SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 24/MAY/2005
Date Updated: 14/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name STYRENE, REAGENTPLUS(TM), 99%
Product Number S4972
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
STYRENE 100-42-5 202-851-5 601-026-00-0
Formula C8H8
Molecular Weight 104.15 AMU
Synonyms Benzene, vinyl- * Cinnamene * Ethenylbenzene *
Ethylene, phenyl- * NCI-C02200 * Phenethylene *
Phenylethene * Phenylethylene (OSHA) * Stirolo
(Italian) * Styreen (Dutch) * Styren (Czech) *
Styrene (OSHA) * Styrene, monomer (ACGIH) *
Styrol (German) * Styrole * Styrolene *
Vinylbenzen (Czech) * Vinylbenzene * Vinyl
benzene (OSHA) * Vinylbenzol * Vinylbenzene *
Phenylethylene
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Harmful by inhalation. Irritating to eyes and skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
SPECIAL RISKS
Specific Hazard(s): Vapor may travel considerable distance to
source of ignition and flash back. Flammable liquid.
Explosion Hazards: Container explosion may occur under fire
conditions. Forms explosive mixtures in air.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
SPECIFIC METHOD(S) OF FIRE FIGHTING
Use water spray to cool fire-exposed containers.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame.
Store at 2-8掳C
SPECIAL REQUIREMENTS: Light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath. Use
nonsparking tools.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
ALDRICH - S4972 www.sigma-aldrich.com Page 2
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 50 MG/M3
Poland NDSCh 200 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 105 mg/m3
25 ppm
Remarks: LHK
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 85 mg/m3
20 ppm
Remarks: 4
Remarks: Y
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 105 mg/m3
25 ppm
Remarks: M
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level90 mg/m3
20 ppm
Remarks: H
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 85 mg/m3
20 ppm
Remarks: C M
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 430 mg/m3
100 ppm
OEL STEL 1,080 mg/m3
250 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 145 - 146 掳C 760 mmHg
MP/MP Range -31 掳C
Flash Point 32 掳C Method: closed cup
Flammability N/A
Autoignition Temp 480 掳C
ALDRICH - S4972 www.sigma-aldrich.com Page 3
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.1 %
Upper: 8.9 %
Vapor Pressure 4.3 mmHg 15 掳C
SG/Density 0.906 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 3.6 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Insoluble.
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: May polymerize on exposure to light.
Materials to Avoid: Oxidizing agents Copper, Copper alloys.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
STABILIZERS PRESENT
Inhibited with 10-15 ppm 4-tert-butylcatechol.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: May occur
11 - Toxicological Information
RTECS NUMBER: WL3675000
ACUTE TOXICITY
LCLO
Inhalation
Human
10,000 ppm
30M
LD50
Oral
Rat
2650 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Liver:Other changes.
LC50
Inhalation
Rat
12,000 mg/m3
4H
LD50
ALDRICH - S4972 www.sigma-aldrich.com Page 4
Intraperitoneal
Rat
898 MG/KG
LD50
Oral
Mouse
316 mg/kg
LC50
Inhalation
Mouse
9,500 mg/m3
4H
LD50
Intraperitoneal
Mouse
660 MG/KG
LD50
Intravenous
Mouse
90 MG/KG
LD50
Oral
Mammal
> 1500 mg/kg
IRRITATION DATA
Skin
Human
500 mg
Skin
Rabbit
500 mg
Remarks: Open irritation test
Skin
Rabbit
100 %
Remarks: Moderate irritation effect
Eyes
Rabbit
100 mg
Remarks: Severe irritation effect
Eyes
Rabbit
100 mg
24H
Remarks: Moderate irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Dermatitis. CNS depression. Nausea,
dizziness, and headache.
ROUTE OF EXPOSURE
ALDRICH - S4972 www.sigma-aldrich.com Page 5
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation. Lachrymator.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Central nervous system. Blood. Lymphatic system. Endocrine
system.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be possibly carcinogenic based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 43W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Skin and Appendages: Other: Tumors.
Rat
Route of Application: Inhalation
Exposure Time: 4H/5D/1Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Skin and
Appendages: Other: Tumors. Blood:Leukemia
Mouse
Route of Application: Inhalation
Exposure Time: 6H/2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Lungs,
Thorax, or Respiration:Tumors.
