SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 01/NOV/2005
Date Updated: 13/MAR/2004
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name BROMOFORM, 99+%
Product Number 241032
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
BROMOFORM (AMYLENE STABILIZED) 75-25-2 200-854-6 602-007-00-X
(OEKANAL)
Formula CHBr3
Molecular Weight 252.75 AMU
Synonyms Bromoform (ACGIH:OSHA) * Bromoforme (French) *
Bromoformio (Italian) * Methenyl tribromide *
Methyl tribromide * NCI-C55130 * RCRA waste
number U225 * Tribrommethaan (Dutch) *
Tribrommethan (German) * Tribromometan (Italian)
* Tribromomethane
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic by inhalation. Irritating to eyes and skin. Toxic to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
prolonged or repeated exposure. Do not get in eyes, on skin, on
clothing.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 5 MG/M3
Poland NDSCh -
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 5 mg/m3
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0.5 ppm
Remarks: H
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 5 mg/m3
0.5 ppm
Remarks: HK
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 5 mg/m3
0.5 ppm
Remarks: H
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 5.3 mg/m3
0.5 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 146.0 - 150.0 掳C 760 mmHg
MP/MP Range 8 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 5 mmHg 20 掳C
SG/Density 2.894 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 8.7 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Light.
Materials to Avoid: Incompatible with aluminum, magnesium, and
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their alloys, Alkali metals.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen bromide gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: PB5600000
ACUTE TOXICITY
LDLO
Oral
Human
143 mg/kg
LD50
Oral
Rat
933 mg/kg
Remarks: Lungs, Thorax, or Respiration:Dyspnea.
LD50
Intraperitoneal
Rat
414 MG/KG
Remarks: Behavioral:Antipsychotic. Behavioral:Somnolence
(general depressed activity). Sense Organs and Special Senses
(Nose, Eye, Ear, and Taste):Eye:Lacrimation.
LD50
Oral
Mouse
1072 mg/kg
Remarks: Lungs, Thorax, or Respiration:Dyspnea.
LD50
Intraperitoneal
Mouse
1274 MG/KG
LD50
Subcutaneous
Mouse
1820 MG/KG
LC50
Inhalation
Mammal
12,100 mg/m3
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
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Eye Contact: Causes eye irritation.
Inhalation: Toxic if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Liver. Nerves. Kidneys. Lungs.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be probably carcinogenic based on its IARC, OSHA,
ACGIH, NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Gastrointestinal:Tumors. Tumorigenic:Carcinogenic by
RTECS criteria.
Mouse
Route of Application: Intraperitoneal
Exposure Time: 8W
Result: Lungs, Thorax, or Respiration:Tumors.
Tumorigenic:Neoplastic by RTECS criteria.
IARC CARCINOGEN LIST
Rating: Group 3 Group 3
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Human
80 UMOL/L
Cell Type: lymphocyte
Sister chromatid exchange
Rat
25300 UG/KG
Intraperitoneal
Cytogenetic analysis
Rat
1265 MG/KG
Oral
5D
Cytogenetic analysis
Rat
20 UMOL/L
Cell Type: leukocyte
Sister chromatid exchange
Mouse
800 MG/KG
Intratracheal
48H
Micronucleus test
Mouse
100 MG/KG
Oral
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4D
Sister chromatid exchange
Mouse
800 GM/L
Intratracheal
Sister chromatid exchange
Mouse
200 MG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
110 UG/L
Cell Type: ovary
Cytogenetic analysis
Hamster
290 UG/L
Cell Type: ovary
Sister chromatid exchange
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: other fish
Time: 96 h
Value: 7 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2515
Class: 6.1
PG: III
Proper Shipping Name: Bromoform
IMDG
UN#: 2515
Class: 6.1
PG: III
Proper Shipping Name: Bromoform
Marine Pollutant: Yes
Severe Marine Pollutant: No
IATA
UN#: 2515
Class: 6.1
PG: III
Proper Shipping Name: Bromoform
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Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 602-007-00-X
INDICATION OF DANGER: T-N
Toxic. Dangerous for the environment.
R-PHRASES: 23-36/38-51/53
Toxic by inhalation. Irritating to eyes and skin. Toxic to
aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
S-PHRASES: 28-45-61
After contact with skin, wash immediately with plenty of
soap-suds. In case of accident or if you feel unwell, seek
medical advice immediately (show the label where possible).
Avoid release to the environment. Refer to special
instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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