Eng
Material Safety Data Sheet
Conforms to 93/112/EC and ISO 11014-1
Responsible Name MSDS Administrator
Section 1. Chemical Product and Company Identification
HaltTM Protease Inhibitor Cocktail (100X)
Product Name
Product no. 1858566
Supplier In USA: In Europe: Manufacturer Pierce
Thermo Fisher Scientific Perbio Science 3747 N. Meridian Road
P.O. Box 117 Industriezone III P.O. Box 117
Rockford, IL 61105 Industrielaan 27 Rockford, IL 61105
USA 9320 Erembodegem-Aalst USA
815.968.0747 or Belgium 815.968.0747 or
1.800.874.3723 Tel:+32 53 83 44 04 1.800.874.3723
Fax:+32 53 83 76 38 (815)968-7316 fax
In case of emergency CHEMTREC: www.thermo.com
Print date 7/3/2007
800.424.9300
Validation date 7/3/2007
OUTSIDE US:
703.527.3887 MSDS# 3880
Use of the Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications.
substance/preparation
Section 2. Composition, Information on Ingredients
Substance/preparation Substance
:
No hazardous ingredient according to 29 CFR 1910.1200 Hazard Communication Standard (USA) and Directives 1999/45/EC-2001/59/EC (EU)
Section 3. Hazards identification
United States Review the most current and approved institutional guideline, protocol, standard operating procedure(s) and MSDS(s)
for the proper handling of institutional materials/equipment associated with the use of this product.
Emergency overview Warning!
CAUSES RESPIRATORY TRACT, EYE AND SKIN IRRITATION.
CONTAINS MATERIAL WHICH CAUSES DAMAGE TO THE FOLLOWING ORGANS:
SKIN, CENTRAL NERVOUS SYSTEM, EYE, LENS OR CORNEA.
Avoid contact with skin and clothing. Avoid breathing vapor or mist. Keep container closed. Use only with adequate
ventilation. Wash thoroughly after handling.
Target organs Contains material which causes damage to the following organs: skin, central nervous system
(CNS), eye, lens or cornea.
Routes of entry Dermal contact. Eye contact. Inhalation. Ingestion.
Potential acute health effects
Eyes Irritating to eyes.
Skin Irritating to skin.
Inhalation Irritating to respiratory system.
Ingestion No known significant effects or critical hazards.
Potential chronic health effects
Carcinogenic effects CARCINOGENIC EFFECTS: Classified None. by OSHA, None. by NIOSH [dimethyl sulfoxide].
MUTAGENIC EFFECTS: Classified POSSIBLE for human [dimethyl sulfoxide]. Mutagenic for mammalian somatic
cells. [dimethyl sulfoxide]. Mutagenic for bacteria and/or yeast. [dimethyl sulfoxide].
TERATOGENIC EFFECTS: Classified POSSIBLE for human [dimethyl sulfoxide].
Medical conditions aggravated Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or
by overexposure many human organs.
Over-exposure signs/symptoms Not available.
Continued on Next Page
Page: 2/7
HaltTM Protease Inhibitor Cocktail
(100X)
Europe
Classification Not classified.
Physical/chemical hazards Not applicable.
Human health hazards Not applicable.
Environmental hazards Not applicable.
See toxicological Information (section 11)
Section 4. First aid measures
Effects and symptoms
Inhalation Slightly hazardous in case of inhalation (lung irritant).
Ingestion Hazardous in case of ingestion.
Skin contact Sensitization of the product: Not available.
Very hazardous in case of skin contact (permeator). Slightly hazardous in case of skin contact (irritant). Skin inflammation
is characterized by itching, scaling, reddening, or, occasionally, blistering.
Eye contact Slightly hazardous in case of eye contact (irritant).
Aggravating conditions Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many
human organs.
First-Aid measures
Inhalation If inhaled, remove to fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration. Get medical
attention.
Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious
person. Get medical attention if symptoms appear.
Skin contact In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing
before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Eye contact In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention if irritation
occurs.
