SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 24/MAY/2005
Date Updated: 13/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name STRYCHNINE FREE BASE
Product Number S0532
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
(-)-STRYCHNINE 57-24-9 200-319-7 614-003-00-5
Formula C21H22N2O2
Molecular Weight 334.42 AMU
Synonyms Boomer-rid * Certox * Dolco mouse cereal *
Gopher bait * Gopher-gitter * Hare-Rid *
Kwik-kil * Mole death * Mouse-nots * Mouse-rid *
Mouse-tox * Pied piper mouse seed * RCRA waste
number P108 * Ro-Dex * Sanaseed * Stricnina
(Italian) * Strychnidin-10-one (9CI) * Strychnin
(German) * Strychnine (ACGIH:OSHA) * Strychnos
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Very toxic in contact with skin and if swallowed. Very toxic to
aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 0.15 MG/M3
Poland NDSCh -
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 0.15 mg/m3
Remarks: L
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EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 0.15 mg/m3, E
Remarks: 4
Remarks: H
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 0.15 mg/m3
Remarks: T
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 0.15 mg/m3
Remarks: E
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 0.15 mg/m3
OEL STEL 0.45 mg/m3
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: Faintly yellow
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 284 - 286 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
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STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: WL2275000
ACUTE TOXICITY
LDLO
Oral
Human
30 mg/kg
LDLO
Oral
Man
30 mg/kg
LDLO
Oral
Man
5143 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Coma. Cardiac: Change in rate.
LD50
Oral
Rat
2.35 mg/kg
LD50
Intraperitoneal
Rat
1100 UG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Subcutaneous
Rat
1200 UG/KG
LD50
Intravenous
Rat
582 UG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Other changes.
LD50
Intramuscular
Rat
1400 UG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
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Lungs, Thorax, or Respiration:Other changes.
LD50
Oral
Mouse
2 mg/kg
LD50
Intraperitoneal
Mouse
980 UG/KG
Remarks: Behavioral:Tremor. Behavioral:Convulsions or effect on
seizure threshold. Behavioral:Excitement.
LD50
Subcutaneous
Mouse
474 UG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Intravenous
Mouse
410 UG/KG
LD50
Intramuscular
Mouse
628 UG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Other changes.
LD50
Parenteral
Mouse
1060 UG/KG
LD50
Oral
Dog
0.5 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Intravenous
Dog
800 UG/KG
Remarks: Behavioral:Tremor. Behavioral:Convulsions or effect on
seizure threshold. Behavioral:Ataxia.
LD50
Oral
Cat
0.5 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Intravenous
Rabbit
400 UG/KG
Remarks: Behavioral:Tremor. Behavioral:Convulsions or effect on
seizure threshold. Behavioral:Ataxia.
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LD50
Oral
Pigeon
21 mg/kg
LD50
Oral
Quail
23 mg/kg
LD50
Oral
Duck
3 mg/kg
LD50
Oral
Bird (wild)
16 mg/kg
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: CNS stimulation. Convulsions.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be fatal if absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: May be fatal if swallowed.
TARGET ORGAN INFORMATION
Central nervous system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 500 UG/KG
Route of Application: Intramuscular
Exposure Time: (5D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Newborn: Stillbirth.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1692
Class: 6.1
PG: I
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Proper Shipping Name: Strychnine
IMDG
UN#: 1692
Class: 6.1
PG: I
Proper Shipping Name: Strychnine
Marine Pollutant: Yes
Severe Marine Pollutant: No
IATA
UN#: 1692
Class: 6.1
PG: I
Proper Shipping Name: Strychnine
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 614-003-00-5
NOTA: A
INDICATION OF DANGER: T+ N
Very toxic. Dangerous for the environment.
R-PHRASES: 27/28 50/53
Very toxic in contact with skin and if swallowed. Very toxic to
aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
S-PHRASES: 36/37 45 60 61
Wear suitable protective clothing and gloves. In case of
accident or if you feel unwell, seek medical advice immediately
(show the label where possible). This material and its
container must be disposed of as hazardous waste. Avoid release
to the environment. Refer to special instructions/safety data
sheets.
SWITZERLAND
SWISS POISON CLASS: 1
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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