MSDS for Pyridine Pharma grade                                                                Page 1 of 6

Ref. no.: .: 0001C05 Div 03 msds Pyridine Pharma grade                         Jubilant Organosys Limited

Date of Issue: 01 September 2005

Revision: 05





                          MATERIAL SAFETY DATA SHEET





1.               CHEMICAL PRODUCT & MANUFACTURER’S DETAILS



PRODUCT NAME : Pyridine Pharma Grade

MANUFACTURER

FACTORY & REGISTERED OFFICE:                              HEAD OFFICE:

Jubilant Organosys Limited,                               Jubilant Organosys Limited

Bhartiagram, Gajraula                                     Plot 1-A, Sector 16-A,

District: Jyotiba Phuley Nagar                            Institutional Area, Noida,

Uttar Pradesh-244223 , India                              Uttar Pradesh-201301 India.

PHONE NO: +91-5924-252353 unto 252360                     PHONE NO: +91-120-2516601

Contact Department-Safety: Extension 298                  Contact department: EHS

FAX NO : 91-5924-252352                                   FAX NO : +91-120-2516629

EMERGENCY PHONE: +91-5924-268141                          Email: support@jubl.com







2.                                CHEMICAL IDENTIFICATION

�    CHEMICAL NAME                                : Pyridine

�    SYNONYMS                                     : Azabenzene

�    REGIONAL NAMES

                                                      De :      Pyridin

                                                      Es :      Piridina

                                                      Fr :      Pyridine

�    CHEMICAL CLASSIFICATION                      : Aromatic Heterocyclic Compound

�    CHEMICAL FORMULA                             : C5H5N

�    C.A.S. NO.                                   : 110-86-1

�    EINECS                                       : 203-809-9



3.              HAZARD IDENTIFICATION & HEALTH HAZARD

�    Highly flammable

�    Harmful if swallowed

�    Harmful in contact with skin

�    Harmful if inhaled

MSDS for Pyridine Pharma grade                                                                  Page 2 of 6

Ref. no.: .: 0001C05 Div 03 msds Pyridine Pharma grade                           Jubilant Organosys Limited

Date of Issue: 01 September 2005

Revision: 05







                                     FIRST AID MEASURES

4.

Eye: Immediately flush eyes with plenty of water for at least 15 minutes by separating eyelids with

fingers. Get medical help if irritation persists. (If easy to do so remove contact lenses if worn).

Skin: Remove contaminated clothing and shoes. Flush skin with copious amount of water for at least

fifteen minutes. Wash contaminated clothing before reuse.

In case of burns, immediately cool affected skin for as long as possible with cold water. Do not

remove clothing adhering to skin.

Inhalation:

Remove the affected person (s) to fresh air. If not breathing, give artificial respiration. If breathing is

difficult, give oxygen.

Ingestion:

If (large quantities of this material are) swallowed, do NOT induce vomiting unless directed to do so

by a physician. Never give anything by mouth to an unconscious person. Call a physician



5.                                FIRE FIGHTING MEASURES

                 0       0

Flash point: 20 C (68 F)

Auto Ignition Temp: 900° F (USCG, 1999)

Lower Exp Limit: 1.8% (NTP, 1992)

Upper Exp Limit: 12.4% (NTP, 1992)



Extinguishing media:

Dry chemical powder, carbon dioxide, and “alcohol� foam.

Unsuitable media: Do not use water jet to extinguish



Special fire fighting procedure:

� As in any fire involving chemicals, fire-fighters will need to wear MSHA/NIOSH or equivalent

   Self Contained Breathing Apparatus (SCBA) in pressure demand.

� Keep upwind.

� No smoking, eliminate ignition sources.

� Consider evacuation of people in immediate danger.

� Minimise number of personnel in risk area.

� Keep container(s) cool with water.

� Extinguish with alcohol resistant foam if available - waterfog (spray) - dry powder, subsequently

   secure with foam blanket.

� Use water spray to knock down fire fumes if possible.

� Avoid unnecessary run-off of extinguishing media which may cause pollution.



Unusual fire and explosion hazard:

Vapor may flow long distance to distant ignition sources and flash back. Forms explosive mixtures in

air. Emits toxic and irritating fumes under fire conditions.

MSDS for Pyridine Pharma grade                                                                 Page 3 of 6

Ref. no.: .: 0001C05 Div 03 msds Pyridine Pharma grade                          Jubilant Organosys Limited

Date of Issue: 01 September 2005

Revision: 05







6.                        ACCIDENTAL RELEASE MEASURES

�    Evacuate the area

�    Wear personal protective equipment as given in section 8.

