TOKU-E COMPANY
MATERIAL SAFETY DATA SHEET
EMERGENCY PHONE (USA only): +1-800-535-5053 INF.: +86-21-5206 9530
. Substance identification
Trimethoprim
. Composition/ information on ingredients
CAS No.: 738-70-5
Formula: C14H18N4O3
. Hazard identification
Label precautionary statements
Avoid contact and inhalation.
In case of accident or if you feel unwell, seek medical advice immediately (show
label when possible). Wear suitable protective clothing, gloves and eye/ face
protection.
. First-aid measures
In case of contact, immediately flush eyes or skin with copious amounts of water
at least 15 minutes while removing contaminated clothing and shoes. Assure
adequate flushing of eyes by separating eyelids with fingers. If inhaled, remove
to fresh air. If breathing is difficult, call a physician. If swallowed, wash out mouth
with water (provided person is conscious). Call a physician immediately. Wash
all contaminated clothing before reuse.
. Fire extinguishing measures
Extinguishing media: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
Wear self-contained breathing apparatus and protective clothing to prevent
contact with eyes and skin.
Unusual fire and explosion hazards: Emits toxic fumes under fire conditions.
. Accidental release measures
Exercise appropriate precautions to minimize direct contact with skin or eyes and
prevent inhalation of dust.
Sweep up; avoid raising dust, place in a bag and hold for waste disposal.
Ventilate area and wash spill site after material pickup is complete.
MSDS Trimethoprim 1/3
. Handling and storage
Wear dust mask, chemical resistant gloves, safety goggles, and all other
protective clothing. Do not breathe dust. Avoid contact with eyes, skin, and
clothing. Avoid prolonged or repeated exposure. Safety shower and eye bath.
Mechanical exhaust required. Use only in a chemical fume hood.
Keep tightly closed. Store at 2 - 8癈
. Physical properties
Appearance: Solid
PH: N/A
Melting point: 199癈
Solubility: 400mg/L in water
. Stability and reactivity
Stable. Avoid strong oxidizing agents.
Hazardous combustion or decomposition products thermal decomposition may
produce carbon monoxide, carbon dioxide, nitrogen oxides.
Hazardous polymerization will not occur.
. Toxicological information
May cause skin irritation. May be harmful if absorbed through the skin. May
cause eye irritation. May be harmful if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract. Harmful if swallowed.
Signs and symptoms of exposure: To the best of our knowledge, the chemical,
physical, and toxicological properties have not been thoroughly investigated.
Target organ(s): Liver. Immune system.
Toxicity data:
Oral Rat LD50: > 5,300mg/Kg, 18220 UG/KG
Intraperitoneal Rat LD50: 500 MG/KG
Subcutaneous Rat LD50: > 5g/Kg
Oral Mouse LD50: 2,764 mg/Kg
Intraperitoneal Mouse LD50: 400mg/Kg
Subcutaneous Mouse LD50: 5g/Kg
Intravenous Mouse LD50: 132 mg/Kg
Chronic exposure: Mutagen
. Ecological information: No data available.
. Disposal considerations
Contact a licensed professional waste disposal service to dispose of this material.
Dissolve or mix the material with a combustible solvent and burn in a chemical
incinerator equipped with an afterburner and scrubber. Observe all federal, state
MSDS Trimethoprim 2/3
and local environmental regulations.
. Transport information
This substance is considered to be non-hazardous for transport.
Non-hazardous for air transport.
. Regulatory information
US information
Avoid contact and inhalation. Target organ(s): Immune system.
SARA list: No.
. Other information
The information and recommendations set forth herein are believed to be
completed and faithful. However, it is the user's responsibility to determine the
suitability for his/ her purpose prior to use. Toku-E Company assumes no
additional liability and responsibility resulting from use and/ or reliance on this
information.
MSDS Trimethoprim 3/3
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