MATERIAL SAFETY DATA SHEET
Syngenta Crop Protection Canada, Inc. In Case of Emergency, Call
140 Research Lane, Research Park
1-800-327-8633 (FAST MED)
Guelph, ON N1G 4Z3
Supersedes date (Y/M/D): NEW
Date of MSDS Preparation (Y/M/D): 2007-12-31
MSDS prepared by:
For further information contact:
Department of Regulatory & Biology Development
1-87-SYNGENTA (1-877-964-3682)
Syngenta Crop Protection Canada, Inc.
SECTION ?1: PRODUCT IDENTIFICATION
Product Identifier: INSTRATA?FUNGICIDE Formulation No.: A14036B
Registration Number: 28861 (Pest Control Products Act)
Chemical Classes: A blend of chlorinated benzonitrile, substituted benzodioxalcarbonitrile and triazole
derivative fungicides.
Synonym: None
Active Ingredient (%): Chlorothalonil (29.9 %) CAS No.: 1897-45-6
Chemical Name : Tetrachloroisophthalonitrile.
Chemical Class: Chlorinated Benzonitrile Fungicide
Active Ingredient (%): Fludioxonil (1.2 %) CAS No.: 131341-86-1
Chemical Name : 4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1H-pyrrole-3-carbonitrile.
Chemical Class: Substituted Benzodioxalcarbonitrile Fungicide
Active Ingredient(%): Propiconazole (4.7 %) CAS No.: 60207-90-1
Chemical Name: 1-[[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole.
Chemical Class: Triazole Derivative Fungicide
Product Use: INSTRATA is a fungicide mixture for control of fungal diseases on turf. For further details
please refer to product label.
SECTION ?2 : COMPOSITION/INFORMATION ON INGREDIENTS
Material OSHA ACGIH Other NTP/IARC/OSHA WHMIS
PEL TLV Carcinogen
Propylene Glycol Not Established Not Established 50 ppm No Yes
CAS No. 57-55-6 TWA ****
Not Established Not Established 0.1 mg/m?TWA IARC Group 2B Not Established
Chlorothalonil
(possible skin and
(29.9 %)
respiratory
sensitizer) ***
Propiconazole Not Established Not Established 10 mg/m? No Not Established
(4.7 %) TWA***
Fludioxonil Not Established Not Established 10 mg/m? No Not Established
(1.2 %) TWA***
*** Syngenta Occupational Exposure Limit (OEL)
**** Recommended by AIHA (American Industrial Hygiene Association)
Material listed in Ingredient Disclosure List under Hazardous Products Act.
INSTRATA?FUNGICIDE
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Ingredients not precisely identified are proprietary or non-hazardous. Values are not product specifications.
Syngenta Hazard Category: C, S.
SECTION ?3: HAZARDS IDENTIFICATION
Symptoms of Acute Exposure
Causes eye, skin or respiratory irritation. May cause sensitization by skin contact.
Hazardous Decomposition Products
Can decompose at high temperatures and form toxic gases.
Physical Properties
Appearance: Grey Liquid.
Odour: Aromatic.
Unusual Fire, Explosion and Reactivity Hazards
During a fire, irritating and possibly toxic gases may be generated by thermal decomposition or combustion.
Potential Health Effects
Relevant routes of exposure: Skin, eyes, mouth, lungs.
SECTION ?4: FIRST AID MEASURES
IF POISONING IS SUSPECTED, immediately contact the poison information centre, doctor or nearest hospital. Have
the product container, label or Material Safety Data Sheet with you when calling Syngenta, a poison control center or
doctor, or going for treatment. Tell the person contacted the complete product name, and the type and amount of exposure.
Describe any symptoms and follow the advice given. Call the Syngenta Emergency Line [1-800-327-8633 (1-800-
FASTMED)], for further information.
