SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 24/MAY/2005
Date Updated: 14/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name STREPTOZOCIN
Product Number 85882
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
STREPTOZOCIN 18883-66-4 242-646-8 None
Formula C8H15N3O7
Molecular Weight 265.23 AMU
Synonyms 2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D
-glucopyranose *
2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyran
ose *
2-Deoxy-2-(3-methyl-3-nitrosoureido)-alpha(and
beta)-D-glucopyranose * D-Glucopyranose,
2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-
* D-Glucose,
2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-
(9CI) * D-Glucose,
2-deoxy-2-(3-methyl-3-nitrosoureido)- *
N-d-Glucosyl(2)-N'-nitrosomethylharnstoff
(German * N-D-Glucosyl-(2)-N'-nitrosomethylurea
* NCI-C03167 * NSC-85598 * NSC-85998 * RCRA
waste number U206 * Streptozocin *
Streptozotocin * STRZ * U-9889 * Zanosar
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Limited evidence of a carcinogenic effect.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at -20掳C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator in
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nonventilated areas and/or for exposure above the TLV or PEL.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid.
Color: Slightly yellow
Form: Fine crystals
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 114 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Strong acids, Strong
bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: LZ5775000
ACUTE TOXICITY
LD50
Oral
Rat
5,150 mg/kg
LD50
Oral
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Mouse
3,000 mg/kg
LD50
Intravenous
Dog
25 - 50 mg/kg
LD50
Intravenous
Mouse
275 mg/kg
LD50
Intraperitoneal
Mouse
219 mg/kg
LD50
Subcutaneous
Mouse
335 mg/kg
LDLO
Intravenous
Woman
440 MG/KG
65W-I
Remarks: Gastrointestinal:Ulceration or bleeding from duodenum.
Kidney, Ureter, Bladder:Urine volume increased. Nutritional and
Gross Metabolic:Changes in:K
LD50
Intravenous
Rat
138 MG/KG
LD50
Intraperitoneal
Mouse
360 MG/KG
Remarks: Tumorigenic:Active as anti-cancer agent.
LD50
Subcutaneous
Mouse
335 MG/KG
LD50
Intravenous
Mouse
275 MG/KG
Remarks: Tumorigenic:Active as anti-cancer agent.
LD50
Parenteral
Mouse
264 MG/KG
Remarks: Tumorigenic:Active as anti-cancer agent.
LD50
Intravenous
Dog
50 MG/KG
Remarks: Tumorigenic:Active as anti-cancer agent.
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SIGNS AND SYMPTOMS OF EXPOSURE
Anemia. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated. Nausea. Vomiting.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Pancreas. Liver. Kidneys. Blood. Reproductive system.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be probably carcinogenic based on its IARC, OSHA,
ACGIH, NTP, or EPA classification.
Rat
Route of Application: Intraperitoneal
Exposure Time: 26W
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Kidney, Ureter, Bladder:Kidney tumors.
Rat
Route of Application: Intravenous
Result: Tumorigenic:Neoplastic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors.
Mouse
Route of Application: Intraperitoneal
Exposure Time: 26W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors. Kidney, Ureter, Bladder:Kidney tumors.
Mouse
Route of Application: Intravenous
Result: Tumorigenic:Carcinogenic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors.
Hamster
Route of Application: Intraperitoneal
Exposure Time: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors. Kidney, Ureter, Bladder:Kidney tumors.
Rat
Route of Application: Intravenous
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Gastrointestinal:Tumors. Kidney, Ureter,
Bladder:Kidney tumors.
Rat
Route of Application: Intravenous
Result: Tumorigenic:Neoplastic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors.
Rat
Route of Application: Intravenous
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Result: Tumorigenic:Neoplastic by RTECS criteria.
Gastrointestinal:Tumors. Kidney, Ureter, Bladder:Kidney tumors.
Rat
Route of Application: Intravenous
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
Rat
Route of Application: Intravenous
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors. Kidney, Ureter, Bladder:Kidney tumors.
Rat
Route of Application: Intravenous
Result: Tumorigenic:Neoplastic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors.
Rat
Route of Application: Intravenous
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Kidney, Ureter, Bladder:Kidney tumors.
Rat
Route of Application: Intravenous
Result: Tumorigenic:Neoplastic by RTECS criteria.
Gastrointestinal:Tumors.
Rat
Route of Application: Intravenous
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Gastrointestinal:Tumors.
