SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 07/JUN/2005
Date Updated: 04/APR/2005
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name IODOMETHANE, REAGENTPLUSTM, 99.5%
Product Number 289566
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
IODOMETHANE, STABILIZED W/ COPPER 74-88-4 200-819-5 602-005-00-9
Formula CH3I
Molecular Weight 141.94 AMU
Synonyms Halon 10001 * Iodometano (Italian) * Iodomethane
* Iodure de methyle (French) * Jod-methan
(German) * Joodmethaan (Dutch) * Methyl iodide
(ACGIH:OSHA) * Methyljodid (German) *
Methyljodide (Dutch) * Metylu jodek (Polish) *
Monoioduro di metile (Italian) * RCRA waste
number U138
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful in contact with skin. Toxic by inhalation and if
swallowed. Irritating to respiratory system and skin. Limited
evidence of a carcinogenic effect.
Carc. Cat.3
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately. Do not induce vomiting.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at 2-8掳C
SPECIAL REQUIREMENTS: Light sensitive. Moisture sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 10 MG/M3
Poland NDSCh 30 MG/M3
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Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 5.6 mg/m3
1 ppm
Remarks: HK
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 2 mg/m3
0.3 ppm
Remarks: 4
Remarks: H,TRGS 901-38
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 5 mg/m3
1 ppm
Remarks: H
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level6 mg/m3
1 ppm
Remarks: H, K
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 2 mg/m3
0.3 ppm
Remarks: H K
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 12 mg/m3
2 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Long rubber or neoprene gauntlet gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 42 - 43 掳C
MP/MP Range -64 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 407.913 mmHg 20 掳C
SG/Density 2.275 g/cm3
Partition Coefficient N/A
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Viscosity N/A
Vapor Density 4.89 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May discolor on exposure to light.
Conditions to Avoid: Moisture.
Materials to Avoid: Strong oxidizing agents, Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen iodide.
STABILIZERS PRESENT
Stabilized with copper.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: PA9450000
ACUTE TOXICITY
LD50
Oral
Rat
76 mg/kg
LC50
Inhalation
Rat
1,300 mg/m3
4H
LD50
Intraperitoneal
Rat
101 MG/KG
LD50
Subcutaneous
Rat
110 MG/KG
LC50
Inhalation
Mouse
5,000 mg/m3
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57M-C
LD50
Intraperitoneal
Mouse
172 MG/KG
LD50
Subcutaneous
Mouse
110 MG/KG
LD50
Skin
Guinea pig
800 mg/kg
LD50
Intraperitoneal
Guinea pig
51 MG/KG
IRRITATION DATA
Skin
Human
1,000 mg
10M
Remarks: Mild irritation effect
Skin
Rat
1,000 mg
30M
Remarks: Mild irritation effect
Skin
Rabbit
500 mg
Remarks: Severe irritation effect
Eyes
Rabbit
100 mg
Remarks: Severe irritation effect
SENSITIZATION
Sensitization: May cause allergic respiratory and skin reactions
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Nausea, dizziness, and headache. Blurred
vision. Weakness. Drowsiness. Ataxia. Confusion. Convulsions.
Narcotic effect. Pulmonary edema. Effects may be delayed.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Prolonged exposure to iodides may produce iodism in
sensitive individuals. Symptoms of exposure include: skin rash,
running nose, headache and irritation of the mucous membrane.
For severe cases the skin may show pimples, boils, hives,
blisters and black and blue spots. Iodides are readily diffused
across the placenta. Neonatal deaths from respiratory distress
secondary to goiter have been reported. Iodides have been known
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to cause drug-induced fevers, which are usually of short
duration.
ROUTE OF EXPOSURE
Skin Contact: Causes blisters on contact with skin.
Skin Absorption: Harmful if absorbed through skin.
Eye Contact: Causes burns.
Inhalation: Toxic if inhaled. Material is extremely destructive
to the tissue of the mucous membranes and upper respiratory
tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Central nervous system. Liver. Kidneys. Thyroid. Lungs.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be possibly carcinogenic based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Subcutaneous
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Gastrointestinal:Colon tumors. Tumorigenic:Tumors at
site or application.
Mouse
Route of Application: Intraperitoneal
Exposure Time: 8W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Mouse
50 MG/L
4H (+S9)
Cell Type: lymphocyte
Mutation in microorganisms
Mouse
3600 UG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
1 MG/L
Cell Type: Embryo
Morphological transformation.
Hamster
2 MG/L
Cell Type: ovary
Mutation in mammalian somatic cells.
CMR CAT.: Carc. Cat.3
12 - Ecological Information
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No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2644
Class: 6.1
PG: I
Proper Shipping Name: Methyl iodide
IMDG
UN#: 2644
Class: 6.1
PG: I
Proper Shipping Name: Methyl iodide
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2644
Class: 6.1
PG: I
Proper Shipping Name: Methyl iodide
Inhalation Packing Group I: Yes
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 602-005-00-9
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 21 23/25 37/38 40
Harmful in contact with skin. Toxic by inhalation and if
swallowed. Irritating to respiratory system and skin. Limited
evidence of a carcinogenic effect.
S-PHRASES: 36/37 38 45
Wear suitable protective clothing and gloves. In case of
insufficient ventilation, wear suitable respiratory equipment.
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
SWITZERLAND
SWISS POISON CLASS: 1
16 - Other Information
WARRANTY
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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