Forane (R) 500
Material Safety Data Sheet
Arkema Inc.
1 PRODUCT AND COMPANY IDENTIFICATION
EMERGENCY PHONE NUMBERS:
DFO
Chemtrec: (800) 424-9300 (24hrs) or (703) 527-3887
2000 Market Street
Medical: Rocky Mountain Poison Control Center
(866) 767-5089 (24Hrs)
Philadelphia, PA 19103
Information Telephone Numbers Phone Number Available Hrs
Product Information 800-245-5858 8:00 am - 5:30 pm (Eastern)
Product Name Forane (R) 500
Product Synonym(s)
R-500, CFC/HFC-500, ISOTRON 500
Chemical Family Chlorofluorocarbon/ Hydrofluorocarbon Blend
Chemical Formula CCl2F2/CH3CHF2
Chemical Name Dichlorodifluoromethane and 1,1-difluoroethane
EPA Reg Num
Product Use Refrigerant
2 COMPOSITION / INFORMATION ON INGREDIENTS
Ingredient Name CAS RegistryNumber Typical Wt. % OSHA
dichlorodifluoromethane (CFC-12) 75-71-8 73.8% Y
1,1-difluoroethane (HFC-152a) 75-37-6 26.2% Y
The substance(s) marked with a "Y" in the OSHA column, are identified as hazardous chemicals according to the
criteria of the OSHA Hazard Communication Standard (29 CFR 1910.1200)
This material is classified as hazardous under Federal OSHA regulation.
The components of this product are all on the TSCA Inventory list.
3 HAZARDS IDENTIFICATION
Emergency Overview
Colorless liquified gas with faint ether odor.
WARNING!
LIQUID AND GAS UNDER PRESSURE, OVERHEATING AND OVERPRESSURIZING MAY CAUSE GAS RELEASE
OR VIOLENT CYLINDER BURSTING. MAY DECOMPOSE ON CONTACT WITH FLAMES OR EXTREMELY HOT
METAL SURFACES TO PRODUCE TOXIC AND CORROSIVE PRODUCTS. VAPOR REDUCES OXYGEN
AVAILABLE FOR BREATHING AND IS HEAVIER THAN AIR. HARMFUL IF INHALED AND MAY CAUSE HEART
IRREGULARITIES, UNCONSCIOUSNESS OR DEATH. LIQUID CONTACT WITH EYES OR SKIN MAY CAUSE
FROSTBITE.
Potential Health Effects
Skin contact and inhalation are expected to be the primary routes of occupational exposure to this material. As with
most liquefied gases, contact with the rapidly volatilizing liquid can cause frostbite to any tissue. High vapor
concentrations are irritating to the eyes and respiratory tract and may result in central nervous system (CNS) effects
such as headache, dizziness, drowsiness and, in severe exposure, loss of consciousness and death. The dense vapor
of this material may reduce the available oxygen for breathing. Prolonged exposure to an oxygen-deficient atmosphere
may be fatal. Inhalation may cause an increase in the sensitivity of the heart to adrenaline, which could result in
Product Code: 04008 Page 1
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Forane (R) 500
Material Safety Data Sheet
Arkema Inc.
irregular or rapid heartbeats. Medical conditions aggravated by exposure to this material include heart disease or
compromised heart function.
4 FIRST AID MEASURES
IF IN EYES, immediately flush with plenty of water. Get medical attention if irritation persists.
IF ON SKIN, Flush exposed skin with lukewarm water (not hot), or use other means to warm skin slowly. Get
medical attention if frostbitten by liquid or if irritation occures.
IF SWALLOWED, Not applicable - product is a gas at ambient temperatures.
IF INHALED, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give
oxygen. Get medical attention. Do not give adrenaline, epinephrin or similar drugs following exposure to this
product.
