Page 1 of 7
MSDS Ref. No: QS-MSD-114
Version: US/Canada
Date Approved: 03/01/2009
Revision No: 8
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
Lithium t-Butoxide in THF
PRODUCT NAME:
Alkali Metal Alkoxide
CHEMICAL FAMILY:
C4H9LiO
MOLECULAR FORMULA:
Lithium tertiary Butoxide, Lithium tertiary Butylate
SYNONYM(s):
Lithium t-Butoxide in Tetrahydrofuran, LTB
ALTERNATE TRADE NAME(S):
Industrial Manufacturing
GENERAL USE:
MANUFACTURER Emergency Telephone Numbers:
FMC CORPORATION CHEMTREC (800) 424-9300
Lithium Division Emergency Phone (704) 629-5361 (Plant) Call
P.O. Box 795 Collect 24 Hr/Day
Bessemer City, NC 28016-0795 Emergency Phone (303) 595-9048 (Medical)
General Information: (704) 868-5300 Call Collect
2. HAZARDS IDENTIFICATION
Flammable liquid, Category 2
CLASSIFICATION:
Corrosive to skin; Category 1A
Specific target organ systemic toxicity ?Single exposure; Category 3
LABELING:
Flame, Corrosion, Exclamation mark
SYMBOLS:
Danger
SIGNAL WORD:
Highly flammable liquid and vapour
HAZARD STATEMENTS:
Causes severe skin burns and eye damage
May cause respiratory irritation
PRECAUTIONARY STATEMENTS: Prevention:
Keep away from heat, sparks or open flame- No smoking.
Keep container tightly closed.
Ground/Bond container and receiving equipment.
Use explosion-proof electrical, ventilation and lighting equipment.
Use only non-sparking tools.
Take precautionary measures against static discharge.
Wear chemical splash goggles with a face shield, rubber gloves and
rubber clothing.
Do not breathe dusts or mists.
Wash thoroughly after handling.
Avoid breathing vapors.
Use only outdoors or in a well ventilated area.
Response:
In case of fire, DO NOT USE WATER OR CARBON DIOXIDE. Use dry
chemical.
First Aid:
See Section 4 of the MSDS.
Storage
See Section 7 of the MSDS.
Disposal
See Section 13 of the MSDS.
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MSDS Ref. No: QS-MSD-114
Version: US/Canada
Date Approved: 03/01/2009
Revision No: 8
3. COMPOSITION / INFORMATION ON INGREDIENTS
Chemical Name CAS # EC No Wt.% Classification, Hazard Statement Codes
Lithium t-Butoxide 1907-33-1 217-611-5 17 - 23 Skin Corr. Cat 1A H314
tert-Butyl alcohol 75-65-0 200-889-7 0.3 - 4 Flam. liq. Cat. 2 H225
Acute Tox. Cat. 4 H332
Tetrahydrofuran 109-99-9 203-726-8 77 - 83 Flam. liq. Cat. 2 H225
Eye Irrit. Cat. 2 H319
STOT SE Cat. 3 H335
4. FIRST AID MEASURES
Immediately flush with water for at least 15 minutes, lifting the
EYES:
upper and lower eyelids intermittently. See a medical doctor or
ophthalmologist immediately.
Immediately flush with plenty of water while removing
SKIN:
contaminated clothing and/or shoes, and thoroughly wash with
soap and water. Obtain immediate medical attention. Contact a
medical doctor if necessary.
Rinse mouth with water. Dilute by giving 1 or 2 glasses of water.
INGESTION:
Do not induce vomiting. Never give anything by mouth to an
unconscious person. See a medical doctor immediately.
Remove to fresh air. If breathing difficulty or discomfort occurs and
INHALATION:
persists, see a medical doctor. If breathing has stopped, give
artificial respiration and see a medical doctor immediately.
NOTES TO MEDICAL DOCTOR:
Product has a high pH and is corrosive to eyes, skin, and mucous membranes. Consideration should be given to
careful endoscopy as stomach or esophageal burns, perforations or strictures may occur. Careful gastric lavage with
an endotracheal tube in place should be considered. Observation may be warranted. Treatment is controlled
removal of exposure followed by symptomatic and supportive care.
