MATERIAL SAFETY DATA SHEET DIXIE CHEMICAL COMPANY, INC.
P.O. Box 130410
Houston, TX 77219-0410
(713) 863-1947
FAX: (713) 863-8316
SECTION 1 ?CHEMICAL IDENTIFICATION
Trade Name: Propyleneimine, Stabilized Date of Issue: May 13, 1991
Synonyms: PI; Aziridine, 2-methyl-; 1,2-Propylenimine; Revised Date: July 24, 2006
2-Methylaziridine; 2-Methylethylenimine;
DL-2-Methylaziridine
Formula: C3H7N
Chemical Family: Secondary amines
Chemical Use: Chemical intermediate
Telephone Number: Information (281) 474-3271
Emergency Number: Chemtrec (800) 424-9300 Domestic
(703) 527-3887 International
HMIS Hazard Rating
Health: 4* 4 = Extreme
Fire: 4 3 = High
Reactivity: 2 2 = Moderate
*-Chronic effect indicator. See Section 11. 1 = Slight
PPE rating to be supplied by user 0 = Least
depending on use conditions.
SECTION 2 ?HAZARDS IDENTIFICATION
Inhalation: Causes burning sensation, coughing, wheezing, laryngitis, shortness of breath,
headache, nausea and vomiting. Causes spasms, inflammation and edema of the
larynx and bronchi, chemical pneumonitis, and pulmonary edema. High exposures
may be fatal.
Skin Contact: Will cause irritation and tissue destruction. Harmful amounts may be absorbed
through the skin. May cause dermatitis.
Eye Contact: Will cause tissue destruction. Whites of the eyes may redden with prolonged
exposure.
Ingestion: May be harmful or fatal if swallowed. Will cause tissue destruction. Delayed
vomiting may occur.
Propyleneimine, Stabilized (PI), Page 2 of 8
SECTION 3 ?COMPOSITION
Components Percentage TLV (ppm) CAS #
Propyleneimine >97.5 2 75-55-8
SECTION 4 ?FIRST AID MEASURES
Inhalation: Remove victim to fresh air. If breathing is difficult, give oxygen. If not breathing,
administer artificial respiration. Get medical attention.
Skin Contact: Immediately remove contaminated clothing and shoes. Wipe excess material from
skin and flush with water for at least 30 minutes. Use soap if available or follow by
washing with soap and water. Do not reuse contaminated clothing without
laundering. Get medical attention.
Eye Contact: Immediately flush with plenty of water for at least 30 minutes while holding eyelids
open. Get medical attention.
Ingestion: DO NOT INDUCE VOMITING. If victim is conscious, immediately give 4 to 8
ounces of water or milk to drink. Keep person quiet. Get medical attention
immediately.
SECTION 5 ?FIREFIGHTING MEASURES
Extinguishing Media: Use water, foam, or dry chemical. DO NOT USE CARBON DIOXIDE FIRE
EXTINGUISHERS ON PI.
Special Firefighting Firefighters should wear NIOSH approved self-contained breathing apparatus.
Procedures/Precautions: Responders should wear protective clothing to prevent skin contact. Move
containers from fire area. If unable to move, cool sealed containers with water.
Containers may explode in fire.
Unusual Fire and Emits toxic fumes of oxides of nitrogen at elevated temperatures. PI may
Explosion Information: polymerize at high temperatures and rupture the containers. PI vapors are
heavier than air and may travel a considerable distance to an ignition source and
flash back.
Environmental Note: Avoid runoff to waterways and sewers.
SECTION 6 ?ACCIDENTAL RELEASE MEASURES
For Spill: Evacuate the affected area. Remove all sources of ignition. Self-contained breathing
apparatus, chemical resistant boots, protective suit, and butyl rubber gloves must be worn to
prevent contact.
Protective Measures: Evacuate area of unprotected personnel. Eliminate sources of ignition. Stay
upwind and out of low areas. Wear personal protective equipment (See section 8) when responding to
spills.
