SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 10/MAY/2005
Date Updated: 25/OCT/2004
Version 1.5
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name PHTHALIC ANHYDRIDE, REAGENTPLUS(TM),
99%
Product Number 125733
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
PHTHALIC ANHYDRIDE 85-44-9 201-607-5 607-009-00-4
Formula C8H4O3
Molecular Weight 148.12 AMU
Synonyms Anhydride phtalique (French) * Anhydrid kyseliny
ftalove (Czech) * Anidride ftalica (Italian) *
1,2-Benzenedicarboxylic acid anhydride *
1,3-Dioxophthalan * ESEN * Ftaalzuuranhydride
(Dutch) * Ftalanhydrid (Czech) * Ftalowy
bezwodnik (Polish) * Isobenzofuran,
1,3-dihydro-1,3-dioxo- * 1,3-Isobenzofurandione
* NCI-C03601 * Phthalandione * 1,3-Phthalandione
* Phthalic acid anhydride * Phthalic anhydride
(ACGIH:OSHA) * Phthalsaeureanhydrid (German) *
RCRA waste number U190 * Retarder AK * Retarder
PD * Vulkalent B
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Irritating to respiratory system and skin.
Risk of serious damage to eyes. May cause sensitization by
inhalation and skin contact.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 1 MG/M3
Poland NDSCh 2 MG/M3
ALDRICH - 125733 www.sigma-aldrich.com Page 2
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 1 mg/m3
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 1 mg/m3, E
Remarks: =1=
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 2 mg/m3
Remarks: A
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level2 mg/m3
Remarks: S
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 4 mg/m3
OEL STEL 12 mg/m3
Remarks: Sensitizer.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Fine plates
Property Value At Temperature or Pressure
pH 2 20 掳C Concentration: 6
g/l
BP/BP Range 284 掳C 760 mmHg
MP/MP Range 130 掳C
Flash Point 152 掳C Method: closed cup
Flammability N/A
Autoignition Temp 570 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.7 %
Upper: 10.4 %
Vapor Pressure < 0.01 mmHg 20 掳C
SG/Density 1.53 g/cm3 20 掳C
Partition Coefficient N/A
Viscosity 1.3 Pas 140 掳C
Vapor Density 5.1 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
ALDRICH - 125733 www.sigma-aldrich.com Page 3
Surface Tension 32.7 mN/m 180 掳C
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:5 mg/ml H2O
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Strong acids, Strong bases, Strong oxidizing
agents, Strong reducing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: TI3150000
ACUTE TOXICITY
LD50
Oral
Rat
1530 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
LC50
Inhalation
Rat
> 210 mg/m3
1H
LD50
Oral
Mouse
1500 mg/kg
LD50
Oral
Cat
800 mg/kg
LD50
Skin
Rabbit
> 10000 mg/kg
LD50
Intraperitoneal
Guinea pig
100 MG/KG
IRRITATION DATA
Skin
Rabbit
500 mg
ALDRICH - 125733 www.sigma-aldrich.com Page 4
24H
Remarks: Mild irritation effect
Eyes
Rabbit
50 mg
MOD
Remarks: Moderate irritation effect
SENSITIZATION
Sensitization: May cause allergic respiratory and skin reactions
SIGNS AND SYMPTOMS OF EXPOSURE
Prolonged exposure can cause: Damage to the liver. Damage to the
kidneys. Exposure to and/or consumption of alcohol may increase
toxic effects. To the best of our knowledge, the chemical,
physical, and toxicological properties have not been thoroughly
investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes severe eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Kidneys. Liver.
CHRONIC EXPOSURE - MUTAGEN
Rat
3 MMOL/L
Cell Type: liver
DNA damage
CHRONIC EXPOSURE - TERATOGEN
Species: Mouse
Dose: 203 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (8-10D PREG)
Result: Specific Developmental Abnormalities: Other
developmental abnormalities.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 1 MG/M3
Route of Application: Inhalation
Exposure Time: (45D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Algae
Species: Selenastrum capricornutum resp.
ALDRICH - 125733 www.sigma-aldrich.com Page 5
Time: 96 h
Value: 60 - 350 mg/l
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 60 d
Value: 44.4 - 48.30 mg/l
Test Type: LC0 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 48 h
Value: 5 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 607-009-00-4
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22 37/38 41 42/43
Harmful if swallowed. Irritating to respiratory system and
skin. Risk of serious damage to eyes. May cause sensitization
by inhalation and skin contact.
S-PHRASES: 23 24/25 26 37/39 46
Do not breathe spray. Avoid contact with skin and eyes. In case
of contact with eyes, rinse immediately with plenty of water
and seek medical advice. Wear suitable gloves and eye/face
protection. If swallowed, seek medical advice immediately and
show this container or label.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
ALDRICH - 125733 www.sigma-aldrich.com Page 6
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
ALDRICH - 125733 www.sigma-aldrich.com Page 7
|