5 FIRE FIGHTING MEASURES
Fire and Explosive Properties
Auto-Ignition Temperature NE
Flash Point NA - GAS Flash Point Method
Flammable Limits- Upper NONE
NONE
Lower
Extinguishing Media
Use extinguishing media appropriate to surrounding fire conditions.
Fire Fighting Instructions
Stop the flow of gas if possible. Use water spray on person making shut-off. Fire fighters and others who may
be exposed to products of combustion should wear full fire fighting turn out gear (full Bunker Gear) and self-
contained breathing apparatus (pressure demand NIOSH approved or equivalent). Fire fighting equipment
should be thoroughly decontaminated after use.
Fire and Explosion Hazards
May decompose on contact with flames or extremely hot metal surfaces to produce toxic and corrosive
products. Liquid and gas under pressure, overheating or overpressurizing may cause gas release and/or violent
cylinder bursting. Container may explode if heated due to resulting pressure rise. Some mixtures of HCFCs
and/or HFCs, and air or oxygen may be combustible if pressurized and exposed to extreme heat or flame.
6 ACCIDENTAL RELEASE MEASURES
In Case of Spill or Leak
Use Halogen leak detector or other suitable means to locate leaks or check atmosphere. Keep upwind.
Evacuate enclosed spaces and disperse gas with floor-level forced-air ventilation. Exhaust vapors outdoors.
Do not smoke or operate internal combustion engines. Remove flames and heating elements.
7 HANDLING AND STORAGE
Handling
Avoid breathing gas. Avoid contact with eyes, skin and clothing. Keep container closed. Use only with
adequate ventilation. Do not enter confined spaces unless adequately ventilated.
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Forane (R) 500
Material Safety Data Sheet
Arkema Inc.
7 HANDLING AND STORAGE
Storage
Do not apply direct flame to cylinder. Do not store cylinder in direct sun or expose it to heat above 120 F.
Do not drop or refill this cylinder. Keep away from heat, sparks and flames.
8 EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering Controls
Investigate engineering techniques to reduce exposures below airborne exposure limits. Provide ventilation
if necessary to control exposure levels below airborne exposure limits (see below). If practical, use local
mechanical exhaust ventilation at sources of air contamination such as open process equipment.
Eye / Face Protection
Where there is potential for eye contact, wear chemical goggles and have eye flushing equipment available.
Skin Protection
Wear appropriate chemical resistant protective clothing and chemical resistant gloves to prevent skin
contact. Consult glove manufacturer to determine appropriate type glove material for given application.
Rinse contaminated skin promptly. Wash contaminated clothing and clean protective equipment before
reuse. Wash skin thoroughly after handling.
Respiratory Protection
Avoid breathing gas. When airborne exposure limits are exceeded (see below), use NIOSH approved
respiratory protection equipment appropriate to the material and/or its components (full facepiece
recommended). Consult respirator manufacturer to determine appropriate type equipment for a given
application. Observe respirator use limitations specified by NIOSH or the manufacturer. For emergency and
other conditions where exposure limit may be significantly exceeded, use an approved full face positive-
pressure, self-contained breathing apparatus or positive-pressure airline with auxiliary self-contained air
supply. Respiratory protection programs must comply with 29 CFR ?1910.134.
Airborne Exposure Guidelines for Ingredients
Exposure Limit Value
dichlorodifluoromethane (CFC-12)
ACGIH TWA - 1000 ppm 4950 mg/m3
OSHA TWA PEL - 1000 ppm 4950 mg/m3
1,1-difluoroethane (HFC-152a)
WEEL TWA - 2700 mg/m3 (1000 ppm)
-Only those components with exposure limits are printed in this section.
-Skin contact limits designated with a "Y" above have skin contact effect. Air sampling alone is insufficient to accurately quantitate
exposure. Measures to prevent significant cutaneous absorption may be required.
-ACGIH Sensitizer designator with a value of "Y" above means that exposure to this material may cause allergic reactions.
