4-(2-HYDROXYETHYL)PIPERAZINE-1-ETHANESULFONIC
MATERIAL SAFETY DATA SHEET ACID, HEPES
PRODUCT CODE NUMBER(S): 4080-5, 4081-5
PRODUCT IDENTIFICATION Hazardous Decomposition Products: COx, NOx, SOx
Chemical Name and Synonyms: 4-(2-Hydroxyethyl)-
FIRE AND EXPLOSION DATA
piperazine-1-ethanesulfonic acid, HEPES, OR
4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid, sodium Flammability: Not combustible. However, as with most or-
salt ganic compounds, fine dust dispersed in air in the presence
of an ignition source is a potential dust explosion hazard.
Chemical Family: Organic sulphonate
Extinguishing Media: Use extinguisher appropriate to the
Chemical Formula: C8H18N2O4S OR C8H18N2O4SNa
surrounding fire. Use water spray or fog to disperse va-
Product Use: Laboratory reagent
pours, and cool fire-exposed containers. Fight fire from
Manufacturer's Name and Address: upwind, from a safe distance. Firefighters must wear protec-
Caledon Laboratories Ltd. tive equipment and clothing sufficient to prevent inhalation of
40 Armstrong Avenue dust or fumes, and contact with skin and eyes.
Georgetown, Ontario L7G 4R9 Flash Point (Method Used): Not applicable
Telephone No: (905) 877-0101 Autoignition Temperature: Not applicable
Fax No: (905) 877-6666 Upper Flammable Limit (% by volume): Not applicable
Emergency Telephone No: CANUTEC (613) 996-6666 Lower Flammable Limit (% by volume): Not applicable
Hazardous Combustion Products: Toxic fumes of sul-
HAZARDOUS INGREDIENTS OF MATERIALS phur, COx, NOx, SOx
Sensitivity to Impact: None identified
Ingredients % TLV Units CAS No.
Sensitivity to Static discharge: As with most organic pow-
HEPES >98 Not available 7365-45-9 ders, mixtures of dust with air may be sensitive under
certain conditions, when ignited by an electrostatic or other
OR
high-voltage spark, or other ignition source.
HEPES, Sodium salt >98 Not available 75277-39-3
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
PHYSICAL DATA
To the best of our knowledge the physical, chemical and tox-
Physical State: Solid icological properties of this substance have not yet been
thoroughly investigated.
Odour and Appearance: White powder, odourless
Odour Threshold (ppm): Not applicable
Toxicological Data:
Vapour Pressure (mm Hg): Not available
LD50: Not available
Vapour Density (Air = 1): Not available
LC50: Not available
Evaporation Rate: Not applicable
Boiling Point (degrees C): Not available
Effects of Acute Exposure to Product:
Melting Point (degrees C): 234癈 (decomposes)
Inhaled: No information available. Mildly acidic; may be irri-
pH: 5.0 to 6.5 (1M, aqueous, 20癈); HEPES, sodium salt
tating to upper respiratory tract, causing coughing, sneezing,
10.0 (1%, aqueous)
and shortness of breath.
Specific Gravity: Not available
In contact with skin: No information available. Dust or so-
Coefficient of Water/Oil distribution: Not available
lutions may be irritating to skin, causing redness and itching.
Severity of effects depends on degree and duration of expo-
SHIPPING DESCRIPTION sure. May be harmful if absorbed.
In contact with eyes: Dust or solutions may cause irrita-
UN: Not regulated
tion, with tearing, redness, and pain, depending on
T.D.G. Class: Not regulated
concentration and duration of exposure.
Pkg. Group: Not regulated
Ingested: May be irritating, causing gastrointestinal irrita-
tion, abdominal pain, vomiting and diarrhea. May be
REACTIVITY DATA harmful; piperazine and its derivatives are usually slightly to
moderately harmful by ingestion.
Chemical Stability: Stable, hygroscopic; absorbs moisture
from air.
