SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 18/JUL/2005
Date Updated: 18/FEB/2005
Version 1.0
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CYCLOHEXANONE, 99.8%
Product Number W390909
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CYCLOHEXANONE, FOR MANUFACTURING 108-94-1 203-631-1 606-010-00-7
Formula C6H10O
Molecular Weight 98.15 AMU
Synonyms Anone * Cicloesanone (Italian) * Cyclohexanon
(Dutch) * Cyclohexanone (ACGIH:OSHA) *
Cyclohexyl ketone * Cykloheksanon (Polish) *
Hexanon * Hytrol O * Ketohexamethylene * Nadone
* NCI-C55005 * Pimelic ketone * Pimelin ketone *
RCRA waste number U057 * Sextone
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Harmful by inhalation.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician. Do not induce vomiting.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat
and open flame. Store in a cool dry place.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 40
Poland NDSCh 80
Poland NDSP -
EXPOSURE LIMITS - EUROPEAN UNION
Source Type Value
OEL OEL 40.8 mg/m3
10 ppm
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Remarks: Skin
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 40 mg/m3
10 ppm
Remarks: H
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 80 mg/m3
20 ppm
Remarks: =1=
Remarks: H,Y
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 80 mg/m3
20 ppm
Remarks: H
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level100 mg/m3
25 ppm
Remarks: H
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 100 mg/m3
25 ppm
Remarks: C H
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 102 mg/m3
25 ppm
OEL STEL 408 mg/m3
100 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).
9 - Physical and Chemical Properties
Appearance Color: Colorless
Form: Clear liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 154 - 156 掳C
MP/MP Range -47 掳C
Flash Point 44 掳C Method: closed cup
Flammability N/A
Autoignition Temp 420 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.1 %
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Upper: 9.4 %
Vapor Pressure 10 mmHg 38.7 掳C
SG/Density 0.947 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 3.4 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Oxidizing agents, Plastics.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: GW1050000
ACUTE TOXICITY
LD50
Oral
Rat
1620 UL/KG
LC50
Inhalation
Rat
8,000 ppm
4H
LD50
Intraperitoneal
Rat
1130 MG/KG
Remarks: Gastrointestinal:Other changes.
LD50
Subcutaneous
Rat
2170 MG/KG
LD50
Oral
Mouse
1400 mg/kg
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LD50
Intraperitoneal
Mouse
1230 MG/KG
Remarks: Gastrointestinal:Other changes.
LD50
Skin
Rabbit
1 ML/KG
LD50
Intraperitoneal
Rabbit
1540 MG/KG
Remarks: Gastrointestinal:Other changes.
LD50
Oral
Mammal
3000 mg/kg
LC50
Inhalation
Mammal
25,000 mg/m3
IRRITATION DATA
Eyes
Human
75 ppm
Skin
Rabbit
500 mg
Remarks: Open irritation test
Eyes
Rabbit
20 mg
Remarks: Severe irritation effect
Eyes
Rabbit
0.25 mg
24H
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Prolonged or repeated exposure to skin causes defatting and
dermatitis. Material is extremely destructive to tissue of the
mucous membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Exposure can cause: CNS depression. Incoordination.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Harmful if absorbed through skin. Readily
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absorbed through skin.
Eye Contact: Causes burns.
Inhalation: Harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Liver. Kidneys. Central nervous system. Lungs.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Human
100 UMOL/L
Cell Type: leukocyte
Cytogenetic analysis
Human
5 UG/L
Cell Type: lymphocyte
Cytogenetic analysis
Hamster
7500 UL/L
Cell Type: ovary
Sister chromatid exchange
Hamster
7500 UL/L
Cell Type: ovary
Mutation in mammalian somatic cells.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Rat
Dose: 105 MG/M3/4H
Route of Application: Inhalation
Exposure Time: (1-20D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Mouse
Dose: 11 GM/KG
Route of Application: Oral
Exposure Time: (8-12D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Mouse
Dose: 1400 PPM/6H
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Route of Application: Inhalation
Exposure Time: (6-17D PREG)
Result: Maternal Effects: Other effects. Effects on Embryo or
Fetus: Fetotoxicity (except death, e.g., stunted fetus).
Specific Developmental Abnormalities: Musculoskeletal system.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
This combustible material may be burned in a chemical incinerator
equipped with an afterburner and scrubber. Contact a licensed
professional waste disposal service to dispose of this material.
Observe all federal, state, and local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1915
Class: 3
PG: III
Proper Shipping Name: Cyclohexanone
IMDG
UN#: 1915
Class: 3
PG: III
Proper Shipping Name: Cyclohexanone
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1915
Class: 3
PG: III
Proper Shipping Name: Cyclohexanone
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 606-010-00-7
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 10 20
Flammable. Harmful by inhalation.
S-PHRASES: 25
Avoid contact with eyes.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
NORWAY
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Labelling for organic solvents where the package is 1liter or
more.
YL-tall m3/l: 8312
YL-group: 5
Risk phrases: 20
Harmful by inhalation.
Safety phrases: 38 42 210
In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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