SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 10/26/2005
Date Updated: 03/11/2004
Version 1.3
Section 1 - Product and Company Information
Product Name 5-FLUOROURACIL
Product Number F6627
Brand SIGMA
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
5'-FLUOROURACIL 51-21-8 Yes
Formula C4H3FN2O2
Synonyms Adrucil * Arumel * Effluderm (free base) * Efudex
* 5-Fluoracil (German) *
5-Fluor-2,4-dihydroxypyrimidin (Czech) *
Fluoroblastin * Fluoroplex *
5-Fluoropyrimidine-2,4-dione *
5-Fluoro-2,4-pyrimidinedione *
5-Fluoro-2,4(1H,3H)-pyrimidinedione *
5-Fluor-2,4-pyrimidindiol (Czech) *
5-Fluor-2,4(1H,3H)-pyrimidindion (Czech) *
Fluorouracil * 5-Fluorouracil * 5-Fluoruracil
(German) * Fluracil * Fluracilum * Fluril * FU *
5-FU * NSC-19893 * 2,4(1H,3H)-Pyrimidinedione,
5-fluoro- * Queroplex * Ro 2-9757 * Timazin *
U-8953 * Ulup
RTECS Number: YR0350000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Toxic (USA) Harmful (EU).
Harmful if swallowed.
Photosensitizer. Target organ(s): Heart. Bone marrow.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 0
REACTIVITY: 0
NFPA RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
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STORAGE
Suitable: Keep tightly closed.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Mechanical exhaust required. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Fine crystals
Property Value At Temperature or Pressure
Molecular Weight 130.08 AMU
pH N/A
BP/BP Range N/A
MP/MP Range 282 藲C
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solvent: Clear 10 mg/ml H2O
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong bases, Strong oxidizing agents.
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HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Hydrogen fluoride, Nitrogen
oxides Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
SENSITIZATION
Sensitization: Causes photosensitivity. Exposure to light can
result in allergic reactions resulting in dermatologic lesions,
which can vary from sunburnlike responses to edematous,
vesiculated lesions, or bullae
TARGET ORGAN(S) OR SYSTEM(S)
Bone marrow. Heart. Immune system. Blood.
SIGNS AND SYMPTOMS OF EXPOSURE
May cause nausea, vomiting, anorexia, diarrhea, stomatitis,
fever, malaise, weakness, headache, depression, skin rash,
erythema, bone marrow depression, bleeding syndrome, and renal
impairment. Deaths have occured.
TOXICITY DATA
Oral
Rat
230 mg/kg
LD50
Intraperitoneal
Rat
70 MG/KG
LD50
Remarks: Gastrointestinal:Hypermotility, diarrhea.
Gastrointestinal:Nausea or vomiting.
Subcutaneous
Rat
217 MG/KG
LD50
Intravenous
Rat
245 MG/KG
LD50
Remarks: Gastrointestinal:Hypermotility, diarrhea.
Gastrointestinal:Nausea or vomiting.
Intramuscular
Rat
240 MG/KG
LD50
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Parenteral
Rat
500 MG/KG
LD50
Rectal
Rat
884 MG/KG
LD50
Remarks: Gastrointestinal:Hypermotility, diarrhea.
Gastrointestinal:Other changes.
Oral
Mouse
115 mg/kg
LD50
Intraperitoneal Intraperitoneal
Mouse Mouse
100 MG/KG 100 MG/KG
LD50 LD50
Subcutaneous
Mouse
169 MG/KG
LD50
Intravenous
Mouse
81 MG/KG
LD50
Intracerebral
Mouse
41600 UG/KG
LD50
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Other. Sense Organs and Special Senses (Nose, Eye,
Ear, and Taste):Eye:Etosis. Peripheral Nerve and
Sensation:Sensory change involving peripheral nerve.
Oral
Dog
30 mg/kg
LD50
Remarks: Gastrointestinal:Nausea or vomiting.
Oral
Rabbit
18.9 mg/kg
LD50
Remarks: Nutritional and Gross Metabolic:Weight loss or
decreased weight gain. Behavioral:Muscle weakness.