EYE CONTACT: Flush eyes with clean water, holding eyelids apart for a minimum of 20 minutes. Remove contact
lenses, if present, after 5 minutes, then continue rinsing eye. Call Syngenta, a poison control
center or doctor for treatment advice. Obtain medical attention immediately if irritation persists.
SKIN CONTACT: Immediately remove contaminated clothing and wash skin, hair and fingernails thoroughly with
soap and water. Flush skin with running water for a minimum of 20 minutes. Obtain medical
attention if irritation occurs.
INHALATION: Remove victim to fresh air. If not breathing, give artificial respiration, preferably mouth-to-
mouth. If breathing is laboured, give oxygen. Obtain immediate medical attention.
INGESTION: If swallowed, immediately contact Syngenta, a poison control centre, doctor or nearest hospital for
treatment advice. Provided the patient is conscious, wash out mouth with water. Do not give
anything by mouth to an unconscious person. Do not induce vomiting unless directed by a
physician or a poison control center. If spontaneous vomiting occurs, have victim lean forward
with head down to avoid breathing in of vomitus, rinse mouth and administer water.
NOTES TO PHYSICIAN:
There is no specific antidote if this product is ingested. Treat symptomatically.
Persons suffering with temporary allergic skin reactions may respond to treatment with oral antihistamines and
topical or oral steroids.
MEDICAL CONDITIONS KNOWN TO BE AGGRAVATED:
None known.
SECTION ?5: FIRE FIGHTING MEASURES
Flash point and method: > 100 篊.
Upper and lower flammable (explosive) limits in air: Not applicable.
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Auto-ignition temperature: > 650 篊.
Flammability: Not applicable.
Hazardous combustion products: During a fire, irritating and possibly toxic gases may be generated by thermal
decomposition or combustion.
Conditions under which flammability could occur: Product is not flammable. Keep fire exposed containers cool by
spraying with water.
Extinguishing media: Use foam, carbon dioxide, dry powder, halon extinguishant or water fog or mist, (avoid use of
water jet). Wear full protective clothing and self-contained breathing apparatus. Evacuate nonessential personnel from the
area to prevent human exposure to fire, smoke, fumes or products of combustion. Prevent use of contaminated buildings,
area, and equipment until decontaminated. Water runoff can cause environmental damage. Contain run-off water with, for
example, temporary earth barriers.
Sensitivity to explosion by mechanical impact: No.
Sensitivity to explosion by static discharge: No.
SECTION ?6: ACCIDENTAL RELEASE MEASURES
Personal Precautions: Make sure all personnel involved in the spill cleanup follow good industrial hygiene practices. A
small spill can be handled routinely. Wear suitable protective clothing and eye protection to prevent skin and eye contact.
Use adequate ventilation and wear an air-supplied respirator to prevent inhalation.
Procedures for dealing with release or spill: Control the spill at its source. Contain the spill to prevent from spreading or
contaminating soil or from entering sewage and drainage systems or any body of water. Clean up spills immediately,
observing precautions outlined in Sections 7 and 8. Pump or scoop large amounts of liquid into a disposable container.
Absorb remaining liquid or smaller spills with clay, sand or vermiculite. Scoop or sweep up material and place into a
disposal container. Wash area with detergent and water. Pick up wash liquid with additional absorbent and place into
compatible disposal container. On soils, skim off the upper contaminated layer and collect for disposal. Once all material is
cleaned up and placed in a disposal container, seal container and arrange for disposition. Spillages or uncontrolled
discharges into watercourses must be alerted to the appropriate regulatory body.
SECTION ?7: HANDLING AND STORAGE
Handling practices: KEEP OUT OF REACH OF CHILDREN and animals. Prevent eating, drinking, tobacco use, and
cosmetic application in areas where there is a potential for exposure to the material. After work, rinse gloves and remove
protective equipment. Wash hands thoroughly with soap and water after handling, and before eating, tobacco use,
drinking, or using the toilet. Wash contaminated clothing before re-use and separate from household laundry. Keep
containers closed when not in use. Keep product, wash or rinse water, and contaminated materials out of water, away
from crops, and away from access by people, animals and birds.