-WEEL-AIHA Sensitizer designator with a value of "Y" above means that exposure to this material may cause allergic skin reactions.
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Forane (R) 500
Material Safety Data Sheet
Arkema Inc.
9 PHYSICAL AND CHEMICAL PROPERTIES
Colorless liquified gas with faint ether odor.
Appearance/Odor
pH NA
Specific Gravity 1.14 @ 25 C
Vapor Pressure 100 PSIA @ 21.1 C (70 F)
Vapor Density (AIR = 1) 3.45
Melting Point NE
Freezing Point -159 C / -254 F
Boiling Point -33.5 C / -28.3 F
Solubility In Water Slight
Percent Volatile 100
Molecular Weight 99.3
10 STABILITY AND REACTIVITY
Stability
This material is chemically stable under specified conditions or storage, shipment and/or use. See
HANDLING AND STORAGE section of this MSDS for specified conditions.
Incompatibility
Avoid contact with strong alkali or alkaline earth metals, finely powdered metals such as aluminum, magnesium
or zinc and strong oxidizers, since they may react or accelerate decomposition.
Hazardous Decomposition Products
Thermal decomposition products could include Halogen acids (HCl and HR), Halogens, Carbon Monoxide,
Carbon Dioxide, and Carbonyl Halides.
11 TOXICOLOGICAL INFORMATION
Toxicological Information
Dichlorodifluoromethane
Inhalation of high concentrations (40,000 ppm) by humans has been reported to cause a tingling sensation,
humming in the ears, electrocardiogram changes, slurred speech, decreased psychological test scores, and in
severe cases, partial loss of consciousness with amnesia and heart arrhythmia. Acute inhalation exposure
produced anesthesia, heart arrhythmia, reduced heart function, effects on blood pressure, heart sensitization to
adrenaline and other effects on the heart and respiratory systems in dogs, rats, mice, rabbits and monkeys.
Repeated inhalation exposure produced tremors, mild narcosis and some blood changes in guinea pigs, dogs
and monkeys; slight liver changes in guinea pigs; and no adverse effects in rats and rabbits. Slight irritation was
observed in rats following repeated skin exposure. Following repeated oral exposure, no adverse effects were
observed in rats or dogs. Reduced survival was observed in long-term high dose oral exposure studies in rats;
however no adverse effects or increase the incidence of tumors were observed in rats or dogs at lower doses.
Following exposure during pregnancy, no birth defects were observed in the offspring of rats (oral, inhalation) or
rabbits (inhalation). No effects were seen on the ability of male or female rats to reproduce when exposed orally
for 3 generations. No genetic changes were observed in tests using bacteria, animal cells or animals. Single
exposure (acute) studies indicate:
Oral - No More than Slightly Toxic to Rats (LD50 >1,000 mg/kg)
Inhalation - Practically Non-toxic to Rats (30-min LC50 >800,000 ppm) and Mice (3-hr LC50 620,000 ppm)
Eye Irritation - Practically Non-irritating to Rabbits
Skin Irritation - Practically Non-irritating to Rabbits
1,1-Difluoroethane (HFC-152a)
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Forane (R) 500
Material Safety Data Sheet
Arkema Inc.
11 TOXICOLOGICAL INFORMATION
Studies of workers exposed in industry operations did not indicate that this material causes heart arrhythmias.
Acute inhalation exposure produced signs of sedation and heart arrhythmias in rats, but no adverse effects were
observed in mice or monkeys. Rats did not exhibit increased sensitivity to cardiac effects after chemically
induced heart injury, but did show an increased sensitivity after chemically induced injury to lung arteries.
