Right to Know
Hazardous Substance Fact Sheet
N-NITROSOPYRROLIDINE
Common Name:
Synonyms: NPYR; NO-PYR CAS Number: 930-55-2
Chemical Name: Pyrrolidine, 1-Nitroso- RTK Substance Number: 3000
Date: July 1999 Revision: July 2008 DOT Number: UN 3082
Description and Use EMERGENCY RESPONDERS >>>> SEE PAGE 6
Hazard Summary
N-Nitrosopyrrolidine is a yellow liquid. It is used as a
research chemical. N-Nitrosopyrrolidine is not produced Hazard Rating NJDHSS NFPA
commercially but is released during the cooking of Nitrite-
HEALTH 3 -
preserved foods.
FLAMMABILITY 2 -
REACTIVITY 0 -
CARCINOGEN
COMBUSTIBLE
POISONOUS GASES ARE PRODUCED IN FIRE
Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious;
Reasons for Citation 4=severe
N-Nitrosopyrrolidine is on the Right to Know Hazardous
N-Nitrosopyrrolidine can affect you when inhaled.
Substance List because it is cited by DOT, NTP, IARC, IRIS
N-Nitrosopyrrolidine should be handled as a
and EPA.
CARCINOGEN--WITH EXTREME CAUTION.
This chemical is on the Special Health Hazard Substance
Contact can irritate the skin and eyes.
List.
N-Nitrosopyrrolidine may damage the liver and kidneys.
Workplace Exposure Limits
SEE GLOSSARY ON PAGE 5.
No occupational exposure limits have been established for
FIRST AID N-Nitrosopyrrolidine. However, it may pose a health risk.
Always follow safe work practices.
Eye Contact
Immediately flush with large amounts of water for at least 15
minutes, lifting upper and lower lids. Remove contact N-Nitrosopyrrolidine may be a CARCINOGEN in humans.
lenses, if worn, while rinsing. There may be no safe level of exposure to a carcinogen, so
all contact should be reduced to the lowest possible level.
Skin Contact
Remove contaminated clothing and wash contaminated skin
with soap and water.
Inhalation
Remove the person from exposure.
Begin rescue breathing (using universal precautions) if
breathing has stopped and CPR if heart action has stopped.
Transfer promptly to a medical facility.
EMERGENCY NUMBERS
Poison Control: 1-800-222-1222
CHEMTREC: 1-800-424-9300
NJDEP Hotline: 1-877-927-6337
National Response Center: 1-800-424-8802
Page 2 of 6
N-NITROSOPYRROLIDINE
Determining Your Exposure Other Effects
N-Nitrosopyrrolidine may damage the liver and kidneys.
Read the product manufacturer's Material Safety Data
Sheet (MSDS) and the label to determine product
ingredients and important safety and health information
Medical
about the product mixture.
Medical Testing
For each individual hazardous ingredient, read the New
If symptoms develop or overexposure is suspected, the
Jersey Department of Health and Senior Services following are recommended:
Hazardous Substance Fact Sheet, available on the RTK
Program website (www.nj.gov/health/eoh/rtkweb) or in Liver and kidney function tests
your facility's RTK Central File or Hazard Communication
Any evaluation should include a careful history of past and
Standard file.
present symptoms with an exam. Medical tests that look for
You have a right to this information under the New Jersey damage already done are not a substitute for controlling
Worker and Community Right to Know Act, the Public exposure.
Employees Occupational Safety and Health (PEOSH) Act
Request copies of your medical testing. You have a legal right
if you are a public worker in New Jersey, and under the
to this information under the OSHA Access to Employee
federal Occupational Safety and Health Act (OSHA) if you
Exposure and Medical Records Standard (29 CFR 1910.1020).
are a private worker.
The New Jersey Right to Know Act requires most Mixed Exposures
employers to label chemicals in the workplace and More than light alcohol consumption can cause liver
damage. Drinking alcohol may increase the liver damage
requires public employers to provide their employees with
caused by N-Nitrosopyrrolidine.
information concerning chemical hazards and controls.
The federal OSHA Hazard Communication Standard (29
CFR 1910.1200) and the PEOSH Hazard Communication
Standard (N.J.A.C. 12:100-7) require employers to provide
similar information and training to their employees.
This Fact Sheet is a summary of available information
regarding the health hazards that may result from exposure.