Appropriate storage practices/requirements: Store in original container only in a well-ventilated, cool, dry, secure area.
Protect from heat, sparks and flame. Do not expose sealed containers to temperatures above 40 癈 and prevent product
from freezing. Keep separate from other products to prevent cross contamination. Rotate stock. Clean up spilled material
immediately.
National Fire Code classification: Not applicable.
SECTION ?8: EXPOSURE CONTROLS/PERSONAL PROTECTION
Applicable control measures, including engineering controls: This product is intended for use outdoors where engineering
controls are not necessary. If necessary, ensure work areas have ventilation, containment, and procedures sufficient to
maintain airborne levels below the TLV. Warehouses, production area, parking lots and waste holding facilities must have
adequate containment to prevent environmental contamination. Provide separate shower and eating facilities.
THE FOLLOWING RECOMMENDATIONS FOR EXPOSURE CONTROLS/PERSONAL PROTECTION ARE INTENDED
FOR THE MANUFACTURE, FORMULATION, PACKAGING AND USE OF THIS PRODUCT.
FOR COMMERCIAL APPLICATIONS AND/OR ON-FARM APPLICATIONS CONSULT THE PRODUCT LABEL.
INSTRATA?FUNGICIDE
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Personal protective equipment for each exposure route:
General: Avoid breathing dust, vapours or aerosols. Avoid contact with eye, skin and clothing. Wash thoroughly after
handling and before eating, drinking, or handling tobacco.
INGESTION: Do not eat, drink, handle tobacco, or apply cosmetics in areas where there is a potential for exposure to
this material. Always wash thoroughly after handling.
EYES: Where eye contact is likely, use chemical splash goggles. Facilities storing or utilizing this material
should be equipped with an eyewash facility and a safety shower.
SKIN: Where contact is likely, wear chemical-resistant gloves (such as nitrile or butyl), coveralls, socks and
chemical-resistant footwear. For overhead exposure, wear chemical-resistant headgear.
INHALATION: A respirator is not normally required when handling this substance. Use process enclosures, local
exhaust ventilation, or other engineering controls to keep airborne levels below exposure limits. A
NIOSH-certified combination air-purifying respirator with an N, P or R 95 or HE class filter and an
organic vapor cartridge may be permissible under certain circumstances where airborne concentrations
are expected to exceed exposure limits. Protection provided by air-purifying respirators is limited. Use a
pressure demand atmosphere-supplying respirator if there is any potential for uncontrolled release,
exposure levels are not known, or under any other circumstances where air-purifying respirators may not
provide adequate protection.
SECTION ?9: PHYSICAL AND CHEMICAL PROPERTIES
Appearance: Grey Liquid.
Formulation Type: Flowable solution.
Odour: Aromatic.
pH: 5.5 @ 25 篊.
5.7 x 10-7 mmHg @ 25 篊 (Chlorothalonil Technical)
Vapour pressure and reference temperature:
4.2 x 10-7 mmHg @ 25癈 (Propiconazole Technical)
2.9 x 10-9 mmHg @ 25 癈 (Fludioxonil Technical)
Vapour density: Not available.
Boiling point: Not available.
Melting point: Not available.
Freezing point: Not available.
Specific gravity or density: 1.21 g/cm3.
Evaporation Rate: Not available.
Water/oil partition coefficient: Not available.
Odour threshold: Not available.
Viscosity: 450 ?750 LVT #2 @ 30 rpm.
Solubility in Water: 0.81 mg/L @ 25 篊 (Chlorothalonil Technical)
100 mg/L @ 20 篊 (Propiconazole Technical)
1.8 mg/L @ 25 篊 (Fludioxonil Technical)
SECTION ?10: STABILITY AND REACTIVITY
Chemical stability: Stable under normal use and storage conditions.
