SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 10/FEB/2005
Date Updated: 13/MAR/2004
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name BROMOBENZENE, REAGENTPLUSTM, >=99%
Product Number 239879
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
BROMOBENZENE 108-86-1 203-623-8 602-060-00-9
Formula C6H5Br
Molecular Weight 157.02 AMU
Synonyms Monobromobenzene * NCI-C55492 * Phenyl bromide
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Irritating to skin. Toxic to aquatic organisms, may
cause long-term adverse effects in the aquatic environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid breathing vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat
and open flame.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Color: Almost colorless
Form: Clear liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 154 - 155 藲C
MP/MP Range -31 藲C
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Flash Point 51 藲C Method: closed cup
Flammability N/A
Autoignition Temp 566 藲C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 6 %
Upper: 36.5 %
Vapor Pressure 4 mmHg 25 藲C
SG/Density 1.494 g/cm3
Partition Coefficient Log Kow: 2.99
Viscosity N/A
Vapor Density 5.41 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen bromide gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: CY9000000
ACUTE TOXICITY
LD50
Oral
Rat
2383 mg/kg
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Chromodacryorrhea. Gastrointestinal:Hypermotility,
diarrhea. Nutritional and Gross Metabolic:Weight loss or
decreased weight gain.
LC50
Inhalation
Rat
20,411 mg/m3
LD50
Intraperitoneal
Rat
3882 MG/KG
LD50
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Oral
Mouse
2700 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Muscle contraction or spasticity.
LC50
Inhalation
Mouse
21,000 mg/m3
2H
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Muscle contraction or spasticity.
LD50
Intraperitoneal
Mouse
817 MG/KG
LD50
Subcutaneous
Mouse
2 GM/KG
Remarks: Peripheral Nerve and Sensation:Flaccid paralysis
without anesthesia (usually neuromuscular blockage). Lungs,
Thorax, or Respiration:Respiratory stimulation. Lungs, Thorax,
or Respiration:Other changes.
LD50
Oral
Rabbit
3300 mg/kg
LD50
Oral
Guinea pig
1700 mg/kg
LD50
Oral
Mammal
2700 mg/kg
LC50
Inhalation
Mammal
14,400 mg/m3
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Liver. Kidneys.
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CHRONIC EXPOSURE - MUTAGEN
Mouse
125 MG/KG
Intraperitoneal
24H
Micronucleus test
Hamster
500 MG/L
Cell Type: ovary
Sister chromatid exchange
12 - Ecological Information
BIOACCUMULATION POTENTIAL: No indication of
bioaccumulation.
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 35.7 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. This combustible material may be burned in a
chemical incinerator equipped with an afterburner and scrubber.
Observe all federal, state, and local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2514
Class: 3
PG: III
Proper Shipping Name: Bromobenzene
IMDG
UN#: 2514
Class: 3
PG: III
Proper Shipping Name: Bromobenzene
Marine Pollutant: Yes
Severe Marine Pollutant: No
IATA
UN#: 2514
Class: 3
PG: III
Proper Shipping Name: Bromobenzene
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 602-060-00-9
INDICATION OF DANGER: Xi N
Irritant. Dangerous for the environment.
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R-PHRASES: 10 38 51/53
Flammable. Irritating to skin. Toxic to aquatic organisms, may
cause long-term adverse effects in the aquatic environment.
S-PHRASES: 61
Avoid release to the environment. Refer to special
instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2 (self-classification)
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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