BioVendor - Laboratorn铆 medic铆na a.s.
CTPark Mod艡ice, Evropsk谩 873
664 42 Mod艡ice, Czech Republic
Phone: +420 549 124 185
Fax: +420 549 211 460
E-mail: info@biovendor.com
Web: www.biovendor.com
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. MATERIAL SAFETY DATA SHEET .
. .
Human IL-8 ELISA
Product name:
ROIL08001R
Catalog number:
11th October 2003
Date of issue:
7th February 2008
Date of review:
1. Product
ELISA test kit for quantitative determination of human IL-8.
2. Physical chemical characteristics
Appearance: Test kit consisting of assay plates, reagents, standards, buffer and stop solution. This kit contains biological material.
The stop solution has the following characteristics:
Boiling Point: 327 EF
Specific Gravity: 1.84
Solubility: Complete
pH: 1.0
Vapor Pressure: <0.3
3. Composition
The physical, chemical and toxicological properties of these components have not been fully investigated. It is recommended that all
laboratory personnel follow standard laboratory safety procedures when handling this product. Safety procedures should include
wearing OSHA approved safety glasses, gloves, and protective clothing. Direct physical contact with all components in this product
should be avoided.
Potentially Hazardous Ingredients:
1. Human source material (in standards).
2. Sulfuric acid (stop solution); Content: 2 N; CAS #: 7664-93-9, OSHA PEL: 1 mg/ m3; ACGIH TLV: 1 mg/m3 with a STEL of
3 mg/ m3 .
3. Thimerosal (as preservative in the conjugate); CAS#:54-64-8; Content: <0.02%; OSHA PEL - 0.01 mg (Hg)/ m3; ACGIH
TLV - 0.1 mg (Hg)/ m3.
4. n,n-dimethylformamide (in substrate solution); CAS#: 68-12-2; OSHA PEL: 30 mg/ m3; ACGIH TLV - 10 ppm with Skin A4
and BEI notations.
5. 3,3',5,5' tetramethylbenzidine (in substrate solution); CAS#: 54827-17-7.
6. Gentamicin sulfate in sample diluent and conjugate diluent; CAS#: 1405-41-0
7. Rabbit serum: Potential Biohazard
4. Hazards
Gentamicin-Sulfate with which Sample Diluent is formulated is very toxic. Avoid contact with eyes, skin and clothing.
Thimerosal with which Sample Diluent and standards are formulated is very toxic.
Avoid contact with eyes, skin and clothing.
Human Serum with which standards are formulated could be infectious. The human serum has been tested and found nonreactive
for HIV-1 and Hepatitis B surface antigen. However, no known test method can offer assurance that products derived from human
serum will not be infectious.
_________________________________________________________________________________________________________________________________________________________________
BioVendor - Laboratorn铆 medic铆na a.s. Phone: +420 549 124 185 E-mail: info@biovendor.com
CZECH REPUBLIC Fax: +420 549 211 460 Web: www.biovendor.com
page: 1 of 3
Animal origin Serum with which antibodies are formulated could be infectious. No known test method can offer assurance that
products derived from animals will not be infectious.
5. Toxikology/health effects
Occupational exposure to this product is not expected to produce adverse human health effects following prudent workplace
practices. Contact with skin or eyes may produce irritation or burns. Wash with plenty of water and seek medical advice if irritation
develops.
If swallowed, wash mouth with water and seek medical advice.
The stop solution is a poison and cause severe burns. The oral LD50 (rat) for sulfuric acid is 2140 mg/kg. The oral LD50 (rat) for
n,ndimethylformamide is 2800 mg/kg. It is not classified by NTP as a carcinogen; however it is classified by IARC as Category 3
(unclassifiable as to carcinogenicity to humans). 3,3',5,5'- tetramethylbenzidine may cause skin and eye irritation.
6. First aid
Route of Entry: Inhalation, ingestion and skin contact.
Emergency and First Aid Procedures:
Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician or poison control.
Skin Contact
Flush with copious amounts of water and wash with soap and water for at least 15 minutes. Remove contaminated clothing and
shoes. Call a physician if irritation or discomfort develops.
Inhalation
Remove victim to fresh air. If breathing becomes difficult, give oxygen. If breathing stops, administer artificial respiration. Call a
physician.
Eye Contact
Flush with copious amounts of water for at least 15 minutes. Check for and remove contact lenses. Assure adequate flushing by
separating the eyelids. Call a physician. If medical attention is required, provide product label and/or MSDS.
7. Fire and explosion hazard data
Condition: No fire or explosion hazards. Packaging material will burn in a fire.
Extinguishing Media: Use standard fire fighting procedures depending on the source of the surrounding fire.
8. Reactivivty data
Incompatibilities: The stop solution is incompatible with strong oxidizing agents, alkalis, metals, strong reducing agents and many
other reactive
substances.
Hazardous Polymerization: Will not occur.
Conditions to Avoid: This product is stable. If involved in a fire, poisonous gas may be produced by the packaging material and the
stop solution may release oxides of sulfur.
Hazardous Decomposition or Byproducts: This product is stable. If involved in a fire, poisonous gas may be produced by the
packaging materials. The stop solution will produce oxides of sulfur and hydrogen.
9. Precauitons for safe handling
General: Read the package insert. The controls are derived from human source material, and normal laboratory precautions should
be taken for handling such material. Always follow good laboratory practices when using this product. Employee exposure to human
source material is regulated under the Code of Federal Regulations 29 CFR 1910.1030.
Refer to the Centers for Disease Control/National Institutes of Health manual 鈥楤iosafety in Microbiological and Biomedical
Laboratories鈥?.
Steps to Be Taken in Case Material is Spilled: If stop solution spills, neutralize with soda ash, lime, or a commercially available
acid neutralizer.
Waste Disposal Method: Place material in a sealed container and dispose of as medical waste in accordance with applicable
environmental regulations.
10. Control measures
Personal Protective Equipment: Barrier gloves, eye protection, and laboratory coat may be required as laboratory conditions
indicate.
Ventilation: No special ventilation is necessary, however, a biosafety cabinet, as recommended in the CDC/NIH manual, may be
necessary.
_________________________________________________________________________________________________________________________________________________________________
BioVendor - Laboratorn铆 medic铆na a.s. Phone: +420 549 124 185 E-mail: info@biovendor.com
CZECH REPUBLIC Fax: +420 549 211 460 Web: www.biovendor.com
page: 2 of 3
11. Accidental release measures
Ventilate area. Shut off all sources of ignition. Wear appropriate protective gear. Wipe or pick-up materials, place in dealer container,
dispose of in accordance with federal, state, and local regulations. Wash spill site thoroughly with soap and water after material pick-
up is complete.
12. Handling and storage
This kit should be stored as recommended on the product label. All components should be kept in tightly closed containers. Refer to
the Storage section of the kit insert for further information. This kit should only be handled and used by qualified, trained
professionals.
13. Stability and reactivity
This product is stable until the expiration date indicated on the label under the specified storage conditions. There are no known
reactivities with these components. Refer to the kit insert for further information.
14. Ecological information
None available.
15. Other information
The above information is believed to be correct but does not purport to be all-inclusive and shall be used as a guide only. BioVendor
shall not be held liable for any damage resulting from handling or contact with the above product. The burden of safe use of these
materials rests solely with the user.
_________________________________________________________________________________________________________________________________________________________________
BioVendor - Laboratorn铆 medic铆na a.s. Phone: +420 549 124 185 E-mail: info@biovendor.com
CZECH REPUBLIC Fax: +420 549 211 460 Web: www.biovendor.com
page: 3 of 3
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