0019A01 Div.03 sds 2-Amino-6-methylpyridine GHS Format
SAFETY DATA SHEET
Section 1: IDENTIFICATION
Product Name 2-Amino-6-methylpyridine
CAS RN 1824-81-3
EC# 217-360-1
SYNONYMS 2-Amino-6-Picoline, 2-Pyridinamine, 6-Methyl,
6-Amino-2-picoline, 6-Methyl-2-aminopyridine
6-Methyl-2-pyridinamine
OTHER LANGUAGES
De: 6-Methyl-2-pyridylamin
Es: 6-metil-2-piridilamina
Fr: 6-m閠hyl-2-pyridylamine
SYSTEMATIC NAME 2-Picoline, 6-amino- (8CI), 2-Pyridinamine, 6-methyl-
MOLECULAR FORMULA: C6H8N2
STRUCTURAL FORMULA: CH3
N
INGREDIENTS H2N
Chemical CAS Purity Unit
2-Amino-6-Methylpyridine 1824-81-3 >98% w/w
PRODUCT USES
2-Amino-6-Methylpyridine is used as an intermediate in the pharmaceutical industry
for the manufacture of nalidixic acid etc. It is also used for laboratory utilization,
analysis, research and fine chemistry.
FACTORY & REGISTERED HEAD OFFICE:
Jubilant Organosys Limited
OFFICE:
Jubilant Organosys Limited, Plot 1-A, Sector 16-A,
Bhartiagram, Gajraula Institutional Area, Noida,
District: Jyotiba Phuley Nagar Uttar Pradesh-201301 India.
Uttar Pradesh-244223 , India PHONE NO: +91-120-2516601
PHONE NO: +91-5924-252353 unto Contact department: EHS
252360 FAX NO : +91-120-2516834
Contact Department-Safety: Ext. 7424 Email: support@jubl.com
FAX NO : 91-5924-252352
Medical and Transport Emergencies: +91-9997022412 (India)
Logistics emergencies +91-120-4365441 (India)
Jubilant Organosys Limited Page 1 of 11
0019A01 Div.03 sds 2-Amino-6-methylpyridine GHS Format
Section 2: HAZARD IDENTIFICATION
GHS CLASSIFICATION
Skin corrosion / irritant: Category 2
Serious eye damage/eye irritant: Category 2B
Acute toxicity Oral: Category 3
Acute Toxicity Dermal: Category 2
OVERVIEW
Off-white to yellow crystalline solid with a typical odor. It is hygroscopic. It is non-
flammable and is freely soluble in water. It causes irritation to skin, eyes and respiratory
tract.
Danger!
Toxic if swallowed.
Fatal in contact with skin
Warning!
Causes eye irritation.
Causes skin irritation.
PRECAUTIONARY STATEMENTS
Prevention
?Keep container tightly closed.
?Keep away from ignition sources such as heat/sparks/open flame?No smoking.
?Wear protective gloves/clothing and eye/face protection.
?Use explosion-proof electrical/ventilating/ lighting/equipment.
?Take precautionary measures against static discharge.
?Use only non-sparking tools.
?Do not eat, drink or smoke when using this product.
?Wash hands thoroughly after handling.
?Use only outdoors or in a well-ventilated area.
?Avoid breathing vapor or mist.
Response
In case of fire, use appropriate media as specified by the manufacturer for extinction.
If On Skin (Or Hair): Remove/take off immediately all contaminated clothing.
Rinse skin with water/shower. Immediately call a doctor or poison center in all incidents.
Immediately take off all contaminated clothing. Wash thoroughly with water for at least
15 minutes. Wash contaminated clothes before reuse.
If in Eyes: Rinse cautiously with water for several minutes. Remove contact lenses if
present and easy to do so. If eye irritation persists call a doctor.
Ingestion: Rinse mouth. If swallowed do NOT induce vomiting.
Jubilant Organosys Limited Page 2 of 11
0019A01 Div.03 sds 2-Amino-6-methylpyridine GHS Format
In case of Inhalation: Remove to fresh air and keep at rest in a position comfortable for
breathing. Call a physician if you feel unwell.