IARC CARCINOGEN LIST
Rating: Group 2B
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
Human
50 MG/L
Cell Type: Other cell types
DNA damage
Human
1 MMOL/L
Cell Type: kidney
DNA damage
Human
100 UMOL/L
Cell Type: HeLa cell
DNA inhibition
Human
1 GM/L
3H
Cell Type: lung
DNA inhibition
Human
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500 MG/L
Cell Type: lung
Cytogenetic analysis
Human
100 UMOL/L
Cell Type: Other cell types
Sister chromatid exchange
Rat
2 MMOL/L
Cell Type: Other cell types
Morphological transformation.
Rat
1 MMOL/L
Cell Type: kidney
DNA damage
Rat
1 MMOL/L
Cell Type: Other cell types
DNA damage
Rat
20 MG/KG
Oral
DNA damage
Rat
300 UMOL/L
Cell Type: liver
DNA damage
Rat
250 MG/KG
Intraperitoneal
Unscheduled DNA synthesis
Rat
50 UMOL/L
Cell Type: liver
Unscheduled DNA synthesis
Rat
2 MMOL/L
Cell Type: Other cell types
Unscheduled DNA synthesis
Rat
200 UMOL/L
Cell Type: Other cell types
Sister chromatid exchange
Rat
111 MG/KG
Cell Type: S. typhimurium
Host-mediated assay
Mouse
150 MG/KG
Intraperitoneal
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DNA
Mouse
500 UMOL/L
Cell Type: leukocyte
DNA damage
Mouse
200 MG/KG
Cell Type: leukocyte
Other mutation test systems
Mouse
200 MG/KG
Cell Type: Other cell types
DNA inhibition
Mouse
12 MG/KG
Cell Type: S. typhimurium
Body fluid assay
Mouse
10 MG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Mouse
500 UG/KG
Cell Type: S. typhimurium
Host-mediated assay
Mouse
1 MG/KG
Cell Type: E. coli
Host-mediated assay
Hamster
250 MG/L
Cell Type: lung
DNA damage
Hamster
38 UMOL/L
Cell Type: ovary
Cytogenetic analysis
Hamster
189 UMOL/L
Cell Type: ovary
Sister chromatid exchange
Hamster
189 UMOL/L
Cell Type: lung
Sister chromatid exchange
Hamster
100 UMOL/L
Cell Type: ovary
Mutation in mammalian somatic cells.
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Hamster
500 UMOL/L
Cell Type: lung
Mutation in mammalian somatic cells.
CHRONIC EXPOSURE - TERATOGEN
Result: Laboratory experiments have shown teratogenic effects.
Species: Rat
Dose: 50 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D PRE)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord).
Species: Rat
Dose: 50 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (8D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus). Specific
Developmental Abnormalities: Cardiovascular (circulatory) system.
Species: Rat
Dose: 50 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (7D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Craniofacial (including nose and tongue).
Species: Rat
Dose: 50 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (12D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
Species: Rat
Dose: 35 MG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Rat
Dose: 30 MG/KG
Route of Application: Intravenous
Exposure Time: (5D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Newborn: Growth statistics
(e.g., reduced weight gain).
Species: Rat
Dose: 40 MG/KG
Route of Application: Intravenous
Exposure Time: (5D PREG)
Result: Specific Developmental Abnormalities: Endocrine system.
Effects on Newborn: Biochemical and metabolic.
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Species: Rat
Dose: 65 MG/KG
Route of Application: Unreported
Exposure Time: (5D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 70 MG/KG
Route of Application: Intravenous
Exposure Time: (1D PRE)
Result: Maternal Effects: Ovaries, fallopian tubes.
Species: Rat
Dose: 40 MG/KG
Route of Application: Intravenous
Exposure Time: (1D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Central nervous system.
Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
Species: Rat
Dose: 60 MG/KG
Route of Application: Intravenous
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rat
Dose: 40 MG/KG
Route of Application: Parenteral
Exposure Time: (1D PRE)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Specific Developmental Abnormalities: Other
developmental abnormalities.
Species: Hamster
Dose: 150 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (3D PRE)
Result: Maternal Effects: Menstrual cycle changes or disorders.
Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
per total number of implants).
Species: Domestic Animals
Dose: 100 MG/KG
Route of Application: Intravenous
Exposure Time: (85-95D PREG)
Result: Maternal Effects: Other effects. Endocrine:Diabetes
mellitus.
12 - Ecological Information
No data available.
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13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
IMDG
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 40
Limited evidence of a carcinogenic effect.
S-PHRASES: 36
Wear suitable protective clothing.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
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For R&D use only. Not for drug, household or other uses.
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