MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC and ISO 11014-1 Responsible Name: Diazyme Administration
Effective 08/06/08
SECTION 1: PRODUCT and COMPANY IDENTIFICATION
PRODUCT NAME: CATALOG #
Cystatin C Assay DZ133A
Reagent R2 DZ133A-R2
Reagent R1 DZ133A-R1
Calibrator DZ133A-Cal
Control DZ133A-Con
Supplier: Diazyme Laboratories Manufacturer: Diazyme Laboratories Authorized Representative: MDSS GmbH
12889 Gregg Court 12889 Gregg Court Schiffgraben 41
Poway, CA 92064, USA Poway, CA 92064, USA 30175 Hannover
858-455-4754 858-455-4754 Germany
In case of Emergency: Call Diazyme Laboratories (858-455-4754)
Intended Use: Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications.
SECTION 2: HAZARDOUS INGREDIENTS
Product Ingredient Amount CAS # EINECS # Symbols R-Phrase S-Phrase
Reagent R1 Tris(hydroxymethyl)aminomethane 77-86-1 201-064-4 XI 36/37/38 None Listed
Reagent R1, Sodium Azide 0.09% 26628-22-8 None Listed None Listed None Listed None Listed
R2, Calibra-
tor & Control
NOTE: Physical and health hazard information on reagent mixtures has not been determined. Any physical and health information noted is based on 1) evaluation of
data for the pure ingredients, and 2) concentration of ingredients as packaged.
SECTION 3: HAZARD INDENTIFICATION
TRIS(HYDROXYMETHYL)AMINOMETHANE: SODIUM AZIDE:
EMERGENCY OVERVIEW EMERGENCY OVERVIEW
POISON! DANGER! MAY BE FATAL IF SWALLOWED OR ABSORBED
Irritating to eyes, respiratory system and skin.The toxicological properties of
THROUGH SKIN. HARMFUL IF INHALED. HAZARDOUS SOLID. CON-
this material have not been fully investigated.Hygroscopic (absorbs moisture
TACT WITH OTHER MATERIAL MAY CAUSE FIRE OR EXPLOSION.
from the air).
CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. AF-
Potential Health Effects FECTS CENTRAL NERVOUS SYSTEM, KIDNEYS, AND CARDIOVASCU-
LAR SYSTEM.
Eye: Causes eye irritation.
Skin: Causes skin irritation.
SAF-T-DATA(tm) Ratings (Provided here for your convenience)
Ingestion: May cause severe gastrointestinal tract irritation with nausea, ----------------------------------------------------------------------------------------------
vomiting and possible burns. May cause liver and kidney -------------
damage. The toxicological properties of this substance have Health Rating: 4 - Extreme (Poison)
not been fully investigated. May cause metabolic changes in- Flammability Rating: 1 - Slight
cluding hypoglycemia, and hyperkalemia. May depress respi- Reactivity Rating: 4 - Extreme (Explosive)
ratory center. Contact Rating: 4 - Extreme (Life)
Inhalation: May cause irritation of the respiratory tract with burning pain Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON;
in the nose and throat, coughing, wheezing, shortness of VENT HOOD; PROPER GLOVES; CLASS B EXTINGUISHER
breath and pulmonary edema. The toxicological properties of Storage Color Code: Yellow Stripe (Store Separately)
this substance have not been fully investigated.
Chronic: Prolonged or repeated skin contact may cause dermatitis. Potential Health Effects
May cause liver and kidney damage.
Inhalation:
May cause irritation to the respiratory tract and mucous membranes, sore
throat, coughing, dizziness, shortness of breath, and fainting. May be absorbed
through inhalation. Symptoms may parallel ingestion.
Ingestion:
Highly Toxic! May cause breathlessness, pulmonary edema and rapid heart
beat within 5 minutes. Nausea, vomiting, headache, restlessness, and diarrhea
may occur within 15 minutes. Other symptoms may include low blood pres-
sure, abnormal breathing, reduced body temperature, reduced body pH, con-
MSDS 1032 Rev C Page 1 of 6
MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC and ISO 11014-1 Responsible Name: Diazyme Administration
Effective 08/06/08
vulsions, collapse and death.
Skin Contact:
the skin; symptoms may parallel ingestion.
Highly Toxic! Causes irritation, redness, and pain. May be absorbed through
Eye Contact:
Causes irritation, redness, pain, and blurred vision.
Chronic Exposure:
No information found.
Aggravation of Pre-existing Conditions:
No information found.