Duration of exposure, concentration of the substance and other
factors will affect your susceptibility to any of the potential
effects described below.
Health Hazard Information
Acute Health Effects
The following acute (short-term) health effects may occur
immediately or shortly after exposure to N-Nitrosopyrrolidine:
Contact can irritate the skin and eyes.
Chronic Health Effects
The following chronic (long-term) health effects can occur at
some time after exposure to N-Nitrosopyrrolidine and can
last for months or years:
Cancer Hazard
N-Nitrosopyrrolidine may be a CARCINOGEN in humans
since it has been shown to cause liver and lung cancer in
animals.
Many scientists believe there is no safe level of exposure to
a carcinogen.
Reproductive Hazard
There is limited evidence that N-Nitrosopyrrolidine may
damage the male reproductive system (including decreasing
the sperm count) in animals.
Page 3 of 6
N-NITROSOPYRROLIDINE
Workplace Controls and Practices Eye Protection
Wear indirect-vent, impact and splash resistant goggles
Very toxic chemicals, or those that are reproductive hazards or
when working with liquids.
sensitizers, require expert advice on control measures if a less
Wear a face shield along with goggles when working with
toxic chemical cannot be substituted. Control measures
corrosive, highly irritating or toxic substances.
include: (1) enclosing chemical processes for severely
irritating and corrosive chemicals, (2) using local exhaust
Respiratory Protection
ventilation for chemicals that may be harmful with a single
Improper use of respirators is dangerous. Respirators
exposure, and (3) using general ventilation to control
exposures to skin and eye irritants. For further information on should only be used if the employer has implemented a written
workplace controls, consult the NIOSH document on Control program that takes into account workplace conditions,
Banding at www.cdc.gov/niosh/topics/ctrlbanding/. requirements for worker training, respirator fit testing, and
medical exams, as described in the OSHA Respiratory
The following work practices are also recommended:
Protection Standard (29 CFR 1910.134).
Label process containers.
Where the potential for overexposure exists, use a NIOSH
Provide employees with hazard information and training.
approved supplied-air respirator with a full facepiece
Monitor airborne chemical concentrations.
operated in a pressure-demand or other positive-pressure
Use engineering controls if concentrations exceed
mode. For increased protection use in combination with an
recommended exposure levels.
auxiliary self-contained breathing apparatus operated in a
Provide eye wash fountains and emergency showers.
pressure-demand or other positive-pressure mode.
Wash or shower if skin comes in contact with a hazardous
material.
Always wash at the end of the workshift.
Change into clean clothing if clothing becomes
Fire Hazards
contaminated.
If employees are expected to fight fires, they must be trained
Do not take contaminated clothing home.
Get special training to wash contaminated clothing. and equipped as stated in the OSHA Fire Brigades Standard
Do not eat, smoke, or drink in areas where chemicals are (29 CFR 1910.156).
being handled, processed or stored.
Wash hands carefully before eating, smoking, drinking, N-Nitrosopyrrolidine is a COMBUSTIBLE LIQUID.
applying cosmetics or using the toilet. Use dry chemical, CO2, water spray or foam as extinguishing
agents.
In addition, the following may be useful or required: POISONOUS GASES ARE PRODUCED IN FIRE, including
Nitrogen Oxides.
Use a Class I, Type B, biological safety hood when mixing, Use water spray to keep fire-exposed containers cool.
handling, or preparing N-Nitrosopyrrolidine.
Personal Protective Equipment
The OSHA Personal Protective Equipment Standard (29 CFR
1910.132) requires employers to determine the appropriate
personal protective equipment for each hazard and to train
employees on how and when to use protective equipment.
The following recommendations are only guidelines and may
not apply to every situation.
Gloves and Clothing
Avoid skin contact with N-Nitrosopyrrolidine. Wear
personal protective equipment made from material that can
not be permeated or degraded by this substance. Safety
equipment suppliers and manufacturers can provide
recommendations on the most protective glove and clothing
material for your operation.
Safety equipment manufacturers recommend Neoprene for
gloves and DuPont Tyvek?as protective material for
clothing.
All protective clothing (suits, gloves, footwear, headgear)
should be clean, available each day, and put on before work.
