SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 12/MAY/2005
Date Updated: 13/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name 4-TERT-BUTYLBENZOIC ACID, 99%
Product Number 150355
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
4-TERT-BUTYLBENZOIC ACID 98-73-7 202-696-3 None
Formula C11H14O2
Molecular Weight 178.23 AMU
Synonyms Benzoic acid, 4-(1,1-dimethylethyl)- (9CI) *
p-tert-Butyl benzoic acid * Kyselina
p-terc.butylbenzoova (Czech) * p-TBBA
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful by inhalation and if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Store in a cool dry
place.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
PERSONAL PROTECTIVE EQUIPMENT
Special Protective Measures: Wear appropriate government approved
respirator, chemical-resistant gloves, safety goggles, other
protective clothing.
9 - Physical and Chemical Properties
Appearance Color: White
Form: Fine plates
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 162 掳C
Flash Point 158 掳C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
ALDRICH - 150355 www.sigma-aldrich.com Page 2
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Materials to Avoid: Strong oxidizing agents, Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
11 - Toxicological Information
RTECS NUMBER: DG4708000
ACUTE TOXICITY
LD50 LD50
Oral Oral
Rat Rat
473 mg/kg 700 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Ataxia. Lungs, Thorax, or Respiration:Dyspnea.
Behavioral:Change in motor activity (specific assay). Lungs,
Thorax, or Respiration:Respiratory depression. Skin and
Appendages: Other: Hair.
LC50 LC50
Inhalation Inhalation
Rat Rat
> 1,900 mg/m3 > 1,900 mg/m3
4H 4H
LD50
Skin
Rat
300 mg/kg
LD50
Intravenous
Rat
>200 MG/KG BGT
LD50
Oral
Mouse
568 mg/kg
Remarks: Peripheral Nerve and Sensation:Spastic paralysis with
or without sensory change. Behavioral:Tremor. Blood: Hemorrhage.
LD50
Intraperitoneal
Mouse
242 MG/KG
Remarks: Brain and Coverings:Other degenerative changes.
ALDRICH - 150355 www.sigma-aldrich.com Page 3
Behavioral:Convulsions or effect on seizure threshold. Blood:
Hemorrhage.
LD50
Skin
Rabbit
> 900 mg/kg
IRRITATION DATA
Eyes
Rabbit
100 mg
Remarks: Mild irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Damage to the liver. Damage to the kidneys. To the best of our
knowledge, the chemical, physical, and toxicological properties
have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Eye Contact: May cause eye irritation.
Multiple Routes: Harmful if swallowed, inhaled, or absorbed
through skin.
TARGET ORGAN INFORMATION
Damage to the liver. Damage to the kidneys.
CONDITIONS AGGRAVATED BY EXPOSURE
May cause nervous system disturbances.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Rat Rat
Dose: 106 MG/M3/6H 106 MG/M3/6H
Route of Application: Inhalation Inhalation
Exposure Time: (7D MALE) (7D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Paternal Effects: Testes, epididymis, sperm duct.
Species: Rat Rat
Dose: 12500 UG/M3/6H 12500 UG/M3/6H
Route of Application: Inhalation Inhalation
Exposure Time: (7D MALE) (7D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Spermatogenesis (including genetic material, sperm
morphology,motility, and count).
Species: Rat Rat
Dose: 4550 MG/KG 4550 MG/KG
Route of Application: Skin Skin
Exposure Time: (65D MALE) (65D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct. Paternal Effects:
Spermatogenesis (including genetic material, sperm
morphology,motility, and count). Paternal Effects: Testes,
epididymis, sperm duct.
ALDRICH - 150355 www.sigma-aldrich.com Page 4
Species: Rat Rat
Dose: 2450 MG/KG 2450 MG/KG
Route of Application: Skin Skin
Exposure Time: (7W MALE) (7W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct. Paternal Effects: Other
effects on male. Paternal Effects: Spermatogenesis (including
genetic material, sperm morphology,motility, and count).
Paternal Effects: Testes, epididymis, sperm duct. Paternal
Effects: Other effects on male.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.
14 - Transport Information
RID/ADR
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
IMDG
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 20/22
Harmful by inhalation and if swallowed.
S-PHRASES: 22 24/25
Do not breathe dust. Avoid contact with skin and eyes.
COUNTRY SPECIFIC INFORMATION
ALDRICH - 150355 www.sigma-aldrich.com Page 5
Germany
WGK: 3
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
ALDRICH - 150355 www.sigma-aldrich.com Page 6
|