SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 18/AUG/2005
Date Updated: 03/MAR/2005
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name MERCAPTOACETIC ACID, 99+% (TGA99)
(WORLD WIDE EXCEPT NORTH AMERICA)
Product Number 528056
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
THIOGLYCOLIC ACID 68-11-1 200-677-4 607-090-00-6
Formula C2H4O2S
Molecular Weight 92.12 AMU
Synonyms Acide thioglycolique (French) * Glycolic acid,
thio- * Glycolic acid, 2-thio- * Kyselina
merkaptooctova (Czech) * Kyselina thioglykolova
(Czech) * Mercaptoacetate * Mercaptoacetic acid
* alpha-Mercaptoacetic acid * 2-Mercaptoacetic
acid * Thioglycolic acid * 2-Thioglycolic acid *
Thioglycolic acid (ACGIH) * Thioglycollic acid *
Thiovanic acid * USAF CB-35
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic by inhalation, in contact with skin and if swallowed. Causes
burns.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at 2-8掳C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 4 MG/M3
Poland NDSCh 8 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
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OEL TWA 5 mg/m3
1 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 4 mg/m3
Remarks: H,NL
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 5 mg/m3
1 ppm
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level4 mg/m3
1 ppm
Remarks: H
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 4 mg/m3
1 ppm
Remarks: H
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 3.8 mg/m3
1 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH 1.5 20 掳C Concentration: 10
g/l
BP/BP Range 96 掳C 5 mmHg
MP/MP Range -16 掳C
Flash Point 130 掳C Method: closed cup
Flammability N/A
Autoignition Temp 350 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 5.9 %
Vapor Pressure 0.4 mmHg 25 掳C
SG/Density 1.325 g/cm3
Partition Coefficient Log Kow: 0.059
Viscosity 6.55 Pas 20 掳C
Vapor Density 3.2 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
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Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Miscible.
Other Solvents: MISCIBLE WITH ALCOHOL,
ETHER CHLOROFORM, BENZENE
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Strong acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Sulfur oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: AI5950000
ACUTE TOXICITY
LC50
Inhalation
Rat
21 mg/m3
4
LD50
Skin
Rabbit
848 mg/kg
LD50
Oral
Rat
114 mg/kg
LD50
Intraperitoneal
Rat
70 MG/KG
LD50
Oral
Mouse
242 mg/kg
LD50
Skin
Mouse
47 mg/kg
Remarks: Behavioral:Tremor. Behavioral:Convulsions or effect on
seizure threshold.
LD50
Intraperitoneal
Mouse
138 MG/KG
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LD50
Intravenous
Mouse
145 MG/KG
LD50
Oral
Rabbit
119 mg/kg
LD50
Intravenous
Rabbit
100 MG/KG
LD50
Oral
Guinea pig
126 mg/kg
LD50
Intraperitoneal
Guinea pig
157 MG/KG
LD50
Oral
Mammal
250 mg/kg
IRRITATION DATA
Skin
Human
3%
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting.
ROUTE OF EXPOSURE
Skin Contact: Causes burns. Causes blisters on contact with skin.
Skin Absorption: May be fatal if absorbed through skin. Readily
absorbed through skin.
Eye Contact: Causes burns.
Inhalation: May be fatal if inhaled.
Ingestion: Toxic if swallowed.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 30 mg/l
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Test Type: LC50 Fish
Species: Leuciscus idus
Value: 103 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1940
Class: 8
PG: II
Proper Shipping Name: Thioglycolic acid
IMDG
UN#: 1940
Class: 8
PG: II
Proper Shipping Name: Thioglycolic acid
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1940
Class: 8
PG: II
Proper Shipping Name: Thioglycolic acid
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 607-090-00-6
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 23/24/25 34
Toxic by inhalation, in contact with skin and if swallowed.
Causes burns.
S-PHRASES: 25 27 28 45
Avoid contact with eyes. Take off immediately all contaminated
clothing. After contact with skin, wash immediately with plenty
of soap-suds. In case of accident or if you feel unwell, seek
medical advice immediately (show the label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 2
16 - Other Information
WARRANTY
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The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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