File No: NA/656
April 1999
NATIONAL INDUSTRIAL CHEMICALS NOTIFICATION
AND ASSESSMENT SCHEME
FULL PUBLIC REPORT
Golpanol ATPN
This Assessment has been compiled in accordance with the provisions of the Industrial
Chemicals (Notification and Assessment) Act 1989 (the Act) and Regulations. This legislation
is an Act of the Commonwealth of Australia. The National Industrial Chemicals Notification
and Assessment Scheme (NICNAS) is administered by the National Occupational Health and
Safety Commission which also conducts the occupational health & safety assessment. The
assessment of environmental hazard is conducted by the Department of the Environment and
the assessment of public health is conducted by the Department of Health and Aged Care.
For the purposes of subsection 78(1) of the Act, copies of this full public report may be
inspected by the public at the Library, National Occupational Health and Safety Commission,
92-94 Parramatta Road, Camperdown NSW 2050, between the following hours:
Monday - Wednesday 8.30 am - 5.00 pm
Thursday 8.30 am - 8.00 pm
Friday 8.30 am - 5.00 pm
Copies of this full public report may also be requested, free of charge, by contacting the
Administration Coordinator on the fax number below.
For enquiries please contact the Administration Coordinator at:
Street Address: 92 Parramatta Rd Camperdown, NSW 2050, AUSTRALIA
Postal Address: GPO Box 58, Sydney 2001, AUSTRALIA
Telephone: (61) (02) 9577-9514 FAX (61) (02) 9577-9465
Director
Chemicals Notification and Assessment
NA/656
FULL PUBLIC REPORT
Golpanol ATPN
1. APPLICANT
BASF Australia Ltd of 500 Princes Highway NOBLE PARK VICTORIA 3174 has
submitted a limited notification statement in support of their application for an assessment
certificate for Golpanol ATPN.
2. IDENTITY OF THE CHEMICAL
Chemical Name: propanoic acid, 3-[(aminoiminomethyl)thio]-
Chemical Abstracts Service 5398-29-8
(CAS) Registry No.:
-isothiureidopropionic acid;
Other Names:
3-(aminoiminomethyl)thiopropanoic acid;
propionic acid, 3-(amidinothio)-;
carboxyethyl isothiuronium betaine
Trade Name: Golpanol ATPN
Molecular Formula: C4H8N2O2S
Structural Formula:
HN O
C S C C C
H2 H2
H2 N OH
Molecular Weight: 148.2
Method of Detection purity of notified chemical determined by
and Determination: potentiographic titration and HPLC with UV/Vis
detection; identity confirmation by infrared and nuclear
magnetic resonance spectroscopy
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Spectral Data: infrared spectroscopy (KBr disc): major peaks
identified at 492, 731, 782, 1084, 1116, 1160, 1278,
1384, 1560, 1689, 2914 and 3298 cm-1;
1
H nuclear magnetic resonance confirmed structure
3. PHYSICAL AND CHEMICAL PROPERTIES
Appearance at 20癈 white powder
and 101.3 kPa:
Particle Size Distribution: 3 - 200 祄.
Melting Point: 160.0 ?0.3癈
Specific Gravity: 1.469 at 20癈
Vapour Pressure: not determined; see comments below
Water Solubility: 12.01 ?0.37 g/L at 20癈; see comments below
Partition Co-efficient
(n-octanol/water): log Pow = <-2.16 ?0.16 at 24癈; see comments below
Hydrolysis as a Function T 1/2 at pH 7.0 and 20癈 = 4 000 days
of pH: T 1/2 at pH 7.0 and 50癈 = 737 hours
T 1/2 at pH 7.0 and 65癈 = 82.5 hours
T 1/2 at pH 7.0 and 80癈 = 8.8 hours
T 1/2 at pH 9.0 and 28.6癈 = 70.8 hours
T 1/2 at pH 9.0 and 50癈 = 31.5 hours
Adsorption/Desorption: log Koc = -0.4 at 20癈
Dissociation Constant: pK a = 9.76 ?0.05 at 23癈
Flash Point: > 100癈; see comments below
Flammability Limits: not determined
Autoignition Temperature: > 200癈
Explosive Properties: not determined; see comments below
Reactivity/Stability: not reactive (stable solid)
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Comments on Physico-Chemical Properties
Tests were conducted in accordance with OECD (OECD,1995-1996) and EC test guidelines
(European Commission, 1992). They were performed by the analytical department (ZAX
Analytik) of BASF, Ludwigshafen, Germany, which complies with the OECD principles of
good laboratory practice. Full test reports were submitted for all parameters measured,
except for the flash point and autoignition temperature.