�    Shut-off all sources of ignition

�    Stop leaks if possible.

�    Contain spillage by any means available.

�    Use low sparking hand tools and intrinsically safe equipment.

�    Absorb substance in sand or earth or any other suitable material, or cover with alcohol resistant

     foam.

�    If substance has entered a water course or sewer, inform the responsible authority.

�    Ventilate sewers and basements where there is no risk to personnel or public.



7.                                HANDLING AND STORAGE

�    Handling

�    Prevent direct contact by all routes. Check section 8.

�    Ground containers and equipment before use.

�    Empty containers may contain trace of material that may pose a danger.

�    Use with adequate ventilation.

�    Wash thoroughly after use.

�    Storage

�    Keep containers closed

�    Store in a cool, dry place and in a designated flame proof area.

�    Store away from acids and oxidizing agents.



8.          EXPOSURE CONTROLS/PERSONAL PROTECTION

�    Exposure control: Use under mechanical local exhaust ventilation. Facilities will have standard

     emergency showers (Quick drench) and eye-bath facilities.

�    Personal Protection:

     � Eyes: Goggles or face mask required.

     � Hands: Appropriate gloves required. Check break through time. Butyl gloves>3 hrs, PE 1-3

        hrs, PE/EVAL/PE > 3 hrs (Nat rubber<1hr.)

     � Protective clothing: Wear appropriate work clothing to prevent skin contact.

     � Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European

     � Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator

        when condition demand or are anticipated to require use

     � Personal Hygeine: Remove work clothes that are wet. Wash thoroughly after handling.

�    Exposure levels

     � NIOSH REL: TWA 5 ppm (15 mg/m3)

     � OSHA PEL: TWA 5 ppm (15 mg/m3)

     � IDLH 1000 ppm

     � ACGIH TLV TWA: 5 ppm (ACGIH, 2001)

MSDS for Pyridine Pharma grade                                                               Page 4 of 6

Ref. no.: .: 0001C05 Div 03 msds Pyridine Pharma grade                        Jubilant Organosys Limited

Date of Issue: 01 September 2005

Revision: 05





9. PHYSICOCHEMICAL PROPERTIES & FIRE/ EXPLOSION HAZARD DATA

         PHYSICAL STATE                   : liquid

         APPEARANCE                       : Colourless to pale yellow

         ODOUR                            : Characteristic fish like smell

                                          : 115 °C

         BOILING POINT

                                          : (-) 42 °C

         MELTING POINT

         FLASH POINT                      : 20°C

         VAPOR PRESSURE                  : 18 mm Hg at 68° F ; 20 mm Hg at 77° F

         SPECIFIC GRAVITY (WATER=1)       : 0.98

         VAPOR DENSITY (AIR=1)            : 2.72

         SOLUBILITY IN WATER              : Soluble

         pH                               : 10.3 (approx. 10% solution)

         pKa                               : 5.23

         Log Pow                           : 0.65

         FLAMMABILITY                     : Flammable liquid

         LEL                              : 1.8%

         UEL                              : 12.4%

                                          : 482 °C (9000 F)

         AUTO IGNITION TEMPERATURE

         EXPLOSIVE SENSITIVITY TO IMPACTS : Data not available

         EXPLOSIVE SENSITIVITY TO

                     STATIC ELECTRICITY : Data not available

         COMBUSTIBLE LIQUID               : Yes

         FLAMMABLE MATERIAL               : Yes

         PYROPHORIC MATERIAL              : No

         EXPLOSIVE MATERIAL                : No

         OXIDISER                          : No

         ORGANIC PEROXIDE                 : No

         CORROSIVE MATERIAL                : No

          MOLECULAR WEIGHT                : 79.1





10.                              STABILITY AND REACTIVITY

�     Stability: Chemically stable. Stable for transportation. Slightly hygroscopic. Highly soluble in

      water.

�     Conditions to avoid: High temperatures and incompatible chemicals. Avoid ignition sources and

      static discharge.

�     Incompatible chemicals

      � Oxidizing agents;

      � Exothermic reaction with Acids, acid chlorides and anhydrides

      � Mixing pyridine in equal molar portions with any of the following substances in a closed

          container caused the temperature and pressure to increase: chlorosulfonic acid, nitric acid

          (70%), oleum, sulfuric acid (96%), or propiolactone [NFPA 1991].

      � A 0.1% solution of pyridine (or other tertiary amine) in maleic anhydride at 185°C gives an

          exothermic decomposition with rapid evolution of gas [Chem Eng. News 42(8); 41 1964].