Absorb spillage to prevent material damage.
Do not use water to extinguish. Use water fog (spray), foam, Dry Chemical Powder or
carbon dioxide.
Storage
Store locked up
Store in a corrosive resistant container. .
Disposal
Dispose of the container as per local norms and regulations.
Section 3: Composition of ingredients
Sr.No. Chemical CAS # EC# Purity
1 2-Amino-6- 1824-81-3 217-360-1 >98%
Methylpyridine
Section 4: First Aid Measures
Key symptoms
?Acute effects:
It is fatal in contact with skin. Toxic if swallowed. Causes convulsions. Irritating
to eye, skin and upper respiratory tract.
? Target organs:
Lungs, Respiratory, Kidney, Bladder
FIRST AID:
Eyes: If in eyes rinse cautiously with water for at least 15 minutes. Remove contact
lenses if easy to do so. Continue rinsing. Seek medical attention.
Skin: Immediately take off all contaminated clothing. Wash thoroughly with water for at
least 15 minutes. Wash contaminated clothes before reuse. Seek immediate medical
attention.
Ingestion: If swallowed call a poison center if you feel unwell. Rinse mouth. Do NOT
induce vomiting by use of emetics. Seek medical attention.
Section 5: Fire Fighting Measures
Jubilant Organosys Limited Page 3 of 11
0019A01 Div.03 sds 2-Amino-6-methylpyridine GHS Format
Flash Point: 1030C (217.4 deg F) Non-Flammable
Extinguishing media
Water spray, dry chemical powder, carbon dioxide, and appropriate foam.
General Information:
Wear NIOSH/MSHA approved breathing apparatus and protective clothing. Flammable
solid. Dusts can also form explosive mixtures. Emits toxic fumes and CO, CO2 and NOx
under fire conditions.
Special fire fighting hazards:
May form explosive mixtures with the air. The fumes are heavier than air, so they may
spread at floor level. Do not allow extinguishing water into surface or underground
watercourses.
NFPA Rating: Not published.
Explosion Limits, Lower: Not available.
Upper: Not available.
Section 6: Accidental Release Measures
Minor Spills
?Clean up all spills immediately following relevant Standard Operating
Procedures.
?Avoid contact with skin and eyes.
?Shut off leak source if possible.
?Shut off all possible sources of ignition.
?Wear protective clothing, boots, impervious gloves and safety glasses.
?Wipe up.
?Decontaminate all equipment.
Major Spill
? Alert Emergency Responders and tell them location and nature of hazard.
? Shut off all possible sources of ignition and increase ventilation.
? Wear protective clothing, full boots, impervious gloves, safety glasses and
Self Contained Breathing Apparatus (SCBA), as may be deemed
appropriate.
? Clear area of personnel and move upwind.
? Stop leaks if possible.
? Prevent, by any means available, spillage from entering drains or water
and watercourses.
? Collect recoverable product into labeled containers for recycling, recovery
or disposal.
? Contain spill with sand, earth or vermiculite.
Jubilant Organosys Limited Page 4 of 11
0019A01 Div.03 sds 2-Amino-6-methylpyridine GHS Format
? Spread area with lime or absorbent material, and leave for at least 1 hour
before washing.
? Clean up all tools and equipment.
? Inform authorities in event of contamination of any public sewers, drains
or water bodies.
Section 7: Handling & Storage
Handling
? Wear protective gloves/clothing and eye/face protection.
? Wash thoroughly after handling.
? Ground and secure containers when dispensing or pouring product.
? Avoid contact with incompatible materials.
? When handling, DO NOT eat, drink or smoke.
? Launder contaminated clothing before re-use.
? If on skin or hair, IMMEDIATELY remove all contaminated clothing and
rinse/shower with plenty of water.
Storage
? Store in a flame proof area
? Store away from incompatible materials.
? Keep only in original container.
? Keep securely closed when not in use.
