SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 14/JUN/2005
Date Updated: 12/MAR/2004
Version 1.7
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name 2,6-DI-TERT-BUTYL-P-CRESOL
Product Number 34750
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
BUTYLATED HYDROXYTOLUENE 128-37-0 204-881-4 None
Formula C15H24O
Molecular Weight 220.36 AMU
Synonyms Advastab 401 * Agidol * Agidol 1 * Alkofen BP *
Antioxidant DBPC * Antioxidant 4 * Antioxidant
29 * Antioxidant 30 * Antioxidant 4K *
Antioxidant KB * Antrancine 8 * AO 29 * AO 4K *
BHT * BHT (food grade) *
2,6-Bis(1,1-dimethylethyl)-4-methylphenol * BUKS
* Butylated hydroxytoluene * Butylhydroxytoluene
* Butylohydroksytoluenu (Polish) * CAO 1 * CAO 3
* Catalin cao-3 * Chemanox 11 * Dalpac * DBMP *
DBPC * DBPC (technical grade) * Deenax * Dibunol
* Dibutylated hydroxytoluene *
2,6-Di-tert-butyl-p-cresol (ACGIH) *
2,6-Di-terc.butyl-p-kresol (Czech) *
2,6-Di-tert-butyl-1-hydroxy-4-methylbenzene *
3,5-Di-tert-butyl-4-hydroxytoluene *
2,6-Di-tert-butyl-p-methylphenol *
2,6-Di-tert-butyl-4-methylphenol *
4-Hydroxy-3,5-di-tert-butyltoluene * Impruvol *
Ionol * Ionol 1 * Ionol (antioxidant) * Ionol CP
* Ionole * Kerabit * 4-Methyl-2,6-di-terc.
butylfenol (Czech) * Methyldi-tert-butylphenol *
4-Methyl-2,6-di-tert-butylphenol * NCI-C03598 *
Nocrac 200 * Nonox TBC * P 21 * Parabar 441 *
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Irritating to eyes, respiratory system and
skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
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EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 10 mg/m3
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 10 mg/m3, E
Remarks: 29,NL
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 10 mg/m3
Remarks: E
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 10 mg/m3
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 265 掳C 760 mmHg
MP/MP Range 69 - 70 掳C
Flash Point 127 掳C Method: closed cup
Flammability N/A
Autoignition Temp 470 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 0.01 mmHg 20 掳C
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density 7.6 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Acid chlorides, Acid anhydrides, Oxidizing
agents, Bases, Brass Copper, Copper alloys.
HAZARDOUS DECOMPOSITION PRODUCTS
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Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: GO7875000
ACUTE TOXICITY
LD50
Oral
Rat
890 mg/kg
LD50
Oral
Mouse
650 mg/kg
Remarks: Behavioral:Tremor. Lungs, Thorax, or
Respiration:Chronic pulmonary edema.
LD50
Intraperitoneal
Mouse
138 MG/KG
Remarks: Lungs, Thorax, or Respiration:Chronic pulmonary edema.
Lungs, Thorax, or Respiration:Other changes. Blood: Hemorrhage.
LD50
Intravenous
Mouse
180 MG/KG
Remarks: Behavioral:Sleep.
LD50
Oral
Guinea pig
10700 mg/kg
Remarks: Gastrointestinal:Hypermotility, diarrhea.
Behavioral:Tremor. Lungs, Thorax, or Respiration:Respiratory
depression.
IRRITATION DATA
Skin
Human
500 mg
48H
Remarks: Mild irritation effect
Skin
Rabbit
500 mg
48H
Remarks: Moderate irritation effect
Eyes
Rabbit
100 mg
24H
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Remarks: Moderate irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 32W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Kidney,
Ureter, Bladder:Tumors. Tumorigenic:Cells (cultured) transformed.
Mouse
Route of Application: Oral
Exposure Time: 69W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Lungs,
Thorax, or Respiration:Tumors. Gastrointestinal:Tumors.
Rat
Route of Application: Oral
Exposure Time: 3Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Tumorigenic
Effects: Uterine tumors. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 3Y
Result: Tumorigenic:Neoplastic by RTECS criteria. Tumorigenic
Effects: 0varian tumors.
Mouse
Route of Application: Oral
Exposure Time: 43W
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Rat
Route of Application: Oral
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
Rat
Route of Application: Oral
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Gastrointestinal:Tumors.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
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Human
500 UMOL/L
Cell Type: HeLa cell
DNA inhibition
Human
20 UMOL/L
Cell Type: lymphocyte
DNA inhibition
Rat
1400 MG/KG
Oral
DNA damage
Rat
16800 MG/KG
Oral
4W
Unscheduled DNA synthesis
Rat
100 PMOL/L
Cell Type: liver
Unscheduled DNA synthesis
Rat
1200 MG/KG
Intraperitoneal
3D
Unscheduled DNA synthesis
Rat
5460 MG/KG
Oral
10W
Dominant lethal test
Mouse
6 MG/L (+S9)
Cell Type: lymphocyte
Mutation in microorganisms
Mouse
500 MG/KG
Oral
Other mutation test systems
Mouse
250 MG/KG
Intraperitoneal
DNA inhibition
Mouse
12 GM/KG
Oral
10W
Dominant lethal test
Mouse
6 MG/L
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Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Mouse
350 MG/KG
Intraperitoneal
5D
sperm
Hamster
100 UG/L
Cell Type: ovary
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Species: Mouse
Dose: 1200 MG/KG
Route of Application: Oral
Exposure Time: (9D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 6 GM/KG
Route of Application: Oral
Exposure Time: (13W MALE/13W PRE-3W POST)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Rat
Dose: 18 GM/KG
Route of Application: Oral
Exposure Time: (2W MALE/2W PRE-3W POST)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Newborn: Behavioral.
Species: Rat
Dose: 9 GM/KG
Route of Application: Oral
Exposure Time: (2W MALE/2W PRE-3W POST)
Result: Effects on Newborn: Weaning or lactation index (e.g., #
alive at weaning per # alive at day 4).
Species: Rat
Dose: 35 GM/KG
Route of Application: Oral
Exposure Time: (10W MALE)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Mouse
Dose: 43800 MG/KG
Route of Application: Oral
Exposure Time: (52D PRE/1-21D PREG)
Result: Maternal Effects: Parturition. Effects on Newborn:
Weaning or lactation index (e.g., # alive at weaning per # alive
at day 4). Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
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Species: Mouse
Dose: 12600 MG/KG
Route of Application: Oral
Exposure Time: (1-21D PREG)
Result: Effects on Newborn: Behavioral.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Daphnia
Species: Daphnia pulex
Time: 48 h
Value: 1.44 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22 36/37/38
Harmful if swallowed. Irritating to eyes, respiratory system
and skin.
S-PHRASES: 26 36
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
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information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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