The notified chemical is a stable, white solid powder. It has a high melting point (160癈) and
is expected to have negligible volatility under ambient conditions. Consequently, the vapour
pressure for the notified chemical was not determined. It is expected to be low.
The water solubility was determined using the piston method and HPLC for analysis of the
test substance. In this method excess samples of the test substance are agitated with water at
30 OC for 1, 2 and 3 days in separate vessels. Each test was performed in triplicate and after
the allotted time for dissolution the mixtures were allowed to equilibrate at 24oC and the
aqueous phase filtered and then analysed for the solute using High Performance Liquid
Chromatography. The solute concentration was determined to be between 11.4 and 12.5 g/L,
regardless of the period allowed for dissolution, and consequently the solubility at 24 OC was
determined to be 12.01 ?.37 g/L. The pH of the solutions was always between 4.77 and
5.00, which is the "natural" pH of the solutions prepared in the manner indicated.
Hydrolysis was determined at pH 4, 7 and 9 according to the indicated standard method. At
50OC the half lives (t_) at pH 7 and 9 were determined in range finding tests to be respectively
737 and 31.5 hours. The compound appeared to be stable at pH 4 at this temperature. More
extensive tests at pH 7 for temperatures of 80 and 65oC gave t_ values of 8.8 and 82.5 hours
respectively, and extrapolations (Arrhenius relation) provided an estimate for t_ at 25 oC and
pH 7 of around 98,000 hours (4 000 days). A separate test at pH 9 and
28.60C gave t_ = 71 hours, and so it can be concluded that hydrolysis is very slow under
ambient temperature conditions at pH 7, but considerably faster under mild alkaline
conditions.
The n-octanol/water partition coefficient was determined using the shake flask method by
vigorously mixing known volumes of n-octanol with 250 mL of a 3.7 g/L solution of the
compound in water, followed by analysis of both phases for the test material using HPLC.
The concentration in the n-octanol phase was found to be below the detection limits of the
instrumentation, and consequently log Pow was determined as < -2.2.
The value of log Koc was determined by the HPLC screening method, and the low value of
-0.4 determined is in good accord with expectations from the log Pow values, and indicates
that the new compound would have little affinity for the organic component of soils and
sediments, and would remain in the aqueous compartment.
The pKa value of 9.76 is indicative of the deprotonation of the amino group. Under the usual
environmental pH region (4-9) and in an aqueous solution, the zwitterionic form.
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[(NH 3+ )C(=NH)SCH 2CH2COO -] of the notified chemical is likely to predominate.
The flash point for the notified chemical was found to be above 100癈. In view of its high
melting point, exact determination of the flash point was considered unnecessary.
The molecular structure of the notified chemical does not indicate an explosion hazard. Being
an organic powder, however, the risk of dust explosions exists if electrostatic accumulation
occurs
The chemical contains a variety of functional groups, including amino, imino, carboxylate and
a thioether group. All these groups have the potential to complex with various transition
metal ions in aqueous solution. This property is probably of importance in the compound's
action as a brightening agent in electroplating baths.
4. PURITY OF THE CHEMICAL
Degree of Purity: >98% by weight
Toxic or Hazardous Impurities:
Chemical name: thiourea
Synonyms: thiocarbamide
CAS No.: 62-56-6
Weight percentage: <1% by weight
harmful if swallowed (R22),
Toxic properties:
carcinogen category 3 (R40) (NOHSC 1999a)
Non-hazardous Impurities none
> 1%:
Additives/Adjuvants: none
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5. USE, VOLUME AND FORMULATION
The notified chemical Golpanol ATPN will not be manufactured in Australia. It will be
imported as a solid form white powder in 50kg drums. Over the next five years, the amount
imported will be less than 200kg per year to the customer. Only one or two deliveries are to
be made per year.
The notified chemical is to be used as a raw material to produce a nickel brightener solution
(containing 0.21% of the chemical) for the electroplating industry. It will be used as a
component of a Class 1 brightener for nickel and nickel-iron alloy electroplating baths and in a
brightener for copper plating. In nickel electrolytes, it improves ductility and throwing
power. It has the added ability to improve the tolerance for metal impurities in electroplating
baths.
