SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 11/09/2007
Date Updated: 02/07/2007
Version 1.8
Section 1 - Product and Company Information
Product Name 2-AMINOTHIAZOL
Product Number 09480
Brand FLUKA
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
2-AMINOTHIAZOL 96-50-4 No
Formula C3H4N2S
Synonyms Abadol * Abadole * Aminothiazole *
2-Aminothiazole * Basedol * CP 1585 *
2-Thiazolamine * 2-Thiazolylamine *
2-Thiazylamine * USAF EK-P-5501
RTECS Number: XJ2100000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Toxic (USA) Harmful (EU).
Harmful if swallowed. Irritating to eyes.
Target organ(s): Thyroid. Possible sensitizer.
HMIS RATING
HEALTH: 2
FLAMMABILITY: 0
REACTIVITY: 0
NFPA RATING
HEALTH: 2
FLAMMABILITY: 0
REACTIVITY: 0
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Avoid breathing dust. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a dust mask type N95 (US) or type P1 (EN 143)
respirator.
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Other: Wear appropriate government approved respirator,
chemical-resistant gloves, safety goggles, other protective
clothing.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: Light brown
Form: Powder
Property Value At Temperature or Pressure
Molecular Weight 100.14 AMU
pH N/A
BP/BP Range N/A
MP/MP Range 85 癈
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content <3%
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient Log Kow: - 0.038
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Strong acids, Acid
chlorides, Acid anhydrides.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Sulfur oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
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ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
SENSITIZATION
Sensitization: Possible sensitizer.
Skin: The preceding data, or interpretation of data, was
determined using Quantitative Structure Activity Relationship
(QSAR) modeling. Prolonged or repeated exposure may cause
allergic reactions in certain sensitive individuals.
TARGET ORGAN(S) OR SYSTEM(S)
Thyroid.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
TOXICITY DATA
Oral
Rat
480 mg/kg
LD50
Remarks: Behavioral:Tremor. Behavioral:Coma. Lungs, Thorax, or
Respiration:Dyspnea.
Intravenous
Rat
570 MG/KG
LD50
Intraperitoneal
Mouse
200 MG/KG
LD50
Oral
Rabbit
370 mg/kg
LD50
Remarks: Lungs, Thorax, or Respiration:Dyspnea. Behavioral:Coma.
Behavioral:Tremor.
CHRONIC EXPOSURE - MUTAGEN
Species: Mouse
Dose: 1214 MG/L (+S9)
Cell Type: lymphocyte
Mutation test: Mutation in microorganisms
Species: Mouse
Dose: 557 MG/L
Cell Type: lymphocyte
Mutation test: Mutation in mammalian somatic cells.
Section 12 - Ecological Information
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No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: None
Non-Hazardous for Transport: This substance is
considered to be non-hazardous for transport.
IATA
Non-Hazardous for Air Transport: Non-hazardous for air
transport.
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: Xn
Indication of Danger: Harmful.
R: 22-36
Risk Statements: Harmful if swallowed. Irritating to eyes.
S: 26-36/37
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing and gloves.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Toxic (USA) Harmful (EU).
Risk Statements: Harmful if swallowed. Irritating to eyes.
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing and gloves.
US Statements: Target organ(s): Thyroid. Possible sensitizer.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
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information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2007 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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