SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 11/MAY/2005
Date Updated: 18/AUG/2004
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name POTASSIUM DICHROMATE, 99.95-100.05%
Product Number 309176
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
POTASSIUM DICHROMATE 7778-50-9 231-906-6 024-002-00-6
Formula K2Cr2O7
Molecular Weight 294.19 AMU
Synonyms Bichromate of potash * Dipotassium dichromate *
Iopezite * Kaliumdichromat (German) * Potassium
bichromate * Potassium dichromate * Potassium
dichromate(VI)
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause cancer by inhalation. May cause heritable genetic
damage. Also harmful in contact with skin. Also toxic if
swallowed. Also very toxic by inhalation. Risk of serious damage
to eyes. May cause sensitization by skin contact. Very toxic to
aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
Carc. Cat.2 Muta. Cat.2
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Contact with other material may cause fire.
Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
For fires involving this material, do not enter any enclosed or
confined fire space without proper protective equipment. This
may include self-contained breathing apparatus to protect
against the hazardous effects of the normal products of
combustion or oxygen deficiency
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from
combustible materials, heat, sparks, and open flame. Store in a
cool dry place.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
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Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Form: Fine crystals
Property Value At Temperature or Pressure
pH 3.5 - 5
BP/BP Range N/A
MP/MP Range 390 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 2.68 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:0.1 M in H2O, 20掳C
Complete, orange
10 - Stability and Reactivity
STABILITY
Materials to Avoid: Organic materials Avoid contact with acid.,
Finely powdered metals
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Potassium oxides, Chromium (VI)
oxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: HX7680000
ACUTE TOXICITY
LC50
Inhalation
Rat
35 mg/m3
4H
LC50
Inhalation
Rat
29 mg/m3
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LDLO
Oral
Child
26 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Respiratory stimulation.
Gastrointestinal:Nausea or vomiting.
LDLO
Oral
Man
143 mg/kg
Remarks: Vascular:BP lowering not charactertized in autonomic
section. Lungs, Thorax, or Respiration:Dyspnea. Kidney, Ureter,
Bladder:Urine volume decreased.
LDLO
Oral
Child
50 mg/kg
LD50
Oral
Rat
25 mg/kg
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Other. Behavioral:Somnolence (general depressed
activity). Behavioral:Ataxia.
LD50
Intraperitoneal
Rat
28 MG/KG
LD50
Oral
Mouse
190 mg/kg
LD50
Intraperitoneal
Mouse
37 MG/KG
LD50
Skin
Rabbit
14 mg/kg
Remarks: Lungs, Thorax, or Respiration:Acute pulmonary edema.
Gastrointestinal:Hypermotility, diarrhea. Skin and
Appendages:Skin: After systemic exposure: Dermatitis, other
SENSITIZATION
Respiratory: May cause allergic respiratory reaction.
Skin: May cause allergic skin reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
Inhalation of dichromate dusts can cause ulceration and
perforation of the nasal septum. Contact with breaks in the skin
can cause ulceration (chrome sores). Other symptoms of exposure
include erosion and discoloration of the teeth, nephritis,
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epigastric pain (inflammation and ulceration of the
gastrointestinal tract). Material is extremely destructive to
tissue of the mucous membranes and upper respiratory tract,
eyes, and skin. Inhalation may result in spasm, inflammation and
edema of the larynxand bronchi, chemical pneumonitis, and
pulmonary edema. Symptoms of exposure may include burning
sensation, coughing, wheezing, laryngitis, shortness of breath,
headache, nausea, and vomiting. Ingestion can cause: Vomiting.
Cyanosis. Coma.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be fatal if absorbed through skin.
Eye Contact: Causes burns.
Inhalation: Material is extremely destructive to the tissue of
the mucous membranes and upper respiratory tract. May be fatal
if inhaled.
Ingestion: May be fatal if swallowed.
TARGET ORGAN INFORMATION
Lungs. Kidneys. Blood.