Effects of Chronic Exposure to Product:
Incompatibility with other substances: May react vio-
lently or explosively with strong oxidizers. Carcinogenicity: No information available
Reactivity: Avoid excessive heat, ignition sources, genera- Teratogenicity: No information available
tion of dust, incompatible materials.
Reproductive Effects: No information available
4-(2-HYDROXYETHYL)PIPERAZINE-
MSDS 1-ETHANESULFONIC ACID, HEPES
CODE: 4080-5, 4081-5
REFERENCES USED
Mutagenicity: No information available
Synergistic Products: None known Sax, Lewis: Hawley's Condensed Chemical Dictionary, 11th
ed., 1987
PREVENTIVE MEASURES
Sax: Dangerous Properties of Industrial Materials, 5th ed.,
Engineering Controls: Local exhaust ventilation recom- 1979
mended Suppliers' Material Safety Data Sheets
Respiratory Protection: Dust mask. NIOSH/OSHA ap-
proved, half-face dust/mist respirator for dusty conditions. ADDITIONAL INFORMATION
For high or unknown concentrations, as in fire or spill condi-
tions, positive-pressure, full face-piece supliied-air respirator Date Issued: May 31, 1991
or self contained breathing apparatus. Revision: January 2009
Eye Protection: Chemical safety glasses MSDS: 4080-5, 4081-5
Skin Protection: Chemical resistant gloves. Other protec- Proposed WHMIS Designation: D2B (Irritation)
tive clothing sufficient to limit contact.
Other Personal Protective Equipment: Safety shower
Prepared by: Caledon Laboratories Ltd. (905) 877-0101
and eye-wash fountain in work area.
Caledon Laboratories Ltd. believes the information contained
Leak and Spill Procedure: Ventilate area of spill.
herein is reliable and accurate. Caledon makes no warranty
Clean-up personnel must be thoroughly trained in the han-
with respect thereto and expressly disclaims all liability for reli-
dling of hazardous materials, and must wear protective
ance thereon. Such information is solely for your consider-
equipment and clothing sufficient to prevent inhalation of
ation, investigation, and verification.
dust or fumes, and contact with skin and eyes. Mix with in-
ert absorbent or wet to control dust. Gather up in a manner
that does not generate dust, and collect in suitable contain-
ers for reclamation or disposal.
Waste Disposal: Dispose of in compliance with local, pro-
vincial and federal regulations.
Handling Procedures and Equipment: COMBUSTIBLE
DUST under some conditions. Workers using this chemical
must be properly trained in its hazards and its safe use, and
must wear appropriate protective equipment and clothing.
Avoid generating dust. If there is dust, keep away from heat,
sparks, and all sources of ignition, avoid the accumulation of
static charge, use anti-sparking tools, ground and bond
equipment and containers. Use good housekeeping proce-
dures to prevent accumulations of dust. Use the smallest
amount possible for the purpose, in an area with adequate
ventilation. Avoid contact with skin and eyes. Avoid inhala-
tion. Wash thoroughly after handling.
Storage Requirements: Keep in suitable, labelled contain-
ers, stored in a cool, dry, ventilated area, out of direct
sunlight and away from incompatible materials. Protect
against physical damage.
FIRST AID MEASURES
Specific Measures:
Eyes: Immediately flush eyes with running water, holding
eyelids open during flushing, for five to ten (5-10) minutes,
or until no trace of chemical remains. Take care not to flush
contaminated water into unaffected eye. If irritation devel-
ops, get medical attention.
Skin: Remove contaminated clothing. Brush or wipe off dry
material. Flush skin with plenty of running water until no evi-
dence of chemical remains. If irritation develops get medical
attention.
Inhalation: Remove to fresh air. Give oxygen and get
medical attention for any breathing difficulty. .
Ingestion: If the victim is alert and not convulsing, rinse
mouth thoroughly with water and give 2 to 4 glasses of wa-
ter to drink to dilute. If victim feels unwell, or if a large
amount has been ingested, get medical attention.
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