The types of products that will be electroplated using the new chemical include automotive
parts, shop fittings (in particular shopping trolleys), bathroom fittings and building products
(predominantly fasteners).
6. OCCUPATIONAL EXPOSURE
As the notified chemical is a fine powder the potential routes of exposure are dermal and
inhalation.
Transport and Storage
It is estimated by the notifier that two people would be involved in receiving the drums of
notified chemical at the dock. A further two people would be involved in its transport by
road, either to the BASF warehouse, or to the facilities of the customer or toll manufacturer
(formulator). It is estimated by the notifier that there will only be one or two deliveries per
year. Upon delivery at the BASF warehouse, the notified chemical will be handled by
approximately two personnel (e.g. forklift operators) for a maximum of 30 minutes.
Similarly, at the customer facilities up to two workers will be required to unload the
containers with the notified chemical. These workers would handle the containers for about
one hour per year. It is unlikely that transport and storage workers will be exposed to the
notified chemical unless the drums are damaged. No repackaging of the notified chemical is
carried out before the drums are received by the formulator.
Formulation
At the toll manufacturers site, 2 to 4 compounders will use the notified chemical to produce
nickel brightener solution. It is estimated by the notifier that these workers will be handling
the notified chemical for approximately one hour per day and 11 days per year.
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The notified chemical will be weighed out and added to a 1 000L mixer for blending, after
which the nickel brightener solution will be transported to product containers for sale and
dispatch to the electroplating industry. Inhalation and dermal exposure to the notified
chemical may occur during weighing out from the 50 kg drum and addition to the mixer. An
extraction booth is provided to minimise exposure to the fine dust. The MSDS for Golpanol
ATPNstates that overalls, goggles and gloves should be worn when handling, with a dust
mask to be also worn in the event of likely dust exposure. The notifier indicated that a face
shield may also be worn.
The notifier did not indicate whether the mixer was closed or open. If open, skin
contamination may occur in the event of splashing. Skin contamination may also occur during
transfer of nickel brightener solution to the filling machine and during filling of product
containers if any spills or leaks develop or in the event of overfilling of containers. It is
expected that overalls, goggles and gloves will be worn during the formulation operations.
Dermal exposure to the notified chemical may also occur during the cleaning and maintenance
of process equipment.
End Use (Electroplating)
At the electroplating facility, there are series electroplating baths containing solutions of the
nickel brightener, metal and other ingredients or rinsing water. The nickel brightener,
containing Golpanol ATPN at 0.21% w/v, is present in the bath at a concentration of 0.05%
w/v, that is, the notified chemical is in the bath at a concentration of 1 ppm. Items to be
plated are attached to a rack and lowered into the baths either automatically by means of a
computerised pulley system, or semi-automatically with a worker pushing a button to lower
items into the bath. The metal is plated onto the items (at room temperature) and the coated
items are then dried. Water from the rinsing baths is recycled into the metal solution baths.
All the nickel brightener is adsorbed onto the metal surface and once incorporated the notified
chemical will not be bioavailable.
Although the electroplating operation is an open system, there is little potential for exposure
of operators to fumes and/or spills whilst handling solutions containing the notified chemical
because the process is automated. The chemical is present in very low concentrations (0.21%
before addition to the bath, 1 ppm in the bath). Skin contamination to the notified chemical
may occur when handling the nickel brightener solution during addition to the bath. Fumes
will be removed by local exhaust ventilation and all personnel will wear standard protective
equipment (for example, industrial clothing, safety glasses/goggles, face shields, gloves,
respirator) that comply with the corresponding Australian Standard.
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7. PUBLIC EXPOSURE
The notified chemical will be used only in the electroplating industry and will not be sold to
the general public. Although members of the public will make dermal contact with
electroplated products (e.g. automotive parts; shop fittings, in particular shopping trolleys,
bathroom fittings and building products, predominantly fasteners) containing the notified
chemical, exposure will be negligible because of the low concentration of the encapsulated
form of the notified chemical in the final products from which the notified chemical is not
expected to leach.
