SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 20/NOV/2005
Date Updated: 14/MAY/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CLOTRIMAZOLE CRYSTALLINE
Product Number C6019
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CLOTRIMAZOLE CRYSTALLINE 23593-75-1 245-764-8 None
Formula C22H17ClN2
Molecular Weight 344.8 AMU
Synonyms BAY 5097 *
Bis-fenil-(2-clorofenil)-1-imidazolil-metano
(Italian) * BAY b 5097 *
Bisphenyl-(2-chlorphenyl)-1-imidazolyl-methan
(German) * Canesten *
1-(o-Chloro-alpha,alpha-diphenylbenzyl)imidazole
* 1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole
*
1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole
(9CI) * (Chlorotrityl)imidazole *
1-(o-Chlorotrityl)imidazole * Chlotrimazole *
Clotrimazol * Clotrimazole *
Diphenyl-(2-chlorophenyl)-1-imidazolylmethane *
Empecid * FB 5097 * 1H-Imidazole,
1-((2-chlorophenyl)diphenylmethyl)- * Lotrimin *
Mycelex * Mycosporin * Trimysten
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Irritating to eyes and skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
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Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: NI4377000
ACUTE TOXICITY
LD50
Oral
Rat
708 mg/kg
LD50
Intraperitoneal
Rat
445 MG/KG
LD50
Oral
Mouse
761 mg/kg
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LD50
Intraperitoneal
Mouse
108 MG/KG
LD50
Intravenous
Mouse
198 MG/KG
LD50
Oral
Dog
> 2000 mg/kg
Remarks: Gastrointestinal:Nausea or vomiting.
LD50
Oral
Cat
> 1000 mg/kg
Remarks: Gastrointestinal:Nausea or vomiting.
LD50
Oral
Rabbit
> 1000 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Somnolence (general depressed activity).
Behavioral:Muscle weakness.
LD50
Oral
Mammal
750 mg/kg
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Gastrointestinal disturbances.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat Rat
Dose: 2750 MG/KG 2750 MG/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (7-17D PREG) (7-17D PREG)
Result: Effects on Newborn: Viability index (e.g., # alive at
day 4 per # born alive). Effects on Embryo or Fetus: Fetal
death. Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetotoxicity
(except death, e.g., stunted fetus). Effects on Embryo or Fetus:
Fetal death. Effects on Newborn: Viability index (e.g., # alive
at day 4 per # born alive).
Species: Rat Rat
Dose: 6500 MG/KG 6500 MG/KG
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Route of Application: Subcutaneous Subcutaneous
Exposure Time: (17-21D PREG/21D POST) (17-21D PREG/21D POST)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Newborn: Live birth index (#
fetuses per litter; measured after birth). Effects on Newborn:
Growth statistics (e.g., reduced weight gain). Effects on Embryo
or Fetus: Fetotoxicity (except death, e.g., stunted fetus).
Effects on Newborn: Live birth index (# fetuses per litter;
measured after birth). Effects on Newborn: Growth statistics
(e.g., reduced weight gain).
Species: Mouse Mouse
Dose: 600 MG/KG 600 MG/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (7-12D PREG) (7-12D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat Rat
Dose: 600 MG/KG 600 MG/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (9-14D PREG) (9-14D PREG)
Result: Effects on Newborn: Weaning or lactation index (e.g., #
alive at weaning per # alive at day 4). Effects on Newborn: Live
birth index (# fetuses per litter; measured after birth).
Effects on Newborn: Weaning or lactation index (e.g., # alive at
weaning per # alive at day 4). Effects on Newborn: Live birth
index (# fetuses per litter; measured after birth).
Species: Rat Rat
Dose: 4200 MG/KG 4200 MG/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (9W MALE/2W PRE-7D PREG) (9W MALE/2W PRE-7D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Effects on
Fertility: Pre-implantation mortality (e.g., reduction in number
of implants per female; total number of implants per corpora
lutea). Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
pregnant per # females mated ). Effects on Embryo or Fetus:
Fetal death. Effects on Fertility: Pre-implantation mortality
(e.g., reduction in number of implants per female; total number
of implants per corpora lutea). Effects on Fertility: Female
fertility index (e.g., # females pregnant per # sperm positive
females; # females pregnant per # females mated ).
Species: Mouse Mouse
Dose: 1400 MG/KG 1400 MG/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (14D PRE) (14D PRE)
Result: Maternal Effects: Ovaries, fallopian tubes. Maternal
Effects: Ovaries, fallopian tubes.
Species: Mouse Mouse
Dose: 7 GM/KG 7 GM/KG
Route of Application: Subcutaneous Subcutaneous
Exposure Time: (14D PRE) (14D PRE)
Result: Maternal Effects: Uterus, cervix, vagina. Maternal
Effects: Uterus, cervix, vagina.
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12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22-36/38
Harmful if swallowed. Irritating to eyes and skin.
S-PHRASES: 26-36
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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