SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 10/FEB/2005
Date Updated: 14/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name BROMOMETHANE, 99.5+%
Product Number 295485
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
BROMOMETHANE 74-83-9 200-813-2 602-002-00-2
Formula CH3Br
Molecular Weight 94.94 AMU
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic by inhalation and if swallowed. Irritating to eyes,
respiratory system and skin. Harmful: danger of serious damage to
health by prolonged exposure through inhalation. Very toxic to
aquatic organisms. Dangerous for the ozone layer. Possible risk of
irreversible effects.
Muta. Cat.3
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
Contamination of the eyes should be treated by immediate and
prolonged irrigation with copious amounts of water. Assure
adequate flushing of the eyes by separating the eyelids with
fingers.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
GENERAL INFORMATION
Symptoms may be delayed. Keep under medical observation.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Use water spray or fog nozzle to keep cylinder cool.
Move cylinder away from fire if there is no risk.
SPECIAL RISKS
Specific Hazard(s): Extremely flammable. Vapor may travel
considerable distance to source of ignition and flash back.
Emits toxic fumes under fire conditions.
Explosion Hazards: May form explosive mixtures with air Vapor
may travel considerable distance to source of ignition and flash
back. Container explosion may occur under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
SPECIFIC METHOD(S) OF FIRE FIGHTING
Do not extinguish burning gas if flow cannot be shut off
immediately. Use water spray or fog nozzle to keep cylinder
cool. Move cylinder away from fire if there is no risk.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area and keep personnel upwind. Shut off all sources of
ignition. Shut off leak if there is no risk.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe gas. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame. Use with equipment rated for cylinder
pressure, and of compatible materials of construction. Close
valve when not in use and when empty. Make sure cylinder is
properly secured when in use or stored Cylinder temperature
should not exceed 125癋 (52癈).
Unsuitable: Store away from heat and direct sunlight
SPECIAL REQUIREMENTS: Contents under pressure. Refrigerate
before opening.
8 - Exposure Controls / Personal Protection
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ENGINEERING CONTROLS
Warning: suck-back into cylinder may cause rupture. Use
back-flow-preventive device in piping.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 20 mg/m3
5 ppm
Remarks: H
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 20 mg/m3
5 ppm
Remarks: HK
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level19 mg/m3
5 ppm
Remarks: H
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 20 mg/m3
5 ppm
Remarks: H
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 20 mg/m3
5 ppm
OEL STEL 59 mg/m3
15 ppm
Remarks: Skin
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator in
nonventilated areas and/or for exposure above the TLV or PEL.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: Colorless
Form: Clear liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 4 癈 760 mmHg
MP/MP Range -94 癈
Flash Point N/A
Flammability N/A
Autoignition Temp 536 癈
Oxidizing Properties N/A
Explosive Properties N/A
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Explosion Limits Lower: 10 %
Upper: 16 %
Vapor Pressure 1420 mmHg 20 癈
SG/Density 1.73 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 3.3 g/l 20 癈
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Plastics, Rubber,
Aluminum, Strong bases, Magnesium, Zinc, Alkali metals.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen bromide gas.
11 - Toxicological Information
ACUTE TOXICITY
LCLO
Inhalation
Man
60,000 ppm
2H
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Respiratory stimulation.
Gastrointestinal:Nausea or vomiting.
LCLO
Inhalation
Child
1,000 mg/m3
2H
Remarks: Blood:Change in clotting factors.
LD50
Oral
Rat
214 mg/kg
LC50
Inhalation
Rat
302 ppm
8H
Remarks: Behavioral:Change in motor activity (specific assay).
Nutritional and Gross Metabolic:Weight loss or decreased weight
gain. Nutritional and Gross Metabolic:Changes in:Body
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temperature decrease.
LD50
Subcutaneous
Rat
135 MG/KG
LC50
Inhalation
Mouse
1,540 mg/m3
2H
LC50
Inhalation
Rabbit
28,900 mg/m3
30M
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Nausea, dizziness, and headache. Anorexia.
Vomiting. Weakness. Blurred vision. Confusion. Tremors.
Convulsions. Pulmonary edema. Effects may be delayed. Cyanosis.
Coma. and possibly death.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Can cause rapid suffocation. Toxic if inhaled.
Material is irritating to mucous membranes and upper respiratory
tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Central nervous system. Kidneys.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 13W
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Gastrointestinal:Peritonitis. Gastrointestinal:Tumors.
Rat
Route of Application: Inhalation
Exposure Time: 6H/2.5Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Human
95 MG/L
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Cell Type: lymphocyte
Cytogenetic analysis
Human
43000 PPM
Cell Type: lymphocyte
Sister chromatid exchange
Human
5 MG/L
Cell Type: lymphocyte
Sister chromatid exchange
Rat
338 PPM
Inhalation
6H/14D
Micronucleus test
Mouse
100 PPM
Inhalation
6H/14D
Micronucleus test
Mouse
200 PPM
Inhalation
6H/14D
Sister chromatid exchange
Mouse
300 UG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 300 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Maternal Effects: Other effects.
Species: Rabbit
Dose: 130 MG/KG
Route of Application: Oral
Exposure Time: (6-18D PREG)
Result: Maternal Effects: Other effects.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
CONTAMINATED CONTAINER DISPOSAL
Caution: no-return cylinder. Do not reuse. Empty cylinder will
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contain hazardous residue. Follow proper disposal techniques.
14 - Transport Information
RID/ADR
UN#: 1062
Class: 2
Proper Shipping Name: Methyl bromide
IMDG
UN#: 1062
Class: 2.3
Subrisk: 2.1
Proper Shipping Name: Methyl bromide
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1062
Class: 2.3
Proper Shipping Name: Methyl bromide
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 602-002-00-2
INDICATION OF DANGER: T N
Toxic. Dangerous for the environment.
R-PHRASES: 23/25 36/37/38 48/20 50 59 68
Toxic by inhalation and if swallowed. Irritating to eyes,
respiratory system and skin. Harmful: danger of serious damage
to health by prolonged exposure through inhalation. Very toxic
to aquatic organisms. Dangerous for the ozone layer. Possible
risk of irreversible effects.
S-PHRASES: 15 27 38 45 59 61 36/39
Keep away from heat. Take off immediately all contaminated
clothing. In case of insufficient ventilation, wear suitable
respiratory equipment. In case of accident or if you feel
unwell, seek medical advice immediately (show the label where
possible). Refer to manufacturer/supplier for information on
recovery/recycling. Avoid release to the environment. Refer to
special instructions/safety data sheets. Wear suitable
protective clothing and eye/face protection.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
SWITZERLAND
SWISS POISON CLASS: 1*
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
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shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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