Page 4 of 6
N-NITROSOPYRROLIDINE
Spills and Emergencies Occupational Health Information
If employees are required to clean-up spills, they must be
Resources
properly trained and equipped. The OSHA Hazardous Waste
The New Jersey Department of Health and Senior Services,
Operations and Emergency Response Standard (29 CFR
Occupational Health Service, offers multiple services in
1910.120) may apply.
occupational health. These services include providing
informational resources, educational materials, public
If N-Nitrosopyrrolidine is spilled or leaked, take the following
presentations, and industrial hygiene and medical
steps:
investigations and evaluations.
Evacuate personnel and secure and control entrance to the
area.
Eliminate all ignition sources.
For more information, please contact:
Absorb liquids in vermiculite, dry sand, earth, or a similar
material and deposit in sealed containers.
New Jersey Department of Health & Senior Services
Ventilate and wash area after clean-up is complete.
Right to Know Program
DO NOT wash into sewer.
It may be necessary to contain and dispose of PO Box 368
N-Nitrosopyrrolidine as a HAZARDOUS WASTE. Contact Trenton, NJ 08625-0368
your state Department of Environmental Protection (DEP) or Phone: 609-984-2202
your regional office of the federal Environmental Protection
Fax: 609-984-7407
Agency (EPA) for specific recommendations.
E-mail: rtk@doh.state.nj.us
Web address: http://www.nj.gov/health/eoh/rtkweb
Handling and Storage
The Right to Know Hazardous Substance Fact Sheets
Prior to working with N-Nitrosopyrrolidine you should be
are not intended to be copied and sold
trained on its proper handling and storage.
for commercial purposes.
N-Nitrosopyrrolidine reacts vigorously with REDUCING
AGENTS (such as LITHIUM, SODIUM, ALUMINUM and
their HYDRIDES) and OXIDIZING AGENTS (such as
PERCHLORATES, PEROXIDES, PERMANGANATES,
CHLORATES, NITRATES, CHLORINE, BROMINE and
FLUORINE).
Store in tightly closed containers in a cool, well-ventilated
area away from LIGHT.
Sources of ignition, such as smoking and open flames, are
prohibited where N-Nitrosopyrrolidine is used, handled, or
stored in a manner that could create a potential fire or
explosion hazard.
Page 5 of 6
N-NITROSOPYRROLIDINE
GLOSSARY
ACGIH is the American Conference of Governmental Industrial LEL or Lower Explosive Limit, is the lowest concentration of
Hygienists. They publish guidelines called Threshold Limit a combustible substance (gas or vapor) in the air capable of
Values (TLVs) for exposure to workplace chemicals. continuing an explosion.
Acute Exposure Guideline Levels (AEGLs) are established mg/m3 means milligrams of a chemical in a cubic meter of air.
by the EPA. They describe the risk to humans resulting from It is a measure of concentration (weight/volume).
once-in-a lifetime, or rare, exposure to airborne chemicals.
A mutagen is a substance that causes mutations. A mutation
Boiling point is the temperature at which a substance can is a change in the genetic material in a body cell. Mutations
change its physical state from a liquid to a gas. can lead to birth defects, miscarriages, or cancer.
A carcinogen is a substance that causes cancer. NFPA is the National Fire Protection Association. It classifies
substances according to their fire and explosion hazard.
The CAS number is unique, identifying number, assigned by
the Chemical Abstracts Service, to a specific chemical. NIOSH is the National Institute for Occupational Safety and
Health. It tests equipment, evaluates and approves
CFR is the Code of Federal Regulations, which are the respirators, conducts studies of workplace hazards, and
regulations of the United States government. proposes standards to OSHA.
A combustible substance is a solid, liquid or gas that will burn. NTP is the National Toxicology Program which tests chemicals
and reviews evidence for cancer.
A corrosive substance is a gas, liquid or solid that causes
destruction of human skin or severe corrosion of containers. OSHA is the federal Occupational Safety and Health
Administration, which adopts and enforces health and safety
DEP is the New Jersey Department of Environmental standards.
Protection.
PEOSHA is the New Jersey Public Employees Occupational
DOT is the Department of Transportation, the federal agency Safety and Health Act, which adopts and enforces health and
that regulates the transportation of chemicals. safety standards in public workplaces.
EPA is the Environmental Protection Agency, the federal Permeated is the movement of chemicals through protective
agency responsible for regulating environmental hazards. materials.