IARC CARCINOGEN LIST
Rating: Group 2B
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
Human
100 UMOL/L
Cell Type: lymphocyte
Unscheduled DNA synthesis
Human
28 MMOL/L
Cell Type: HeLa cell
DNA inhibition
Human
300 MG/KG
Cell Type: lymphocyte
Body fluid assay
Human
7500 PPB/8H/5D-I
Inhalation
Cytogenetic analysis
Human
ALDRICH - S4972 www.sigma-aldrich.com Page 6
300 PPM
72H
Cell Type: lymphocyte
Cytogenetic analysis
Human
1204 MG/M3/5Y-I
Inhalation
Sister chromatid exchange
Human
10 UMOL/L
Cell Type: lymphocyte
Sister chromatid exchange
Rat
145 UG/PLATE
Cell Type: Embryo
Morphological transformation.
Rat
3 MMOL/L
Cell Type: liver
DNA damage
Rat
3800 UMOL/L
Cell Type: liver
Unscheduled DNA synthesis
Rat
300 PPM
Inhalation
8W
Cytogenetic analysis
Rat
750 MG/KG
Intraperitoneal
Sister chromatid exchange
Rat
40 GM/KG
Intraperitoneal
8W
sperm
Mouse
250 MG/KG
Intraperitoneal
Micronucleus test
Mouse
10 MMOL/KG
Intraperitoneal
DNA damage
Mouse
450 MG/KG
Intraperitoneal
Sister chromatid exchange
ALDRICH - S4972 www.sigma-aldrich.com Page 7
Mouse
125 PPM
Inhalation
4D
Sister chromatid exchange
Mouse
1 GM/KG
Cell Type: S. cerevisiac
Host-mediated assay
Mouse
1 GM/KG
Cell Type: S. pombe
Host-mediated assay
Mouse
3500 MG/KG
Intraperitoneal
7W
sperm
Hamster
240 UMOL/PLATE (+S9)
Cell Type: lung
Mutation in microorganisms
Hamster
100 MG/L
Cell Type: lung
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 4 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 11470 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Species: Rat
Dose: 1500 UG/M3/24H
Route of Application: Inhalation
Exposure Time: (1-22D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 8600 MG/KG
Route of Application: Oral
Exposure Time: (1-22D PREG/21D POST)
Result: Effects on Newborn: Behavioral.
ALDRICH - S4972 www.sigma-aldrich.com Page 8
Species: Rat
Dose: 5575 MG/KG
Route of Application: Oral
Exposure Time: (MULTIGENERATIONS)
Result: Effects on Newborn: Viability index (e.g., # alive at
day 4 per # born alive). Effects on Newborn: Weaning or
lactation index (e.g., # alive at weaning per # alive at day 4).
Species: Rat
Dose: 293 PPM/6H
Route of Application: Inhalation
Exposure Time: (7-21D PREG)
Result: Effects on Newborn: Behavioral.
Species: Rat
Dose: 5 MG/M3/24H
Route of Application: Inhalation
Exposure Time: (1-22D PREG)
Result: Effects on Newborn: Stillbirth. Effects on Newborn:
Weaning or lactation index (e.g., # alive at weaning per # alive
at day 4).
Species: Rat
Dose: 1500 UG/M3/24H
Route of Application: Inhalation
Exposure Time: (1-7D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
per total number of implants).
Species: Rat
Dose: 50 PPM/6H
Route of Application: Inhalation
Exposure Time: (7-12D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Mouse
Dose: 500 PPM/6H
Route of Application: Inhalation
Exposure Time: (6-16D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Hamster
Dose: 1000 PPM/6H
Route of Application: Inhalation
Exposure Time: (6-18D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
12 - Ecological Information
ELIMINATION
Elimination: 60 %
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Leuciscus idus
ALDRICH - S4972 www.sigma-aldrich.com Page 9
Time: 48 h
Value: 17 - 66 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 182 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2055
Class: 3
PG: III
Proper Shipping Name: Styrene monomer, inhibited
IMDG
UN#: 2055
Class: 3
PG: III
Proper Shipping Name: Styrene monomer, inhibited
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2055
Class: 3
PG: III
Proper Shipping Name: Styrene monomer, stabilized
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 601-026-00-0
NOTA: D
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 10 20 36/38
Flammable. Harmful by inhalation. Irritating to eyes and skin.
S-PHRASES: 23
Do not breathe vapor.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 3
NORWAY
ALDRICH - S4972 www.sigma-aldrich.com Page 10
Labelling for organic solvents where the package is 1liter or
more.
YL-tall m3/l: 8571
YL-group: 5
Safety phrases: 38 42 210
In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
ALDRICH - S4972 www.sigma-aldrich.com Page 11
|