MATERIAL SAFETY DATA SHEET AMPICILLIN
PRODUCT CODE NUMBER(S): 1440-5, 1441-5
PRODUCT IDENTIFICATION Reactivity Avoid excessive heat, ignition sources, incom-
patible materials, moisture. Avoid generation of dust.
Chemical Name and Synonyms: Ampicillin, sodium salt, Hazardous Decomposition Products: COx, NOx, SOx
Aminobenzylpenicillin; Amcill-S; Penbritin-S OR Ampicillin
trihydrate; Aminobenzylpenicillin trihydrate; Acillin; Amcill
FIRE AND EXPLOSION DATA
Chemical Family: Penicillins
Flammability: Not combustible. However, as with most or-
Chemical Formula: C16H18N3NaO4S OR
ganic compounds, fine dust dispersed in air in the presence
C16H19N3O4S.3H2O
of an ignition source is a potential dust explosion hazard.
Product Use: Laboratory reagent
Extinguishing Media: Use extinguishing media appropri-
Manufacturer's Name and Address:
ate to the surrounding fire. Water in flooding amounts can
Caledon Laboratories Ltd. be used to cool containers, prevent dust formation, flush
40 Armstrong Avenue chemcial away from fire. Fight fire from upwind, from a safe
Georgetown, Ontario L7G 4R9 distance. Firefighters should wear protective equipment and
clothing sufficient to prevent inhalation of dust or fumes and
Telephone No: (905) 877-0101
contact with skin and eyes.
Fax No: (905) 877-6666
Flash Point (Method Used): Not applicable
Emergency Telephone No: CANUTEC (613) 996-6666
Autoignition Temperature: Not applicable
HAZARDOUS INGREDIENTS OF MATERIALS Upper Flammable Limit (% by volume): Not applicable
Lower Flammable Limit (% by volume): Not applicable
Ingredients % TLV Units CAS No. Hazardous Combustion Products: COx, NOx, SOx
Ampicillin sodium salt 99 Not established 69-52-3 Sensitivity to Impact: None identified
Sensitivity to Static discharge: As with most organic pow-
OR
ders, mixtures of dust with air may be sensitive under
Ampicillin trihydrate 99 Not established 7177-48-2 certain conditions, when ignited by an electrostatic or other
high-voltage spark, or other ignition source.
PHYSICAL DATA TOXICOLOGICAL PROPERTIES AND HEALTH DATA
Physical State: Solid To the best of our knowledge, the physical, chemical and
Odour and Appearance: White to off-white crystalline toxicological properties of this substance have not yet been
powder, odourless thoroughly investigated.
Odour Threshold (ppm): Not applicable
Toxicological Data:
Vapour Pressure (mm Hg): Not available
Vapour Density (Air = 1): Not available LD50: (oral, rat) >5 g/kg
Evaporation Rate: Not applicable LC50: Not available
Boiling Point (degrees C): Not applicable - decomposes
Effects of Acute Exposure to Product:
Melting Point (degrees C): 215癈 (decomposes)
pH: Not available Inhaled: May cause irritation of the nasal and respiratory
passages, causing sore throat, coughing. May cause al-
Specific Gravity: Not available
lergic respiratory reaction.
Coefficient of Water/Oil distribution: Not available
In contact with skin: May cause irritation, with redness,
itching. May be harmful if absorbed. Risk of skin absorption
SHIPPING DESCRIPTION
not known. May cause skin sensitization, with skin rash and
UN: Not regulated eruptiosn on repeat exposure.
In contact with eyes: May cause mild mechanical irritation,
T.D.G. Class: Not regulated
with temporary redness, itching, tearing, pain.
Pkg. Group: Not regulated
Ingested: May cause gastrointestinal irritation with nausea,
vomiting and diarrhea. May cause kidney damage. Can
REACTIVITY DATA
cause allergic reaction with nausea, vomiting, glossitis,
rashes, in some sensitive individuals, usually those who
Chemical Stability: Stable in dry air.
have a history of allergic reaction, asthma, hay fever, urti-
Incompatibility with other substances: Can react vio-
caria. Allergic individuals may also develop blood effects
lently with strong oxidizing agents. May cake on exposure
and central nervous system toxicity (including hallucinations,
to moisture.
confusion, unconsciousness, and seizures, even fatal
alaphylactic reaction.
