SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 18/JUL/2005
Date Updated: 29/APR/2005
Version 2.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CYCLOHEXANE, CHROMASOLV庐, FOR HPLC,
>=99.7%
Product Number 34855
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CYCLOHEXANE 110-82-7 203-806-2 601-017-00-1
Formula C6H12
Molecular Weight 84.16 AMU
Synonyms Benzene, hexahydro- * Cicloesano (Italian) *
Cyclohexaan (Dutch) * Cyclohexan (German) *
Cyclohexane (ACGIH:OSHA) * Cykloheksan (Polish)
* Hexahydrobenzene * Hexamethylene *
Hexanaphthene * RCRA waste number U056
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Irritating to skin. Harmful: may cause lung
damage if swallowed. Vapors may cause drowsiness and dizziness.
Very toxic to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician. Do not induce vomiting.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Carbon Dioxide, dry chemical powder, or appropriate
foam. Water can be applied as a spray or fog and if properly
applied is capable of extinguishing the fire by sweeping the
flames off the surface of the burning liquid.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion can occur
under fire conditions. In advanced or massive fires the area
should be evacuated and the fire should be fought from a remote
explosion-resistant location.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
SPECIFIC METHOD(S) OF FIRE FIGHTING
Use water spray to cool fire-exposed containers.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame. Store in a cool dry place. Store
under nitrogen.
SPECIAL REQUIREMENTS: Store under inert gas.
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8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 300 MG/M3
Poland NDSCh 1000 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 172 mg/m3
50 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 700 mg/m3
200 ppm
Remarks: 4
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 525 mg/m3
150 ppm
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level1,000 mg/m3
300 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 700 mg/m3
200 ppm
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 350 mg/m3
100 ppm
OEL STEL 1,050 mg/m3
300 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
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BP/BP Range 80.7 掳C 760 mmHg
MP/MP Range 6.5 掳C
Flash Point -18 掳C Method: closed cup
Flammability N/A
Autoignition Temp 260 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1 %
Upper: 9 %
Vapor Pressure 77 mmHg 20 掳C
SG/Density 0.778 g/cm3
Partition Coefficient N/A Log Kow: 3.44
Viscosity N/A
Vapor Density 2.9 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: GU6300000
ACUTE TOXICITY
LC50
Inhalation
Rat
13,900 mg/m3
4H
LD50
Skin
Rabbit
> 2,000 mg/kg
LD50
Oral
Rat
12705 mg/kg
LD50
Oral
Mouse
813 mg/kg
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LC50
Inhalation
Mammal
70,000 mg/m3
IRRITATION DATA
Skin
Rabbit
Remarks: No irritation effect
Eyes
Rabbit
Remarks: Mild irritation effect
Skin
Rabbit
1,548 mg
2D
I
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause CNS depression, drowsiness, light-headedness,
and irritability. Damage to the lungs. Gastrointestinal
disturbances. Lung irritation, chest pain, and edema which may
be fatal.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Lungs. Central nervous system.
12 - Ecological Information
ELIMINATION
Classification: Not significantly biodegradable.
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 3.78 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 34.7 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 32 - 93 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
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of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1145
Class: 3
PG: II
Proper Shipping Name: Cyclohexane
IMDG
UN#: 1145
Class: 3
PG: II
Proper Shipping Name: Cyclohexane
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1145
Class: 3
PG: II
Proper Shipping Name: Cyclohexane
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 601-017-00-1
INDICATION OF DANGER: F Xn N
Highly Flammable. Harmful. Dangerous for the environment.
R-PHRASES: 11 38 65 67 50/53
Highly flammable. Irritating to skin. Harmful: may cause lung
damage if swallowed. Vapors may cause drowsiness and dizziness.
Very toxic to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
S-PHRASES: 9 16 25 33 60 61 62
Keep container in a well-ventilated place. Keep away from
sources of ignition - no smoking. Avoid contact with eyes. Take
precautionary measures against static discharges. This material
and its container must be disposed of as hazardous waste. Avoid
release to the environment. Refer to special
instructions/safety data sheets. If swallowed, do not induce
vomiting: seek medical advice immediately and show this
container or label.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
SWITZERLAND
SWISS POISON CLASS: 4
NORWAY
Labelling for organic solvents where the package is 1liter or
more.
YL-tall m3/l: 2080
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YL-group: 4
Risk phrases: 20
Harmful by inhalation.
Safety phrases: 38 42 210
In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
Declaration Number: 7380
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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