SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 09/FEB/2005
Date Updated: 12/MAR/2004
Version 1.2
According to 91/155/EEC
1 - Product and Company Information
Product Name BORIC ACID MOLECULAR BIOLOGY REAGENT
Product Number B6768
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
BORIC ACID 10043-35-3 233-139-2 None
Formula H3BO3
Molecular Weight 61.83 AMU
Synonyms Basilit B * Boracic acid * Borofax * Boron
trihydroxide * Borsaure (German) * Dr.'s 1 Flea
Terminator DF * Dr.'s 1 Flea Terminator DFPBO *
Dr.'s 1 Flea Terminator DT * Dr.'s 1 Flea
Terminator DTPBO * Flea Prufe * NCI-C56417 *
Orthoboric acid * Super Flea Eliminator * Three
elephant * Trihydroxyborone
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Not hazardous according to Directive 67/548/EC.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Exercise appropriate precautions to minimize direct contact with
skin or eyes and prevent inhalation of dust.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid inhalation. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Moisture sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Wear dust mask.
Hand Protection: Protective gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH 5.1 Concentration: 1.8 g/l
BP/BP Range 300 掳C
MP/MP Range 160 掳C
Flash Point N/A
Flammability N/A
SIGMA - B6768 www.sigma-aldrich.com Page 2
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 2.6 mmHg 20 掳C
SG/Density 1.44 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Potassium, Acid anhydrides.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Boron oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: ED4550000
ACUTE TOXICITY
LDLO
Oral
Man
429 mg/kg
Remarks: Cardiac:Other changes. Kidney, Ureter, Bladder:Changes
in tubules (including acute renal failure, acute tubular
necrosis).
LDLO
Oral
Woman
200 mg/kg
Remarks: Behavioral:Fluid intake.
Gastrointestinal:Hypermotility, diarrhea.
Gastrointestinal:Nausea or vomiting.
LDLO
Oral
Infant
934 mg/kg
LDLO
Skin
SIGMA - B6768 www.sigma-aldrich.com Page 3
Infant
1200 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Skin and Appendages:Skin: After systemic exposure: Dermatitis,
other Nutritional and Gross Metabolic:Changes in:Body
temperature increase.
LDLO
Skin
Child
4000 mg/kg
4D
LDLO
Skin
Man
2430 mg/kg
Remarks: Gastrointestinal:Hypermotility, diarrhea. Skin and
Appendages:Skin: After topical exposure:Primary irritation.
Nutritional and Gross Metabolic:Changes in:Body temperature
increase.
LDLO
Skin
Child
1500 mg/kg
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Conjunctive irritation. Lungs, Thorax, or
Respiration:Respiratory depression.
Gastrointestinal:Hypermotility, diarrhea.
LDLO
Subcutaneous
Infant
1100 MG/KG
Remarks: Behavioral:Tremor. Gastrointestinal:Hypermotility,
diarrhea. Gastrointestinal:Nausea or vomiting.
LD50
Oral
Rat
2660 mg/kg
LD50
Subcutaneous
Rat
1400 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Ataxia. Nutritional and Gross Metabolic:Changes
in:Body temperature decrease.
LD50
Intravenous
Rat
1330 MG/KG
Remarks: Behavioral:Tremor. Gastrointestinal:Hypermotility,
diarrhea. Gastrointestinal:Nausea or vomiting.
LD50
Oral
Mouse
3450 mg/kg
SIGMA - B6768 www.sigma-aldrich.com Page 4
LD50
Subcutaneous
Mouse
1740 MG/KG
LD50
Intravenous
Mouse
1240 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Respiratory depression.
Gastrointestinal:Hypermotility, diarrhea.
LD50
Subcutaneous
Guinea pig
1200 MG/KG
Remarks: Behavioral:Tremor. Gastrointestinal:Hypermotility,
diarrhea. Gastrointestinal:Nausea or vomiting.
IRRITATION DATA
Skin
Human
15 mg
3D
I
Remarks: Mild irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Toxicity reported for borates in humans: ingestion or absorption
may cause nausea, vomiting, diarrhea, abdominal cramps,
anderythematous lesions on the skin and mucous membranes. Other
symptoms include: circulatory collapse, tachycardia, cyanosis,
delirium, convulsions, and coma. Death has been reported to
occur in infants from less than 5 grams and in adults from 5 to
20 grams.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Testes.
CHRONIC EXPOSURE - TERATOGEN
Result: Laboratory experiments have shown teratogenic effects.
Species: Rat
Dose: 1600 MG/KG
Route of Application: Oral
Exposure Time: (6-9D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 6600 MG/KG
SIGMA - B6768 www.sigma-aldrich.com Page 5
Route of Application: Oral
Exposure Time: (1-21D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system. Specific Developmental Abnormalities:
Other developmental abnormalities.
Species: Rat
Dose: 1596 MG/KG
Route of Application: Oral
Exposure Time: (0-20D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Mouse
Dose: 7684 MG/KG
Route of Application: Oral
Exposure Time: (1-17D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 800 MG/KG
Route of Application: Oral
Exposure Time: (7D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rabbit
Dose: 3500 MG/KG
Route of Application: Oral
Exposure Time: (6-19D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Specific
Developmental Abnormalities: Cardiovascular (circulatory) system.
Species: Rabbit
Dose: 3500 MG/KG
Route of Application: Oral
Exposure Time: (6-19D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Other developmental abnormalities.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: May cause reproductive disorders.
Species: Rat
Dose: 45 GM/KG
Route of Application: Oral
Exposure Time: (90D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Rat
Dose: 5390 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetal death. Specific Developmental
Abnormalities: Musculoskeletal system.
SIGMA - B6768 www.sigma-aldrich.com Page 6
Species: Rat
Dose: 52 MG/KG
Route of Application: Oral
Exposure Time: (26W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Rat
Dose: 9600 UG/M3/4H
Route of Application: Inhalation
Exposure Time: (16W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct.
Species: Mouse
Dose: 17051 MG/KG
Route of Application: Oral
Exposure Time: (1-17D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Mouse
Dose: 18054 MG/KG
Route of Application: Oral
Exposure Time: (1-18D PREG)
Result: Maternal Effects: Uterus, cervix, vagina. Effects on
Fertility: Post-implantation mortality (e.g., dead and/or
resorbed implants per total number of implants).
Species: Mouse
Dose: 8136 MG/KG
Route of Application: Oral
Exposure Time: (1-18D PREG)
Result: Maternal Effects: Other effects. Effects on Embryo or
Fetus: Fetotoxicity (except death, e.g., stunted fetus).
Species: Rabbit
Dose: 3500 MG/KG
Route of Application: Oral
Exposure Time: (6-19D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth). Specific Developmental Abnormalities:
Cardiovascular (circulatory) system.
Species: Rabbit
Dose: 3500 MG/KG
Route of Application: Oral
Exposure Time: (7-20D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Rabbit
Dose: 1750 MG/KG
Route of Application: Oral
Exposure Time: (7-20D PREG)
Result: Maternal Effects: Uterus, cervix, vagina. Maternal
SIGMA - B6768 www.sigma-aldrich.com Page 7
Effects: Other effects.
12 - Ecological Information
N/A
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 133 mg/l
Test Type: LC0 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: > 1,021 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
Not hazardous according to Directive 67/548/EC.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
SIGMA - B6768 www.sigma-aldrich.com Page 8
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
SIGMA - B6768 www.sigma-aldrich.com Page 9
|