8. ENVIRONMENTAL EXPOSURE
Release
Very little release to the environment is expected during formulation of the brightener at the
toll manufacturer, since preparation of a 1000 L batch requires only 2.1kg of the Golpanol
ATPN and volume is made up in water. The weighing is performed in an extraction booth
where fugitive particulate matter is extracted and assumed to be captured on the associated
filter pads. These would then be incinerated or placed into landfill.
The formulated solution is then repackaged, presumably into drums. The notifier did not
provide details of methods for cleaning the batch tanks or disposal of waste wash-water, but
this is presumed to be discharged to the sewer system. No estimate of overall losses to the
environment during the production of brightener were provided in the submission, but in the
worst case 10% of the new material could be released as a consequence of spills and accidents.
This amounts to an expected annual release of 20kg of the chemical into the Melbourne South
Eastern sewer system.
Little release is expected from the intended use of the chemical in electrochemical plating
baths. Concentrated solutions of metal salts (in this case nickel and/or copper salts) in water
- usually containing dilute sulfuric or hydrochloric acid - are passed through electrochemical
cells in which the articles to be plated with metal form the cathode. The metal is deposited
onto the articles and consequently the dissolved concentration is continuously reduced.
Periodically, fresh metal salts are added to the baths, along with other additives such as
brightening agents, in order to replenish the dissolved metal concentration. Articles removed
from the baths are rinsed to remove residual electrolyte solution and the rinse is returned to
the plating cells. This is an efficient process and involves negligible release of the solutions to
the environment.
However, periodically the solution has to be "bled" to remove unwanted impurities which
build up in the circuit as a consequence of acid neutralisation and other causes. It is then
usual to precipitate the metals with lime or other bases, filter the effluent and discharge it to
sewer. As mentioned above, most of the brightening agent is assimilated into the plated
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metal, but it could be expected that since the ambient concentration in the baths is around 1
mg/L, some would be released with the discharged bleed stream.
Fate
The notified chemical is very water soluble and regardless of the means of disposal or release,
almost all the chemical is likely to enter the water compartment. Due to the low Koc the
chemical is not likely to associate with sewer sediments or soils and could be expected to
remain in the water compartment. However, due to the high water solubility and low log Pow,
it is unlikely to bioaccumulate. The compound was shown not to be readily biodegradable
and less than 10% degradation occurred after 28 days in a "die away test". Nevertheless, the
compound is not expected to be persistent in the environment, due to slow hydrolytic
degradation.
The chemical has a very low potential for bioaccumulation and data from the US
Environmental Protection Agency database ASTER Agency (US EPA, 1998) indicate a
bioconcentration factor of 1 (for fathead minnow) based on Quantitative Structure Activity
Relationships (QSAR).
9. EVALUATION OF TOXICOLOGICAL DATA
No toxicology data were provided for the notified chemical. This is acceptable for chemicals
that are to be introduced at less than 1 tonne per year. Toxicological information on an
analogous chemical was provided on the MSDS. The MSDS reports that the chemical is
harmful if swallowed and may cause serious damage to eyes. The MSDS states that the
chemical is a hazardous substance.
10. ASSESSMENT OF ENVIRONMENTAL EFFECTS
While not required by the Act for chemicals with import volumes of less than 1 tonne per
annum, the notifier provided the following ecotoxicological data. The ecotoxicity tests were
performed in accordance with OECD test guidelines (OECD,1995-1996).
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Test Species Results (measured)
acute immobilisation Daphnia magna EC50(48h) = 20.8 mg/L
[OECD TG 202 Part 1]
inhibition of algal growth Scenedesmus subspicatus EbC50 (72h) = 23.2 mg/L
[OECD TG 201] NOEC (72h) = 3.13 mg/L
LOEC (72h) = 6.25 mg/L
inhibition of bacterial respiration activated sludge bacteria NOEC > 1000 mg/L
[OECD TG 209]
No data for acute toxicity to fish was submitted
The acute immobilisation tests on daphnia were performed using solutions of the notified
chemical made up in dechlorinated water. Five solutions of the chemical with nominal
concentrations of 1.56, 3.13, 6.25, 12.5, 25, 50 and 100 mg/L were tested, together with one
control. Solution analysis was conducted at the nominal concentrations of 1.56 and 100 mg/L,
with the resultant measured concentrations of 2 and 96 mg/L respectively.
Five daphnia were tested at each concentration, with each test performed with four replicates.
