SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/MAY/2005
Date Updated: 13/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name TETRAMETHYL ORTHOSILICATE, 98%
Product Number 218472
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
TETRAMETHOXYSILANE 681-84-5 211-656-4 None
Formula C4H12O4Si
Molecular Weight 152.22 AMU
Synonyms Methyl silicate (ACGIH) * Silicic acid, methyl
ester of ortho- * Tetramethoxysilane *
Tetramethyl silicate * Tetramethylsilikat
(Czech) * TL 190
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Very toxic by inhalation. Irritating to respiratory
system and skin. Risk of serious damage to eyes.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Vapor may travel
considerable distance to source of ignition and flash back.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions. Forms explosive mixtures in air.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
SPECIFIC METHOD(S) OF FIRE FIGHTING
Use water spray to cool fire-exposed containers.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame.
SPECIAL REQUIREMENTS: Readily hydrolyzed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath. Use
nonsparking tools.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Discard contaminated clothing and
shoes.
EXPOSURE LIMITS - DENMARK
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Source Type Value
OEL TWA 6 mg/m3
1 ppm
Remarks: L
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 6 mg/m3
Remarks: NL
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 6 mg/m3
1 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 6 mg/m3
1 ppm
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 6.3 mg/m3
1 ppm
OEL STEL 32 mg/m3
5 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 120 - 122 掳C
MP/MP Range -4 掳C
Flash Point 26 掳C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 0.88 %
Upper: 23.8 %
Vapor Pressure 173.195 mmHg 20 掳C
SG/Density 1.032 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 5.25 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
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Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May decompose on exposure to moist air
or water.
Materials to Avoid: Oxidizing agents, Acids, Bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Silicon oxide, Methanol.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: VV9800000
ACUTE TOXICITY
LC50
Inhalation
Rat
400 mg/m3
4H
LD50
Intraperitoneal
Rat
100 MG/KG
LD50
Intraperitoneal
Mouse
250 MG/KG
LD50
Skin
Rabbit
17 ML/KG
LD50
Oral
Mammal
1000 mg/kg
IRRITATION DATA
Eyes
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Warning: avoid eye contact because tetramethyl orthosilicate
undergoes hydrolysis readily, producing methanol which causes
irreversible blindness. Contact with moisture liberates
methanol. Ingestion of methanol may cause blindness, nausea,
headache, vomiting, gastrointestinal upset, dizziness, irregular
breathing, weakness, confusion, drowsiness, unconsciousness, and
death. Material is extremely destructive to tissue of the mucous
ALDRICH - 218472 www.sigma-aldrich.com Page 4
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes severe eye irritation. Can cause blindness.
Inhalation: Highly toxic by inhalation. Material is irritating
to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Eyes. Kidneys. Lungs.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2606
Class: 6.1
PG: I
Proper Shipping Name: Methyl orthosilicate
IMDG
UN#: 2606
Class: 6.1
PG: I
Subrisk: 3
Proper Shipping Name: Methyl orthosilicate
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2606
Class: 6.1
PG: I
Subrisk: 3
Proper Shipping Name: Methyl orthosilicate
Inhalation Packing Group I: Yes
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T+
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Very toxic.
R-PHRASES: 10 26 37/38 41
Flammable. Very toxic by inhalation. Irritating to respiratory
system and skin. Risk of serious damage to eyes.
S-PHRASES: 16 26 36/37/39 45
Keep away from sources of ignition - no smoking. In case of
contact with eyes, rinse immediately with plenty of water and
seek medical advice. Wear suitable protective clothing, gloves,
and eye/face protection. In case of accident or if you feel
unwell, seek medical advice immediately (show the label where
possible).
SWITZERLAND
SWISS POISON CLASS: 2
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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