Tris(hydroxymethyl)aminomethane
HEALTH: 2
HMIS RATING FLAMMABILITY: 0
REACTIVITY: 0
HEALTH: 2
NFPA RATING FLAMMABILITY: 0
REACTIVITY: 0
HAZARD SYMBOLS: XI
R-Phrase: 36/37/38
S-Phrase: 26-37/39
SECTION 4: FIRST AID MEASURES
TRIS(HYDROXYMETHYL)AMINOMETHANE: SODIUM AZIDE:
Eyes: Flush eyes with plenty of water for at least 15 minutes, Inhalation:
occasionally lifting the upper and lower eyelids. Get Remove to fresh air. If not breathing, give artificial respiration. If breathing is
medical aid immediately. difficult, give oxygen. Get medical attention immediately.
Ingestion:
Skin: Get medical aid. Flush skin with plenty of water for at
Induce vomiting immediately as directed by medical personnel. Never give
least 15 minutes while removing contaminated clothing
anything by mouth to an unconscious person. Get medical attention immedi-
and shoes. Wash clothing before reuse.
ately.
Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk
Skin Contact:
or water. Never give anything by mouth to an uncon-
Wipe off excess material from skin then immediately flush skin with plenty of
scious person. Get medical aid.
soap and water for at least 15 minutes. Remove contaminated clothing and
Inhalation: Get medical aid immediately. Remove from exposure shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean
and move to fresh air immediately. If not breathing, shoes before reuse.
give artificial respiration. If breathing is difficult, give Eye Contact:
oxygen. Immediately flush eyes with plenty of water for at least 15 minutes, lifting
Notes to Physician: Treat symptomatically and supportively. lower and upper eyelids occasionally. Get medical attention immediately.
Note to Physician:
Accidental ingestion of sodium azide is potentially life threatening. Treatment
includes gastric lavage, followed by saline catharsis. EKG and blood pressure
monitoring and support are recommended.
SECTION 5: FIRE FIGHTING MEASURES
TRIS(HYDROXYMETHYL)AMINOMETHANE:
General Information: As in any fire, wear a self-contained breathing
apparatus in pressure-demand, MSHA/NIOSH
SODIUM AZIDE:
(approved or equivalent), and full protective gear.
During a fire, irritating and highly toxic gases
Fire:
may be generated by thermal decomposition or
Combustible solid. May pose a fire hazard upon heating, shock, concussion,
combustion.
or friction.
Extinguishing Media: In case of fire, use water, dry chemical, chemical Explosion:
foam, or alcohol-resistant foam. Decomposes explosively upon heating, shock, concussion, or friction. Reacts
with both copper and lead to produce explosive azides. Explosions in labora-
tory plumbing containing these metals is possible. Sensitive to mechanical
impact.
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-
MSDS 1032 Rev C Page 2 of 6
MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC and ISO 11014-1 Responsible Name: Diazyme Administration
Effective 08/06/08
contained breathing apparatus with full facepiece operated in the pressure exposed containers cool. Poisonous gases are produced in fire, including
demand or other positive pressure mode. Water spray may be used to keep fire nitrogen oxides.
SECTION 6: ACCIDENTAL RELEASE MEASURES
TRIS(HYDROXYMETHYL)AMINOMETHANE: SODIUM AZIDE:
General Information: Use proper personal protective equipment as Remove all sources of ignition. Ventilate area of leak or spill. Wear appropri-
indicated in Section 8. ate personal protective equipment as specified in
Section 8. Spills: Clean up spills in a manner that
Spills/Leaks: Clean up spills immediately, observing precau-
does not disperse dust into the air. Use non-
tions in the Protective Equipment section. Sweep
sparking tools and equipment. Reduce airborne
up or absorb material, then place into a suitable
dust and prevent scattering by moistening with
clean, dry, closed container for disposal. Avoid
water. Pick up spill for recovery or disposal and
generating dusty conditions. Provide ventilation.
place in a closed container. US Regulations
(CERCLA) require reporting spills and releases to
soil, water and air in excess of reportable quanti-
ties.
SECTION 7: HANDLING AND STORAGE
TRIS(HYDROXYMETHYL)AMINOMETHANE:
Handling: Wash thoroughly after handling. Remove contaminated
clothing and wash before reuse. Use with adequate ventila-
SODIUM AZIDE:
tion. Avoid contact with eyes, skin, and clothing. Keep con-
tainer tightly closed. Avoid ingestion and inhalation. Discard
Store in a tightly closed container. Store in a cool, dry, ventilated area away
contaminated shoes.
from sources of heat or ignition. Protect container from physical damage.
Storage: Store in a tightly closed container. Store in a cool, dry, well- Isolate from incompatible substances. Containers of this material may be
ventilated area away from incompatible substances. Keep hazardous when empty since they retain product residues (dust, solids); ob-
away from acids. Keep containers tightly closed. Store pro- serve all warnings and precautions listed for the product.
tected from moisture. Store at room temperature.