Gastrointestinal:Hypermotility, diarrhea.
Intravenous
Guinea pig
25 MG/KG
LD50
Remarks: Vascular:BP elevation not charactertized in autonomic
section.
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IRRITATION DATA
Skin
Human
84 mg
3W
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Species: Mouse
Route of Application: Intraperitoneal
Dose: 1500 MG/KG
Exposure Time: 50W
Frequency: I
Result: Blood:Tumors. Lungs, Thorax, or Respiration:Tumors.
Tumorigenic:Carcinogenic by RTECS criteria.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - TERATOGEN
Species: Woman
Dose: 240 MG/KG
Route of Application: Intravenous
Exposure Time: (11-14W PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 35 MG/KG
Route of Application: Oral
Exposure Time: (7-13D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 30 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (12D PREG)
Result: Specific Developmental Abnormalities: Gastrointestinal
system. Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Rat
Dose: 30 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (12D PREG)
Result: Specific Developmental Abnormalities: Homeostasis
Species: Rat
Dose: 20 MG/KG
Route of Application: Subcutaneous
Exposure Time: (14D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
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Species: Rat
Dose: 30 MG/KG
Route of Application: Subcutaneous
Exposure Time: (14D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 330 MG/KG
Route of Application: Intravenous
Exposure Time: (7-17D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 175 MG/KG
Route of Application: Oral
Exposure Time: (7-13D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Mouse
Dose: 50 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (13D PREG)
Result: Effects on Embryo or Fetus: Cytological changes
(including somatic cell genetic material).
Species: Mouse
Dose: 20 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Musculoskeletal system.
Species: Mouse
Dose: 10 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Eye, ear.
Species: Hamster
Dose: 24 MG/KG
Route of Application: Intramuscular
Exposure Time: (9D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Hamster
Dose: 56 MG/KG
Route of Application: Intramuscular
Exposure Time: (11D PREG)
Result: Specific Developmental Abnormalities: Homeostasis
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
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Species: Human Human
Dose: 13 MG/L 13 MG/L
Cell Type: Other cell types Other cell types
Mutation test: DNA damage DNA damage
Species: Human Human
Dose: 1 MMOL/L 1 MMOL/L
Cell Type: Other cell types Other cell types
Mutation test: DNA damage DNA damage
Species: Human Human
Dose: 5 UMOL/L 5 UMOL/L
Exposure Time: 6H 6H
Cell Type: Other cell types Other cell types
Mutation test: Other mutation test systems Other mutation test
systems
Species: Human Human
Dose: 2600 NMOL/L 2600 NMOL/L
Cell Type: leukocyte leukocyte
Mutation test: DNA DNA
Species: Human Human
Dose: 2600 NMOL/L 2600 NMOL/L
Cell Type: leukocyte leukocyte
Mutation test: Other mutation test systems Other mutation test
systems
Species: Human Human
Dose: 20 MG/L 20 MG/L
Cell Type: Other cell types Other cell types
Mutation test: Unscheduled DNA synthesis Unscheduled DNA
synthesis
Species: Human Human
Dose: 1 MMOL/L 1 MMOL/L
Cell Type: Other cell types Other cell types
Mutation test: Unscheduled DNA synthesis Unscheduled DNA