Propyleneimine, Stabilized (PI), Page 3 of 8
Spill Management: Stop source of leak if safe to do so. Use a water spray to protect personnel and
minimize vapors. Dilute product with large amounts of water. Dike and contain spill. Prevent entry
into waterways, sewer, or confined areas. Neutralize and eliminate odors with 10% acetic acid or
phosphoric acid. If acetic acid is used, an odor of vinegar should be evident when the PI is neutralized.
Remove contaminated trace residues from soil and dispose of in same manner as material. Place in
non-leaking container and dispose of material properly.
Disposal: Proper disposal should be evaluated based on regulatory status of this material (refer to
section 13).
SECTION 7 ?HANDLING AND STORAGE
Wear the required protective equipment. Open cylinder valves slowly due to high vapor pressure of
the material. Protect against static electricity. Protect against physical container damage. Keep away
from heat, sparks, and flames. PI is stored and shipped in the presence of anhydrous sodium
hydroxide. PI inhibited with sodium hydroxide has an indefinite shelf life.
SECTION 8 ?EXPOSURE CONTROLS AND PERSONAL PROTECTION
NIOSH approved Respiratory Protection:
2-99 ppm: Supplied-air respirator with a full facepiece operated in demand, pressure-demand, or
positive-pressure modes. Any self-contained breathing apparatus with a full facepiece operated in
demand, pressure-demand, or positive-pressure modes.
Greater than 100 ppm (IDLH) or entry/escape from unknown concentration: Self-contained
breathing apparatus with a full facepiece operated in pressure-demand or positive-pressure modes.
Combination-type, pressure-demand air-line respirator with a full facepiece and auxiliary self-contained
air supply (due care should be exercised to ensure adequate time for escape from IDLH atmosphere when
using this method).
Ventilation: This product should be confined in a closed system, in which case general
mechanical ventilation is expected to be adequate. Special local ventilation is
required at points where vapor can be expected to escape into the workplace.
Eye Protection: Chemical goggles and possibly a face shield. Have eyewash facilities readily
available.
Other Protective Wear additional protective clothing to prevent skin contact. This may include
Equipment: chemical resistant boots and chemical resistant suits.
Work Practices: Use good personal hygiene practices. Wash hands before eating, drinking,
smoking or using toilet facilities. Promptly remove soiled clothing and wash
thoroughly before reuse. Shower after work using plenty of soap and water.
Hand protection:
Data is based on test method EN 374-3: 2003:
Glove Material: PVC Nitrile Rubber Neoprene Rubber Butyl Rubber
Layer Thickness: 1.06-1.22 mm 0.40-0.42 mm 2.06-2.16 mm 0.69-0.72 mm
Breakthrough time: 9-11 minutes 10-11 minutes 49-50 minutes 149-185 minutes
Propyleneimine, Stabilized (PI), Page 4 of 8
SECTION 9 ?PHYSICAL AND CHEMICAL PROPERTIES
155癋 (68.3oC)
Boiling Point:
-65 to -53癋 (-54 to -47oC)
Melting Point:
Molecular Weight: 57.11
Volatility/Vol (%): 100
140 @ 77癋 (25oC)
Vapor Pressure (mm Hg):
Vapor Density (Air = 1): Not Established
Solubility in H2O (%): 100
Appearance/Odor: Water white oily liquid / Strong, ammonia-like odor.
Odor Threshold 2 ppm
Viscosity (cps): Not Established
0.801 @ 77癋 (25oC)
Specific Gravity (H2O = 1):
Evap. Rate (Butyl Acetate = 1): >1
25oF (-4oC) PMCC, ASTM D93
Flash Point:
Lower Explosive Limit: 1.32%
Upper Explosive Limit: 15.58%
498oF (259oC)
Autoignition Temperature
SECTION 10 ?STABILITY AND REACTIVITY
Chemical Stability: Stable.
Conditions to Avoid: Corroded storage vessels, incompatibles and sources of ignition.
Incompatible Materials: Strong oxidizing agents, acids, acid chlorides, acid anhydrides carbonyl
compounds, quinones, sulfonyl halides, water, and carbon dioxide.
