SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 07/JUN/2005
Date Updated: 18/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name INDOMETHACIN CRYSTALLINE
Product Number I7378
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
INDOMETHACIN 53-86-1 200-186-5 None
Formula C19H16ClNO4
Molecular Weight 357.8 AMU
Synonyms Amuno * Artracin * Artrinovo * Artrivia *
N-p-Chlorbenzoyl-5-methoxy-2-methylindole-3-aceti
c acid *
1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-essi
gsaeure (German) *
1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-ac
etic acid *
(1-p-Chlorobenzoyl-5-methoxy-2-methylindol-3-yl)a
cetic acid *
1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-ac
etic acid *
1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indole-a
cetic acid *
alpha-(1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-i
ndolyl)acetic acid *
1-p-Cloro-benzoil-5-metoxi-2-metilindol-3-acido
acetico (Spanish) * Confortid * Dolovin *
Idomethine * Imbrilon * Inacid * Indacin *
Indocid * Indomecol * Indomed * Indomee *
Indometacin * Indometacine * Indometacyna
(Polish) * Indomethacin * Indomethacine *
Indometicina (Spanish) * Indoptic *
Indo-rectolmin * Indo-tablinen * Inflazon *
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Very toxic if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
SIGMA - I7378 www.sigma-aldrich.com Page 2
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: Faintly beige
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 155 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solvent: 50 mg/ml EtOH clear, faintly
yellow-green
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: Light.
Materials to Avoid: Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: NL3500000
ACUTE TOXICITY
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LDLO
Oral
Man
15 mg/kg
2W-I
Remarks: Blood:Aplastic anemia.
LD50
Oral
Rat
2.42 mg/kg
Remarks: Gastrointestinal:Ulceration or bleeding from stomach.
LD50
Intraperitoneal
Rat
13 MG/KG
LD50
Subcutaneous
Rat
12 MG/KG
LD50
Intravenous
Rat
21 MG/KG
LD50
Intramuscular
Rat
26300 UG/KG
LD50
Rectal
Rat
31900 UG/KG
LD50
Oral
Mouse
11.841 mg/kg
LD50
Intraperitoneal
Mouse
10 MG/KG
LD50
Subcutaneous
Mouse
18300 UG/KG
LD50
Intravenous
Mouse
30 MG/KG
LD50
Intramuscular
Mouse
18200 UG/KG
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LD50
Oral
Dog
160 mg/kg
LD50
Intravenous
Dog
100 MG/KG
LD50
Oral
Cat
320 mg/kg
LD50
Oral
Rabbit
135 mg/kg
LD50
Oral
Guinea pig
100 mg/kg
LD50
Intraperitoneal
Guinea pig
143 MG/KG
LD50
Intravenous
Guinea pig
180 MG/KG
LD50
Oral
Hamster
81 mg/kg
LD50
Oral
Mammal
8 mg/kg
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: May be fatal if swallowed.
TARGET ORGAN INFORMATION
Blood.
CHRONIC EXPOSURE - CARCINOGEN
Rat
Route of Application: Oral
Exposure Time: 92W
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Result: Tumorigenic:Neoplastic by RTECS criteria. Skin and
Appendages: Other: Tumors.
CHRONIC EXPOSURE - MUTAGEN
Human
10 MG/L
Cell Type: lymphocyte
DNA inhibition
Rat
12 MG/KG
Oral
3D
Other mutation test systems
Rat
10 MG/L
Cell Type: Other cell types
Other mutation test systems
Rat
17 MG/KG
Oral
13W
Dominant lethal test
Rat
10 MG/KG
Cell Type: Other cell types
Host-mediated assay
Mouse
72 MG/KG
Oral
24H
Micronucleus test
Mouse
72 MG/KG
Intraperitoneal
24H
Micronucleus test
Mouse
44 UMOL/KG
Skin
DNA inhibition
Mouse
10 MG/L
Cell Type: Other cell types
DNA inhibition
Mouse
84 MG/KG
Oral
1W
Cytogenetic analysis
Mouse
60 MG/KG
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Intraperitoneal
5D
sperm
Mouse
60 MG/KG
Oral
5D
sperm
CHRONIC EXPOSURE - TERATOGEN
Result: Laboratory experiments have shown teratogenic effects.
Species: Woman
Dose: 1500 UG/KG
Route of Application: Oral
Exposure Time: (36W PREG)
Result: Specific Developmental Abnormalities: Respiratory
system. Effects on Newborn: Other neonatal measures or effects.