Notes to physician Not available.
Protection of first-aiders Not available.
Section 5. Fire fighting measures
Flammability of the product Combustible.
Flash Points The lowest known value is Closed cup: 87掳C (188.6掳F). Open cup: 95掳C (203掳F). (dimethyl sulfoxide)
Fire hazards in presence of various Not available.
substances
Fire fighting media and instructions Use an extinguishing agent suitable for surrounding fires.
Protective clothing (fire) Be sure to use an approved/certified respirator or equivalent.
Special Remarks on Fire Hazards Combustible when exposed to heat or flame.
Upon heating above 100C (212 F), sulfur dioxide is emitted.
When DMSO undergoes hazardous thermo-oxidative degradation it may produce formaldehyde, methyl mercaptan, and
sulfur dioxide. May form explosive mixtures with air. (dimethyl sulfoxide)
Hazardous thermal decomposition These products are carbon oxides (CO, CO2), sulfur oxides (SO2, SO3...).
products
Continued on Next Page
Page: 3/7
HaltTM Protease Inhibitor Cocktail
(100X)
Section 6. Accidental release measures
Personal precautions Safety glasses. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Impervious
gloves.
Environmental precautions and Keep away from heat. Keep away from sources of ignition. Stop leak if without risk.
clean-up methods
Small spill and leak Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container.
Section 7. Handling and storage
Handling Wash thoroughly after handling.
Storage Keep container tightly closed. Keep container in a cool, well-ventilated area.
Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications.
Packaging materials
Suitable / Not suitable Use original container.
Czech Republic - Storage III
code
Section 8. Exposure Controls, Personal Protection
Engineering Controls Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their
respective occupational exposure limits. Ensure that eyewash stations and safety showers are proximal to the work-
station location.
Exposure Limit Values
Ingredient Name Occupational Exposure Limits
United States
Dimethyl Sulfoxide (DMSO) AIHA WEEL (United States, 1/2006).
TWA: 250 ppm 8 hour(s).
Sweden
Dimethyl Sulfoxide (DMSO) AFS (Sweden, 0/1996). Skin
NGV: 50 ppm
TGV: 150 ppm
KTV: 500 ppm
NGV: 150 mg/m3
KTV: 500 mg/m3
KTV: 500 mg/m3 15 minute(s).
NGV: 150 mg/m3 8 hour(s).
Denmark
Dimethyl Sulfoxide (DMSO) DK-Arbejdstilsynet (Denmark, 0/1996).
GV: 100 ppm
Arbejdstilsynet (Denmark, 4/2005).
GV: 160 mg/m3 8 hour(s).
GV: 50 ppm 8 hour(s).
Netherlands
Dimethyl Sulfoxide (DMSO) Arbeidsinspectie (Netherlands, 0/2000).
TGG: 50 ppm
TGG: 150 mg/m3
Nationale MAC-lijst (Netherlands, 7/2006). Skin Notes: Administrative
TGG: 150 mg/m3 8 hour(s).
TGG: 50 ppm 8 hour(s).
Germany
Dimethyl Sulfoxide (DMSO) BAUA (Germany, 0/1999). Skin
TWA: 160 mg/m3
Austria
Continued on Next Page
Page: 4/7
HaltTM Protease Inhibitor Cocktail
(100X)
Dimethyl Sulfoxide (DMSO) GKV_MAK (Austria, 6/2006). Skin
TWA: 160 mg/m3 8 hour(s).
TWA: 50 ppm 8 hour(s).
Switzerland
Dimethyl Sulfoxide (DMSO) SUVA (Switzerland, 0/1997). Skin
MAK: 50 ppm 8 hour(s).
MAK: 160 mg/m3 8 hour(s).
Personal Protection
Splash goggles.
Eyes
Lab coat.
Body
Gloves.
Hands
Respirator is not needed under normal and intended conditions of use, if exposures are kept below established limits.
Respiratory
Protective Clothing
(Pictograms)
Section 9. Physical and chemical properties
Physical State Liquid. Color Cloudy. Odor Not available.