The pH of the test solutions was 8.3 ?0.1, while dissolved oxygen levels remained between
9.0 and 11.0 mg/L and water hardness was 250 mg/L as CaCO3. The results indicate that the
chemical is slightly toxic to daphnia with a 48 hour EC50 of 20.8 mg/L determined using probit
analysis.
A test on the inhibition of algal growth was conducted on Scenedesmus subspicatus over a 72
hour incubation period at 23 ?2 oC with nominal concentrations of the notified chemical of
0.39, 0.78, 1.56, 3.13, 6.25, 12.5, 25, 50 and 100 mg/L, together with a negative control. The
results show the notified chemical is slightly toxic to this species of green algae.
The test on inhibition of bacterial respiration was conducted with activated sludge suspended
in an artificial medium (OECD synthetic medium) at 20 ?2oC. After three hours exposure of
the bacteria to a range of concentrations of the notified chemical, no discernible inhibition of
respiration was observed at test concentrations up to 1000 mg/L. Consequently, the NOEC
is taken as greater than 1000 mg/L. The reference material used in these tests (3,5-
dichlorophenol) produced greater than 70% inhibition when present at 100 mg/L.
The QSAR ASTER database calculations for this chemical (US EPA, 1998) predicted the
acute toxicity LC50 for several fish species, including rainbow trout (9.2 mg/L), fathead
minnow (16.9 mg/L), bluegill (11.6 mg/L), and channel catfish (7.2 mg/L). They also provided
an acute LC50 of 6.6 mg/L for immobilisation of daphnia and a chronic Maximum Allowable
Toxicant Concentration (MATC) of 17.5 mg/L for fathead minnow.
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11. ASSESSMENT OF ENVIRONMENTAL HAZARD
It is anticipated that a maximum of 20kg per annum will be released as a result of product
formulation, all into the Melbourne South Eastern sewer system. This sewer services
900,000 people and has an annual flow of around 85 x 109 litres, giving a mean predicted
environmental concentration (PEC) in this sewer of 0.25 礸/L. If all 20kg were released on a
single day (for example as result of an accident), the PEC for the chemical would be
approximately 0.07 mg/L.
The submission indicates that most of the chemical is adsorbed into the plated metal mass.
However, as a worst case scenario where all the material (a maximum of 200kg per annum) is
released to the sewer of one large city (for example, Melbourne) over a 350 day period, then
the mean PEC for the chemical in the city sewer system is estimated as l 礸/L. The predicted
worst case scenarios lead to very small sewer concentrations, which will be further reduced
through dilution in the receiving waters. If it is assumed that sewage effluent is diluted by a
factor of 10 on discharge to receiving waters, then the PEC is reduced to 0.1 礸/L, which is
four orders of magnitude below toxic levels.
The notified chemical has a very low potential for bioaccumulation and is not likely to be
adsorbed onto sediments, or to be readily biodegradable. Nevertheless the chemical is
expected to degrade slowly through abiotic hydrolysis and is therefore not expected to be
persistent in the environment.
In conclusion, the notified chemical is not likely to present a hazard to the environment when
it is stored, transported and used in the manner indicated in the submission.
12. ASSESSMENT OF PUBLIC AND OCCUPATIONAL HEALTH AND
SAFETY EFFECTS
Golpanol ATPN is determined to be a hazardous substance, under the National
Occupational Health and Safety Commission Approved Criteria for Classifying Hazardous
Substances (NOHSC, 1999b) according to toxicology summary information provided in the
submission for an analogous chemical. The oral LD50 in the rat is reportedly between 200
and 1000 mg/kg. It is also considered an eye irritant in rabbits, with a risk of serious damage
to eyes. Inhalation of dust may result in respiratory irritation but skin contact is not
expected to cause irritation. Chronic effects are not known. These health effects are
described on the MSDS. The overall health hazard classification is Harmful (Xn) with risk
phrases R22-Harmful if Swallowed and R41-Risk of Serious Damage to Eyes, assigned.
The notifier stated that particles of Golpanol ATPN range in size from 3-200 祄. Hence,
the notified polymer is comprised of respirable particles (i.e. <10祄), as well as inspirable
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particles (<180祄) that may be lodged in the upper respiratory tract leading to respiratory
irritation, as noted on the MSDS.
Once the chemical is diluted for blending (0.21%) and electroplating (0.001%) it will be
below the concentrations likely to cause health effects in humans.