AMPICILLIN
MSDS
CODE: 1440-5, 1441-5
Effectsof Chronic Exposure to Product: Skin: Remove contaminated clothing. Brush or wipe off
dry material. Flush skin with plenty of running water until no
Prolonged or repeated exposures may cause allergic reac- evidence of chemical remains. If irritation develops, or if
tions in sensitive individuals (see "Ingested"). person has a known allergy to penicillin, get medical atten-
Carcinogenicity: Some evidence of carcinogenicity in ani- tion.
mal testing. Inadequate human evidence, IARC Group 3 Inhalation: Remove to fresh air. Give oxygen and get
Teratogenicity: No human nformation available. Has medical attention immediately for any breathing difficulty.
caused effects in animal testing. Ingestion: If victim is alert and NOT convulsing, rinse
Reproductive Effects: No human nformation available. mouth, give several glasses of water to drink to dilute. If
Has caused effects in animal testing. discomfort occurs, if a large amount has been ingested, or if
person has a known allergy to penicillin, get medical atten-
Mutagenicity: No information available
tion.
Synergistic Products: None known
REFERENCES USED
PREVENTIVE MEASURES
Sax, Lewis: Hawley's Condensed Chemical Dictionary, 11th
Engineering Controls: Local exhaust ventilation required.
ed., 1987
Respiratory Protection: Dust/mist mask. For conditions
Suppliers' Material Safety Data Sheets
where dust or mist is present, to the maximum use specified
by the respirator supplier, NIOSH approved half- face
ADDITIONAL INFORMATION
high-efficiency dust/mist filter respirator, or NIOSH approved
full face-piece high-efficiency dust/mist filter respirator.
Date Issued: March 16, 1999
Higher or unknown concentrations, or for fire or spill condi-
Revision: March 2008
tions, self-contained breathing apparatus, or full face-piece,
positive-pressure supplied-air respirator. MSDS: 1440-5, 1441-5
Eye Protection: Safety glasses. Proposed WHMIS Designation: D2B (sensitizer)
Skin Protection: Rubber or plastic gloves. Other protec-
tive clothing (apron, sleeves) as required to limit contact. Prepared by: Caledon Laboratories Ltd. (905) 877-0101
Other Personal Protective Equipment: Safety shower Caledon Laboratories Ltd. believes the information contained
and eye-wash fountain in work area. herein is reliable and accurate. Caledon makes no warranty
Leak and Spill Procedure: Ventilate area. Eliminate with respect thereto and expressly disclaims all liability for reli-
sources of ignition. Cleanup personnel should be trained in ance thereon. Such information is solely for your consider-
the handling of hazardous chemicals and should wear pro- ation, investigation, and verification.
tective equipment and clothing sufficient to prevent
inhalation of dust, mist or fumes, and contact with skin and
eyes. Prevent from entering sewers or waterways. Collect
in a manner that does not raise dust, transfer carefully into
container, and arrange removal by disposal company. Wash
site of spillage thoroughly with water and detergent.
Waste Disposal: Comply with federal, provincial and local
regulations.
Handling Procedures and Equipment: COMBUSTIBLE
DUST. Workers using this chemical must be properly
trained in its hazards and its safe use, and must wear appro-
priate protective equipment and clothing. Avoid generating
dust. If there is dust, keep away from heat, sparks, and all
sources of ignition; avoid the accumulation of static charge,
use anti-sparking tools and ground and bond equipment and
containers. Use the smallest amount possible for the pur-
pose, in a designated area with adequate ventilation. Use
good housekeeping to prevent accumulations of dust. Avoid
contact with skin and eyes. Avoid inhalation. Wash thor-
oughly after handling.
Storage Requirements: Store in suitable, labelled contain-
ers, in a cool, dry, well-ventilated area, out of direct sunlight
and away fromheat and ignition sources and incompatible
materials. Keep containers tightly closed when not in use
and when empty. Protect from moisture.
FIRST AID MEASURES
Specific Measures:
Eyes: Flush eyes thoroughly with gently running water,
holding eyelids open while flushing, for five to ten (5-10)
minutes, or until no trace of chemical remains. Get medical
advice if irritation develops.
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