Species: Woman
Dose: 1500 MG/KG
Route of Application: Oral
Exposure Time: (27W PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
Species: Woman
Dose: 18 MG/KG
Route of Application: Intravenous
Exposure Time: (33-34W PREG)
Result: Specific Developmental Abnormalities: Homeostasis
Species: Woman
Dose: 6 MG/KG
Route of Application: Unreported
Exposure Time: (39W PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Species: Woman
Dose: 4 MG/KG
Route of Application: Unreported
Exposure Time: (10W PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Species: Woman
Dose: 2 MG/KG
Route of Application: Unreported
Exposure Time: (28W PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Specific Developmental Abnormalities: Homeostasis
Species: Woman
Dose: 22 MG/KG
Route of Application: Multiple
Exposure Time: (33W PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Effects on Newborn: Apgar score (human only).
Species: Woman
Dose: 12 MG/KG
Route of Application: Rectal
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Exposure Time: (28W PREG)
Result: Specific Developmental Abnormalities: Blood and
lymphatic system (including spleen and marrow). Specific
Developmental Abnormalities: Gastrointestinal system. Specific
Developmental Abnormalities: Urogenital system.
Species: Rat
Dose: 1 MG/KG
Route of Application: Oral
Exposure Time: (21D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
Species: Rat
Dose: 10 MG/KG
Route of Application: Oral
Exposure Time: (17-22D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Specific Developmental Abnormalities:
Respiratory system.
Species: Rat
Dose: 12 MG/KG
Route of Application: Oral
Exposure Time: (5-16D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 3 MG/KG
Route of Application: Parenteral
Exposure Time: (19-21D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Specific Developmental Abnormalities:
Respiratory system.
Species: Rat
Dose: 3 MG/KG
Route of Application: Unreported
Exposure Time: (20D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
Species: Mouse
Dose: 10 MG/KG
Route of Application: Oral
Exposure Time: (7D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Central nervous system. Specific Developmental Abnormalities:
Eye, ear.
Species: Mouse
Dose: 10 MG/KG
Route of Application: Oral
Exposure Time: (7D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Musculoskeletal system.
Species: Mouse
Dose: 4 MG/KG
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Route of Application: Oral
Exposure Time: (13D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Mouse
Dose: 40 MG/KG
Route of Application: Subcutaneous
Exposure Time: (8-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Monkey
Dose: 747 MG/KG
Route of Application: Oral
Exposure Time: (21-26W PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord).
Species: Rabbit
Dose: 10 MG/KG
Route of Application: Oral
Exposure Time: (29D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
Species: Rabbit
Dose: 1590 UG/KG
Route of Application: Subcutaneous
Exposure Time: (6D PREG)
Result: Effects on Embryo or Fetus: Maternal-fetal exchange.
Species: Rabbit
Dose: 20 MG/KG
Route of Application: Subcutaneous
Exposure Time: (26-29D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Specific
Developmental Abnormalities: Cardiovascular (circulatory) system.
Species: Rabbit
Dose: 30 MG/KG
Route of Application: Intramuscular
Exposure Time: (24-26D PREG)
Result: Specific Developmental Abnormalities: Respiratory
system. Effects on Newborn: Biochemical and metabolic.
Species: Mammal
Dose: 1 MG/KG
Route of Application: Oral
Exposure Time: (21D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Woman
Dose: 12 MG/KG
Route of Application: Oral
Exposure Time: (33-34W PREG)
Result: Effects on Newborn: Stillbirth.
Species: Woman
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Dose: 525 MG/KG
Route of Application: Oral
Exposure Time: (16-32W PREG)
Result: Maternal Effects: Parturition. Maternal Effects: Other
effects. Specific Developmental Abnormalities: Urogenital system.
Species: Woman
Dose: 12 MG/KG
Route of Application: Unreported
Exposure Time: (32W PREG)
Result: Effects on Newborn: Stillbirth.
Species: Woman
Dose: 14 MG/KG
Route of Application: Unreported
Exposure Time: (34W PREG)
Result: Effects on Newborn: Other neonatal measures or effects.
Species: Rat
Dose: 300 UG/KG
Route of Application: Oral
Exposure Time: (21-22D PREG)
Result: Maternal Effects: Parturition. Effects on Newborn:
Stillbirth. Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth).
Species: Rat
Dose: 20 MG/KG
Route of Application: Oral
Exposure Time: (1-21D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetal death. Specific Developmental
Abnormalities: Other developmental abnormalities.
Species: Rat
Dose: 325 MG/KG
Route of Application: Oral
Exposure Time: (65D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct.
Species: Rat
Dose: 2500 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rat
Dose: 28 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (7D MALE)
Result: Effects on Fertility: Male fertility index (e.g., #
males impregnating females per # males exposed to fertile
nonpregnant females).
Species: Rat
Dose: 4150 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
SIGMA - I7378 www.sigma-aldrich.com Page 10
Species: Rat
Dose: 5 MG/KG
Route of Application: Subcutaneous
Exposure Time: (5D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Rat
Dose: 2500 UG/KG
Route of Application: Subcutaneous
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rat
Dose: 12 MG/KG
Route of Application: Subcutaneous
Exposure Time: (3-4D PREG)
Result: Maternal Effects: Uterus, cervix, vagina. Effects on
Fertility: Pre-implantation mortality (e.g., reduction in number
of implants per female; total number of implants per corpora
lutea).