synthesis
Species: Human Human
Dose: 1 MMOL/L 1 MMOL/L
Cell Type: Other cell types Other cell types
Mutation test: Other mutation test systems Other mutation test
systems
Species: Human Human
Dose: 200 MG/L 200 MG/L
Cell Type: Other cell types Other cell types
Mutation test: DNA inhibition DNA inhibition
Species: Human Human
Dose: 1 UMOL/L 1 UMOL/L
Cell Type: Other cell types Other cell types
Mutation test: DNA inhibition DNA inhibition
Species: Human Human
Dose: 1 UMOL/L 1 UMOL/L
Cell Type: Other cell types Other cell types
Mutation test: Other mutation test systems Other mutation test
systems
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Species: Human Human
Dose: 1 MG/L 1 MG/L
Cell Type: ovary ovary
Mutation test: DNA inhibition DNA inhibition
Species: Human Human
Route: Skin Skin
Dose: 1 PPH 1 PPH
Mutation test: Other mutation test systems Other mutation test
systems
Species: Human Human
Dose: 1 MG/L 1 MG/L
Cell Type: Other cell types Other cell types
Mutation test: Other mutation test systems Other mutation test
systems
Species: Human Human
Dose: 50 MG/L 50 MG/L
Cell Type: HeLa cell HeLa cell
Mutation test: Other mutation test systems Other mutation test
systems
Species: Human Human
Dose: 7 MG/KG 7 MG/KG
Cell Type: S. typhimurium S. typhimurium
Mutation test: Body fluid assay Body fluid assay
Species: Human Human
Dose: 100 PMOL/L 100 PMOL/L
Cell Type: lymphocyte lymphocyte
Mutation test: Sister chromatid exchange Sister chromatid
exchange
Species: Rat Rat
Route: Intraperitoneal Intraperitoneal
Dose: 250 MG/KG 250 MG/KG
Mutation test: Micronucleus test Micronucleus test
Species: Rat Rat
Route: Intraperitoneal Intraperitoneal
Dose: 50 MG/KG 50 MG/KG
Mutation test: Cytogenetic analysis Cytogenetic analysis
Species: Mouse Mouse
Route: Intraperitoneal Intraperitoneal
Dose: 12500 UG/KG 12500 UG/KG
Mutation test: Micronucleus test Micronucleus test
Species: Mouse Mouse
Route: Intraperitoneal Intraperitoneal
Dose: 26018 UG/KG 26018 UG/KG
Mutation test: Micronucleus test Micronucleus test
Species: Mouse Mouse
Dose: 10 UMOL/L 10 UMOL/L
Exposure Time: 24H 24H
Cell Type: Embryo Embryo
Mutation test: Morphological transformation. Morphological
transformation.
Species: Mouse Mouse
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Dose: 20 UMOL/L 20 UMOL/L
Cell Type: Bone marrow Bone marrow
Mutation test: DNA damage DNA damage
Species: Mouse Mouse
Dose: 19 UMOL/L 19 UMOL/L
Cell Type: Bone marrow Bone marrow
Mutation test: Other mutation test systems Other mutation test
systems
Species: Mouse Mouse
Dose: 66 UMOL/L 66 UMOL/L
Cell Type: lymphocyte lymphocyte
Mutation test: Other mutation test systems Other mutation test
systems
Species: Mouse Mouse
Route: Intraperitoneal Intraperitoneal
Dose: 500 UMOL/KG 500 UMOL/KG
Mutation test: Other mutation test systems Other mutation test
systems
Species: Mouse Mouse
Route: Intravenous Intravenous
Dose: 40 MG/KG 40 MG/KG
Mutation test: Unscheduled DNA synthesis Unscheduled DNA
synthesis
Species: Mouse Mouse
Route: Oral Oral
Dose: 40 MG/KG 40 MG/KG
Mutation test: Unscheduled DNA synthesis Unscheduled DNA
synthesis
Species: Mouse Mouse
Dose: 40 MG/L 40 MG/L
Cell Type: Ascites tumor Ascites tumor
Mutation test: Unscheduled DNA synthesis Unscheduled DNA
synthesis
Species: Mouse Mouse
Dose: 40 MG/L 40 MG/L
Cell Type: Ascites tumor Ascites tumor
Mutation test: Other mutation test systems Other mutation test
systems
Species: Mouse Mouse
Route: Intraperitoneal Intraperitoneal
