8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: 2,3,4,5,6-Pentafluorobenzyl Bromide
Code: 270587
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
SECTION 1 ..................................................... PRODUCT IDENTIFICATION ........................................................................
Name: 2,3,4,5,6-Pentafluorobenzyl Bromide
Code: 270587
SECTION 2 .................................. COMPOSITION, INFORMATION ON INGREDIENTS .....................................................
Synonyms
PFB-Br; -Bromo-2,3,4,5,6-pentafluorotoluene; 1-(Bromomethyl)-2,3,4,5,6-pentafluorobenzene;
1-(Bromomethyl)pentafluorobenzene; Pentafluorobenzyl bromide; 2,3,4,5,6-Pentafluoro--bromotoluene;
(Bromomethyl)pentafluorobenzene; 2,3,4,5,6-Pentafluorobenzyl bromide; (Pentafluorophenyl)methyl bromide
CAS #: 1765-40-8 MF: C7H2BrF5
Ingredients Concentration (%/wt)
Pentafluorobenzyl Bromide (1765-40-8)............................................................................. NLT 98.0 %
Manufacturing Impurities.................................................................................................... NMT 2.0 %
SECTION 3 ..................................................... HAZARDS IDENTIFICATION ........................................................................
Precautionary Statements See Sections 8 and 11 for further details.
Corrosive. Causes burns. Lachrymator
........................................................ Emergency Overview .......................................................
NFPA Ratings (Scale 0-4); Health = 3; Fire = 2; Reactivity = 2; W
Liquid: colorless. Odor: pungent, biting,
Corrosive combustible liquid and vapor--Keep away from ignition sources. Do NOT use
straight streams of water--Hydrolyzes readily producing hydrobromic acid that in
contact with metals can generate flammable/explosive hydrogen gas.
Contact with water produces a large evolution of heat and possible violent reaction. Under
fire conditions corrosive hydrogen fluoride may be evolved. Sufficient dilution of water
may reduce the acidity of the solution.
The properties of this material have not been fully investigated. Use due caution in
handling and use of this material.
Corrosive--Cause burns to all body tissues. Permanent eye damage possible.
Lachrymator--vapors will cause severe tearing. Toxic, possibly fatal if swallowed or
inhaled. May cause dizziness and drowsiness.
Emits toxic fumes under fire conditions--potential products: carbon monoxide, carbon dioxide,
hydrogen bromide, hydrogen fluoride
Standard chemical handling precautions: Avoid ingestion or breathing mists. Avoid contact
with eyes, skin, and clothing. Wash thoroughly after handling.
Target organs: skin, eyes, mucous membranes, respiratory tract
See Sections 4, 5, 6, 8, 9, and 10.
.....................................................................................................................................................
Other Hazard Information
This compound has not fully been tested for toxicological, irritation, or similar tendencies.
Primary Route(s) of Entry: Inhalation, Ingestion, Eye, Skin
Corrosive hydrobromic acid or hydrofluoric acid (strong acids) may be formed on contact with the water in
body tissues and they are very destructive to skin, eye, and mucous membrane tissues.
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 270587c2 Effective Date: 07/22/08 Version #: 3.2 Page 1 of 8
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: 2,3,4,5,6-Pentafluorobenzyl Bromide
Code: 270587
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
Eye: Lachrymator. Can cause burns. May cause severe irritation, itching, severe tearing, redness,
corneal inflammation, blurred vision, and lens damage. Permanent eye damage possible.
Skin: Can cause burns with redness and possible blistering. May cause severe irritation with itchiness
and possible dryness, cracking and dermatitis due to the loss of natural skin oils.
Inhalation: Can cause burns or severe irritation to mucous membranes, respiratory tract, and lung damage.
May be harmful or fatal if inhaled in large quantities due to spasm, inflammation and edema of
the larynx and bronchi, chemical pneumonitis, and pulmonary edema (fluid retention and swelling
in lungs) . In large quantities may produce sedative effects resulting in dizziness and drowsiness.
Prolonged or repeated inhalation may cause tooth decay.
Ingestion: Can cause burns. May be toxic or fatal if ingested due to mucous membrane corrosion and other
tissue in the esophagus and GI tract. Symptoms include sore throat, pain, nausea, vomiting, and
diarrhea. In large quantities may produce sedative effects resulting in dizziness and drowsiness.
