SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/MAY/2005
Date Updated: 13/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name THALLIUM(I) CHLORIDE, 99.999%
Product Number 229962
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
THALLIUM(I) CHLORIDE 7791-12-0 232-241-4 081-002-00-9
Formula TlCl
Molecular Weight 239.82 AMU
Synonyms RCRA waste number U216 * Thallium chloride *
Thallium(1+) chloride * Thallium monochloride *
Thallous chloride
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Very toxic by inhalation and if swallowed. Danger of cumulative
effects. Toxic to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
GENERAL INFORMATION
For thallium antidote, see Eur. J. Pharmacol., 6, 340 (1969).
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 0.1 mg/m3
Remarks: SKIN
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL TWA 0.1MG(TL)/M3
Remarks: Skin
PERSONAL PROTECTIVE EQUIPMENT
ALDRICH - 229962 www.sigma-aldrich.com Page 2
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 430 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 10 mmHg 517 掳C
SG/Density 7 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May discolor on exposure to light.
Conditions to Avoid: Moisture.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Thallium.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: XG4200000
ACUTE TOXICITY
LD50
Oral
Mouse
24 mg/kg
ALDRICH - 229962 www.sigma-aldrich.com Page 3
LD50
Intraperitoneal
Mouse
23982 UG/KG
LD50
Intraperitoneal
Rabbit
150 MG/KG
Remarks: Gastrointestinal:Hypermotility, diarrhea. Kidney,
Ureter, Bladder:Other changes.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
The most characteristic symptom of thallium exposure is alopecia
(loss of hair). Cutaneous effects may include dry, scaly skin
and impairment of nail growth often resulting in the appearance
of crescent-shaped strips across fingernails and toenails (Mees'
line). Other symptoms in acute poisoning relate chiefly to the
gastrointestinal tract, nervous system, skin, eyes, and
cardiovascular system. Acute poisoning results in swelling of
the feet and legs, arthralgia, vomiting, insomnia, hyperesthesia
and paresthesia of the hands and feet, mental confusion,
polyneuritis with severe pain in the legs and loins, partial
paralysis of the legs, angina-like pains, nephritis, wasting and
weakness, and lymphocytosis and eosinophilia. In chronic
poisoning, central and peripheral nervous system abnormalities
may persist including ataxia, tremor, incoordination, paralysis
of extremities, endocrine disorders, memory loss, and psychoses
may develop.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation. Can cause blindness.
Inhalation: May be fatal if inhaled. Material may be irritating
to mucous membranes and upper respiratory tract.
Ingestion: May be fatal if swallowed.
TARGET ORGAN INFORMATION
Nerves. Cardiovascular system. Eyes. Skin. Liver. Kidneys. Male
reproductive system.
CHRONIC EXPOSURE - MUTAGEN
Hamster
100 UMOL/L
Cell Type: Embryo
Morphological transformation.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 30 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
12 - Ecological Information
ALDRICH - 229962 www.sigma-aldrich.com Page 4
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1707
Class: 6.1
PG: II
Proper Shipping Name: Thallium compound, n.o.s..
IMDG
UN#: 1707
Class: 6.1
PG: II
Proper Shipping Name: THALLIUM COMPOUND, N.O.S.
Marine Pollutant: Yes
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 1707
Class: 6.1
PG: II
Proper Shipping Name: THALLIUM COMPOUND, N.O.S.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 081-002-00-9
NOTA: A
INDICATION OF DANGER: T+ N
Very toxic. Dangerous for the environment.
R-PHRASES: 26/28 33 51/53
Very toxic by inhalation and if swallowed. Danger of cumulative
effects. Toxic to aquatic organisms, may cause long-term
adverse effects in the aquatic environment.
S-PHRASES: 13 28 45 61
Keep away from food, drink, and animal feedingstuffs. After
contact with skin, wash immediately with plenty of soap-suds.
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). Avoid release to
the environment. Refer to special instructions/safety data
sheets.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
ALDRICH - 229962 www.sigma-aldrich.com Page 5
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
ALDRICH - 229962 www.sigma-aldrich.com Page 6
|