Inhalation, followed by intravenous injection of epinephrine to simulate stress reactions, resulted in cardiac
sensitization in dogs. Following repeated inhalation exposure, respiratory irritation, sedation and an increase in
urinary excretion of fluoride were observed in rats. Effects on nasal tissue and reversible kidney changes were
observed in rats following long-term inhalation, but no increase in the incidence of tumors was observed. No
birth defects were noted in the offspring of rats exposed by inhalation during pregnancy. No genetic changes
were observed in a test using bacteria, but were observed in a test using human cells. Single exposure (acute)
studies indicate:
Inhalation - Practically Non-toxic to Rats (4-hr LC50 383,000 ppm)
12 ECOLOGICAL INFORMATION
Ecotoxicological Information
No data are available.
Chemical Fate Information
Dichlorodifluoromethane (CFC 12)
This material is biodegradable in anaerobic environments. The log Pow is 2.08-2.16.
13 DISPOSAL CONSIDERATIONS
Waste Disposal
Recover, reclaim or recycle when practical. Dispose of in accordance with federal, state and local regulations.
Note: Chemical additions to, processing of, or otherwise altering this material may make this waste
management information incomplete, inaccurate, or otherwise inappropriate. Furthermore, state and local
waste disposal requirements may be more restrictive or otherwise different from federal laws and regulations.
14 TRANSPORT INFORMATION
DOT Name Dichlorodifluoromethane and Difluoroethane Azeotropic Mixture
DOT Technical Name (R-500)
DOT Hazard Class 2.2
UN Number UN 2602
DOT Packing Group PG NA
RQ
15 REGULATORY INFORMATION
Hazard Categories Under Criteria of SARA Title III Rules (40 CFR Part 370)
Immediate (Acute) Health Y Fire N
Reactive
Delayed (Chronic) Health N N
Sudden Release of Pressure Y
The components of this product are all on the TSCA Inventory list.
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Forane (R) 500
Material Safety Data Sheet
Arkema Inc.
Ingredient Related Regulatory Information:
CERCLA RQ SARA TPQ
SARA Reportable Quantities
dichlorodifluoromethane (CFC-12) 5000 LBS
1,1-difluoroethane (HFC-152a) NE
SARA Title III, Section 313
This product does contain chemical(s) which are defined as toxic chemicals under and subject to the reporting requirements of, Section
313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 and 40 CFR Part 372. See Section 2
dichlorodifluoromethane (CFC-12)
Massachusetts Right to Know
This product does contain the following chemicals(s), as indicated below, currently on the Massachusetts Right to Know Substance
List.
1,1-difluoroethane (HFC-152a)
dichlorodifluoromethane (CFC-12)
New Jersey Right to Know
This product does contain the following chemical(s), as indicated below, currently on the New Jersey Right-to-Know Substances List.
1,1-difluoroethane (HFC-152a)
dichlorodifluoromethane (CFC-12)
Pennsylvania Environmental Hazard
This product does contain the following chemical(s), as indicated below, currently on the Pennsylvania Environmental Hazard List.
dichlorodifluoromethane (CFC-12)
Pennsylvania Right to Know
This product does contain the following chemical(s), as indicated below, currently on the Pennsylvania Hazardous Substance List.
dichlorodifluoromethane (CFC-12)
16 OTHER INFORMATION
Revision Information
Revision Number 8
11 OCT 2004
Revision Date
Supercedes Revision Dated 30-SEP-2004
Revision Summary
ATOFINA Chemicals, Inc. has changed its name to Arkema Inc.
Key
NE= Not Established NA= Not Applicable (R) = Registered Trademark
Arkema Inc. believes that the information and recommendations contained herein (including data and
statements) are accurate as of the date hereof. NO WARRANTY OF FITNESS FOR ANY PARTICULAR
PURPOSE, WARRANTY OF MERCHANTABILITY, OR ANY OTHER WARRANTY, EXPRESSED OR
IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED HEREIN. The information provided
herein relates only to the specific product designated and may not be valid where such product is used in
combination with any other materials or in any process. Further, since the conditions and methods of use are
beyond the control of Arkema Inc., Arkema Inc. expressly disclaims any and all liability as to any results
obtained or arising from any use of the product or reliance on such information.
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