Acute: See above route.
Chronic: See above route.
Symptoms: See specific route above.
Pre-existing conditions that may be aggravated: skin, eye, liver, respiratory, GI tract
See Section 11 for additional toxicological data.
SECTION 4 ......................................................... FIRST AID MEASURES ............................................................................
Eye contact: Immediately flush eyes with copious amounts of water or eyewash solution for at least 15
minutes; lift eyelids occasionally. If irritation persists, consult physician.
Skin contact: Immediately remove contaminated clothing and shoes, then wash skin with soap and copious
amounts of water. If irritation persists, consult physician.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration and keep person warm and at
rest. If breathing is difficult, give oxygen; consult physician.
Ingestion: Wash out mouth with water provided person is conscious; give large amounts of water or milk.
Repeat if vomiting occurs. Ingested corrosive should be diluted approximately 100 times to
render it harmless to tissues (Dreisbach & Robertson; Handbook of Poisoning; 12th Ed.);
consult physician; DO NOT induce vomiting without first consulting physician. If vomiting
occurs, keep head lower than hips to help prevent aspiration. Maintain airway and respiration.
Treat symptomatically and supportively.
Wash contaminated clothing before reuse. Discard contaminated footware.
Physician note: Symptomatic and supportive care. No specific antidote. Treatment based on physician
judgment in response to reactions of the patient.
SECTION 5 ..................................................... FIRE FIGHTING MEASURES ........................................................................
Flash Point: 181癋 (82.77癈) Method: cc Autoignition: NE
OSHA Flammability Class: IIIA Explosion Limits: upper: NE
NFPA: See Section 3 Hazards Identification Emergency Overview above. lower: NE
Extinguishing Media
Carbon dioxide, dry chemical powder, sand, fog, or appropriate foam.
Water may be effective for cooling, but may not effect extinguishment. Do NOT use straight streams of water.
Special Fire Fighting Procedures
Self-contained breathing apparatus (SCBA) and protective clothing to prevent contact with skin and eyes should
be worn in fighting large fires involving chemicals.
Prevent eye contact with vapors--Lachrymator--will cause severe tearing.
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 270587c2 Effective Date: 07/22/08 Version #: 3.2 Page 2 of 8
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: 2,3,4,5,6-Pentafluorobenzyl Bromide
Code: 270587
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
Standard Fire and Explosion Hazards
Avoid inhalation of material or combustion by-products.
Unusual Fire and Explosion Hazards
Corrosive combustible liquid and vapor--hydrolyzes on contact with water to produce hydrobromic acid, that in
contact with metals can generate flammable/explosive hydrogen gas.
Contact with water produces a large evolution of heat and possible violent reaction. Sufficient dilution of water
may reduce the acidity of the solution.
Under fire conditions, corrosive hydrogen fluoride and hydrogen bromide may be evolved.
Containers may build pressure or rupture when heated. Container explosion may occur under fire conditions.
Water spray may be used to cool fire-exposed containers.
Emits toxic fumes under fire conditions.
Hazardous Combustion or Decomposition Products
carbon monoxide, carbon dioxide, hydrogen bromide, hydrogen fluoride
SECTION 6 ............................................. ACCIDENTAL RELEASE MEASURES ................................................................
Eliminate all ignition sources. Use spark proof tools.
Evacuate unnecessary people from area. Isolate spilled material.
Ventilate area.
Material is a lachrymator--will cause severe tearing. Use full-face respirator or safety goggles that seal to the
face, thus enclosing the eyes to protect them from vapors.
Corrosive--Wear protective clothing to prevent contact with skin (lab coat, and gloves).
Wear NIOSH/MSHA approved respirator for organic/acid gas, dust, and mists to prevent inhalation of mists.
Contain and recover material when possible.
Use chemically compatible spill pillows, or similar adsorbent material. They will help blanket corrosive vapors.
Sweep up, seal in appropriate hazardous waste container, and hold for proper waste disposal.
Note: Neutralize waste to pH 6-8 prior to disposal, if it possible to do so safely.
Avoid raising contaminated dust.
Wash spill site after material pickup is complete.
Standard chemical precautions: Keep out of water supplies and sewers.