5. FIRE FIGHTING MEASURES
Upper: 11.8% (THF) Lower: 2% (THF)
FLAMMABLE LIMITS:
Flammable liquid. Reacts vigorously with water to give off flammable
GENERAL HAZARD:
fumes and corrosive dust.
DO NOT USE WATER OR CARBON DIOXIDE. Use dry chemical.
EXTINGUISHING MEDIA:
Lithium hydroxide, carbon dioxide, carbon monoxide.
HAZARDOUS COMBUSTION PRODUCTS:
Wear full protective clothing and self-contained breathing apparatus
FIRE FIGHTING PROCEDURES:
(SCBA) approved for fire fighting. This is necessary to protect against
the hazards of heat, products of combustion and oxygen deficiency.
Do not breathe smoke, gases or vapors generated.
Not available
AUTOIGNITION TEMPERATURE:
Water reactivity and volatility of solvents.
PROPERTIES CONTRIBUTING TO
FLAMMABILITY:
-20篊 (-8篎)
FLASH POINT:
Yes
SENSITIVITY TO STATIC DISCHARGE:
None
SENSITIVITY TO IMPACT:
COMMENTS:
(See Section 10, Stability and Reactivity)
6. ACCIDENTAL RELEASE MEASURES
Remove all sources of ignition. Do not use water in the initial phases
RELEASE NOTES:
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MSDS Ref. No: QS-MSD-114
Version: US/Canada
Date Approved: 03/01/2009
Revision No: 8
of clean up. Contain spill with absorbant. Transfer to approved
transport container and clean up spillage with an absorbant. Dispose
of waste according to local and Federal laws and regulations.
Before cleanup measures begin, review the entire MSDS with
particular attention to Section 3, Emergency Overview and Potential
Health Effects; and Section 8, Recommended Personal Protective
Equipment.
7. HANDLING AND STORAGE
Use in a closed system under argon or nitrogen. Do not get in eyes,
HANDLING:
on skin or clothing. Do not breathe vapors or mist.
Store in a cool place. Keep container closed. Keep away from
STORAGE:
sources of ignition, water, air, acids and oxidizing agents.
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE LIMITS
Chemical Name TWA STEL/Ceiling PEL STEL/Ceiling
(ACGIH) (ACGIH) (OSHA) (OSHA)
tetrahydrofuran 200 ppm 250 ppm 200 ppm
tert-Butyl alcohol, hydrolysis 100 ppm 100 ppm
product and impurity
ENGINEERING CONTROLS:
Use in closed system under argon or nitrogen. If personal contact can occur, use local exhaust ventilation
(explosion-proof), to keep airborne concentrations below exposure limits.
PERSONAL PROTECTIVE EQUIPMENT
Chemical splash goggles with a face shield.
Eyes And Face:
When engineering controls are not adequate, wear a NIOSH/MSHA
Respiratory:
respirator approved for protection against organic vapors and mists.
Rubber gloves and rubber clothing.
Protective Clothing:
Quick-drench eyewash and safety shower.
Work Hygienic Practices:
9. PHYSICAL AND CHEMICAL PROPERTIES
Of tetrahydrofuran
ODOR:
Liquid, colorless to yellow
APPEARANCE:
Reacts vigorously with water to give pH >12
pH:
77 to 83
PERCENT VOLATILE:
162.1 mm Hg at 20 C?(THF), 31 mm Hg (tert-butyl alcohol),
VAPOR PRESSURE:
@20篊
(Air = 1): 2
VAPOR DENSITY:
66 篊 (THF)
BOILING POINT:
<-35篊 (-26篎)
MELTING POINT:
Exothermic reaction to form basic lithium hydroxide and tertiary
SOLUBILITY IN WATER:
butanol
8 (THF)
EVAPORATION RATE(Butyl Acetate = 1):
0.886 g/ml
SPECIFIC GRAVITY:
80.05
MOLECULAR WEIGHT:
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MSDS Ref. No: QS-MSD-114
Version: US/Canada
Date Approved: 03/01/2009
Revision No: 8
Not applicable
COEFF. OIL/WATER:
Not applicable
ODOR THRESHOLD:
Upper: 11.8% (THF) Lower: 2% (THF)
FLAMMABLE LIMITS:
-20篊 (-8篎)
FLASH POINT:
Not available
AUTOIGNITION TEMPERATURE:
Not available
VISCOSITY:
Water reactive material in flammable liquid solvent
FLAMMABILITY:
Not available
DECOMPOSITION TEMPERATURE:
Not explosive
EXPLOSIVE PROPERTIES:
Not an oxidizer
OXIDIZING PROPERTIES:
10. STABILITY AND REACTIVITY
Water, heat, sparks, open flame.
