SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/MAY/2005
Date Updated: 13/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name THIOUREA
Product Number T7875
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
THIOUREA 62-56-6 200-543-5 612-082-00-0
Formula CH4N2S
Molecular Weight 76.12 AMU
Synonyms Isothiourea * Pseudothiourea * RCRA waste number
U219 * Sulourea * Thiocarbamide * Thiocarbonic
acid diamide * Thiomocovina (Czech) *
beta-Thiopseudourea * 2-Thiopseudourea *
Thiourea * 2-Thiourea * THU * Tsizp 34 * Urea,
thio- (8CI) * USAF EK-497
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Limited evidence of a carcinogenic effect.
Toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment. Possible risk of harm to the unborn child.
Carc. Cat.3 Repr. Cat.3
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Fine crystals
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Property Value At Temperature or Pressure
pH 5-7 20 掳C Concentration: 50
g/l
BP/BP Range N/A
MP/MP Range 176 - 178 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp 440 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 1.405 g/cm3 20 掳C
Partition Coefficient Log Kow: -0.92
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density 0.64 kg/l
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:soluble
Other Solvents: ALCOHOL, AMMONIUM
THIOCYANATE
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Heat.
Materials to Avoid: Strong oxidizing agents, Strong acids, Strong
bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Sulfur oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: YU2800000
ACUTE TOXICITY
LC50
Inhalation
Rat
> 170 mg/m3
4H
LD50
Skin
Rabbit
> 2,800 mg/kg
LD50
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Oral
Rat
125 mg/kg
LD50
Intraperitoneal
Rat
436 MG/KG
LD50
Intraperitoneal
Mouse
100 MG/KG
LD50
Intraperitoneal
Mammal
3500 MG/KG
IRRITATION DATA
Eyes
Rabbit
14 %
SENSITIZATION
Skin: May cause allergic skin reaction.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Liver. Thyroid. Bone marrow.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be possibly carcinogenic based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 56W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Eye:Tumors. Sense
Organs and Special Senses (Nose, Eye, Ear, and Taste):Ear:Tumors.
Rat
Route of Application: Multiple
Exposure Time: 52W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Eye:Tumors. Sense
Organs and Special Senses (Nose, Eye, Ear, and Taste):Ear:Tumors.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
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Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Multiple effects. Lungs, Thorax, or
Respiration:Other changes.
Rat
Route of Application: Multiple
Exposure Time: 1Y
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Skin and Appendages: Other: Tumors.
Rat
Route of Application: Oral
Exposure Time: 1Y
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Endocrine:Thyroid tumors.
IARC CARCINOGEN LIST
Rating: Group 2B
CHRONIC EXPOSURE - MUTAGEN
Mutation test: Histidine reversion (Ames)
Human
60 MMOL/L
Cell Type: fibroblast
DNA inhibition
Human
20 MMOL/L
Cell Type: lymphocyte
DNA inhibition
Human
140 MMOL/L
Cell Type: HeLa cell
DNA inhibition
Rat
100 MG/L
Cell Type: Embryo
Morphological transformation.
Rat
30 MMOL/L
Cell Type: liver
DNA damage
Rat
10 MMOL/L
Cell Type: liver
Unscheduled DNA synthesis
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Mouse
18 MMOL/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Mouse
125 MG/KG
Cell Type: S. typhimurium
Host-mediated assay
Hamster
100 UG/L
Cell Type: Embryo
Morphological transformation.
Hamster
100 UG/L
Cell Type: Embryo
Morphological transformation.
Hamster
10 MMOL/L
Cell Type: lung
Mutation in mammalian somatic cells.
CHRONIC EXPOSURE - TERATOGEN
Result: Possible risk of congenital malformation in the fetus.
Species: Rat
Dose: 240 MG/KG
Route of Application: Oral
Exposure Time: (12D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 1400 MG/KG
Route of Application: Oral
Exposure Time: (16-22D PREG)
Result: Specific Developmental Abnormalities: Endocrine system.
Species: Rat
Dose: 4800 MG/KG
Route of Application: Oral
Exposure Time: (17-22D PREG/10D POST)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 1 GM/KG
Route of Application: Oral
Exposure Time: (12D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Mouse
Dose: 1 GM/KG
Route of Application: Oral
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Exposure Time: (10D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Hamster
Dose: 22400 MG/KG
Route of Application: Oral
Exposure Time: (10W PRE)
Result: Maternal Effects: Uterus, cervix, vagina. Maternal
Effects: Other effects.
Species: Domestic Animals
Dose: 9 GM/KG
Route of Application: Oral
Exposure Time: (90D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Other effects on male.
SWEDISH OE CARCINOGEN: Substances which according to 23搂, AFS
2000:3, is allowed to use only after authorization from The
Swedish Work Environment Authority.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 5.6 - 18 mg/l
Test Type: LC50 Fish
Species: Brachydanio rerio
Time: 96 h
Value: 10,000 mg/l
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 48 h
Value: > 10,000 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 110 mg/l
Test Type: EC50 Algae
Species: Scenedesmus subspicatus
Time: 96 h
Value: 6.8 mg/l
Test Type: EC50 Algae
Time: 96 h
Value: 4.8 - 1 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
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environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
IMDG
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 612-082-00-0
INDICATION OF DANGER: Xn N
Harmful. Dangerous for the environment.
R-PHRASES: 22 40 51/53 63
Harmful if swallowed. Limited evidence of a carcinogenic
effect. Toxic to aquatic organisms, may cause long-term adverse
effects in the aquatic environment. Possible risk of harm to
the unborn child.
S-PHRASES: 36/37 61
Wear suitable protective clothing and gloves. Avoid release to
the environment. Refer to special instructions/safety data
sheets.
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
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For R&D use only. Not for drug, household or other uses.
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