SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 05/MAY/2005
Date Updated: 22/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name PENTOBARBITAL SODIUM DEA SCHEDULE II
ITEM
Product Number P3761
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
PENTOBARBITAL SODIUM 57-33-0 200-323-9 None
Formula C11H17N2NaO3
Molecular Weight 248.3 AMU
Synonyms Auropan * Barpental * Biosedan * Butylmethyl
ethyl malonyl urea sodium * Butylone * Carbrital
* Continal * Diabutal * Embutal * Etaminal
sodium * Ethaminal sodium *
5-Ethyl-5-(1-methylbutyl)barbituric acid sodium
salt *
5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimid
inetrione monosodium salt * Euthatal * Isobarb *
Mebubarbital sodium * Mebumal natrium * Mebumal
sodium * Mintal * Napental * Nembutal sodium *
Pacifan * Palapent * Penbar * Pentabarbital
sodium * Pental * Pentobarbital sodium *
Pentobarbitone sodium * Pentonal * Pentone *
Pentyl * Propylmethylcarbinylethyl barbituric
acid sodium salt *
2,4,6(1H,3H,5H)-Pyrimidinetrione,
5-ethyl-5-(1-methylbutyl)-, monosodium salt *
Rivadorn * Sagatal * Sodium ethaminal * Sodium
5-ethyl-5-(1-methylbutyl)barbiturate * Sodium
nembutal * Sodium-Pent * Sodium pentabarbital *
Sodium pentabarbitone * Sodium pentobarbital *
Sodium pentobarbitone * Sodium pentobarbiturate
* Soluble pentobarbital * Somnopentyl * Sonistan
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
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GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: CQ6125000
ACUTE TOXICITY
LD50
Oral
Rat
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118 mg/kg
LD50
Intraperitoneal
Rat
36 MG/KG
LD50
Subcutaneous
Rat
47 MG/KG
LD50
Intravenous
Rat
65 MG/KG
LD50
Intraduodenal
Rat
39 MG/KG
LD50
Oral
Mouse
239 mg/kg
LD50
Intraperitoneal
Mouse
126 MG/KG
LD50
Subcutaneous
Mouse
122 MG/KG
LD50
Intravenous
Mouse
81 MG/KG
LD50
Intramuscular
Mouse
124 MG/KG
LD50
Intracerebral
Mouse
6500 UG/KG
LD50
Oral
Dog
65 mg/kg
LD50
Oral
Cat
100 mg/kg
Remarks: Behavioral:General anesthetic. Behavioral:Excitement.
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Behavioral:Ataxia.
LD50
Oral
Rabbit
175 mg/kg
LD50
Intraperitoneal
Rabbit
65 MG/KG
LD50
Intravenous
Rabbit
40 MG/KG
LD50
Oral
Guinea pig
60 mg/kg
LD50
Subcutaneous
Guinea pig
70 MG/KG
Remarks: Autonomic Nervous System:Parasympatholytic.
LD50
Intramuscular
Guinea pig
70300 UG/KG
Remarks: Behavioral:Sleep.
LD50
Oral
Pigeon
133 mg/kg
LD50
Intraperitoneal
Chicken
51540 UG/KG
LD50
Intravenous
Chicken
48 MG/KG
LD50
Oral
Duck
75 mg/kg
LD50
Oral
Bird (wild)
75 mg/kg
SIGNS AND SYMPTOMS OF EXPOSURE
Prolonged or repeated exposure can lead to habituation or
addiction. Respiratory depression and sedation. Exposure can
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cause: Gastrointestinal disturbances.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Central nervous system.
CHRONIC EXPOSURE - MUTAGEN
Mouse
64800 UG/KG
Intraperitoneal
Micronucleus test
Mouse
500 UMOL/L
Cell Type: Other cell types
DNA inhibition
Mouse
60 MG/KG
Unreported
DNA inhibition
Mouse
60 MG/KG
Unreported
Other mutation test systems
Mouse
500 UMOL/L
Cell Type: Other cell types
Other mutation test systems
Mouse
1500 UMOL/L
Cell Type: lymphocyte
Other mutation test systems
Hamster
100 MG/KG
Subcutaneous
Cytogenetic analysis
Hamster
100 MG/KG
Subcutaneous
Dominant lethal test
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 22 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Effects on Embryo or Fetus: Other effects to embryo.
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Species: Hamster
Dose: 920 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (8-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Hamster
Dose: 100 MG/KG
Route of Application: Subcutaneous
Exposure Time: (1D PREG)
Result: Effects on Embryo or Fetus: Cytological changes
(including somatic cell genetic material). Effects on Embryo or
Fetus: Fetal death.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Rat
Dose: 20 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rat
Dose: 80 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D PRE)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Rat
Dose: 94500 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (2D PRE)
Result: Effects on Fertility: Other measures of fertility
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Effects on Embryo or Fetus: Fetal death.
Species: Rat
Dose: 520 MG/KG
Route of Application: Subcutaneous
Exposure Time: (9-21D PREG)
Result: Effects on Newborn: Behavioral.
Species: Rat
Dose: 30 MG/KG
Route of Application: Unreported
Exposure Time: (19D PREG)
Result: Effects on Newborn: Behavioral.
Species: Rabbit
Dose: 40 MG/KG
Route of Application: Intravenous
Exposure Time: (10D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Guinea pig
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Dose: 30 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (63D PREG)
Result: Effects on Fertility: Abortion. Effects on Newborn:
Stillbirth. Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth).
Species: Guinea pig
Dose: 28 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (63D PREG)
Result: Effects on Newborn: Behavioral. Effects on Newborn:
Physical.
Species: Hamster
Dose: 2320 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (8-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact the Drug Enforcement Administration concerning the
disposal of controlled substances. Contact a licensed professional
waste disposal service to dispose of this material. Dissolve or
mix the material with a combustible solvent and burn in a chemical
incinerator equipped with an afterburner and scrubber. Observe all
federal, state, and local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
IMDG
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
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CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 25
Toxic if swallowed.
S-PHRASES: 45
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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