There have been no reported incidences of adverse health effects or symptoms in humans
exposed to the notified chemical. There have been no work-related injuries or adverse health
effects associated with products currently in use that are similar in composition and
structure to this chemical.
Occupational Health and Safety
The total number of workers who will come in contact with the notified chemical during
handling, reformulation, electroplating and maintenance tasks will be low, probably less than
15. Workers may be exposed to Golpanol ATPN both in the solid and aqueous form.
Exposure to solid Golpanol ATPN is possible when weighing out the powder for
production of the nickel brightener solution, or during transport should accidental spillage
occur. Electroplating workers may be exposed to solutions of the notified chemical, via
fumes, spills and splashes, when preparing and disposing of bathing liquids.
During production of the nickel brightener solution small amounts of chemical are weighed
out (2.1 kg for every 1 000 L batch). Exposure may occur during this activity, however, it is
carried in an extraction booth and all process operators will wear protective equipment (for
example, overalls, safety glasses/goggles, gloves and faceshield or dust mask if necessary)
that complies with the relevant Australian Standard. The MSDS recommends that workers
use a dust mask if ventilation is inadequate or dust exposure is likely. Also the brightener
solution is formulated infrequently during any 12-month period, with the total potential
annual exposure estimated at 11 hours. Therefore, the risk of adverse effects resulting from
exposure to the notified chemical is low.
At the electroplating facility, there is little potential for exposure of operators to fumes
and/or spills as the chemical is present in very low concentrations (0.21%) and all
solutions are aqueous. Once the notified chemical is used in the electroplating process, it
will not be bioavailable as it is bound to the metal substrate. Any fumes from the baths will
be removed by local exhaust ventilation and all workers will wear standard protective
equipment (for example, overalls, safety glasses/goggles and gloves) that comply with the
corresponding Australian Standard. Given the low concentrations of notified chemical
present in solution and the high level of control available, the health risk to workers arising
from exposure to the notified chemical is very low.
The risk to storage and transport workers is very low as exposure will only occur if
packaging is breached. No repacking will take place.
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The notified chemical does carry a risk of dust explosion potential if electrostatic
accumulation occurs. However, this risk is no greater than for most other organic dusts.
Dust exposure can be minimised by moistening any leaked material, then sweeping or
vacuuming the residues using an industrial vacuum cleaner. The solids can be collected in a
waste container. As part of good hygiene practices, dust levels in the workplace should be
controlled to below the NOHSC exposure standard for `Dusts, not otherwise classified, 10
mg/m3 TWA (measured as inspirable fraction)' (NOHSC, 1995). Because the notified
chemical contains respirable particles, the ACGIH respirable particulate threshold limit
value (TLV) of 3 mg/m 3 can be used as guidance for the control of respirable dust in the
workplace (ACGIH, 1998). Employers are responsible for ensuring the exposure standard
is not exceeded.
Public Health
Based on the information provided by the notifier and the use pattern, Golpanaol ATPN is
considered not to pose a significant hazard to public health. It will only be used in the
electroplating industry and will not be sold to the general public. Exposure will be negligible
because once it is incorporated onto the electroplated metal surface, it is bound to the
substrate and becomes chemically and biologically unavailable. In any case, concentrations
of the chemical would be far too low to present a hazard, if it was somehow released.
13. RECOMMENDATIONS
To minimise occupational exposure to the notified chemical, the following guidelines and
precautions should be observed:
Avoid generation of dust when handling the notified chemical in powder form;
?br>
Provide local exhaust ventilation when weighing the notified chemical in powder form;
?br>
Safety goggles should be selected and fitted in accordance with Australian Standard
?br>
(AS) 1336 (Standards Australia, 1994) to comply with Australian/New Zealand
Standard (AS/NZS) 1337 (Standards Australia/Standards New Zealand, 1992);
Industrial clothing should conform to the specifications detailed in AS 2919
?br>
(Standards Australia, 1987) and AS 3765.1 (Standards Australia, 1990);
Impermeable gloves should conform to AS/NZS 2161.2 (Standards
?br>
Australia/Standards New Zealand, 1998);
All occupational footwear should conform to AS/NZS 2210 (Standards
?br>
Australia/Standards New Zealand, 1994a);
Respirators should conform to AS 1715 and AS 1716 (Standards Australia/Standards
?br>
New Zealand, 1994b,c);
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Spillage of the notified chemical should be avoided. Spillages should be cleaned up
?br>
promptly with absorbents which should be put into containers for disposal;
Good personal hygiene should be practised to minimise the potential for ingestion;
?br>
A copy of the MSDS should be easily accessible to employees.