ERG is the Emergency Response Guidebook. It is a guide for PIH is a DOT designation for chemicals which are Poison
emergency responders for transportation emergencies Inhalation Hazards.
involving hazardous substances.
ppm means parts of a substance per million parts of air. It is a
Emergency Response Planning Guideline (ERPG) values measure of concentration by volume in air.
are intended to provide estimates of concentration ranges
where one reasonably might anticipate observing adverse A reactive substance is a solid, liquid or gas that releases
effects. energy under certain conditions.
A fetus is an unborn human or animal. STEL is a Short Term Exposure Limit which is usually a 15-
minute exposure that should not be exceeded at any time
A flammable substance is a solid, liquid, vapor or gas that will during a work day.
ignite easily and burn rapidly.
A teratogen is a substance that causes birth defects by
The flash point is the temperature at which a liquid or solid damaging the fetus.
gives off vapor that can form a flammable mixture with air.
UEL or Upper Explosive Limit is the highest concentration in
IARC is the International Agency for Research on Cancer, a air above which there is too much fuel (gas or vapor) to begin a
scientific group. reaction or explosion.
Ionization Potential is the amount of energy needed to Vapor Density is the ratio of the weight of a given volume of
remove an electron from an atom or molecule. It is measured one gas to the weight of another (usually Hydrogen), at the
in electron volts. same temperature and pressure.
IRIS is the Integrated Risk Information System database The vapor pressure is a measure of how readily a liquid or a
maintained by federal EPA. The database contains solid mixes with air at its surface. A higher vapor pressure
information on human health effects that may result from indicates a higher concentration of the substance in air and
exposure to various chemicals in the environment. therefore increases the likelihood of breathing it in.
INFORMATION FOR EMERGENCY RESPONDERS Page 6 of 6
Common Name: N-NITROSOPYRROLIDINE
Synonyms: NPYR; NO-PYR
CAS No: 930-55-2
Molecular Formula: C4H8N2O
RTK Substance No: 3000
Description: Yellow liquid
HAZARD DATA
Hazard Rating Firefighting Reactivity
N-Nitrosopyrrolidine is a COMBUSTIBLE N-Nitrosopyrrolidine reacts vigorously with
3 - Health
LIQUID. REDUCING AGENTS (such as LITHIUM, SODIUM,
2 - Fire ALUMINUM and their HYDRIDES) and OXIDIZING
Use dry chemical, CO2, water spray or foam as
AGENTS (such as PERCHLORATES, PEROXIDES,
extinguishing agents.
0 - Reactivity
PERMANGANATES, CHLORATES, NITRATES,
POISONOUS GASES ARE PRODUCED IN FIRE,
CHLORINE, BROMINE and FLUORINE).
DOT#: UN 3082 including Nitrogen Oxides.
Use water spray to keep fire-exposed containers
ERG Guide #: 171
cool.
Hazard Class: 6.1
(Poison)
SPILL/LEAKS PHYSICAL PROPERTIES
Odor Threshold: Not available
Isolation Distance:
181oF (83oC)
Flash Point:
Small Spill: 60 meters (200 feet)
Vapor Density: 1.2 (air = 1)
Large Spill: 270 meters (900 feet)
0.06 mm Hg at 68oF (20oC)
Vapor Pressure:
Fire: 800 meters (1/2 mile)
Specific Gravity: 1.1 (water = 1)
Absorb liquids in vermiculite, dry sand, earth, or a
similar material and deposit in sealed containers. Water Solubility: Miscible
417oF (214oC)
DO NOT wash into sewer. Boiling Point:
No environmental information is available. Molecular Weight: 100.1
EXPOSURE LIMITS PROTECTIVE EQUIPMENT
Gloves: Neoprene
No occupational exposure limits have been
established for N-Nitrosopyrrolidine. Coveralls: DuPont Tyvek?br>
Respirator: Supplied air
HEALTH EFFECTS FIRST AID AND DECONTAMINATION
Eyes: Remove the person from exposure.
Irritation
Flush eyes with large amounts of water for at least 15 minutes. Remove
Skin: Irritation
contact lenses if worn.
Chronic: Cancer (liver and lung) in animals
Remove contaminated clothing and wash contaminated skin with soap
and water.
Begin artificial respiration if breathing has stopped and CPR if necessary.
Transfer to a medical facility.
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