CHRONIC EXPOSURE - CARCINOGEN
Result: This is or contains a component that has been reported
to be carcinogenic based on its IARC, OSHA, ACGIH, NTP, or EPA
classification.
IARC CARCINOGEN LIST
Rating: Group 1
CHRONIC EXPOSURE - MUTAGEN
Result: May alter genetic material.
Human
300 UG/L
Cell Type: lymphocyte
Micronucleus test
Human
200 NMOL/L
Cell Type: fibroblast
Morphological transformation.
Human
500 NMOL/L
Cell Type: fibroblast
DNA damage
Human
10 UMOL/L
Cell Type: lung
DNA damage
Human
1 UMOL/L
Cell Type: liver
DNA damage
Human
50 UMOL/L
Cell Type: fibroblast
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Unscheduled DNA synthesis
Human
100 UMOL/L
Cell Type: fibroblast
DNA inhibition
Human
13 UMOL/L
Cell Type: HeLa cell
DNA inhibition
Human
100 UMOL/L
Cell Type: fibroblast
Other mutation test systems
Human
150 UG/L
Cell Type: fibroblast
Other mutation test systems
Human
3 MG/L
Cell Type: lymphocyte
Other mutation test systems
Human
500 MG/L
Cell Type: Other cell types
Other mutation test systems
Human
100 UMOL/L
1H
Cell Type: Other cell types
Other mutation test systems
Human
500 NMOL/L
Cell Type: leukocyte
Cytogenetic analysis
Human
300 UG/L
Cell Type: lymphocyte
Cytogenetic analysis
Human
500 MG/L
Cell Type: Other cell types
Cytogenetic analysis
Human
150 UG/L
Cell Type: fibroblast
Cytogenetic analysis
Human
300 UG/L
Cell Type: lymphocyte
Sister chromatid exchange
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Human
100 NMOL/L
Cell Type: fibroblast
Sister chromatid exchange
Rat
5 MG/KG
Intraperitoneal
Cytogenetic analysis
Rat
1200 NMOL/L
Cell Type: lymphocyte
Cytogenetic analysis
Rat
12 MG/KG
Intravenous
Cytogenetic analysis
Rat
365 MG/KG
Oral
1Y
Cytogenetic analysis
Mouse
50 MG/KG
Intraperitoneal
Micronucleus test
Mouse
200 UMOL/L
Cell Type: leukocyte
DNA damage
Mouse
20 GM/KG
Intraperitoneal
DNA inhibition
Mouse
20 MG/KG
Oral
Cytogenetic analysis
Mouse
1 UMOL/L
48H
Cell Type: mammary gland
Cytogenetic analysis
Mouse
1 UMOL/L
Cell Type: lymphocyte
Sister chromatid exchange
Mouse
1 UMOL/L
Cell Type: Embryo
Sister chromatid exchange
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Mouse
1 UMOL/L
Cell Type: Other cell types
Sister chromatid exchange
Mouse
20 MG/KG
Intraperitoneal
Dominant lethal test
Mouse
20 MG/KG
Unreported
Dominant lethal test
Mouse
1 MG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Mouse
4 MG/KG
Intraperitoneal
sperm
Hamster
20 MG/KG
Intraperitoneal
Micronucleus test
Hamster
200 UG/L
Cell Type: Embryo
Morphological transformation.
Hamster
25 UG/L
Cell Type: kidney
Morphological transformation.