SECTION 7 ..................................................... HANDLING AND STORAGE.........................................................................
General Handling Measures
See Section 8 Below.
General Storage Measures
Store in a cool, dry place with adequate ventilation, in a storage area suitable for flammable corrosives.
Special Storage Instructions
Do not store in metal containers.
Empty containers retain product residue, (liquid/vapor), and can be dangerous.
Special Handling Instructions
Use appropriate precautions for handling flammable and corrosive liquids.
Wash thoroughly after handling.
Immediately remove contaminated clothing, as material is very corrosive to body tissues.
Protect eyes from vapors as lachrymator and will cause severe tearing,
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 270587c2 Effective Date: 07/22/08 Version #: 3.2 Page 3 of 8
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: 2,3,4,5,6-Pentafluorobenzyl Bromide
Code: 270587
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
SECTION 8 ................................. EXPOSURE CONTROLS, PERSONAL PROTECTION ....................................................
TWA (8H) STEL Ceiling Limit Ceiling (skin)
Airborne Exposure Limits
mg/m3 mg/m3 mg/m3 mg/m3
ppm ppm ppm ppm
Pentafluorobenzyl OSHA PEL NE NE NE NE NE NE NE NE
Bromide
1765-40-8 ACGIH - TLV NE NE NE NE NE NE NE NE
Hydrogen Bromide* OSHA 3/3 10/10 NE NE NE NE NE NE
PEL/VPEL
10035-10-6 ACGIH - TLV NE NE NE NE 3 NE NE NE
Hydrogen Fluoride* OSHA 3/6 2 6 5 NE NE NE NE
PEL/VPEL
7664-39-3 ACGIH - TLV NE NE 3 2.6 3 2.6 NE NE
NE = Not established; *Hydrobromic acid may be formed on contact with moisture. HBr and HF may be evolved under fire
conditions
Special/Other Control Measures
Odor threshold: 2 ppm (Hydrogen Bromide)
Personal Protective Equipment (PPE)
OSHA/ANSI approved chemical safety goggles
Compatible chemical-resistant gloves
Wear NIOSH/MSHA approved respirator for organic/acid gas, dust, and mists to prevent inhalation.
Protective Clothing (e.g., lab coat)
Other Standard Safety Equipment and Engineering Preventive Measures
Safety shower and eye wash
Mechanical exhaust required. Hood recommended. Use adequate general and/or local exhaust ventilation to
keep appropriate airborne concentrations below the permissible exposure limits.
General Precautions and Handling Measures
Avoid ingestion, inhalation,
Avoid contact with eyes, skin, and clothing. Material is very destructive to body tissues and a lachrymator.
Avoid prolonged or repeated exposure
Wash thoroughly after handling
Wash contaminated clothing before reuse. Discard contaminated footware.
SECTION 9 ......................................... PHYSICAL AND CHEMICAL PROPERTIES ............................................................
Chemical Family: Halogenated organic acid Use: Analytical Derivatization Acylation Reagent
Appearance, Odor, and Other Properties
Appearance: colorless liquid Odor: pungent, biting--lachrymator
Freeze/MP: NE Water Reactive: yes--hydrolyzes
bp (1atm): 174-175癈 (345-346癋) Water Solubility: insoluble
FW: 260.99 Vapor Density (air=1): 9.0
VP (mmHg): NE Specific Gravity (H20 = 1.0): 1.728
% Volatiles: NE Evap. Rate (BuAc = 1.0): NE
Refractive Index (nD20):
pH: NE 1.4720
Soluble in Organic Solvents: NE
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 270587c2 Effective Date: 07/22/08 Version #: 3.2 Page 4 of 8
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: 2,3,4,5,6-Pentafluorobenzyl Bromide
Code: 270587
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
SECTION 10 .................................................. STABILITY AND REACTIVITY .......................................................................
Stability
Stable
Incompatibilities
Alcohols, amines, alkalies
Metals (finely powdered metals), steel (corrodes)
Strong oxidizers and strong bases
Water, moisture, moist air--possible violent evolution of heat on contact--hydrolyses to corrosive hydrobromic
acid, that on contact with metals may generate flammable/explosive hydrogen gas. Corrosive hydrogen
fluoride gas can be evolved under fire conditions.