?br>
14. MATERIAL SAFETY DATA SHEET
The MSDS for the notified chemical was provided in a format consistent with the National
Code of Practice for the Preparation of Material Safety Data Sheets (NOHSC, 1994c).
This MSDS was provided by the applicant as part of the notification statement. It is
reproduced here as a matter of public record. The accuracy of this information remains the
responsibility of the applicant.
15. REQUIREMENTS FOR SECONDARY NOTIFICATION
Under the Act, secondary notification of the notified chemical shall be required if any of the
circumstances stipulated under subsection 64(2) of the Act arise. No other specific
conditions are prescribed.
16. REFERENCES
OECD (1995-1996) OECD Guidelines for the Testing of Chemicals on CD-Rom. Paris,
Organisation for Economic Co-operation and Development (OECD).
European Commission (1992) Methods for the Determination of Physico-Chemical Properties,
Part A, Commission Directive 92/69/EC. Official Journal of the European Communities No.
L383A, December 1992.
National Occupational Health and Safety Commission (NOHSC, 1999a) List of Designated
Hazardous Substances [NOHSC:10005(1999)]. Australian Government Publishing Service,
Canberra. (In Press)
National Occupational Health and Safety Commission (NOHSC, 1994b) Approved Criteria
for Classifying Hazardous Substances [NOHSC:1008(1999)]. Australian Government
Publishing Service, Canberra. (In Press)
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National Occupational Health and Safety Commission (NOHSC, 1995) Adopted National
Exposure Standards for Atmospheric Contaminants in the Occupational Environment,
[NOHSC:1003(1995)]. In: Exposure Standards for Atmospheric Contaminants in the
Occupational Environment: Guidance Note and National Exposure Standards. Australian
Government Publishing Service, Canberra,.
American Conference of Governmental Industrial Hygienists (ACGIH,1998) 1998 TLV's and
BEI's: Threshold Limit Values and Physical Agents; Biological Exposure Indices. Cincinnati,
American Conference of Governmental Industrial Hygienists (ACGIH).
National Occupational Health and Safety Commission (NOHSC, 1994c) National Code of
Practice for the Preparation of Material Safety Data Sheets [NOHSC:2011(1994)]. Australian
Government Publishing Service, Canberra.
Standards Australia (1987) Australian Standard 2919-1987, Australian Standard Industrial
Clothing. Standards Australia, Sydney.
Standards Australia (1990) Australian Standard 3765.1-1990, Australian Standard Clothing
for Protection Against Hazardous Chemicals Part 1: Protection Against General or Specific
Chemicals. Standards Australia, Sydney.
Standards Australia (1994) Australian Standard 1336-1994, Australian Standard Eye
Protection in the Industrial Environment. Standards Australia, Sydney.
Standards Australia/Standards New Zealand (1992) Australian/New Zealand Standard 1337-
1992, Australian/New Zealand Standard Eye Protectors for Industrial Applications. Standards
Australia and Standards New Zealand, Sydney/Wellington.
Standards Australia/Standards New Zealand (1994a) Australian/New Zealand Standard 2210-
1994, Australian/New Zealand Standard Occupational Protective Footwear. Standards
Australia and Standards New Zealand, Sydney/Wellington.
Standards Australia/Standards New Zealand (1994b) Australian/New Zealand Standard 1715-
1994, Australian/New Zealand Standards for the Selection, Use and Maintenance of
Respiratory Protective Devices. Standards Australia and Standards New Zealand,
Sydney/Wellington.
Standards Australia/Standards New Zealand (1994c) Australian/New Zealand Standard 1716-
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and Standards New Zealand, Sydney/Wellington.
Standards Australia/Standards New Zealand (1998) Australian/New Zealand Standard
2161.2-1998, Australian/New Zealand Standard Occupational Protective Gloves Part 2:
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FULL PUBLIC REPORT 15
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US Environment Protection Agency (US EPA, 1998) ASTER Ecotoxicity Profile: Propanoic
acid, 3-[(aminoiminomethyl)thio]- (CAS No. 5398-29-8). United States Environmental
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FULL PUBLIC REPORT 16
NA/656
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