Hamster
10 MG/L
Cell Type: kidney
DNA damage
Hamster
10 MMOL/L
Cell Type: ovary
DNA damage
Hamster
10 UMOL/L
Cell Type: lung
DNA damage
Hamster
300 UMOL/L
Cell Type: lung
DNA inhibition
Hamster
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1 MG/L
Cell Type: kidney
DNA inhibition
Hamster
100 UMOL/L
Cell Type: fibroblast
DNA inhibition
Hamster
10 MG/L
Cell Type: kidney
Other mutation test systems
Hamster
8 MG/KG
Intraperitoneal
Cytogenetic analysis
Hamster
500 UG/L
Cell Type: lung
Cytogenetic analysis
Hamster
100 UG/L
24H
Cell Type: Embryo
Cytogenetic analysis
Hamster
250 UG/L
Cell Type: ovary
Cytogenetic analysis
Hamster
10 NMOL/L
Cell Type: ovary
Sister chromatid exchange
Hamster
800 UG/L
Cell Type: fibroblast
Sister chromatid exchange
Hamster
16 MG/L
Cell Type: lung
Sister chromatid exchange
Hamster
10 MG/KG
Intraperitoneal
Sister chromatid exchange
Hamster
20 UMOL/L
Cell Type: kidney
Sister chromatid exchange
Hamster
100 UG/L
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Cell Type: lung
Mutation in mammalian somatic cells.
Hamster
7 UMOL/L
Cell Type: ovary
Mutation in mammalian somatic cells.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 1 GM/KG
Route of Application: Oral
Exposure Time: (0-19D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 2546 MG/KG
Route of Application: Oral
Exposure Time: (14-19D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Blood and
lymphatic system (including spleen and marrow).
Species: Mouse
Dose: 20 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D MALE)
Result: Effects on Embryo or Fetus: Fetal death.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 525 MG/KG
Route of Application: Oral
Exposure Time: (21D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
per total number of implants). Specific Developmental
Abnormalities: Musculoskeletal system.
Species: Rat
Dose: 500 MG/KG
Route of Application: Oral
Exposure Time: (0-19D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth). Effects on Embryo or Fetus: Extra
embryonic structures (e.g., placenta, umbilical cord).
Species: Rat
Dose: 1771 MG/KG
Route of Application: Oral
Exposure Time: (90D PRE)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
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per total number of implants). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Rat
Dose: 980 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (7W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Effects on
Fertility: Pre-implantation mortality (e.g., reduction in number
of implants per female; total number of implants per corpora
lutea). Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Mouse
Dose: 1710 MG/KG
Route of Application: Oral
Exposure Time: (19D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Specific Developmental Abnormalities:
Craniofacial (including nose and tongue).
Species: Mouse
Dose: 1 GM/KG
Route of Application: Oral
Exposure Time: (20D PRE)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Extra embryonic structures (e.g.,
placenta, umbilical cord). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Mouse
Dose: 1697 MG/KG
Route of Application: Oral
Exposure Time: (14-19D PREG)
Result: Maternal Effects: Other effects. Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
per total number of implants). Effects on Embryo or Fetus: Extra
embryonic structures (e.g., placenta, umbilical cord).
Species: Mouse
Dose: 700 MG/KG
Route of Application: Unreported
Exposure Time: (35W MALE)
Result: Effects on Fertility: Other measures of fertility
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 25 - 150 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 0.035 mg/l
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13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 3290
Class: 6.1
PG: I
Proper Shipping Name: Toxic solid, corrosive,
inorganic, n.o.s.
IMDG
UN#: 3290
Class: 6.1
PG: I
Subrisk: 8
Proper Shipping Name: TOXIC SOLID, CORROSIVE,
INORGANIC, N.O.S.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 3290
Class: 6.1
PG: I
Subrisk: 8
Proper Shipping Name: Toxic solid, corrosive,
inorganic, n.o.s.
Inhalation Packing Group I: Yes
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 024-002-00-6
INDICATION OF DANGER: T+ N
Very toxic. Dangerous for the environment.
R-PHRASES: 49 46 21 25 26 41 43 50/53
May cause cancer by inhalation. May cause heritable genetic
damage. Also harmful in contact with skin. Also toxic if
swallowed. Also very toxic by inhalation. Risk of serious
damage to eyes. May cause sensitization by skin contact. Very
toxic to aquatic organisms, may cause long-term adverse effects
in the aquatic environment.
S-PHRASES: 53 45 61
Avoid exposure - obtain special instructions before use. In
case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). Avoid release to
the environment. Refer to special instructions/safety data
sheets.
COUNTRY SPECIFIC INFORMATION
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Germany
WGK: 3
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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