species: Mouse
Dose: 20 MG/KG
Route of Application: Subcutaneous
Exposure Time: (8D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Hamster
Dose: 5 MG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Specific Developmental Abnormalities: Homeostasis
Specific Developmental Abnormalities: Craniofacial (including
nose and tongue). Specific Developmental Abnormalities: Central
nervous system.
Species: Hamster
Dose: 8 MG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Specific Developmental Abnormalities: Body wall.
CHRONIC EXPOSURE - MUTAGEN
Species: Human
Dose: 100 NMOL/L
Cell Type: fibroblast
Mutation test: Morphological transformation.
Species: Human
Dose: 2 MG/L
Cell Type: leukocyte
Mutation test: Cytogenetic analysis
Species: Mouse
Route: Oral
Dose: 20 MG/KG
Mutation test: Cytogenetic analysis
Species: Mouse
Dose: 1 UMOL/L
Exposure Time: 48H
Cell Type: mammary gland
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Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 1 UMOL/L
Cell Type: ovary
Mutation test: Micronucleus test
Species: Hamster
Dose: 68 UG/L
Cell Type: Embryo
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 250 UG/L
Cell Type: ovary
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 250 UG/L
Cell Type: ovary
Mutation test: Sister chromatid exchange
Species: Hamster
Dose: 320 UG/L
Cell Type: fibroblast
Mutation test: Sister chromatid exchange
Species: Hamster
Dose: 6 UMOL/L
Cell Type: ovary
Mutation test: Mutation in mammalian somatic cells.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Hamster
Dose: 7500 UG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Hamster
Dose: 7500 UG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Homeostasis
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
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Section 14 - Transport Information
DOT
Proper Shipping Name: Chromium trioxide, anhydrous
UN#: 1463
Class: 5.1
Packing Group: Packing Group II
Hazard Label: Oxidizer
Hazard Label: Corrosive
PIH: Not PIH
IATA
Proper Shipping Name: Chromium trioxide, anhydrous
IATA UN Number: 1463
Hazard Class: 5.1
Packing Group: II
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: O T C N
Indication of Danger: Oxidizing. Toxic. Corrosive. Dangerous for
the environment.
R: 49 8 25 35 43 50/53
Risk Statements: May cause cancer by inhalation. Contact with
combustible material may cause fire. Also toxic if swallowed.
Causes severe burns. May cause sensitization by skin contact.
Very toxic to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
S: 53 45 60
Safety Statements: Restricted to professional users. Attention -
Avoid exposure - obtain special instructions before use. In case
of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). This material and
its container must be disposed of as hazardous waste.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Oxidizing. Toxic.
Risk Statements: May cause cancer by inhalation. Contact with
combustible material may cause fire. Toxic if swallowed. Causes
severe burns. Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Statements: Keep away from combustible material. After
contact with skin, wash immediately with plenty of water. Take
off immediately all contaminated clothing. In case of accident
or if you feel unwell, seek medical advice immediately (show the
label where possible). Wear suitable protective clothing,
gloves, and eye/face protection. Do not breathe dust.
US Statements: Target organ(s): Lungs. Kidneys.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 0.1 %
NOTES: This product is subject to SARA section 313 reporting
requirements - chromium compounds.
TSCA INVENTORY ITEM: Yes
UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65
California Prop - 65: This product is or contains chemical(s)
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known to the state of California to cause cancer.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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