SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 24/MAY/2005
Date Updated: 20/MAR/2004
Version 1.1
According to 91/155/EEC
1 - Product and Company Information
Product Name SUCCINYLCHOLINE CHLORIDE DIHYDRATE
Product Number 85980
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
SUCCINYLCHOLINE CHLORIDE 71-27-2 200-747-4 None
DIHYDRATE*
Formula C14H30N2O4.2Cl
Molecular Weight 397.3 AMU
Synonyms Anectine * Anectine chloride *
Bis(2-dimethylaminoethyl)succinate
bis(methochloride) *
Bis(succinyldichlorocholine) *
Chlorsuccinylcholin (German) * Chlorure de
succinilcoline (French) * Choline succinate
dichloride * Choline, succinyl-, dichloride *
Cloruro di succinilcolina (Italian) *
Diacetylcholine chloride * Diacetylcholine
dichloride * 2-Dimethylaminoethyl succinate
dimethochloride * Ethanaminium,
2,2'-((1,4-dioxo-1,4-butanediyl)bis(oxy))bis(N,N,
N-trimethyl-, dichloride *
(2-Hydroxyethyl)trimethylammonium chloride
succinate * Lysthenon * Lysthenone * Midarine *
Myoplegine * Pantolax * Quelicin chloride *
Scoline * Scoline chloride * Skolin * Succicuran
* Succinic acid, bis(beta-dimethylaminoethyl)
ester, dimethochloride * Succinic acid, diester
with choline chloride * Succinoylcholine
chloride * Succinyl-asta * Succinyl bischoline
chloride * Succinylbischoline dichloride *
Succinylcholine chloride * Succinylcholine
3 - Hazards Identification
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing.
STORAGE
Conditions of Storage: Keep tightly closed. Store in a cool dry
place.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Special Protective Measures: Wear appropriate government approved
FLUKA - 85980 www.sigma-aldrich.com Page 2
respirator, chemical-resistant gloves, safety goggles, other
protective clothing.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: Light.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: GA2360000
ACUTE TOXICITY
LD50
Intraperitoneal
Mouse
1250 UG/KG
LD50
Intravenous
Mouse
430 UG/KG
FLUKA - 85980 www.sigma-aldrich.com Page 3
Remarks: Peripheral Nerve and Sensation:Flaccid paralysis
without anesthesia (usually neuromuscular blockage).
Behavioral:Altered sleep time (including change in righting
reflex). Lungs, Thorax, or Respiration:Cyanosis.
LD50
Intravenous
Rabbit
240 UG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Other. Behavioral:Altered sleep time (including
change in righting reflex). Behavioral:Rigidity (includes
catalepsy).
LD50
Intravenous
Chicken
300 UG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure may be implicated in the development of malignant
hyperpyrexia in those with a genetic predispostion to the
syndrome. Exposure can cause bradycardia, tachycardia,
hypertension, hypotension, cardiac arrhythmias, cardiac arrest,
and a profound and prolonged muscle relaxation resulting in
respiratory depression.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract.
Multiple Routes: May be harmful by inhalation, ingestion, or
skin absorption.
TARGET ORGAN INFORMATION
Skeletal muscle.
CHRONIC EXPOSURE - MUTAGEN
Human
300 UG/CULTURE
Cell Type: leukocyte
Sister chromatid exchange
Mouse
2500 UG/KG
Parenteral
Sister chromatid exchange
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.
FLUKA - 85980 www.sigma-aldrich.com Page 4
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
S-PHRASES: 22 24/25
Do not breathe dust. Avoid contact with skin and eyes.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
FLUKA - 85980 www.sigma-aldrich.com Page 5
|