Hydrolyzes in water to form methylethanolamine.
Decomposition Products: Oxides of carbon and nitrogen.
Hazardous Polymerization: May occur. Subject to violent polymerization in contact with acids
SECTION 11 ?TOXICOLOGICAL INFORMATION
2 ppm (skin) STEL: Not Established
ACGIH TLV:
2 ppm (skin) STEL: Not Established
OSHA PEL:
2 ppm (skin) IDLH: 100 ppm
NIOSH REL:
Carcinogenicity listed by: NTP: Yes IARC: Yes OSHA: No
Propyleneimine, Stabilized (PI), Page 5 of 8
Summary of toxicology: Propyleneimine is a carcinogen in animals and is considered a potential
human carcinogen. This chemical has also produced corneal injury when tested in the eyes of rabbits.
Exposure of rats to 500 ppm of PI vapor for four hours was fatal, but inhalation for two hours resulted
in no deaths. Rats administered 20 mg/kg of PI orally twice per week suffered from advanced flaccid
paralysis after 18 weeks along with a high mortality rate. At 10 mg/kg PI, paralysis occurred to a
lesser extent after 30 weeks. Granulocytic leukemia, squamous cell carcinoma of the ear duct, brain
tumors, and mammary adenocarcinomas (females only) were observed in different animals. A number
of the observed mammary adenocarcinomas metastasized to the lungs. NIOSH considers
propyleneimine a potential occupational carcinogen. ACGIH classifies PI as a category A3
carcinogen. The A3 category denotes chemicals, which are confirmed animal carcinogens, however,
exposures are by routes or mechanisms not considered relevant to worker exposure. Available
epidemiologic studies do not confirm an increased risk in cancer. IARC classifies PI as a Group 2B
carcinogen. There is sufficient animal evidence of carcinogenicity, but no adequate human evidence.
Target Organs:
Brain and coverings (tumors)
Lungs, thorax or respiration (chronic pulmonary edema or congestion)
Lungs, thorax or respiration (dypsnae)
Kidney, ureter, bladder (changes in tubules)
Tumorigenic (carcinogenic by RTECS criteria)
Skin (irritation and/or corrosion)
EPA Genetox Program 1988:
Positive: Carcinogenicity-mouse/rat; she-clonal assay.
Positive: Cell transform-rlv f344 rat embryo; host mediated assay.
Positive: E. coli pola without s9; Histidine Reversion-Ames Test.
Positive: In vitro uds-human fibroblast; s cerevisiae-homozygosis.
Positive: S pombre reversion.
Positive: Dose/response: Cell transform-balb/c-3t3 TSCA chemical inventory,
June, 1990 on EPA Iris Database. TSCA Test Submission (TSCATS)
Database, July, 1992.
LCLo: 500 ppm/4H (rat)
Inhalation:
LCLo: 500 ppm/1H (guinea pig)
LD50: 43 mg/kg (guinea pig)
Dermal:
250 mg open SEV (rabbit)
Eyes:
LD50: 19 mg/kg (rat)
Ingestion:
LD50: 355 mg/kg (mouse)
Intraperitoneal:
SECTION 12 ?ECOLOGICAL INFORMATION
Not expected to photolyze, oxidize, or bioaccumalate significantly in aquatic organisms.
Soil release. May be removed by chemical hydrolysis (half-life on the order of 17.5 days at neutral
pH), ring-opening reactions with naturally occurring chemical species or fairly rapid volatilization
from dry soil surfaces.
Propyleneimine, Stabilized (PI), Page 6 of 8
Water release. May undergo chemical hydrolysis (half-life 17.5 days at neutral pH), volatilization
(half-life greater than or equal to 5 days in water 1 m deep flowing 1 m/sec) or undergo ring-opening
reactions with naturally occurring chemical species.
Atmosphere. Predicted to exist almost entirely in the vapor phase. Expected to be reaction with
photochemically generated hydroxyl radicals (half- life on the order of 1.6 days).
SECTION 13 ?DISPOSAL INFORMATION
Place in a city, state, or federally permitted disposal facility. Handle in accordance with all applicable
hazardous waste regulations.