Taste Not available.
Molecular weight Not applicable.
Boiling/condensation point The lowest known value is 189掳C (372.2掳F) (dimethyl sulfoxide).
Melting/freezing point May start to solidify at 18.55掳C (65.4掳F) based on data for: dimethyl sulfoxide.
Specific Gravity The only known value is 1.101 (Water = 1) (dimethyl sulfoxide).
Vapor pressure The highest known value is 0.06 kPa (0.4 mm Hg) (at 20掳C) (dimethyl sulfoxide).
Vapor density The highest known value is 2.71 (Air = 1) (dimethyl sulfoxide).
Evaporation rate 0.026 (dimethyl sulfoxide) compared to Butyl acetate.
Viscosity Dynamic: The highest known value is 2.47 cP (dimethyl sulfoxide)
Dispersion properties See solubility in water, diethyl ether, acetone.
Solubility Easily soluble in cold water, hot water.
Soluble in diethyl ether, acetone.
Flash point The lowest known value is Closed cup: 87掳C (188.6掳F). Open cup: 95掳C (203掳F). (dimethyl sulfoxide)
Explosive properties Explosive in presence of open flames, sparks and static discharge.
Explosion limits The greatest known range is Lower: 3.5% Upper: 42% (dimethyl sulfoxide)
Section 10. Stability and reactivity
Stability and Reactivity The product is stable.
Conditions to avoid Not available.
Materials to avoid Reactive with oxidizing agents, reducing agents, acids, moisture.
Hazardous polymerization Will not occur.
Hazardous Decomposition Not available.
Products
Continued on Next Page
Page: 5/7
HaltTM Protease Inhibitor Cocktail
(100X)
Section 11. Toxicological information
Toxicity to Animals dimethyl sulfoxide:
ORAL (LD50): Acute: 14500 mg/kg [Rat]. 17400 mg/kg [Rat]. 100 mg/kg
[wild bird species].
DERMAL (LD50): Acute: 40000 mg/kg [Rat]. 50000 mg/kg [Mouse]. >5000
mg/kg [Rabbit].
Chronic Effects on Humans CARCINOGENIC EFFECTS: Classified None. by OSHA, None. by NIOSH [dimethyl sulfoxide].
MUTAGENIC EFFECTS: Classified POSSIBLE for human [dimethyl sulfoxide]. Mutagenic for mammalian somatic cells.
[dimethyl sulfoxide]. Mutagenic for bacteria and/or yeast. [dimethyl sulfoxide].
TERATOGENIC EFFECTS: Classified POSSIBLE for human [dimethyl sulfoxide].
DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female [SUSPECTED] [dimethyl sulfoxide].
Contains material which causes damage to the following organs: skin, central nervous system (CNS), eye, lens or cornea.
Other Toxic Effects on Humans Hazardous in case of ingestion.
Slightly hazardous in case of eye contact (irritant), of inhalation (lung irritant).
Special Remarks on Toxicity to Not available.
Animals
Special Remarks on Chronic Exposure can cause stomach pains, vomiting and diarrhea. Laboratory experiments have shown mutagenic effects. An
Effects on Humans experimental tumorigen. Laboratory experiments have shown mutagenic effects. (dimethyl sulfoxide)
Special Remarks on Other Toxic To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated. Exposure
Effects on Humans can cause nausea, headache and vomiting. Experimentaly tumorigen. (dimethyl sulfoxide)
Carcinogenicity No known significant effects or critical hazards.
Mutagenicity No known significant effects or critical hazards.
Reproductive toxicity No known significant effects or critical hazards.
Over-exposure
signs/symptoms
Inhalation No known significant effects or critical hazards.
Ingestion No known significant effects or critical hazards.
Skin No known significant effects or critical hazards.
Target organs Contains material which causes damage to the following organs: skin, central nervous system
(CNS), eye, lens or cornea.
Section 12. Ecological information
Mobility Not available.
Persistence/degradability Not available.
Bioaccumulative potential Not available.