Jubilant Organosys Limited Page 5 of 11
0019A01 Div.03 sds 2-Amino-6-methylpyridine GHS Format
Section 8: Exposure Controls/Personal Protection
Exposure Limits
Chemical name ACGIH TLV OSHA PEL NIOSH
2-Amino-6- No data No data No data
Methylpyridine
OSHA Vacated PELs:
No OSHA Vacated PELs are listed for this chemical.
Exposure Controls
Provide exhaust ventilation or other engineering controls to keep the relevant airborne
concentrations below their respective occupational exposure limits. Ensure that eyewash
stations and safety showers are close to the workstation location.
Personal Protection:
Protective clothing should be selected specifically for the working place, depending on
concentration and quantity of the hazardous substances handled. The resistance of the
protective clothing to chemicals should be ascertained with the respective supplier.
Hands: Wear appropriate protective gloves to prevent skin exposure.
Eyes: Safety goggles/ Chemical Safety glasses and Face shield.
Clothing: Boots and clothing to prevent contact.
Respirator: Follow the OSHA respirator regulations found in 29CFR 1910.134 or
European Standard EN 149. Always use a NIOSH or European Standard EN 149
approved respirator when necessary.
General Hygiene and general comments:
?Wash hands and face after working with substance.
?Immediately change contaminated clothing.
?Apply skin protective barrier cream.
Jubilant Organosys Limited Page 6 of 11
0019A01 Div.03 sds 2-Amino-6-methylpyridine GHS Format
Section 9: Physical and Chemical Properties
Sr.No. Parameter Typical value
1 Off white to yellow
Appearance crystalline solid
Odor
2 Typical
Odor Threshold Not available
3 Melting point 40-45癈
208-209 癈
4 Boiling point
1030C
Flash point
5
Evaporation rate (n-BuAc=1)
6 Not available
Explosive limits
7 Not available
Vapor pressure
8 0.14
Vapor density (air=1)
9 3.73
Specific gravity (water=1)
10 Not available
11 Freely soluble
Solubility
12 Not available
pH
Log Pow (octonol/water)
13 1.08
Auto-ignition temperature
14 Not available
Decomposition temperature
15 Not available
Viscosity
16 Not available
17 108.14
Molecular Weight
18 5.98
pKa (@250C)
19 72.53
Koc
21 No
Oxidizer
22 No
Corrosive material
23 No
Explosive material
Section 10: Stability and Reactivity
Stability: Stable
Conditions to avoid: Hygroscopic. Keep away from heat, sparks, flame, high
temperature and incompatible chemicals.
Incompatible chemicals: Acids and acid chlorides, oxidizing materials like hydrogen
peroxide and sulphuric acid and Chloroformates.
Hazardous decomposition: Thermal decomposition may produce Cyanide, nitrogen
oxides and carbon monoxide.
Hazardous Polymerization: Not reported.
Jubilant Organosys Limited Page 7 of 11
0019A01 Div.03 sds 2-Amino-6-methylpyridine GHS Format
Section 11: Toxicological Information
? ACUTE STUDIES:
Toxic if swallowed or in contact with skin. Irritating to tissues of the
mucous membranes and upper respiratory tract, eyes and skin. May cause
convulsions.
? TARGET ORGANS:
LUNGS, RESPIRATORY, KIDNEY, BLADDER
? TOXICITY
RTECS#: US1885000
ACUTE ORAL LD50 (RAT) = 100 mg/kg
ACUTE DERMAL LD50:(Guinea Pig) = 125mg/kg
INTRAVENOUS LD50 (MOUSE) = 18mg/kg
SUBCUTANEOUS LD50 (MOUSE) = 52mg/kg
? CARCINOGENICITY
Not listed by NTP, IARC and OSHA.
Not present on the EU CMR list.
According to information presently available 2-Amino-6-Methylpyridine is
not found to be carcinogenic.
? OTHER CHRONIC EFFECTS: Behavioral (convulsions or effect on seizure
threshold)
Section 12: Ecological Information
Mobility:
?Koc=72.53. Very low absorption.
?Henry's Law constant: 2.75E-009 atm-m3/mole. Non- volatile from aqueous
bodies.
