SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/03/2004
Date Updated: 09/07/2002
Version 1.4
Section 1 - Product and Company Information
Product Name 1,1,2,2-TETRACHLOROETHANE, 98%
Product Number 185434
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
1,1,2,2-TETRACHLOROETHANE 79-34-5 Yes
Formula C2H2Cl4
Synonyms Acetylene tetrachloride * Bonoform * Cellon *
1,1,2,2-Czterochloroetan (Polish) *
1,1-Dichloro-2,2-dichloroethane * NCI-C03554 *
RCRA waste number U209 * TCE *
1,1,2,2-Tetrachloorethaan (Dutch) *
1,1,2,2-Tetrachloraethan (German) *
Tetrachlorethane * 1,1,2,2-Tetrachloroethane *
1,1,2,2-Tetrachlorethane (French) *
Tetrachloroethane * s-Tetrachloroethane *
sym-Tetrachloroethane * 1,1,2,2-Tetrachloroethane
(ACGIH:OSHA) * 1,1,2,2-Tetracloroetano (Italian)
* Tetrachlorure d'acetylene (French) * Westron
RTECS Number: KI8575000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Highly Toxic (USA) Very Toxic (EU).
Very toxic by inhalation and in contact with skin Harmful if
swallowed. Toxic to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
Possible Carcinogen (US). Readily absorbed through skin. Target
organ(s): Nerves. Liver. Blood.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 0
REACTIVITY: 0
NFPA RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe vapor. Avoid prolonged or repeated
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exposure. Do not get in eyes, on skin, on clothing.
STORAGE
Suitable: Keep tightly closed.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 1 PPM
Remarks: Skin
USA MSHA Standard-air TWA 5 PPM (35 MG/M3) (SKIN)
USA OSHA. PEL 8H TWA 5 PPM (35 MG/M3) (SKIN)
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 1 PPM
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 5 MG/M3
Poland NDSCh 35 MG/M3
Poland NDSP -
Section 9 - Physical/Chemical Properties
Appearance Color: Colorless
Form: Clear liquid
Property Value At Temperature or Pressure
Molecular Weight 167.85 AMU
pH N/A
BP/BP Range 144 - 146 癈
MP/MP Range -43 癈
Freezing Point N/A
Vapor Pressure 8 mmHg 20 癈
Vapor Density 5.8 g/l
Saturated Vapor Conc. N/A
SG/Density 1.597 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
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Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index 1.494
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Sodium, Strong bases,
Potassium Reacts violently with nitrates and 2,4-dinitrophenyl
disulfide.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be fatal if absorbed through skin. Readily
absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: May be fatal if inhaled. Material may be irritating
to mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Nerves. Liver. Blood.
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Headache. Nausea. Vomiting. Tremors.
Incoordination. Fatigue. Dizziness. Anorexia.
TOXICITY DATA
Oral
Rat
200 mg/kg
LD50
Inhalation
Mouse
4,500 mg/m3
LC50
Intraperitoneal
Mouse
821 MG/KG
LD50
Subcutaneous
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Mouse
1108 MG/KG
LD50
Remarks: Behavioral:Sleep. Behavioral:Ataxia.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be possibly carcinogenic based on its IARC, ACGIH,
NTP, or EPA classification.
Species: Rat
Route of Application: Oral
Dose: 42 GM/KG
Exposure Time: 78W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
Species: Mouse
Route of Application: Oral
Dose: 55 GM/KG
Exposure Time: 78W
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
Species: Mouse
Route of Application: Oral
Dose: 110 GM/KG
Exposure Time: 78W
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
IARC CARCINOGEN LIST
Rating: Group 3
NTP CARCINOGEN LIST
Rating: Clear evidence.
Species: Mouse
Route: Gavage
ACGIH CARCINOGEN LIST
Rating: A4
IRIS/EPA CARCINOGEN LIST
Rating: Group C
CHRONIC EXPOSURE - MUTAGEN
Species: Human
Dose: 6 MMOL/L
Cell Type: HeLa cell
Mutation test: DNA inhibition
Species: Mouse
Route: Oral
Dose: 200 MG/KG
Mutation test: Other mutation test systems
Species: Hamster
Dose: 56 MG/L
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Cell Type: ovary
Mutation test: Sister chromatid exchange
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 20 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Tetrachloroethane
UN#: 1702
Class: 6.1
Packing Group: Packing Group II
Hazard Label: Toxic substances.
PIH: Not PIH
IATA
Proper Shipping Name: 1,1,2,2-Tetrachloroethane
IATA UN Number: 1702
Hazard Class: 6.1
Packing Group: II
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: T+ N
Indication of Danger: Very toxic. Dangerous for the environment.
R: 26/27 51/53
Risk Statements: Very toxic by inhalation and in contact with
skin Toxic to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
S: 38 45 61
Safety Statements: In case of insufficient ventilation, wear
suitable respiratory equipment. In case of accident or if you
feel unwell, seek medical advice immediately (show the label
where possible). Avoid release to the environment. Refer to
special instructions/safety data sheets.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Highly Toxic (USA) Very Toxic (EU).
Risk Statements: Very toxic by inhalation and in contact with
skin Harmful if swallowed. Toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Statements: In case of insufficient ventilation, wear
suitable respiratory equipment. In case of accident or if you
feel unwell, seek medical advice immediately (show the label
where possible). Avoid release to the environment. Refer to
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special instructions/safety data sheets.
US Statements: Possible Carcinogen (US). Readily absorbed
through skin. Target organ(s): Nerves. Liver. Blood.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 0.1 %
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65
California Prop - 65: This product is or contains chemical(s)
known to the state of California to cause cancer.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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