SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 18/JUL/2005
Date Updated: 14/OCT/2004
Version 1.5
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CYCLOHEXIMIDE FROM MICROBIAL SOURCE
Product Number C7698
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CYCLOHEXIMIDE 66-81-9 200-636-0 613-140-00-8
Formula C15H23NO4
Molecular Weight 281.35 AMU
Synonyms Acti-Aid * Actidion * Actidione * Actidione BR *
Actidione PM * Actidione TGF * Aktidion (Czech)
* Cycloheximide *
beta-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxye
thyl)glutarimide *
3-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethy
l)glutarimide * Naramycin * Naramycin A *
NSC-185 * U-4527
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause harm to the unborn child. Also very toxic if swallowed.
Toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment. Also possible risks of irreversible
effects.
Repr. Cat.2 Muta. Cat.3
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame. Store in a cool dry place.
Store at 2-8掳C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
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9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: Slightly beige
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 110 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient Log Kow: 0.55
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Slightly.
Solvent: Soluble.
Other Solvents: CHLOROFORM, MEOH, ACETONE
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Bases, Strong oxidizing agents, Acid
anhydrides, Acid chlorides.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: MA4375000
ACUTE TOXICITY
LD50
Oral
Rat
2 mg/kg
LD50
Intraperitoneal
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Rat
3700 UG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Gastrointestinal:Hypermotility, diarrhea. Skin and Appendages:
Other: Hair.
LD50
Subcutaneous
Rat
2500 UG/KG
LD50
Intravenous
Rat
2 MG/KG
LD50
Oral
Mouse
133 mg/kg
LD50
Intraperitoneal
Mouse
100 MG/KG
LD50
Subcutaneous
Mouse
160 MG/KG
LD50
Intravenous
Mouse
150 MG/KG
LD50
Oral
Dog
65 mg/kg
LD50
Intravenous
Dog
1 MG/KG
Remarks: Gastrointestinal:Nausea or vomiting.
LD50
Oral
Monkey
60 mg/kg
LD50
Intraperitoneal
Cat
4 MG/KG
LD50
Intravenous
Rabbit
17 MG/KG
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LD50
Oral
Guinea pig
65 mg/kg
LD50
Intraperitoneal
Guinea pig
60 MG/KG
LD50
Subcutaneous
Guinea pig
60 MG/KG
IRRITATION DATA
Skin
Rabbit
5 mg
24H
Remarks: Rinsed
Skin
Rabbit
0.0001 ppm
24H
Remarks: Moderate irritation effect
SENSITIZATION
Sensitization: Prolonged or repeated exposure may cause allergic
reactions in certain sensitive individuals.
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Dermatitis. Nausea, vomiting, diarrhea.
Tremors. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: May be fatal if swallowed.
TARGET ORGAN INFORMATION
Nerves. Kidneys. Adrenal cortex. Cardiovascular system.
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
Human
35 UMOL/L
Cell Type: HeLa cell
Other mutation test systems
Human
100 MG/L
Cell Type: Other cell types
DNA inhibition
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Human
1 UMOL/L
Cell Type: HeLa cell
DNA inhibition
Human
10 MG/L
Cell Type: lung
DNA inhibition
Human
100 MG/L
Cell Type: Other cell types
DNA inhibition
Human
300 NMOL/L
Cell Type: Other cell types
DNA inhibition
Human
100 MG/L
Cell Type: Other cell types
Cytogenetic analysis
Human
30 MG/L
Cell Type: lymphocyte
Cytogenetic analysis
Rat
1 MG/KG
Intraperitoneal
Morphological transformation.
Rat
5 MG/KG
Intraperitoneal
Other mutation test systems
Rat
10 MG/L
Cell Type: Other cell types
DNA inhibition
Rat
1500 UG/KG
Intraperitoneal
DNA inhibition
Rat
10 MG/KG
Intraperitoneal
Other mutation test systems
Rat
20 MG/KG
Intravenous
Cytogenetic analysis
Mouse
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10 MG/KG
Intraperitoneal
Micronucleus test
Mouse
50 MG/KG
Parenteral
Micronucleus test
Mouse
50 UMOL/L
Cell Type: lymphocyte
DNA damage
Mouse
10 MG/L
Cell Type: fibroblast
Unscheduled DNA synthesis
Mouse
333 MG/KG
Intraperitoneal
DNA inhibition
Mouse
180 UMOL/L
Cell Type: fibroblast
DNA inhibition
Mouse
333 MG/KG
Intraperitoneal
Other mutation test systems
Mouse
100 MG/KG
Intraperitoneal
Cytogenetic analysis
Mouse
1 UMOL/L
Cell Type: Other cell types
Cytogenetic analysis
Mouse
50600 NMOL/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
5 MG/L
Cell Type: lung
DNA inhibition
Hamster
1 MG/L
Cell Type: fibroblast
DNA inhibition
Guinea pig
10 MG/L
Cell Type: lung
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DNA inhibition
Guinea pig
50 MG/L
Cell Type: Other cell types
Other mutation test systems
Pig
1 MG/L
Cell Type: kidney
DNA inhibition
Pig
1 MG/L
Cell Type: kidney
Other mutation test systems
CHRONIC EXPOSURE - TERATOGEN
Result: May cause congenital malformation in the fetus.
Species: Rat
Dose: 250 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Cardiovascular (circulatory) system.
Species: Rat
Dose: 1 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Hepatobiliary system.
Species: Rat
Dose: 1 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (18D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Rat
Dose: 750 UG/KG
Route of Application: Parenteral
Exposure Time: (18D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Mouse
Dose: 30 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 80 MG/KG
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Route of Application: Subcutaneous
Exposure Time: (11D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Rat
Dose: 250 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Cardiovascular (circulatory) system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 1 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (4D PREG)
Result: Maternal Effects: Uterus, cervix, vagina.
Species: Rat
Dose: 300 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (13D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
Species: Mouse
Dose: 30 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Effects on Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 5 MG/KG
Route of Application: Subcutaneous
Exposure Time: (11D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rabbit
Dose: 5 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rabbit
Dose: 5 UG/KG
Route of Application: Parenteral
Exposure Time: (1D PREG)
Result: Effects on Fertility: Other measures of fertility
Species: Hamster
Dose: 60 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D PRE)
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Result: Effects on Fertility: Other measures of fertility
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2811
Class: 6.1
PG: I
Proper Shipping Name: Toxic solid, organic, n.o.s.
IMDG
UN#: 2811
Class: 6.1
PG: I
Proper Shipping Name: Toxic solid, organic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2811
Class: 6.1
PG: I
Proper Shipping Name: Toxic solid, organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 613-140-00-8
NOTA: E
INDICATION OF DANGER: T+ N
Very toxic. Dangerous for the environment.
R-PHRASES: 61 28 51/53 68
May cause harm to the unborn child. Also very toxic if
swallowed. Toxic to aquatic organisms, may cause long-term
adverse effects in the aquatic environment. Also possible risks
of irreversible effects.
S-PHRASES: 53 45 61
Restricted to professional users. Attention - Avoid exposure -
obtain special instructions before use. In case of accident or
if you feel unwell, seek medical advice immediately (show the
label where possible). Avoid release to the environment. Refer
to special instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
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WGK: 3
SWITZERLAND
SWISS POISON CLASS: 1
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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