?Log Pow=1.08. Low potential to bioaccumulate.
Environmental fate
Based on environmental modeling:
?2-Amino-6-Methylpyridine is expected to be persistent in the environment .
?It is expected to be found predominantly in soil
?It is also expected to be found in water but not in sediment.
?It is not expected to bioaccumulate.
?It does not biodegrade readily.
.
Jubilant Organosys Limited Page 8 of 11
0019A01 Div.03 sds 2-Amino-6-methylpyridine GHS Format
Section 13: Disposal Consideration
? Burn in a chemical incinerator equipped with an afterburner and scrubber.
? Dispose of this material in accordance with standard practice for disposal of
potentially hazardous materials as required by applicable federal, state or local
laws. Note that disposal regulations may also apply to empty containers and
equipment rinsates.
Section 14: Transport Information
It is considered to be Hazardous for Transport by Road/Rail/Sea/Air and regulated by
ADR/RID/IMDG/IATA as given below:
S.No Agency UN Proper Shipping name Hazard Packing
Number Class Group
Toxic solid, Organic,
Land
ADR/RID II
2811 N.O.S 6.1
transport
Toxic solid, Organic,
Maritime
IMDG 2811 N.O.S 6.1 II
Transport
Toxic solid, Organic,
Air
IATA 2811 N.O.S 6.1 II
Transport
Toxic
Hazard Label
Section 15: Regulatory Information
European information
EC# 217-360-1
Classification: T; R24/25 - Xi; R36/37/38
T Toxic
Xi Irritant
RISK PHRASES
?R24/25 Toxic in contact with skin and if swallowed.
?R36/37/38 Irritating to eyes, respiratory system and skin.
Jubilant Organosys Limited Page 9 of 11
0019A01 Div.03 sds 2-Amino-6-methylpyridine GHS Format
SAFETY PHRASES
?S 26 In case of contact with eyes, rinse immediately with plenty of water and seek
medical advice.
?S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
?S45 In case of accident or if you feel unwell, seek medical advice immediately
(show the label where possible).
Pre-Registration Status under REACH Regulation (EC) No. 1907/2006
EC Name Submission Pre-registration Name of the Validity
Number Number Organization
(OR)
6-methyl-2- XQ227150-25 05-2114573066-47-0000 Jubilant 31/05/2018
pyridylamine Pharmaceuticals NV
US INFORMATION
TSCA
CAS# 1824-81-3 is listed on the TSCA inventory.
HEALTH & SAFETY REPORTING LIST
None of the chemicals are on the health & safety reporting list.
CHEMICAL TEST RULES
None of the chemicals in this product are under a chemical test rule.
SECTION 12B:
None of the chemicals are listed under TSCA section 12B.
TSCA SIGNIFICANT NEW USE RULE:
None of the chemicals in this material have a SNUR under TSCA.
SARA
SECTION 302 (RQ):
None of the chemicals in this material have an RQ.
SECTION 302 (TPQ):
None of the chemicals in this product have a TPQ.
CLEAN WATER ACT:
None of the chemicals in this product are listed as hazardous under the CWA.
AIR POLLUTION:
Jubilant Organosys Limited Page 10 of 11
0019A01 Div.03 sds 2-Amino-6-methylpyridine GHS Format
The material is not listed as haps (hazardous air pollutants)
The material is not listed as ozone depletors
OSHA
This material is not considered highly hazardous under OSHA.
Section 16: Other Information
SDS data
Chemical: 2-Amino-6-Methylpyridine
CAS #: 1824-81-3
File Name: 0019A01 Div.03 sds 2-Amino-6-methylpyridine
Date: December 16, 2008
Revision Number: 01
Information contained in this SDS is believed to be correct but no representation;
guarantee or warranties of any kind are made as to its accuracy, suitability for a particular
application or results to be obtained from them. This SDS shall be used as a guide only.
JUBILANT ORGANOSYS LIMITED makes no warranties expressed or implied of the
adequacy of this document for any particular purpose.
Jubilant Organosys Limited Page 11 of 11
|