Dose: 50 MG/KG 50 MG/KG
Mutation test: Unscheduled DNA synthesis Unscheduled DNA
synthesis
Species: Mouse Mouse
Dose: 3 MG/L 3 MG/L
Cell Type: leukocyte leukocyte
Mutation test: DNA inhibition DNA inhibition
Species: Mouse Mouse
Dose: 100 MG/KG 100 MG/KG
Cell Type: leukocyte leukocyte
Mutation test: DNA inhibition DNA inhibition
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Species: Mouse Mouse
Dose: 55 UMOL/L 55 UMOL/L
Cell Type: leukocyte leukocyte
Mutation test: Other mutation test systems Other mutation test
systems
Species: Mouse Mouse
Dose: 500 UG/L 500 UG/L
Cell Type: lymphocyte lymphocyte
Mutation test: DNA inhibition DNA inhibition
Species: Mouse Mouse
Route: Intraperitoneal Intraperitoneal
Dose: 50 MG/KG 50 MG/KG
Mutation test: DNA inhibition DNA inhibition
Species: Mouse Mouse
Route: Oral Oral
Dose: 40 MG/KG 40 MG/KG
Mutation test: Other mutation test systems Other mutation test
systems
Species: Mouse Mouse
Dose: 100 NMOL/L 100 NMOL/L
Cell Type: Embryo Embryo
Mutation test: DNA inhibition DNA inhibition
Species: Mouse Mouse
Dose: 1800 NMOL/L 1800 NMOL/L
Cell Type: Bone marrow Bone marrow
Mutation test: DNA inhibition DNA inhibition
Species: Mouse Mouse
Dose: 7500 UMOL/L 7500 UMOL/L
Cell Type: Ascites tumor Ascites tumor
Mutation test: DNA inhibition DNA inhibition
Species: Mouse Mouse
Dose: 1 UG/L 1 UG/L
Cell Type: Other cell types Other cell types
Mutation test: DNA inhibition DNA inhibition
Species: Mouse Mouse
Route: Oral Oral
Dose: 50 MG/KG 50 MG/KG
Mutation test: Cytogenetic analysis Cytogenetic analysis
Species: Mouse Mouse
Route: Intraperitoneal Intraperitoneal
Dose: 20 MG/KG 20 MG/KG
Mutation test: Cytogenetic analysis Cytogenetic analysis
Species: Mouse Mouse
Dose: 250 MG/KG 250 MG/KG
Cell Type: Ascites tumor Ascites tumor
Mutation test: Cytogenetic analysis Cytogenetic analysis
Species: Mouse Mouse
Route: Intraperitoneal Intraperitoneal
Dose: 50 MG/KG 50 MG/KG
Mutation test: sperm sperm
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Species: Mouse Mouse
Route: Intravenous Intravenous
Dose: 50 MG/KG 50 MG/KG
Mutation test: sperm sperm
Species: Hamster Hamster
Route: Intraperitoneal Intraperitoneal
Dose: 41 MG/KG 41 MG/KG
Mutation test: Micronucleus test Micronucleus test
Species: Hamster Hamster
Route: Intraperitoneal Intraperitoneal
Dose: 41 MG/KG 41 MG/KG
Mutation test: Cytogenetic analysis Cytogenetic analysis
Species: Hamster Hamster
Dose: 1900 UG/L 1900 UG/L
Cell Type: lung lung
Mutation test: Cytogenetic analysis Cytogenetic analysis
Species: Mammal Mammal
Dose: 100 UMOL/L 100 UMOL/L
Cell Type: Other cell types Other cell types
Mutation test: DNA inhibition DNA inhibition
Mutation test: Histidine reversion (Ames)
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Woman Woman
Dose: 150 MG/KG 150 MG/KG
Route of Application: Intravenous Intravenous
Exposure Time: (20-31W PREG) (20-31W PREG)
Result: Effects on Newborn: Other neonatal measures or effects.
Effects on Newborn: Other neonatal measures or effects.
Species: Rat Rat
Dose: 175 MG/KG 175 MG/KG
Route of Application: Oral Oral
Exposure Time: (7-13D PREG) (7-13D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death.
Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth). Effects on Fertility: Litter size (e.g.;
# fetuses per litter; measured before birth). Effects on Embryo
or Fetus: Fetotoxicity (except death, e.g., stunted fetus).
Effects on Embryo or Fetus: Fetal death.
