SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 05/MAY/2005
Date Updated: 13/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name 1,4-BENZOQUINONE, REAGENT GRADE, 98%
Product Number B10358
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
1,4-BENZOQUINONE 106-51-4 203-405-2 606-013-00-3
Formula C6H4O2
Molecular Weight 108.1 AMU
Synonyms Benzo-chinon (German) * 1,4-Benzoquine *
p-Benzoquinone (OSHA) * 1,4-Benzoquinone *
Chinon (Dutch, German) * Chinone * p-Chinon
(German) * 1,4-Cyclohexadienedione *
2,5-Cyclohexadiene-1,4-dione *
1,4-Cyclohexadiene dioxide * 1,4-Diossibenzene
(Italian) * 1,4-Dioxybenzene * 1,4-Dioxy-benzol
(German) * NCI-C55845 * PBQ 2 * Quinone *
Quinone (ACGIH:OSHA) * p-Quinone * RCRA waste
number U197 * Steara PBQ * USAF P-220
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic by inhalation and if swallowed. Irritating to eyes,
respiratory system and skin. Very toxic to aquatic organisms.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXPLOSION DATA
Dust Potential: This material, like most materials in powder
form, is capable of creating a dust explosion.
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Flammable solid. Emits toxic fumes under
fire conditions.
Explosion Hazards: May explode when heated.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame. Store in a cool dry place.
SPECIAL REQUIREMENTS: Moisture sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Use nonsparking tools. Safety
shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
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handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 0.1 MG/M3
Poland NDSCh 0.4 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 0.4 mg/m3
0.1 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 0.4 mg/m3
0.1 ppm
Remarks: =1=
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 0.4 mg/m3
0.1 ppm
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level0.4 mg/m3
0.1 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 0.4 mg/m3
0.1 ppm
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 0.45 mg/m3
0.1 ppm
OEL STEL 1.3 mg/m3
0.3 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: Deep yellow
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 112.5 藲C
Flash Point 77 藲C Method: closed cup
Flammability N/A
Autoignition Temp 435 藲C
Oxidizing Properties N/A
Explosive Properties N/A
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Explosion Limits N/A
Vapor Pressure 0.1 mmHg 25 藲C
SG/Density N/A
Partition Coefficient Log Kow: 0.2
Viscosity N/A
Vapor Density 3.7 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. 243 藲C
Solvent Content N/A
Water Content N/A
Surface Tension 32.58 mN/m 112 藲C
Conductivity N/A
Miscellaneous Data 4.8 MM/S BURNING RATIATA 4.1 PGII FLAMMABLE
E SOLID
Solubility Other Solvents: SOLUBLE IN ALKALIES HOT
PETROLEUM ETHER
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May explode when heated. Do not heat
above: 50藲C
Conditions to Avoid: Moisture.
Materials to Avoid: Reacts violently with:, Strong oxidizing
agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: DK2625000
ACUTE TOXICITY
LD50
Oral
Rat
100 mg/kg
LD50
Oral
Rat
130 mg/kg
LD50
Intraperitoneal
Rat
30 MG/KG
LD50
Intravenous
Rat
25 MG/KG
LD50
Oral
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Mouse
25 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Tremor. Skin and Appendages: Other: Hair.
LD50
Intraperitoneal
Mouse
8500 UG/KG
Remarks: Peripheral Nerve and Sensation:Spastic paralysis with
or without sensory change. Behavioral:Muscle contraction or
spasticity. Lungs, Thorax, or Respiration:Cyanosis.
LD50
Subcutaneous
Mouse
93800 UG/KG
LD50
Subcutaneous
Mammal
296 MG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Damage to the eyes.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Toxic if inhaled. Material is irritating to mucous
membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Eyes.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Mouse
Route of Application: Skin
Exposure Time: 29W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors. Skin and
Appendages: Other: Tumors.
Mouse
Route of Application: Skin
Exposure Time: 43W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors. Skin and
Appendages: Other: Tumors.
IARC CARCINOGEN LIST
Rating: Group 3
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CHRONIC EXPOSURE - MUTAGEN
Human
100 UMOL/L
Cell Type: Bone marrow
DNA
Human
5 UMOL/L
Cell Type: lymphocyte
Other mutation test systems
Human
5 UMOL/L
Cell Type: lymphocyte
Sister chromatid exchange
Mouse
20 MG/KG
Oral
Micronucleus test
Mouse
50 UMOL/L
Cell Type: Embryo
Micronucleus test
Mouse
400 UG/L
Cell Type: Embryo
Morphological transformation.
Mouse
4 UMOL/L
Cell Type: lymphocyte
DNA damage
Mouse
5 UMOL/L
Cell Type: lymphocyte
DNA inhibition
Mouse
10 UMOL/L
Cell Type: lymphocyte
Other mutation test systems
Mouse
6 UMOL/L
Cell Type: Other cell types
Other mutation test systems
Mouse
2100 NMOL/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
6700 UMOL/L
Cell Type: lung
Micronucleus test
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Rabbit
2 UMOL/L
Cell Type: Bone marrow
Other mutation test systems
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Algae
Species: Selenastrum capricornutum resp.
Time: 4 h
Value: 0.08 mg/l
Test Type: LC50 Fish
Time: 96 h
Value: 0.4 mg/l
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 0.04 - 0.125 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2587
Class: 6.1
PG: II
Proper Shipping Name: Benzoquinone
IMDG
UN#: 2587
Class: 6.1
PG: II
Proper Shipping Name: Benzoquinone
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2587
Class: 6.1
PG: II
Proper Shipping Name: Benzoquinone
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 606-013-00-3
INDICATION OF DANGER: T N
Toxic. Dangerous for the environment.
R-PHRASES: 23/25 36/37/38 50
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Toxic by inhalation and if swallowed. Irritating to eyes,
respiratory system and skin. Very toxic to aquatic organisms.
S-PHRASES: 26 28 45 61
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. After contact with skin, wash
immediately with plenty of soap-suds. In case of accident or if
you feel unwell, seek medical advice immediately (show the
label where possible). Avoid release to the environment. Refer
to special instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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