Precautions
Avoid incompatibilities.
Protect from heat, flames, sparks, and ignition sources.
Keep out of water supplies and sewers.
Hazardous Combustion or Decomposition Products
carbon monoxide, carbon dioxide, hydrogen bromide, hydrogen fluoride
Hazardous Polymerization
None
SECTION 11 .............................................. TOXICOLOGICAL INFORMATION....................................................................
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
RTECS # CAS #
not assigned Pentafluorobenzyl Bromide 1765-40-8 Only selected Registry of Toxic Effects of Chemical
MW3850000 Hydrogen Bromide* 10035-10-6 Substances data (RTECS) is presented here.
MW7875000 Hydrogen Fluoride* 7664-39-3 See actual entry in RTECS for complete information.
*Hydrobromic acid may be formed on contact with moisture. HBr and HF may be evolved under fire conditions.
Irritation Data eye skin
Pentafluorobenzyl Bromide NDA NDA
Hydrogen Bromide NDA NDA
Hydrogen Fluoride eye hmn 50 mg sev NDA
NDA = No data available
Toxicity Data oral inhalation dermal/other
Pentafluorobenzyl NDA NDA NDA
Bromide
Hydrogen Bromide NDA ihl rat LC50 2858 ppm/1H; ipr rat LD50 76 mg/kg
ihl mus LC50 814/1H
Hydrogen Fluoride orl man TDLo ihl man TCLo 100 mg/m3/1M; skn mus LDL0 500mg/kg
143mg/kg ihl hmn LCLo 50ppm/30M;
ihl rat LC50 1276ppm/1H
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 270587c2 Effective Date: 07/22/08 Version #: 3.2 Page 5 of 8
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: 2,3,4,5,6-Pentafluorobenzyl Bromide
Code: 270587
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
Carcinogenicity OSHA IARC NTP ACGIH NIOSH Notes
Pentafluorobenzyl NL NL NL NL NL None
Bromide
Hydrogen Bromide NL NL NL NL NL None
Hydrogen Fluoride NL NL NL NL NL None
NL = Not Listed as a carcinogen; Y= Listed with the noted evaluation;
Teratogenicity and Reproductive Effects
No data available on pentafluorobenzyl bromide or hydrogen bromide. Laboratory studies reported in RTECS
indicate that hydrogen fluoride may cause adverse fetal and reproductive effects
Neurotoxicity
No data available on pentafluorobenzyl bromide or hydrogen fluoride. Merck Index reports hydrogen bromide has
been used as a veterinary sedative.
Mutagenicity
No data available.
Miscellaneous
Pentafluorobenzyl bromide is lachrymator and very destructive to body tissue.
Acute and Chronic Effects
Section 3 Hazards Identification above.
SECTION 12 ................................................. ECOLOGICAL INFORMATION.......................................................................
Environmental Fate and Ecotoxicity
No data available.
Standard Chemical Precautions
Keep out of air, water, and soil
SECTION 13 ................................................. DISPOSAL CONSIDERATIONS ......................................................................
That which cannot be recovered or recycled, should be disposed of in accordance with all applicable Federal, State, and
local environmental regulations.
RCRA waste code(s): D002 RCRA Hazard Class (40CFR 261): Corrosive
SECTION 14 .................................................. TRANSPORT INFORMATION........................................................................
Ship in accordance with all applicable local, State, Federal, and International transportation regulations.
The following is a summary only. Check regulations for complete information:
U. S. Department of Transportation (49CFR171.101)
Shipping Name: Corrosive Liquid, n.o.s. (Pentafluorobenzyl bromide)
Hazard Class or Division: 8, Subsidiary Class: none
ID Number: UN1760
Packing Group: II
Labeling: Corrosive
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 270587c2 Effective Date: 07/22/08 Version #: 3.2 Page 6 of 8
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: 2,3,4,5,6-Pentafluorobenzyl Bromide
Code: 270587
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
SECTION 15 ................................................. REGULATORY INFORMATION ......................................................................
Reviews, Standards, and Regulations
...................................................................................... .... 2,3,4,5,6-Pentafluorobenzyl...... Hydrobromic
...................................................................................... ...................Bromide* ......................... Acid**
CAS number ................................................................. .................. 1765-40-8 .................... 10035-10-6
TSCA:.................................................................................. ......................... Y.................................... Y
*This compound is sold strictly for FDA or research and development use.