RCRA Waste Number P067 (Aziridine, 2-methyl-; 1,2-Propylenimine)
SECTION 14 ?TRANSPORTATION INFORMATION
Proper Shipping Name: Propyleneimine, stabilized
Primary Hazard Class: 3
Secondary Hazard Class: 6.1
Identification Number: UN 1921
Packing Group: I
Reportable Quantity: 1 pound
Marine Pollutant: No
Label(s) Required: FLAMMABLE LIQUID, POISON
SECTION 15 ?REGULATORY INFORMATION
U.S. Regulations:
NOTICE: It is unlawful to export this product from the United States without obtaining the
required license or written approval from the Office of Defense Trade Controls, Bureau of
Politico - Military Affairs, Department of State, Washington D.C. 20522-0602.
All substances are listed on, or are exempt from reporting.
TSCA:
TSCA 12(b) Export Notification: Not Listed
States Listings:
California Proposition 65: Propyleneimine is known by the State of California to cause cancer.
Illinois Right-to-Know
Louisiana Right-to-Know
Massachusetts Right-to-Know
Michigan Critical Materials Register
Minnesota Right-to-Know
New Jersey Right-to-Know
Propyleneimine, Stabilized (PI), Page 7 of 8
New York State List of Hazardous Substances
Pennsylvania Right-to-Know
Rhode Island Right-to-Know
SARA Hazard Notification:
Hazard Categories Under Title III: Acute, Chronic, Fire, Reactivity.
Section 302 Extremely Hazardous Substances: 10,000 pounds TPQ
Section 313 Toxic Chemicals: 0.1% De Minimis Limit
CERCLA RQ: 1 pound.
European Regulations:
EINECS Number: 2-methylaziridine (propyleneimine): 200-878-7
EC-No. 613-033-00-6
Labeling according to EC directives.
Symbol: F, T+, N
Fire, Very Toxic, Dangerous For The Environment
R-Phrases: R45 May cause cancer.
R11 Highly flammable.
R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed.
R41 Risk of serious damage to eyes.
S-Phrases: S53 Avoid exposure ?obtain special instructions before use.
S45 In the case of accident or if you feel unwell, seek medical advice immediately
(show the label where possible).
German Water Hazard Classification (WGK) Number: 3.
Canadian Regulations:
Listed on the NDSL.
WHMIS Ingredient List
This product has been classified in accordance with the hazard criteria of the Controlled Products
Regulations and MSDS contains all the information required by the Controlled Products Regulations.
Japanese Regulations:
ENCS Number: 5-3332
Australian Regulations:
Listed on the AICS.
Korean Regulations:
Propyleneimine, Stabilized (PI), Page 8 of 8
ECL Number. KE-05-0858
Philippines Regulations:
Listed on the PICCS.
Swiss Regulations:
Listed on the Giftliste 1.
SWISS Number: G-2806
Taiwan Regulations:
TAIWAN No.: 141-01
SECTION 16 ?OTHER INFORMATION
PPE Codes (NPCA-HMIS)
A ?Glasses G ?Glasses, Gloves, Vapor Respirator
B ?Glasses, Gloves H ?Goggles, Gloves, Apron, Vapor Respirator
C ?Glasses, Gloves, Apron I ?Glasses, Gloves, Dust/Vapor Respirator
D ?Faceshield, Gloves, Apron J ?Goggles, Gloves, Apron, Dust/Vapor Respirator
E ?Glasses, Gloves, Dustmask K ?Supplied Air, Gloves, Full Protective Suit, Boots
F ?Glasses, Gloves, Apron, Dust Respirator
Disclaimer
The information contained in the Material Safety Data Sheet is based on technical data that Dixie Chemical
Company believes to be reliable and is provided to our customers at no cost. It is intended for use by persons
having technical skill and at their own discretion and risk. Dixie Chemical Company will assume no liability
in connection with any uses of this information and no warranties, expressed or implied, are made with
regards to this information since conditions of use are outside Dixie Chemical Company's control.
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