SECTION 8: EXPOSURE CONTROLS / PERSONAL PROTECTION
TRIS(HYDROXYMETHYL)AMINOMETHANE: SODIUM AZIDE:
Engineering Controls:
Airborne Exposure Limits:
Facilities storing or utilizing this material should be equipped with an eye-
-NIOSH Recommended Exposure Limit (REL):
wash facility and a safety shower. Use adequate ventilation to keep airborne
0.1 ppm skin as HN3, 0.3 mg/m3 skin as NaN3 (Ceilings)
concentrations low.
Exposure Limits -ACGIH Threshold Limit Value (TLV):
CAS# 77-86-1: 0.11 ppm as HN3, 0.29 mg/m3 as Na N3 (Ceilings), A4 Not classifiable as a
human carcinogen.
Personal Protective Equipment
Ventilation System:
Eyes: Wear appropriate protective eyeglasses or chemical safety
A system of local and/or general exhaust is recommended to keep employee
goggles as described by OSHA's eye and face protection
exposures below the Airborne Exposure Limits. Local exhaust ventilation is
regulations in 29 CFR 1910.133 or European Standard
generally preferred because it can control the emissions of the contaminant at
EN166.
its source, preventing dispersion of it into the general work area. Please refer
Skin: Wear appropriate protective gloves to prevent skin exposure.
to the ACGIH document, Industrial Ventilation, A Manual of Recommended
Clothing: Wear appropriate protective clothing to prevent skin expo- Practices, most recent edition, for details.
sure. Personal Respirators (NIOSH Approved):
Respirators: A respiratory protection program that meets OSHA's 29 CFR If the exposure limit is exceeded and engineering controls are not feasible,
1910.134 and ANSI Z88.2 requirements or European Stan- wear a supplied air, full-facepiece respirator, airlined hood, or full-facepiece
dard EN 149 must be followed whenever workplace condi- self-contained breathing apparatus. Breathing air quality must meet the re-
tions warrant respirator use. quirements of the OSHA respiratory protection standard (29CFR1910.134).
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron
or coveralls, as appropriate, to prevent skin contact.
Eye Protection:
Use chemical safety goggles and/or full face shield where dusting or splashing
MSDS 1032 Rev C Page 3 of 6
MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC and ISO 11014-1 Responsible Name: Diazyme Administration
Effective 08/06/08
of solutions is possible. Maintain eye wash fountain and quick-drench facili- ties in work area.
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
TRIS(HYDROXYMETHYL)AMINOMETHANE:
SODIUM AZIDE Appearance:
Physical State: Solid Colorless crystals.
Color: white Odor:
Odor: amine-like Odorless.
pH: 10.36(aq. solution) Solubility:
Vapor Pressure: Not available 42 g/100 g water @ 17C (63F)
Viscosity: Not available Specific Gravity:
Boiling Point: 219-220 deg C @ 10 mm Hg 1.85
Freezing/Melting Point: 171.2-172.3 deg C pH:
Autoignition Temperature: Not available. No information found.
Flash Point: Not available % Volatiles by volume @ 21C (70F):
Explosion Limits: Lower: Not available 0
Explosion Limits: Upper: Not available Boiling Point:
Decomposition Temperature: Not available Not applicable.
Solubility in water: Moderately Soluble Melting Point:
Specific Gravity/Density: Not available. 275 (decomposes to sodium and nitrogen)
Molecular Formula: (CH2OH)3CNH2 Vapor Density (Air=1):
Molecular Weight: 121.14 2.2
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.
SECTION 10: STABILITY AND REACTIVITY
TRIS(HYDROXYMETHYL)AMINOMETHANE: SODIUM AZIDE:
Chemical Stability: Stable under normal tempera- Stability:
tures and pressures. Stable under ordinary conditions of use and storage. Decomposes explosively
upon heating, shock, concussion, or friction.
Conditions to Avoid: Dust generation, exposure to
Hazardous Decomposition Products:
moist air or water.
Explodes upon decomposition liberating nitrogen gas (N2) and sodium (Na).
Incompatibilities with Other Materials Strong oxidizing agents, strong
Hazardous Polymerization:
acids.
Will not occur.
Hazardous Decomposition Products Nitrogen oxides, carbon monox- Incompatibilities:
ide, irritating and toxic fumes Benzoyl chloride plus potassium hydroxide, bromine, carbon disulfide, chro-
and gases, carbon dioxide. myl chloride, copper, dibromalononitrile, dimethyl sulfate, lead, barium car-
Hazardous Polymerization Will not occur. bonate, sulfuric acid, water, and nitric acid.
Conditions to Avoid:
Heat, flames, ignition sources and incompatibles.
SECTION 11: TOXICOLOGICAL INFORMATION
TRIS(HYDROXYMETHYL)AMINOMETHANE: SODIUM AZIDE:
RTECS#: CAS# 77-86-1: TY2900000 Oral rat LD50: 27 mg/kg Skin rabbit LD50: 20 mg/kg.