Conditions to avoid: Excessive heat or cold.
Incompatibility with other materials: None known.
Hazardous decomposition products: Can decompose at high temperatures and form toxic gases.
Hazardous polymerization: Will not occur.
SECTION ?11: TOXICOLOGICAL INFORMATION
Acute toxicity/Irritation Studies (Finished Product):
Ingestion: Slightly Toxic
Oral (LD50 Female Rat): 5,000 mg/kg body weight
Dermal: Practically Non-Toxic
Dermal (LD50 Rat): > 5,000 mg/kg body weight
INSTRATA?FUNGICIDE
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Inhalation: Slightly Toxic
Inhalation (LC50 Male Rat): 0.52 ?2.01 mg/L air - 4 hours
Eye Contact: Moderately Irritating (Rabbit)
Skin Contact: Moderately Irritating (Rabbit)
Skin Sensitization: Dermal Sensitizer (Guinea Pig)
Reproductive/Developmental Effects
Chlorothalonil Technical: No evidence of adverse developmental effects in rabbit and rat studies.
Fludioxonil Technical: Delayed development at doses causing maternal toxicity.
Propiconazole Technical: None observed.
Chronic/Subchronic Toxicity Studies
Chlorothalonil Technical: In dogs, 1 years administration caused a significant decrease in body weight
gain and increases in absolute liver and kidney weights.
Neurotoxicity: No evidence in regulatory studies.
Fludioxonil Technical: Liver and kidneys toxicity high dose levels. Changes in urine colour
(predominantly blue) occurred following repeated dosing in all species tested.
Propiconazole Technical: None observed.
Carcinogenicity
Chlorothalonil Technical: No evidence of carcinogenicity in dogs after administration for up to one
year. Treatment related increases in the incidence of renal tubular adenoma
and carcinoma were observed in rats and male mice. Squamous cell adenomas
and carcinomas were also observed in the forestomach of both species.
However, the forestomach tumors seen in rodent studies are not relevant to
human health as humans do not possess an anatomical equivalent of the
rodent forestomach. The relevance of renal tumors to human health is unclear.
However, metabolism data suggest that the dog, a species that is resistant to
chlorothalonil-induced renal injury, may be more representative of humans
than the rat. Subsequently, IARC identifies chlorothalonil as a 2B carcinogen
(possibly carcinogenic to humans).
Fludioxonil Technical: Fludioxonil was not oncogenic in mice. Results of a long-term feeding study
with fludioxonil in rats showed a marginally increased incidence of liver
tumours in female rats at the maximum tolerated dose (3,000 ppm). This was
within historical control range (1 to 10%).
Propiconazole Technical: Long-term exposure of mice to high dose levels of propiconazole produced an
increase in liver tumors in male mice. Propiconazole is not considered to be
carcinogenic.
Other Toxicity Information:
Studies on rats and mice have suggested that technical chlorothalonil (97%), when fed at high levels in the diet,
may have oncogenic potential to these laboratory animals. However, neither chlorothalonil nor its metabolites
interact with DNA and thus are not mutagenic. Tumor formation has been related to a non-genotoxic mechanism
of action for which threshold levels have been established in rats and mice. Comprehensive dietary and worker
exposure studies have shown exposure levels for humans to be well below these threshold levels. In addition,
surveillance of chlorothalonil plant workers for over twenty years has not demonstrated any increase in oncogenic
potential to humans. In addition, exposure of the skin to chlorothalonil may result in weak contact dermatitis.
Toxicity of Other Components
The acute toxicity test results reported in Section 11, above, for the finished product take into account any acute hazards
related to the "other components" in the formulation.