CONDITIONS TO AVOID:
Stable
STABILITY:
Does not polymerize
POLYMERIZATION:
Lithium hydroxide, flammable hydrocarbons and alcohols
HAZARDOUS DECOMPOSITION
PRODUCTS:
Heat, fire, air, water, acids and oxidizing chemicals
INCOMPATIBLE MATERIALS:
11. TOXICOLOGICAL INFORMATION
No data available for the product.
Eye Contact:
Lithium t-Butoxide: Corrosive
No data available for the product.
Skin Contact:
Lithium t-Butoxide: Corrosive
No data available for the product.
Skin Absorption:
Lithium t-Butoxide: Corrosive
t-butanol, hydrolysis product and impurity: Dermal [RTECS]
LD50: >2 mg/kg (rabbit)
No data available for the product.
Ingestion:
Lithium t-Butoxide: Oral LD50: = 1682 mg/kg (mouse) [RTECS]
t-butanol, hydrolysis product and impurity: Oral LD 50: = [RTECS]
2743 mg/kg (rat)
THF: LD50 = 1650 mg/kg (rat) [RTECS]
No data available for the product.
Inhalation:
Lithium t-Butoxide: Corrosive
t-butanol, hydrolysis product and impurity: Inhalation [RTECS]
LC50: >10000 ppm (4 hr. rat)
THF: LC50 = 21,000 ppm , 3 hr., (rat) [RTECS]
Acute Effects From Overexposure:
No data available for the product. This product is corrosive to skin, eyes (may cause blindness), mucous membranes
and upper respiratory tract.
Tetrahydrofuran: Inhalation of vapors may cause dizziness, nausea, anesthesia, numbness, motor weakness in
fingers and toes, incoordination, and headache.
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MSDS Ref. No: QS-MSD-114
Version: US/Canada
Date Approved: 03/01/2009
Revision No: 8
Chronic Effects From Overexposure:
No data available for the product.
Tetrahydrofuran: Repeated or prolonged exposure may cause signs of central nervous system depression and
respiratory irritation. This material has been shown to induce tumors in laboratory animals. Tetrahydrofuran did not
produced genetic damage in bacterial or mammalian cell cultures or in animals. Testing for reproductive effects
showed no change in reproductive performance.
t-Butanol: Oral administration of t-butanol to laboratory animals has caused fetotoxic effects. Mutagenic effects have
been observed in tests with bacteria. Studies conducted by the NTP on long-term drinking water effects of t-butanol
indicate some evidence of carcinogenicity in male rats and female mice, and equivocal evidence in male mice.
No data available for the product.
Sensitization:
EH40: Not listed.
Carcinogenicity:
IARC: Not listed.
NTP: Tetrahydrofuran is listed as a substance that is reasonably
anticipated to be a carcinogen.
OSHA: Not considered a carcinogen under OSHA.
ACGIH: t-Butanol is listed as Category A4, not classifiable as a
human carcinogen. Tetrahydrofuran is listed as Category A3, a
confirmed animal carcinogen with unknown relevance to humans.
No data available for the product.
Mutagenicity:
THF: THF gave negative results in bacterial mutagenicity tests with
and without metabolic activation.
No data available for the product.
Reproductive Toxicity:
THF: One animal study suggests that THF does not cause
reproductive effects at doses which are not maternally toxic.
12. ECOLOGICAL INFORMATION
Ecotoxicological Information:
Environmental toxicity testing of the product has not been carried out.
t-butanol (hydrolysis product):
24-48 hr. EC50 = 5,504 mg/L (daphnia magna) [Handbook Env. Data on Org. Chem. 4th Ed.]