Species: Rat Rat
Dose: 15 MG/KG 13500 UG/KG
Route of Application: Intraperitoneal Intraperitoneal
Exposure Time: (9D PREG) (9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetal death. Specific Developmental
Abnormalities: Other developmental abnormalities. Effects on
Embryo or Fetus: Fetotoxicity (except death, e.g., stunted
fetus). Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetal death.
Species: Rat Rat
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Dose: 20 MG/KG 15 MG/KG
Route of Application: Intraperitoneal Intraperitoneal
Exposure Time: (9D PREG) (9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Specific Developmental Abnormalities: Other
developmental abnormalities. Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
per total number of implants). Effects on Embryo or Fetus: Fetal
death. Specific Developmental Abnormalities: Other developmental
abnormalities.
Species: Mouse Rat
Dose: 245 MG/KG 20 MG/KG
Route of Application: Oral Intraperitoneal
Exposure Time: (7-13D PREG) (9D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth). Effects on Embryo or Fetus:
Fetal death. Effects on Fertility: Post-implantation mortality
(e.g., dead and/or resorbed implants per total number of
implants). Effects on Embryo or Fetus: Fetotoxicity (except
death, e.g., stunted fetus). Specific Developmental
Abnormalities: Other developmental abnormalities.
Species: Mouse Mouse
Dose: 20 MG/KG 245 MG/KG
Route of Application: Intraperitoneal Oral
Exposure Time: (9D PREG) (7-13D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Other developmental
abnormalities. Effects on Fertility: Litter size (e.g.; #
fetuses per litter; measured before birth). Effects on Embryo or
Fetus: Fetal death.
Species: Mouse Mouse
Dose: 30 MG/KG 20 MG/KG
Route of Application: Intraperitoneal Intraperitoneal
Exposure Time: (9D PREG) (9D PREG)
Result: Effects on Fertility: Abortion. Specific Developmental
Abnormalities: Other developmental abnormalities. Effects on
Fertility: Post-implantation mortality (e.g., dead and/or
resorbed implants per total number of implants).
Species: Mouse Mouse
Dose: 30 MG/KG 30 MG/KG
Route of Application: Intraperitoneal Intraperitoneal
Exposure Time: (12D PREG) (9D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Newborn: Viability index (e.g., # alive
at day 4 per # born alive). Effects on Newborn: Live birth index
(# fetuses per litter; measured after birth). Effects on
Fertility: Abortion.
Species: Mouse Mouse
Dose: 67 MG/KG 30 MG/KG
Route of Application: Intravenous Intraperitoneal
Exposure Time: (1D MALE) (12D PREG)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Effects on
Newborn: Viability index (e.g., # alive at day 4 per # born
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alive). Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth). Effects on Newborn: Growth
statistics (e.g., reduced weight gain).
Species: Hamster Mouse
Dose: 28 MG/KG 67 MG/KG
Route of Application: Intramuscular Intravenous
Exposure Time: (9D PREG) (1D MALE)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Paternal Effects: Spermatogenesis (including genetic material,
sperm morphology,motility, and count).
Species: Hamster Hamster
Dose: 20 MG/KG 28 MG/KG
Route of Application: Intramuscular Intramuscular
Exposure Time: (9D PREG) (9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Post-implantation mortality (e.g., dead
and/or resorbed implants per total number of implants). Specific
Developmental Abnormalities: Musculoskeletal system.
Species: Hamster
Dose: 20 MG/KG
Route of Application: Intramuscular
Exposure Time: (9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: None
Non-Hazardous for Transport: This substance is
considered to be non-hazardous for transport.
IATA
Non-Hazardous for Air Transport: Non-hazardous for air
transport.
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: Xn
Indication of Danger: Harmful.
R: 22
Risk Statements: Harmful if swallowed.
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S: 36
Safety Statements: Wear suitable protective clothing.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Toxic (USA) Harmful (EU).
Risk Statements: Harmful if swallowed.
Safety Statements: Wear suitable protective clothing.
US Statements: Photosensitizer. Target organ(s): Heart. Bone
marrow.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 1 %
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65
California Prop - 65: This product is or contains chemical(s)
known to the state of California to cause developmental toxicity.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: No
NDSL: Yes
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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