Ecotoxicity Not available.
Germany water class VCI WGK: No products were found.
Ecotoxicity data
Ingredient name Species Period
Other ecological information
Persistence/degradability
Ingredient name BOD5 COD
Ingredient name Aquatic half-life Photolysis
Bioaccumulative potential
Ingredient name LogPow BCF
Continued on Next Page
Page: 6/7
HaltTM Protease Inhibitor Cocktail
(100X)
Mobility : Not available.
Other adverse effects : No known significant effects or critical hazards.
Section 13. Disposal considerations
Waste Stream Not available.
Methods of disposal The generation of waste should be avoided or minimized wherever possible. Avoid dispersal of
spilled material and runoff and contact with soil, waterways, drains and sewers. Disposal of this
product, solutions and any by-products should at all times comply with the requirements of
environmental protection and waste disposal legislation and any regional local authority
requirements.
European waste catalogue Not available.
(EWC)
Hazardous waste To present knowledge of the supplier, this product is not regarded as hazardous waste as defined
by EU Directive 91/689/EC.
Denmark 鈥? Carcinogenic waste Not available.
Denmark - Waste card number Not available.
Denmark - Waste group Not available.
Sweden - thermoset plastic Not available.
waste
Sweden - Waste group Not available.
Austria - Waste catalogue Not available.
Norway - Waste number Not available.
Norway - Hazardous waste To present knowledge of the supplier, this product is not regarded as hazardous waste as defined
by SFT鈥檚 Directive on special waste.
Switzerland - Waste code Not available.
Section 14. Transport information
Contact the supplier for all information regarding the proper transportation method for this material.
1
Section 15. Regulatory information
Label Requirements
This product is not classified according to the EU regulations.
(Europe)
HCS Classification Irritating material
Target organ effects
U.S. Federal Regulations TSCA 8(b) inventory: dimethyl sulfoxide
SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found.
SARA 302/304/311/312 hazardous chemicals: dimethyl sulfoxide
SARA 311/312 MSDS distribution - chemical inventory - hazard identification: dimethyl sulfoxide: Immediate (Acute) Health Hazard, Delayed
(Chronic) Health Hazard
Clean Water Act (CWA) 307: No products were found.
Clean Water Act (CWA) 311: No products were found.
Clean air act (CAA) 112 accidental release prevention: No products were found.
Continued on Next Page
Page: 7/7
HaltTM Protease Inhibitor Cocktail
(100X)
Clean air act (CAA) 112 regulated flammable substances: No products were found.
Clean air act (CAA) 112 regulated toxic substances: No products were found.
State regulations No products were found.
Class D-1B: Material causing immediate and serious toxic effects (TOXIC).
WHMIS (Canada)
Class D-2A: Material causing other toxic effects (VERY TOXIC).
CEPA DSL: dimethyl sulfoxide
International Regulations
EINECS Not available.
DSCL (EEC) This product is not classified according to the EU regulations.
International Lists Australia: dimethyl sulfoxide
Australia (NICNAS): dimethyl sulfoxide
China: dimethyl sulfoxide
Germany water class: dimethyl sulfoxide
Japan (METI): dimethyl sulfoxide
Korea (TCCL): dimethyl sulfoxide
Philippines (RA6969): dimethyl sulfoxide
State Regulations No products were found.
Section 16. Other information
National Fire Protection
Hazardous Material * 1
Health Flammability
0
Association (U.S.A.)
Information System
0
(U.S.A.) Fire hazard 2 0
Health Instability
0
Reactivity
Special
C
Personal protection
References Not available.
History of Document Changes Any information changes since last document version are marked with a triangle symbol.
Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications.
Date of previous issue No Previous
Validated by MSDS Administrator on 7/3/2007. Verified by MSDS Administrator.
Validation
Printed 7/3/2007. Version 0.03
Notice to reader
To the best of our knowledge, the information contained herein is accurate. However, neither the above named supplier nor any of its
subsidiaries assumes any liability whatsoever for the accuracy or completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and
should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that
exist.
|