SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 18/JUL/2005
Date Updated: 16/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CYCLOHEXYLAMINE, REAGENTPLUSTM, >=99%
Product Number 240648
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CYCLOHEXYLAMINE 108-91-8 203-629-0 612-050-00-6
Formula C6H13N
Molecular Weight 99.18 AMU
Synonyms Aminocyclohexane * Aminohexahydrobenzene *
Aniline, hexahydro- * Benzenamine, hexahydro- *
CHA * Cyclohexanamine * Cyclohexylamine (ACGIH)
* Hexahydroaniline * Hexahydrobenzenamine
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Harmful in contact with skin and if swallowed. Causes
burns.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Carbon Dioxide, dry chemical powder, or appropriate
foam. Water can be applied as a spray or fog and if properly
applied is capable of extinguishing the fire by sweeping the
flames off the surface of the burning liquid.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
Vapor may travel considerable distance to source of ignition and
flash back.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions. Forms explosive mixtures in air.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
SPECIFIC METHOD(S) OF FIRE FIGHTING
Use water spray to cool fire-exposed containers.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Incompatible Materials: Absorbs carbon dioxide from air.
SPECIAL REQUIREMENTS: Handle under inert gas. Air sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Use only in a
chemical fume hood.
GENERAL HYGIENE MEASURES
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Wash thoroughly after handling. Remove and wash contaminated
clothing promptly.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 40 MG/M3
Poland NDSCh 80 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 40 mg/m3
10 ppm
Remarks: H
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 40 mg/m3
10 ppm
Remarks: =1=
Remarks: H
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 40 mg/m3
10 ppm
Remarks: H
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level20 mg/m3
5 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 40 mg/m3
10 ppm
Remarks: H D
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 41 mg/m3
10 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Color: Very faintly yellow
Property Value At Temperature or Pressure
pH 11.5 20 掳C Concentration: 100
g/l
BP/BP Range 134 - 135 掳C
MP/MP Range -17 掳C
Flash Point 27 掳C Method: closed cup
Flammability N/A
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Autoignition Temp 293 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.6 %
Upper: 9.4 %
Vapor Pressure 10 mmHg 22 掳C
SG/Density 0.866 g/cm3
Partition Coefficient Log Kow: 1.4
Viscosity N/A
Vapor Density 3.42 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
Other Solvents: ACETONE, BENZENE, ETHERS
ESTERS
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents Carbon dioxide.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: GX0700000
ACUTE TOXICITY
LD50
Oral
Rat
11 mg/kg
Remarks: Behavioral:Food intake (animal). Lungs, Thorax, or
Respiration:Pulmonary emboli. Gastrointestinal:Other changes.
LC50
Inhalation
Rat
7,500 mg/m3
Remarks: Behavioral:Excitement. Behavioral:Muscle contraction or
spasticity.
LD50
Intraperitoneal
Rat
300 MG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Mydriasis (pupilliary dilation). Behavioral:Ataxia.
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Lungs, Thorax, or Respiration:Dyspnea.
LD50
Oral
Mouse
224 mg/kg
LC50
Inhalation
Mouse
1,070 mg/m3
Remarks: Behavioral:Excitement. Behavioral:Muscle contraction or
spasticity.
LD50
Intraperitoneal
Mouse
129 MG/KG
LD50
Subcutaneous
Mouse
1150 MG/KG
LD50
Intravenous
Mouse
200 MG/KG
LD50
Intravenous
Dog
200 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Skin
Rabbit
320 UL/KG
LD50
Intraperitoneal
Mammal
200 MG/KG
Remarks: Brain and Coverings:Other degenerative changes.
Vascular:Shock. Liver:Other changes.
IRRITATION DATA
Skin
Human
125 mg
48H
Remarks: Severe irritation effect
Skin
Rabbit
2 mg
24H
Remarks: Severe irritation effect
Eyes
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Rabbit
0.05 mg
24H
Remarks: Severe irritation effect
Eyes
Rabbit
0.1 ml
5M
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Toxic if absorbed through skin. Readily
absorbed through skin.
Eye Contact: Causes burns.
Inhalation: Toxic if inhaled. Material is extremely destructive
to the tissue of the mucous membranes and upper respiratory
tract.
Ingestion: May be fatal if swallowed.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Human
100 UG/L
Cell Type: HeLa cell
DNA inhibition
Human
10 UMOL/L
5H
Cell Type: leukocyte
Cytogenetic analysis
Rat
5 MG/KG
Intraperitoneal
5D
Cytogenetic analysis
Mouse
200 MG/KG
Intraperitoneal
specific locus test
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Mouse
500 MG/KG
Intraperitoneal
5D
Dominant lethal test
Hamster
60 MG/L
Cell Type: Embryo
Morphological transformation.
Hamster
10 MG/L
Cell Type: fibroblast
Cytogenetic analysis
Hamster
450 MG/KG
3D
Cell Type: leukocyte
Host-mediated assay
Domestic Animals
50 MG/KG
Unreported
Cytogenetic analysis
Mammal
50 MG/L
8H
Cell Type: kidney
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Species: Mouse
Dose: 120 MG/KG
Route of Application: Oral
Exposure Time: (6-11D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 61 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (11D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 5600 MG/KG
Route of Application: Oral
Exposure Time: (4W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Rat
Dose: 300 MG/KG
Route of Application: Intraperitoneal
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Exposure Time: (1D MALE)
Result: Effects on Fertility: Other measures of fertility
Species: Rat
Dose: 100 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D MALE)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Rat
Dose: 5 MG/KG
Route of Application: Unreported
Exposure Time: (1D MALE)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Mouse
Dose: 600 MG/KG
Route of Application: Oral
Exposure Time: (6-11D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 77 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (11D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Mouse
Dose: 200 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Effects on Fertility: Other measures of fertility
Species: Mouse
Dose: 250 MG/KG
Route of Application: Parenteral
Exposure Time: (5D MALE)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Dog
Dose: 14 GM/KG
Route of Application: Oral
Exposure Time: (8W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Dog
Dose: 15750 MG/KG
Route of Application: Oral
Exposure Time: (9W MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
12 - Ecological Information
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ELIMINATION
Elimination: > 90 %
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Algae
Species: Selenastrum capricornutum resp.
Time: 96 h
Value: 20 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 49 mg/l
Test Type: EC0 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 22 mg/l
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 96 h
Value: 44 mg/l
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 44 - 90 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2357
Class: 8
PG: II
Proper Shipping Name: Cyclohexylamine
IMDG
UN#: 2357
Class: 8
PG: II
Subrisk: 3
Proper Shipping Name: Cyclohexylamine
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2357
Class: 8
PG: II
Subrisk: 3
Proper Shipping Name: Cyclohexylamine
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Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 612-050-00-6
INDICATION OF DANGER: C
Corrosive.
R-PHRASES: 10 21/22 34
Flammable. Harmful in contact with skin and if swallowed.
Causes burns.
S-PHRASES: 36/37/39 45
Wear suitable protective clothing, gloves, and eye/face
protection. In case of accident or if you feel unwell, seek
medical advice immediately (show the label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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