Inhalation rat LC50: 37 mg/m3 Investigated as a tumorigen and mutagen.
LD50/LC50: RTECS:
--------\Cancer Lists\------------------------------------------------------
CAS# 77-86-1: Oral, rat: LD50 = 5900 mg/kg;.
---NTP Carcinogen---
Carcinogenicity: Tris (hydroxymethyl) aminomethane - Not listed as a
Ingredient Known Anticipated IARC Category
carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
------------------------------------ ----- ----------- -------------
Other: See actual entry in RTECS for complete information. Sodium Azide (26628-22-8) No No None
SECTION 12: ECOLOGICAL INFORMATION
MSDS 1032 Rev C Page 4 of 6
MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC and ISO 11014-1 Responsible Name: Diazyme Administration
Effective 08/06/08
TRIS(HYDROXYMETHYL)AMINOMETHANE: SODIUM AZIDE:
Other: No information available. Environmental Fate:
When released into the soil, this material is not expected to biodegrade. When
released into the soil, this material is expected to leach into groundwater.
When released into the air, this material may be moderately degraded by
photolysis.
Environmental Toxicity:
Dangerous to the environment. Very toxic to aquatic organisms; may cause
long term adverse effects in the aquatic environment. Freshwater Fish Species
Data:
96 Hr LC50 Oncorhynchus mykiss: 0.8 mg/L;
96 Hr LC50 Lepomis macrochirus: 0.7 mg/L;
96 Hr LC50 Pimephales promelas: 5.46 mg/L [flow-through]
SECTION 13: DISPOSAL CONSIDERATIONS
TRIS(HYDROXYMETHYL)AMINOMETHANE: SODIUM AZIDE:
Products considered hazardous for supply are classified as Special Waste and Whatever cannot be saved for recovery or recycling should be handled as
the disposal of such chemicals is covered by regulations which may vary hazardous waste and sent to a RCRA approved waste facility. Processing, use
according to location. Contact a specialist disposal company or the local au- or contamination of this product may change the waste management options.
thority or advice. Empty containers must be decontaminated before returning State and local disposal regulations may differ from federal disposal regula-
for recycling. tions. Dispose of container and unused contents in accordance with federal,
state and local requirements.
SECTION 14: TRANSPORTATION INFORMATION
TRIS(HYDROXYMETHYL)AMINOMETHANE
IATA IMO RID/ADR
Shipping Name: Not regulated. Not regulated. Not regulated.
Hazard Class:
UN Number:
Packing Group:
SODIUM AZIDE
Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: SODIUM AZIDE
Hazard Class: 6.1
UN/NA: UN1687
SECTION 15: REGULATORY INFORMATION
TRIS(HYDROXYMETHYL)AMINOMETHANE: Canada
CAS# 77-86-1 is listed on Canada's DSL List
European/International Regulations
US Federal
European Labeling in Accordance with EC Directives
TSCA
Hazard Symbols: XI
CAS# 77-86-1 is listed on the TSCA Inventory.
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately with
plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face protection.
WGK (Water Danger/Protection)
CAS# 77-86-1: 1
MSDS 1032 Rev C Page 5 of 6
MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC and ISO 11014-1 Responsible Name: Diazyme Administration
Effective 08/06/08
Ingredient RQ TPQ List Chemical Catg.
SODIUM AZIDE:
----------------------------------------- --- ----- ---- --------------
--------\Chemical Inventory Status - Part 1\--------------------------------- Sodium Azide (26628-22-8) 1000 500 Yes No
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- --------- --------\Federal, State & International Regulations - Part 2\----------------
Sodium Azide (26628-22-8) Yes Yes Yes Yes -RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
--------\Chemical Inventory Status - Part 2\--------------------------------- ----------------------------------------- ------ ------ ------
--Canada-- Sodium Azide (26628-22-8) 1000 P105 No
Ingredient Korea DSL NDSL Phil. Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
----------------------------------------------- ----- --- ---- -----
Sodium Azide (26628-22-8) Yes Yes No Yes
SARA 311/312: Acute: Yes Chronic: No Fire: Yes Pressure: No
--------\Federal, State & International Regulations - Part 1\---------------- Reactivity: Yes (Pure / Solid)
-SARA 302- ------SARA 313------
SECTION 16: OTHER INFORMATION
PREPARED BY: Diazyme Administration
PHONE NO: 858-455-4754
DATE PREPARED: 25 February 2008
The information provided on this Material Safety Data Sheet is provided in the interest of promoting safe handling of the material. While this information is believed to
be correct Diazyme makes no warranty in respect to any of the information disclosed. Observe all federal, provincial, state and local laws concerning health and pollu-
tion.
MSDS 1032 Rev C Page 6 of 6
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