**Hydrobromic acid may be present in negligible quantities as a result of hydrolysis of product.
EINECS: .............................................................................. ......................... Y.................................... Y
Number ................................................................................. ..................... 217-182-4.......................... 233-113-0
CERCLA [Section 103 (40 CFR 302.4)]: ........................... ........................ NL ................................. NL
RQ (lbs)................................................................................. ...........................NA .....................................NA
RCRA Waste Code ............................................................... ...........................NA .....................................NA
OSHA Process Safety [29 CFR 1910.119]: ....................... ........................ NL ................................. NL
TQ (lbs) ................................................................................. ...........................NA .....................................NA
Clean Air Act
[Section 112r (40 CFR 68)]: .................................................. ........................... NL......................................NL
TQ (lbs) ............................................................................ ...........................NA .....................................NA
Contains Ozone Depleters (Class I or Class II)..................... ............................ N........................................N
State Lists: .......................................................................... ........................ NL ................................. NL
States.................................................................................... ........................... NL..................................... NL
On CA 65 Significant Risk Level ........................................... ........................... NL......................................NL
SARA Title III Notification [40 CFR 302.4]:
Section 302/304 (EHS) Ingredient
[40 CFR 355.3]...................................................................... ........................... NL......................................NL
TPQ (lbs........................................................................... ...........................NA .....................................NA
RQ (lbs)............................................................................ ...........................NA .....................................NA
Section 313 Ingredient [40 CFR 372.65] ............................... ........................... NL......................................NL
Hazard Classes
Sara Acute Chronic Fire Pressure Reactivity
Title III Y N N N Y
Health Flammability Reactivity Special Hazards
NFPA 3 2 2 W
HMIS 3 2 2 None
Risk Phrases:
Caution: The properties of this material have not been fully investigated.
Corrosive
R20/21/22............ Harmful by inhalation, in contact with skin and if swallowed
R34...................... Causes burns.
R36/37/38............ Irritating to eyes (severely), respiratory system, and skin.
R40...................... Possible risk of irreversible effects.
R41...................... Risk of serious damage to eyes.
R67...................... Vapors may cause drowsiness and dizziness
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 270587c2 Effective Date: 07/22/08 Version #: 3.2 Page 7 of 8
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: 2,3,4,5,6-Pentafluorobenzyl Bromide
Code: 270587
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
Safety Phrases:
S23/24/25 ............ Do not breath vapors. Avoid contact with skin and eyes
S26/28 ................. In case of contact with eyes or skin, rinse immediately with plenty of water and seek medical
advice.
S27 ...................... Take off immediately all contaminated clothing.
S36/37/39 ............ Wear suitable protective clothing, gloves, and eye/face protection.
S44 ...................... If you feel unwell, seek medical advice immediately (show the label where possible.)
SECTION 16 ........................................................OTHER INFORMATION .............................................................................
Miscellaneous
The health and toxicological hazards of this compound have not been fully investigated; therefore, this substance
must be handled only by, or under close supervision of those qualified in the handling and use of potentially
hazardous substances.
This MSDS was revised as follows:
This is a new MSDS format. Consider all sections to contain new information.
Disclaimer
The above information is believed to be correct, but does not purport to be all-inclusive and shall be used only as
a guide. Regis Technologies, Inc., does not guarantee said information is accurate or complete, nor shall any of
this information constitute a warranty, whether expressed or implied, as to the safety of the goods, the
merchantability of the goods, or the fitness of the goods for a particular purpose. Adjustment may be required to
conform to the actual conditions of usage. Regis Technologies, Inc. shall not be held liable for any damage
resulting from handling or from contact with the above product, nor for the results obtained, or for incidental or
consequential damage arising from the use of these data. No freedom from infringement of any patent, copyright
or trademark is to be inferred.
Approved of by: M. Bryce-Fritts, CHMM This is the last page of this MSDS.
Reviewed and re-approved of with minor changes to the abbreviations in the footer and format.
by: Jon Pilli 07/22/2008
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 270587c2 Effective Date: 07/22/08 Version #: 3.2 Page 8 of 8
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