Propylene Glycol
Reported to cause central nervous system depression (anesthesia, dizziness, confusion), headache and
nausea. Also, eye irritation may occur with lacrimation but no residual discomfort or injury. Prolonged
INSTRATA?FUNGICIDE
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contact to skin may cause mild to moderate irritation and possible allergic reactions. Chronic dietary
exposure caused kidney and liver injury in experimental animals.
Other materials that show synergistic toxic effects together with the product: None known.
Target Organs
Active Ingredients
Chlorothalonil Technical: Lung, eye, kidney.
Fludioxonil Technical: Liver, kidney.
Propiconazole Technical: Liver.
Inert Ingredients
Propylene Glycol CNS, skin, eye, kidney, liver.
SECTION ?12: ECOLOGICAL INFORMATION
Summary of Effects
INSTRATA is a mixture of three fungicide (chlorothalonil, fludioxonil, propiconazole) used for control of fungal diseases
on turf. Chlorothalonil, is practically nontoxic to plants, algae, mammals, birds and insects (bees), but is highly toxic to
fish and aquatic invertebrates (water flea). Fludioxonil, is moderately to very highly toxic to fish (rainbow trout, bluegill
sunfish) and aquatic invertebrates (water flea), but is practically non-toxic to insects (bees) and birds. The third active
ingredient, propiconazole, is moderately toxic to aquatic organisms, but practically non-toxic to birds and bees.
Eco-Acute Toxicity
Chlorothalonil Technical:
Bees LC50/EC50 > 181 礸/bee
Invertebrates (Daphnia magna) LC50/EC50 > 0.070 mg/L
Fish (Trout) LC50/EC50 0.047 mg/L
Fish (Bluegill) LC50/EC50 0.060 mg/L
Birds (8-day dietary - Bobwhite Quail) LC50/EC50 > 5,200 ppm
Birds (8-day dietary - Mallard Duck) LC50/EC50 > 5,200 ppm
Fludioxonil Technical:
> 100 礸/bee
Bees LC50/EC50
Invertebrates (Daphnia magna) 48-hour LC50/EC50 0.90 mg/L
Fish (Rainbow Trout) 96-hour LC50/EC50 0.23 mg/L
Fish (Bluegill) 96-hour LC50/EC50 0.74 mg/L
Bobwhite Quail LD50 > 2,000 mg/kg bw
Mallard Duck LD50 > 2,000 mg/kg bw
Birds (8-day dietary - Bobwhite Quail) LC50/EC50 > 5,200 ppm
Birds (8-day dietary - Mallard Duck) LC50/EC50 > 5,200 ppm
Propiconazole Technical:
Bees LC50/EC50 > 25礸/bee
Invertebrates (Daphnia magna) 48-hour LC50/EC50 3.3 ?10.2 mg/L
Fish (Rainbow Trout) 96-hour LC50/EC50 4.3 mg/L
Fish (Bluegill) 96-hour LC50/EC50 5.7 ?6.4 mg/L
Bobwhite Oral LD50 2,825 mg/kg
Mallard Oral LD50 > 2,510 mg/kg
Birds (8-day dietary - Bobwhite Quail) LC50/EC50 > 5,620 ppm
Birds (8-day dietary - Mallard Duck) LC50/EC50 > 5,620 ppm
Eco-Chronic Toxicity
Chlorothalonil Technical:
Invertebrates: Daphnia magna
21-Day reproduction MATC 0.05 mg/L
Fish: Fathead minnow: 21 Day MATC > 0.003 and < 0.0065 mg/L
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Fludioxonil Technical:
Fish (Fathead minnow) Early Life Stage MATC 0.028 mg/L
Fish (Rainbow trout) 21-day NOEC 0.032 mg/L
Invertebrate (Daphnia magna) Life Cycle MATC 0.025 mg/L
Mallard Reproduction NOEC 700 ppm
Bobwhite Reproduction NOEC 125 ppm
Propiconazole Technical:
Fish (Fathead minnow) Early Life Stage MATC > 0.43 and < 0.97 mg/L
Invertebrate (Daphnia magna) Life Cycle MATC > 0.31 and < 0.69 mg/L
Mallard Reproduction NOEC 300 ppm
Bobwhite Reproduction NOEC 1,000 ppm
Environmental Fate
The active ingredient, chlorothalonil has a low bioaccumulation potential, and low mobility in soil but is not persistent in
soil or water. The dissipation half-life in soil is 10-60 days and in water it is <8 days. The main route of degradation is by
microbial degradation and formation of bound residues. Fludioxonil has a low bioaccumulation potential, low mobility in
soil, and low persistence in soil and water. The dissipation half-life in soil and water is <10 days. The main route of
degradation is by microbial degradation and formation of bound residues. Propiconazole has a low bioaccumulation
potential, and low mobility in soil but is not persistent in soil or water. The dissipation half-life in soil is 70 days.