�     Hazardous combustion or decomposition products:

MSDS for Pyridine Pharma grade                                                                   Page 5 of 6

Ref. no.: .: 0001C05 Div 03 msds Pyridine Pharma grade                            Jubilant Organosys Limited

Date of Issue: 01 September 2005

Revision: 05

10.                              STABILITY AND REACTIVITY

      Thermal decomposition may produce carbon monoxide and oxides of nitrogen

�     Hazardous Polymerization: Not expected.



11.                      TOXICOLOGICAL INFORMATION

�     Acute effects:

         Harmful if swallowed, inhaled or absorbed through skin.

         High concentrations are extremely destructive to tissues of the mucous membranes and upper

         respiratory tract, eyes and skin. Symptoms of exposure may include burning sensation,

         coughing, wheezing, laryngitis, shortness of breath, headache, nausea and vomiting. Exposure

         can cause gastrointestinal disturbance.

�     Chronic effects:

        Damage to the liver, kidneys and bone marrow



�     Toxicity: RTECS # UR8400000

      � ORAL RAT LD50                 : 891 mg/kg

         Effects: Eye: Ptosis D28; Behavioral: Somnolence (general depressed activity) F07;

         Behavioural Coma F24.

      � SKN RBT LD50                  : 1121 mg/kg

         Effects: Behavioural Ataxia F19; Liver (Other changes) L30, Changes in structure or function

         of salivary glands K01.

      � IHL RAT LD50           : 28500mg/m3/1H



Carcinogenic, Mutagenic, Reproductive Toxicity (CMR)

       � Pyridine is not classifiable as to its carcinogenicity to humans (Group 3). (IARC)

       � Tumor data: Equivocal evidence of mononuclear cell leukemia in female rats and

          testicular adenoma in male rats.

       � Ames Mutagenic test: Negative









12.                      ECOLOGICAL INFORMATION

�     Not classified as a marine pollutant.

�     Do not dispose of this material into environmental bodies.





13.                      DISPOSAL CONSIDERATION

�     Burn in a chemical incinerator equipped with an afterburner and scrubber.

�     Exert extra care in igniting, as this material is highly flammable.

�     Observe all federal, state and local environmental regulations

�     RCRA Chemical Code: U196

MSDS for Pyridine Pharma grade                                                                 Page 6 of 6

Ref. no.: .: 0001C05 Div 03 msds Pyridine Pharma grade                          Jubilant Organosys Limited

Date of Issue: 01 September 2005

Revision: 05





14.                              TRANSPORT INFORMATION

       Classification as per IMDG/IMO/IATA/ADR/RID

       PROPER SHIPPING NAME              :    Pyridine

       UN/ID NUMBER                      :    1282

       UN HAZARD CLASS                   :    3

       UN PACKING GROUP                  :    II







15.                              REGULATORY INFORMATION

European information

Pictogram : F, Xn

� EINECS NO.                 :       203-809-9

� R-11 (highly flammable)

� R-20/21/22 (harmful by inhalation/ contact with skin/ ingestion)

� R-36/37 (irritating to eyes and respiratory system)

� S-26 (in case of contact with eyes, rinse immediately with plenty of water and seek medical

    advice)

� S-28 (after contact with skin, wash immediately with plenty of water)

� S-36/37 (wear suitable protective clothing/gloves)



US information

� Is listed in EPA TSCA chemical inventory.

� None of the chemicals in this product are listed under TSCA section 12b

� CERCLA Chemical: Yes RQ: 1000lbs

� EPCRA EHS Chemical: Not listed EHS TPQ: nil lbs

� EPCRA Section 313: Listed

� None of the chemicals in this product contain any class1 & class2 ozone depletors , neither

   contain any hazardous air pollutants under ‘Clean Air Act�

� None of the chemicals in this product are listed as Hazardous substances or priority pollutants or

   Toxic substances list under ‘Clean Water

� RCRA Chemical Code: U196

� NFPA: F3, H3, R0



16.                              OTHER INFORMATION

Information contained in this MSDS is believed to be correct but no representation, guarantee or

warranties of any kind are made as to its accuracy, suitability for a particular application or results to

be obtained from them. This MSDS shall be used as a guide only. JUBILANT ORGANOSYS

LIMITED makes no warranties expressed or implied of the adequacy of this document for any

particular purpose.

Document Name:        0001C05 Div 03 msds Pyridine Pharma grade

Date: 01 September 2005

Revision Number:      05