SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 16/NOV/2005
Date Updated: 13/MAR/2004
Version 1.5
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name COPPER(II) SULFATE PENTAHYDRATE, 99.999%
Product Number 203165
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
COPPER (II) SULFATE PENTAHYDRATE 7758-99-8 231-847-6 029-004-00-0
Formula CuSO4.5H2O
Molecular Weight 249.68 AMU
Synonyms Blue copper AS * Copper(II) sulfate pentahydrate
* Copper(2+) sulfate pentahydrate * Cupric
sulfate pentahydrate * Kupfersulfat-pentahydrat
(German) * Kupfervitriol (German) * Salzburg
vitriol * Sulfuric acid, copper(2+) salt,
pentahydrate * Sulfuric acid copper(2+) salt
(1:1), pentahydrate (8CI,9CI) * Vencedor
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Irritating to eyes and skin. Very toxic to
aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Handle and store
under argon. Store in a cool dry place.
SPECIAL REQUIREMENTS: Air sensitive. Hygroscopic. Handle and
store under inert gas.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL LTEL LTEL 0.2 MG(CU)/M3 1 MG(CU)/M3
Remarks: fumes
PERSONAL PROTECTIVE EQUIPMENT
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Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: Blue
Form: Crystals
Property Value At Temperature or Pressure
pH 3.7 - 4.5
BP/BP Range N/A
MP/MP Range 110 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 7.3 mmHg 25 掳C
SG/Density 2.284 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Hygroscopic. Air sensitive.
Materials to Avoid: Anhydrous copper(II) sulfate reacts violently
with: hydroxylamine, magnesium, Finely powdered metals.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Sulfur oxides, Copper oxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: GL8900000
ACUTE TOXICITY
LDLO
Oral
Human
1088 mg/kg
Remarks: Behavioral:Coma. Liver:Jaundice (or hyperbilirubinemia)
hepatocellular. Blood:Other hemolysis with or withot anemia.
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LD50
Oral
Rat
300 mg/kg
LD50
Skin
Rat
> 2000 mg/kg
LD50
Intraperitoneal
Rat
18700 UG/KG
LD50
Intraperitoneal
Mouse
33 MG/KG
LD50
Intraperitoneal
Mammal
7500 UG/KG
Remarks: Gastrointestinal:Nausea or vomiting.
Behavioral:Somnolence (general depressed activity).
Gastrointestinal:Changes in structure or function of salivary
glands.
SENSITIZATION
Skin: Prolonged or repeated exposure may cause allergic
reactions in certain sensitive individuals.
SIGNS AND SYMPTOMS OF EXPOSURE
Chronic copper poisoning is typified by hepatic cirrhosis, brain
damage and demyelination, kidney defects, and copper deposition
in the cornea as exemplified by humans with Wilson's disease. It
has also been reported that copper poisoning has lead to
hemolytic anemia and accelerates arteriosclerosis. To the best
of our knowledge, the chemical, physical, and toxicological
properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Liver. Kidneys. Blood.
CHRONIC EXPOSURE - MUTAGEN
Human
76 UMOL/L
Cell Type: lymphocyte
DNA inhibition
Rat
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31 UMOL/L
Cell Type: liver
Unscheduled DNA synthesis
Rat
300 MG/KG
Cell Type: Ascites tumor
Cytogenetic analysis
Mouse
5 MG/KG
Intraperitoneal
Micronucleus test
Mouse
1100 UG/KG
Intraperitoneal
Cytogenetic analysis
Mouse
5 MG/KG
Intraperitoneal
5D
sperm
Chicken
7500 UG/KG
Intraperitoneal
Micronucleus test
Chicken
10 MG/KG
Oral
Micronucleus test
Chicken
10 MG/KG
Oral
Cytogenetic analysis
Chicken
7500 UG/KG
Intraperitoneal
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Result: Possible risk of congenital malformation in the fetus.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Time: 96 h
Value: 1.0 - 2.5 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
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Time: 48 h
Value: 0.024 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
IMDG
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
Marine Pollutant: No
Severe Marine Pollutant: Yes
Technical Name: Required
IATA
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 029-004-00-0
INDICATION OF DANGER: Xn-N
Harmful. Dangerous for the environment.
R-PHRASES: 22-36/38-50/53
Harmful if swallowed. Irritating to eyes and skin. Very toxic
to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-PHRASES: 22-60-61
Do not breathe dust. This material and its container must be
disposed of as hazardous waste. Avoid release to the
environment. Refer to special instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 3
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16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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