SECTION ?13: DISPOSAL CONSIDERATIONS
Waste disposal information: Do not reuse empty containers. Empty container retains product residue. Triple rinse, or
equivalent, empty container, return rinse water to dilution mixture, and dispose of dilution mixture as a hazardous waste if
it cannot be disposed of by use according to label instructions. Dispose of empty containers in accordance with local
regulations. Consult provincial environment ministry for advice on waste disposal. Industrial/commercial waste may be
handled at licensed facilities only. Waste shipments must be securely packaged and properly labelled. Only licensed carriers
may be used, and proper documents must accompany the shipment.
SECTION ?14 : TRANSPORT INFORMATION
Shipping information such as shipping classification:
TRANSPORTATION OF DANGEROUS GOODS CLASSIFICATION - ROAD/RAIL.
Not Regulated.
IATA CLASSIFICATION - AIR
Not Regulated.
SECTION ?15: REGULATORY INFORMATION
WHMIS classification for product: Exempt
A statement that the MSDS has been prepared to meet WHMIS requirements, except for use of the 16 headings.
This MSDS has been prepared in accordance with WHMIS requirements, but the data are presented under 16 headings.
Other regulations; restrictions and prohibitions
Pest Control Products (PCP) Act Registration No.: 28861
SECTION ?16: OTHER INFORMATION
The information contained herein is offered only as a guide to the handling of this specific material and has been prepared
in good faith by technically knowledgeable personnel. It is not intended to be all-inclusive and the manner and conditions
of use and handling may involve other and additional considerations. No warranty of any kind is given or implied and
Syngenta will not be liable for any damages, losses, injuries or consequential damages which may result from the use of or
reliance on any information contained herein. This Material Safety Data Sheet is valid for three years. This product is
INSTRATA?FUNGICIDE
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under the jurisdiction of the Pest Control Products Act and is exempt from the requirements for a WHMIS compliant
MSDS. Hazardous properties of all ingredients have been considered in the preparation of this MSDS. Read the entire
MSDS for the complete hazard evaluation of this product.
Prepared by: Syngenta Crop Protection Canada, Inc.
1-87S-YNGENTA (1-877-964-3682)
Syngenta Crop Protection Canada, Inc. believes that the information and recommendations contained herein (including
data and statements) are accurate as of the date thereof. NO WARRANTY OF FITNESS FOR ANY PARTICULAR
PURPOSE, WARRANTY OF MERCHANTABILITY, OR ANY OTHER WARRANTY, EXPRESS OR IMPLIED, IS
MADE CONCERNING THE INFORMATION PROVIDED HEREIN. The information provided herein relates to the
specific product designated and may no be valid where such product is used in combination with any other materials or in
any process. Further, since the conditions and methods of use of the product and of the information referred to herein are
beyond the control of Syngenta Crop Protection Canada, Inc., Syngenta Crop Protection Canada, Inc. expressly disclaims
any and all liability as to any results obtained or arising from any use of the product or reliance on such information.
Product names marked ?or TM are registered trademarks of a Syngenta Group Company
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