SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 07/JUN/2005
Date Updated: 14/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name IMIDAZOLE
Product Number 56749
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
IMIDAZOLE 288-32-4 206-019-2 None
Formula C3H4N2
Molecular Weight 68.08 AMU
Synonyms 1,3-Diaza-2,4-cyclopentadiene * 1,3-Diazole *
Formamidine, N,N'-vinylene- * Glioksal (Polish)
* Glyoxalin * Glyoxaline * Imidazol * Iminazole
* Imutex * Miazole * Pyrro(b)monazole * USAF
EK-4733
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Causes burns.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately. Do not induce vomiting.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
ENVIRONMENTAL PRECAUTION(S)
Avoid contaminating sewers and waterways with this material.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Ventilate
area and wash spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Fine crystals
Property Value At Temperature or Pressure
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pH 9.5 - 11
BP/BP Range 256 掳C 760 mmHg
MP/MP Range 89 - 91 掳C
Flash Point 145 掳C Method: closed cup
Flammability N/A
Autoignition Temp 480 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 0.002 mmHg 20 掳C
SG/Density 1.03 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density 550 kg/l
Decomposition Temp. N/A
Solvent Content N/A
Water Content < 0.2 %
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:0.1 M in H2O, 20掳C
complete, colorless
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Acids, Acid anhydrides, Strong oxidizing
agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Hydrogen cyanide, Ammonia.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: NI3325000
ACUTE TOXICITY
LD50
Oral
Rat
220 mg/kg
LD50
Subcutaneous
Rat
626 MG/KG
LD50
Oral
Mouse
880 mg/kg
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LD50
Intraperitoneal
Mouse
300 MG/KG
LD50
Subcutaneous
Mouse
817 MG/KG
LD50
Intravenous
Mouse
475 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Subcutaneous
Dog
28 MG/KG
LD50
Oral
Guinea pig
760 mg/kg
LD50
Oral
Mammal
1000 mg/kg
IRRITATION DATA
Skin
Rabbit
Remarks: Corrosive.
Eyes
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Material is extremely destructive to tissue of the
mucous membranes and upper respiratory tract, eyes, and skin. To
the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes burns.
Inhalation: May be harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: Harmful if swallowed.
CHRONIC EXPOSURE - MUTAGEN
Human
1 MMOL/L
Cell Type: Other cell types
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DNA inhibition
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Mouse
Dose: 150 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D MALE)
Result: Paternal Effects: Impotence.
12 - Ecological Information
ELIMINATION
Elimination: > 70 %
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Daphnia
Species: Daphnia
Time: 48 h
Value: 341.5 mg/l
Test Type: EC50 Algae
Time: 72 h
Value: 130 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 3263
Class: 8
PG: III
Proper Shipping Name: Corrosive solid, basic, organic,
n.o.s.
IMDG
UN#: 3263
Class: 8
PG: III
Proper Shipping Name: CORROSIVE SOLID, BASIC, ORGANIC,
N.O.S.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 3263
Class: 8
PG: III
Proper Shipping Name: Corrosive solid, basic, organic,
n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
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15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: C
Corrosive.
R-PHRASES: 22 34
Harmful if swallowed. Causes burns.
S-PHRASES: 26 36/37/39 45
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing, gloves, and eye/face protection. In case of accident
or if you feel unwell, seek medical advice immediately (show
the label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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