96 hr. LC50 = 6,410 mg/L (Leuciscus idus - orfe) [Handbook Env. Data on Org. Chem. 4th Ed.]
THF: 48 hr. LC50 = 2820; 2930 mg/l (orfe) [Handbook Env. Data on Org. Chem., 4th Ed]
96 hr. LC50 = 2160 mg/L (fathead minnow) [Handbook Env. Data on Org. Chem., 4th Ed]
Chemical Fate Information:
No data available for the product. Lithium t-butoxide reacts violently with water to form t-butanol and lithium
hydroxide.
Tetrahydrofuran: THF is expected to volatilize from both water and soil and leach into groundwater. It will not
photodegrade or adsorb to sediment. Limited evidence suggests it may biodegrade. Based on a relatively low Kow
(0.47), it is not expected to bioconcentrate.
t-Butanol: t-Butanol is expected to readily volatize from both water and soil. It is not expected to adsorb to sediment
or bioconcentrate in aquatic organisms. t-Butanol is expected to be very mobile in soil (estimated Koc of 36.9), and
may leach to groundwater. It is expected to biodegrade in both soil and groundwater. An estimated bioconcentration
factor (BCF) of 1.08 indicates a very low tendency to bioaccumulate. It is not expected to bioaccumulate (BCF 1.08).
13. DISPOSAL CONSIDERATIONS
Dispose of waste according to local and Federal laws and
DISPOSAL METHOD:
regulations.
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MSDS Ref. No: QS-MSD-114
Version: US/Canada
Date Approved: 03/01/2009
Revision No: 8
14. TRANSPORT INFORMATION
UN2924
UN NUMBER:
Flammable liquid, corrosive, N.O.S. (lithium t-butoxide in THF)
PROPER SHIPPING NAME:
3, Flammable liquid, (8, Corrosive)
CLASSIFICATION:
Flammable, Corrosive
LABELS:
II
PACKING GROUP:
-20篊 (-8篎)
FLASH POINT:
2905.14.1000
CUSTOM TARIFF NO:
No
MARINE POLLUTANT:
Not designated Poison Inhalation Hazard by US DOT.
PIH:
15. REGULATORY INFORMATION
UNITED STATES
SECTION 311 HAZARD CATEGORY (40 CFR 370): Reactive, fire hazard, immediate (acute) health hazard.
This product contains tertiary butanol which is a substance
SECTION 313 REPORTABLE INGREDIENTS (40
subject to the reporting requirements of Section 313 of the
CFR 372):
Emergency Planning and Community Right-To-Know Act of
1986.
This information must be included in all MSDS's that are
copied and distributed for this material.
SECTION 302 EXTREMELY HAZARDOUS
SUBSTANCES (40 CFR 355): Not listed
CERCLA HAZARDOUS SUBSTANCE (40 CFR Tetrahydrofuran is listed. The reportable quantity is 1000
302.4): pounds.
TSCA SEC 12B EXPORT NOTIFICATION: This product is subject to TSCA 12(b) export notification
requirements due to the presence of tetrahydrofuran.
TSCA INVENTORY STATUS (40 CFR 710): Listed
Product Identification No.: 2924
CANADA
Hazard Classification: Class B, Division 2 (Flammable
WHMIS:
liquid)
Class B, Division 6 (Reactive Flammable
Materials/Flammable gas on contact with water)
Class D, Division 2B (Toxic Material with Chronic Effects)
Class E, (Corrosive)
Ingredient Disclosure List: Tetrahydrofuran and t-butanol are
listed.
16. OTHER INFORMATION
REVISION SUMMARY: Revision # 8: Regular review completed. Sections 2, 3, 9, 14 & 16 revised.
NFPA RATING HEALTH: 3
FLAMMABILITY: 3
REACTIVITY: 2
SPECIAL: W
This MSDS has been prepared to meet U. S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and
Page 7 of 7
MSDS Ref. No: QS-MSD-114
Version: US/Canada
Date Approved: 03/01/2009
Revision No: 8
Canada's Workplace Hazardous Materials Information System (WHMIS) requirements.
type 2c
Copyright 2009. FMC Corporation, Lithium Division. All Rights Reserved. FMC Lithium and the FMC Lithium logo
are trademarks of FMC Corporation.
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