SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/MAY/2005
Date Updated: 08/SEP/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ETHYLMERCURITHIOSALICYLIC ACID, SODIUM
SALT
Product Number E35257
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
THIMEROSAL 54-64-8 200-210-4 080-004-00-7
Formula C9H9HgO2S.Na
Molecular Weight 404.81 AMU
Synonyms ((o-Carboxyphenyl)thio)ethylmercury sodium salt
* Elicide * Ethyl(2-mercaptobenzoato-S)mercury
sodium salt * o-(Ethylmercurithio)benzoic acid
sodium salt * Ethylmercurithiosalicylic acid
sodium salt * Ethylmerkurithiosalicilan sodny
(Czech) * Ethyl (sodium
o-mercaptobenzoato)mercury * Mercurate(1-),
ethyl(2-mercaptobenzoate(2-)-O,S)-, sodium salt
* Mercurothiolate * Mercury,
ethyl(2-mercaptobenzoate-S)-, sodium sal *
Merfamin * Merthiolate * Merthiolate sodium *
Mertorgan * Merzonin * Merzonin sodium * SET *
Sodium ethylmercuric thiosalicylate * Sodium
o-(ethylmercurithio)benzoate * Sodium
ethylmercurithiosalicylate * Sodium merthiolate
* Thimerosal * Thimerosalate * Thiomersal *
Thiomersalate
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Very toxic by inhalation, in contact with skin and if swallowed.
Danger of cumulative effects. Very toxic to aquatic organisms, may
cause long-term adverse effects in the aquatic environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXPLOSION DATA
Dust Potential: This material, like most materials in powder
form, is capable of creating a dust explosion.
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
ALDRICH - E35257 www.sigma-aldrich.com Page 2
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 0.05 mg/m3
Remarks: SKIN
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL LTEL 0.05 MG(HG)/M3
OEL STEL 0.15 mg(Hg)/m3
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: Slightly beige
Form: Powder
Property Value At Temperature or Pressure
pH 6.7 - 8.2 20 掳C Concentration: 10
g/l
BP/BP Range N/A
MP/MP Range 234 掳C
Flash Point 250 掳C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 0.5 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density 500 kg/l
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solvent: 0.1 g/ml MeOH Clear
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May discolor on exposure to light.
Materials to Avoid: Strong oxidizing agents, Strong acids, Strong
bases.
ALDRICH - E35257 www.sigma-aldrich.com Page 3
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide
Mercury/mercury oxides., Sulfur oxides
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: OV8400000
ACUTE TOXICITY
LD50
Oral
Rat
98 mg/kg
LDLO
Intraaural
Child
60 MG/KG
4W-I
Remarks: Behavioral:Ataxia. Gastrointestinal:Nausea or vomiting.
Nutritional and Gross Metabolic:Changes in:Metabolic acidosis.
LD50
Oral
Rat
75 mg/kg
LD50
Subcutaneous
Rat
98 MG/KG
LD50
Oral
Mouse
91 mg/kg
LD50
Intraperitoneal
Mouse
54 MG/KG
LD50
Subcutaneous
Mouse
66 MG/KG
LD50
Intravenous
Mouse
45 MG/KG
Remarks: Kidney, Ureter, Bladder:Changes in tubules (including
acute renal failure, acute tubular necrosis).
IRRITATION DATA
Eyes
Rabbit
0.008 mg
ALDRICH - E35257 www.sigma-aldrich.com Page 4
Remarks: Mild irritation effect
SENSITIZATION
Sensitization: Prolonged or repeated exposure may cause allergic
reactions in certain sensitive individuals.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be fatal if absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: May be fatal if inhaled. Material may be irritating
to mucous membranes and upper respiratory tract.
Ingestion: May be fatal if swallowed.
TARGET ORGAN INFORMATION
Nerves. Kidneys.
CHRONIC EXPOSURE - CARCINOGEN
Rat
Route of Application: Subcutaneous
Exposure Time: 1Y
Result: Tumorigenic:Neoplastic by RTECS criteria. Tumorigenic
Effects: Uterine tumors Tumorigenic:Tumors at site or
application.
CHRONIC EXPOSURE - MUTAGEN
Human
9 MG/L
Cell Type: lymphocyte
SLN
Mouse
45 MG/KG
Intraperitoneal
Micronucleus test
Mouse
45 MG/KG
Intraperitoneal
SLN
Hamster
125 UG/L
Cell Type: lung
Micronucleus test
Hamster
900 UG/L
Cell Type: Embryo
Other mutation test systems
Hamster
450 UG/L
Cell Type: Embryo
SLN
ALDRICH - E35257 www.sigma-aldrich.com Page 5
Hamster
125 UG/L
Cell Type: lung
SLN
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 1300 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (6-18D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Rabbit
Dose: 112 MG/KG
Route of Application: Ocular
Exposure Time: (6-18D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Rabbit
Dose: 65 UG/KG
Route of Application: Ocular
Exposure Time: (6-18D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 130 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (6-18D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Abortion.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2025
Class: 6.1
PG: III
Proper Shipping Name: Mercury compound, solid, n.o.s.
IMDG
UN#: 2025
Class: 6.1
PG: III
Proper Shipping Name: MERCURY COMPOUND, SOLID, N.O.S.
Marine Pollutant: No
ALDRICH - E35257 www.sigma-aldrich.com Page 6
Severe Marine Pollutant: Yes
Technical Name: Required
IATA
UN#: 2025
Class: 6.1
PG: III
Proper Shipping Name: Mercury compound, solid, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 080-004-00-7
NOTA: A, 1
INDICATION OF DANGER: T+ N
Very toxic. Dangerous for the environment.
R-PHRASES: 26/27/28 33 50/53
Very toxic by inhalation, in contact with skin and if
swallowed. Danger of cumulative effects. Very toxic to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment.
S-PHRASES: 13 28 36 45 60 61
Keep away from food, drink, and animal feedingstuffs. After
contact with skin, wash immediately with plenty of soap-suds.
Wear suitable protective clothing. In case of accident or if
you feel unwell, seek medical advice immediately (show the
label where possible). This material and its container must be
disposed of as hazardous waste. Avoid release to the
environment. Refer to special instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
ALDRICH - E35257 www.sigma-aldrich.com Page 7
|