Species: Rat
Dose: 9 MG/KG
Route of Application: Subcutaneous
Exposure Time: (9D PRE)
Result: Maternal Effects: Other effects.
Species: Rat
Dose: 500 UG/KG
Route of Application: Intrauterine
Exposure Time: (4D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Rat
Dose: 125 MG/KG
Route of Application: Intravaginal
Exposure Time: (7D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth). Effects on Fertility: Other measures of
fertility
Species: Mouse
Dose: 9 MG/KG
Route of Application: Subcutaneous
Exposure Time: (2D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Mouse
Dose: 40 MG/KG
Route of Application: Subcutaneous
Exposure Time: (8-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
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Effects on Embryo or Fetus: Fetal death. Specific Developmental
Abnormalities: Body wall.
Species: Mouse
Dose: 8 MG/KG
Route of Application: Subcutaneous
Exposure Time: (1D PRE)
Result: Maternal Effects: Uterus, cervix, vagina. Effects on
Fertility: Other measures of fertility
Species: Mouse
Dose: 8 MG/KG
Route of Application: Parenteral
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Monkey
Dose: 496 MG/KG
Route of Application: Oral
Exposure Time: (21-26W PREG)
Result: Maternal Effects: Parturition. Effects on Newborn:
Growth statistics (e.g., reduced weight gain). Effects on
Newborn: Physical.
Species: Monkey
Dose: 6 MG/KG
Route of Application: Intramuscular
Exposure Time: (2D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rabbit
Dose: 96 MG/KG
Route of Application: Oral
Exposure Time: (20-31D PREG)
Result: Maternal Effects: Parturition.
Species: Rabbit
Dose: 6 MG/KG
Route of Application: Oral
Exposure Time: (2D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rabbit
Dose: 48 MG/KG
Route of Application: Subcutaneous
Exposure Time: (23-28D PREG)
Result: Maternal Effects: Parturition.
Species: Rabbit
Dose: 32 MG/KG
Route of Application: Subcutaneous
Exposure Time: (5-6D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility: Litter size
(e.g.; # fetuses per litter; measured before birth).
Species: Rabbit
Dose: 24 MG/KG
Route of Application: Subcutaneous
Exposure Time: (4-7D PREG)
Result: Effects on Fertility: Other measures of fertility
SIGMA - I7378 www.sigma-aldrich.com Page 12
Effects on Embryo or Fetus: Extra embryonic structures (e.g.,
placenta, umbilical cord). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Rabbit
Dose: 64 MG/KG
Route of Application: Subcutaneous
Exposure Time: (9-12D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth).
Species: Rabbit
Dose: 148 MG/KG
Route of Application: Intravenous
Exposure Time: (1-9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth).
Species: Rabbit
Dose: 20 MG/KG
Route of Application: Intravenous
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rabbit
Dose: 20 MG/KG
Route of Application: Intravenous
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rabbit
Dose: 7500 UG/KG
Route of Application: Intramuscular
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rabbit
Dose: 5500 UG/KG
Route of Application: Intramuscular
Exposure Time: (1-3D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Rabbit
Dose: 2500 NG/KG
Route of Application: Parenteral
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Pig
Dose: 160 MG/KG
Route of Application: Oral
Exposure Time: (16D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Guinea pig
Dose: 240 MG/KG
Route of Application: Subcutaneous
Exposure Time: (12D PRE)
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Result: Maternal Effects: Menstrual cycle changes or disorders.
Species: Guinea pig
Dose: 66640 UG/KG
Route of Application: Intrauterine
Exposure Time: (9D PRE)
Result: Maternal Effects: Menstrual cycle changes or disorders.
Species: Hamster
Dose: 144 MG/KG
Route of Application: Subcutaneous
Exposure Time: (18D PRE)
Result: Maternal Effects: Other effects.
Species: Cattle, Horse
Dose: 40 UG/KG
Route of Application: Unreported
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2811
Class: 6.1
PG: I
Proper Shipping Name: Toxic solid, organic, n.o.s.
(PCDDs and PCDFs)
IMDG
UN#: 2811
Class: 6.1
PG: I
Proper Shipping Name: Toxic solid, organic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2811
Class: 6.1
PG: I
Proper Shipping Name: Toxic solid, organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
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INDICATION OF DANGER: T+
Very toxic.
R-PHRASES: 28
Very toxic if swallowed.
S-PHRASES: 28 36/37 45
After contact with skin, wash immediately with plenty of water.
Wear suitable protective clothing and gloves. In case of
accident or if you feel unwell, seek medical advice immediately
(show the label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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