Material Safety Data Sheet
Revision: 02/16/2006
Hazard information is provided for compliance with both the UK Chemicals
(Hazard Information and Packaging) (CHIP) Regulations and the US Hazard
Communication Standard (HCS)
IDENTIFICATION OF THE PRODUCT NAME: PRODUCT CODE: EEC NUMBER:
SUBSTANCE/PREPARATION Ampicillin Trihydrate 11257 200-709-7
AND COMPANY
SUPPLIER: Emergency Contact:
USB Corporation, 26111 Miles Road, Cleveland, Ohio 44128 Phone: (216) 765-5000 Chemtrec (800) 424-9300
Please visit our website at www.usbweb.com for contact information on USB Outside USA & Canada 703 527 3887
product distributors within your area.
COMPOSITION/
HAZARDOUS COMPONENTS HAZARD CAS NO. %WT TLV CHIP R & S Phrases
Ampicillin Trihydrate 7177-48-2 ~100% --- R:42/43 May cause
sensitization by inhalation and
skin contact.
R:36/37/38 Irritating to eyes,
respiratory system and skin.
S:22 Do not breathe dust.
S:24/25 Avoid contact with
skin and eyes.
S:28 After contact with skin,
wash immediately with plenty
of water.
S:36/37 Wear suitable
protective clothing and gloves.
HAZARDS IDENTIFICATION CHIP
Harmful
HCS
Irritant
FIRST-AID MEASURES EYES: Flush with water for 15 minutes. Seek medical advice if irritation persists.
SKIN: Flush with water, then wash thoroughly with soap and water. Remove contaminated clothing and
wash before reuse. Seek medical attention if irritation persists.
INHALATION: Remove the victim from exposure and move to fresh air. If breathing is difficult, give
oxygen. If not breathing, give artificial respiration. Keep victim quiet and warm. Seek immediate
medical attention.
INGESTION: Drink water and seek immediate medical attention. Avoid alcoholic beverages. Never give
anything by mouth to an unconscious person.
FIRE-FIGHTING INFORMATION Use media suitable to extinguish the supporting or surrounding fire. Wear NIOSH (or equivalent) approved self
contained breathing apparatus. For small fires only: use carbon dioxide, dry powder or foam. Emits toxic fumes
under fire conditions.
Flash Point = No data available.
ACCIDENTAL RELEASE MEASURES Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and
NIOSH-approved respirator. Collect in a manner that does not create dust and place in a suitable waste
container. Avoid contact of material with skin or eyes. Use adequate ventilation.
HANDLING AND STORAGE Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and
NIOSH-approved respirator. Avoid contact of material with skin or eyes. Use adequate ventilation. Store
ambient away from incompatible materials. Keep container tightly closed.
PERSONAL PROTECTION Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and
NIOSH-approved respirator. A qualified industrial hygienist should evaluate the need for respiratory protection.
Use respiratory protection approved by NIOSH (or equivalent) and appropriate to the hazard. Avoid contact of
material with skin or eyes. Mechanical ventilation or local exhaust as needed to control exposure to dust,
vapors or mists. Access to a safety shower and eye-wash.
MSDS information may be continued on back of page.
PHYSICAL AND CHEMICAL Appearance: White crystalline powder Boiling Point: No data available
PROPERTIES Vapor Pressure: No data available Vapor Density: No data available
Solubility (Water): Slightly soluble Specific Gravity: No data available
Percent Volatile: No data available Evaporation Rate: No data available
Chemical Formula: C16-H19-N3-O4-SA3H2O Melting Point: 198-200癈
STABILITY AND REACTIVITY Product is stable. Avoid excessive heat and humidity. Hazardous decomposition products include carbon,
nitrogen and sulfur oxides. Incompatible with strong oxidizing agents. Hazardous polymerization will not occur.
TOXICOLOGICAL INFORMATION EFFECTS OF OVEREXPOSURE:
EYES: Contact may cause irritation.
SKIN: Contact may cause irritation, dermatitis and hypersensitive individuals may experience an allergic
reaction. May cause skin rash and eruptions.
INHALATION: May cause irritation, and hypersensitive individuals may experience an allergic reaction.
INGESTION: Chronic ingestion or excessive dosage may cause irritation with nausea, vomiting and
diarrhea. May cause allergic reaction. May cause central nervous system toxicity with hallucinations,
confusion, unconsciousness and seizures. Persons allergic to penicillin should avoid contact with
Ampicillin Trihydrate. May cause kidney damage.
TARGET ORGAN(S): Blood, Kidneys and CNS.
ADDITIONAL INFORMATION:
May be harmful by inhalation, ingestion or skin absorption. May cause adverse reproductive and fetal effects.
Sensitizer. Reports of serious and/or fatal hypersensitivity (anaphylactic) reactions have occured in individuals
receiving penicillin therapy. These reactions usually occur in people with a history of sensitivity to multiple
allergens, asthma or hay fever. Ingestion may result in glossitis, stomatitis, enterocolitis and
pseudomembranous coloitis. Hypersensitive reactions may include erythematous maculopapular rashes,
erythema multiforme, uticaria and exfoliative dermatis.
Reproductive effects, tumorigenic and toxicity data listed in RTECS under XH8425000.
Only select RTECS information is provided here. Please see actual RTECS entry for complete information.
Oral Rat LD50 = 10 gm/kg (Moscow, USSR - 1975). Toxic effects include tremor, muscle weakness and
hypermotility, diarrhea.
Reproductive: Effects on embryo or fetus - fetotoxicity (except death, e.g. stunted fetus) (1973).
Specific developmental abnormalities - musculoskeletal system (1973).
Fertility - litter size (e.g. # of fetuses per litter; measured before birth) (1973).
Tumorigenic data: equivocal tumorigenic agent by RTECS criteria.
Carcinogenicity data:
IARC Cancer Review: Animal - Limited Evidence (1990).
Human - Inadequate Evidence (1990).
Group 3 - Agent is not classifiable as to its carcinogenicity to humans (1990).
NCI Carcinogenesis Studies (gavage): equivocal evidence: rat. no evidence: mouse.
Definition(s): IARC = International Agency for Research on Cancer.
NCI = National Cancer Institute.
RTECS = Registry of Toxic Effects of Chemical Substances.
ECOLOGICAL INFORMATION No information available.
DISPOSAL CONSIDERATIONS Dispose of material in accordance with applicable local, state, and federal regulations.
TRANSPORTATION INFORMATION US DOT / IATA: No applicable information.
REGULATORY INFORMATION RCRA - No applicable information.
SARA 302 - This material does not have an RQ or TPQ.
SARA 313 - This material is not reportable under 313.
EPA TSCA Section 8(b) - This chemical substance is not specifically listed on the EPA TSCA Inventory. It is
supplied for research and developmental use only, by or directly under the supervision of technically qualified
individuals. Not for manufacturing commercial purposes.
Exposure Limits - Not established.
California Proposition 65 - No applicable information.
This data sheet is based upon information believed to be reliable. The Company makes no statement or warranty as to the accuracy or completeness of the
information contained herein which is offered for your consideration, investigation and verification. Any use of the information contained in this data sheet
must be determined by the user to be in accordance with appropriate applicable regulations.
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