SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 10/FEB/2005
Date Updated: 13/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ETHYL BROMOACETATE, 98%
Product Number 133973
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ETHYL BROMOACETATE 105-36-2 203-290-9 607-069-00-1
Formula C4H7BrO2
Molecular Weight 167.01 AMU
Synonyms Antol * Bromoacetic acid, ethyl ester *
Ethoxycarbonylmethyl bromide * Ethyl bromacetate
* Ethyl alpha-bromoacetate * Ethyl
monobromoacetate
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Very toxic by inhalation, in contact with skin and if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
Vapor may travel considerable distance to source of ignition and
flash back.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions. Forms explosive mixtures in air.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
SPECIFIC METHOD(S) OF FIRE FIGHTING
Use water spray to cool fire-exposed containers.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Use only in a
chemical fume hood.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Remove and wash contaminated
clothing promptly.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
ALDRICH - 133973 www.sigma-aldrich.com Page 2
9 - Physical and Chemical Properties
Appearance Color: Deep brown-yellow
Form: Clear liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 156 - 160 藲C
MP/MP Range N/A
Flash Point 47 藲C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 2.6 mmHg 25 藲C
SG/Density 1.509 g/cm3
Partition Coefficient Log Kow: 1.12
Viscosity N/A
Vapor Density 5.8 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Insoluble.
Other Solvents: SOLUBLE IN ACETONE, BENZENE
ALCOHOL MISCIBLE WITH
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen bromide gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: AF6000000
SIGNS AND SYMPTOMS OF EXPOSURE
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Material is extremely destructive to tissue of the
mucous membranes and upper respiratory tract, eyes, and skin. To
the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ALDRICH - 133973 www.sigma-aldrich.com Page 3
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be fatal if absorbed through skin.
Eye Contact: Causes burns.
Inhalation: Material is extremely destructive to the tissue of
the mucous membranes and upper respiratory tract.
Ingestion: May be fatal if swallowed.
CHRONIC EXPOSURE - CARCINOGEN
Mouse
Route of Application: Subcutaneous
Exposure Time: 63W
Result: Tumorigenic:Neoplastic by RTECS criteria.
Tumorigenic:Tumors at site or application.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1603
Class: 6.1
PG: II
Proper Shipping Name: Ethyl bromoacetate
IMDG
UN#: 1603
Class: 6.1
PG: II
Subrisk: 3
Proper Shipping Name: Ethyl bromoacetate
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1603
Class: 6.1
PG: I
Subrisk: 3
Proper Shipping Name: Ethyl bromoacetate
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 607-069-00-1
INDICATION OF DANGER: T+
Very toxic.
R-PHRASES: 26/27/28
Very toxic by inhalation, in contact with skin and if swallowed.
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S-PHRASES: 7/9 26 45
Keep container tightly closed and in well-ventilated place. In
case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. In case of accident or if you
feel unwell, seek medical advice immediately (show the label
where possible).
SWITZERLAND
SWISS POISON CLASS: 1
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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