SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 14/JUN/2005
Date Updated: 14/MAR/2004
Version 1.5
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name 2,4-DICHLOROPHENOXYACETIC ACID, 98%
Product Number D70724
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
2,4-DICHLOROPHENOXYACETIC ACID 94-75-7 202-361-1 607-039-00-8
Formula C8H6Cl2O3
Molecular Weight 221.04 AMU
Synonyms Acide 2,4-dichloro phenoxyacetique (French) *
Acido(2,4-dicloro-fenossi)-acetico (Italian) *
Acme LV 4 * Agrotect * Amidox * Amoxone *
Aqua-Kleen * Barrage * BH 2,4-D * Brush-rhap *
B-Selektonon * Chipco turf herbicide "D" *
Chloroxone * Citrus fix * Crop rider * 2,4-D
(ACGIH:OSHA) * 2,4-D acid * Debroussaillant 600
* Deherban * (2,4-Dichloor-fenoxy)-azijnzuur
(Dutch) * Dichlorophenoxyacetic acid *
2,4-Dichlorophenoxyacetic acid *
Dichlorophenoxyacetic acid (OSHA) *
2,4-Dichlorphenoxyacetic acid *
(2,4-Dichlor-phenoxy)-essigsaeure (German) *
Dicopur * DMA-4 * Dormone *
2,4-Dwuchlorofenoksyoctowy kwas (Polish) *
Emulsamine BK * Emulsamine E-3 * ENT 8,538 *
Envert 171 * Envert DT * Estone * Farmco *
Fernimine * Fernoxone * Ferxone * Foredex 75 *
Hedonal (the herbicide) * Herbidal * Hivol-44 *
Ipaner * Kwasu 2,4-dwuchlorofenoksyoctowego
(Polish) * Kwas 2,4-dwuchlorofenoksyoctowy
(Polish) * Kyselina 2,4-dichlorfenoxyoctova
(Czech) * Lawn-keep * Macrondray * Miracle *
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Irritating to respiratory system. Risk of
serious damage to eyes. May cause sensitization by skin contact.
Harmful to aquatic organisms, may cause long-term adverse effects
in the aquatic environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
Explosion Hazards: Container explosion may occur under fire
conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Store in a cool dry
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place. Store in the dark.
SPECIAL REQUIREMENTS: Light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 7 MG/M3
Poland NDSCh 20 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 1 mg/m3
Remarks: H
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 1 mg/m3, E
Remarks: 4
Remarks: H,19,Y
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 5 mg/m3
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 1 mg/m3
Remarks: E H C
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 10 mg/m3
OEL STEL 20 mg/m3
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: Slightly brown
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 160 癈
MP/MP Range 134 癈
Flash Point N/A
Flammability N/A
Autoignition Temp > 180 癈
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Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure < 0.75 mmHg 20 癈
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density 720 kg/l
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Insoluble.
Other Solvents: ETHANOL
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May decompose on exposure to light.
Materials to Avoid: Strong oxidizing agents, Copper Iron and iron
salts.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: AG6825000
ACUTE TOXICITY
LDLO
Oral
Human
80 mg/kg
Remarks: Gastrointestinal:Nausea or vomiting. Behavioral:Coma.
Behavioral:Somnolence (general depressed activity).
LDLO
Oral
Man
93 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Oral
Rat
375 mg/kg
LD50
Skin
Rat
1500 mg/kg
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LD50
Intraperitoneal
Rat
666 MG/KG
Remarks: Peripheral Nerve and Sensation:Spastic paralysis with
or without sensory change. Behavioral:Muscle weakness.
Behavioral:Coma.
LD50
Oral
Mouse
347 mg/kg
LD50
Oral
Dog
100 mg/kg
Remarks: Behavioral:Stiffness. Behavioral:Coma.
LD50
Skin
Rabbit
1400 mg/kg
Remarks: Behavioral:Ataxia. Skin and Appendages:Skin: After
topical exposure:Primary irritation.
LD50
Intraperitoneal
Rabbit
400 MG/KG
Remarks: Peripheral Nerve and Sensation:Spastic paralysis with
or without sensory change. Behavioral:Muscle weakness.
Behavioral:Coma.
LD50
Intravenous
Rabbit
400 MG/KG
Remarks: Peripheral Nerve and Sensation:Spastic paralysis with
or without sensory change. Behavioral:Muscle weakness.
Behavioral:Coma.
LD50
Oral
Guinea pig
469 mg/kg
LD50
Intraperitoneal
Guinea pig
666 MG/KG
Remarks: Peripheral Nerve and Sensation:Spastic paralysis with
or without sensory change. Behavioral:Muscle weakness.
Behavioral:Coma.
LD50
Oral
Hamster
500 mg/kg
LD50
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Oral
Chicken
541 mg/kg
Remarks: Gastrointestinal:Gastritis. Behavioral:Somnolence
(general depressed activity). Liver:Fatty liver degeneration.
LD50
Oral
Mammal
375 mg/kg
IRRITATION DATA
Skin
Rabbit
500 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
0.75 mg
24H
Remarks: Severe irritation effect
SENSITIZATION
Sensitization: Prolonged or repeated exposure may cause allergic
reactions in certain sensitive individuals.
SIGNS AND SYMPTOMS OF EXPOSURE
Symptoms include nausea, vomiting, anorexia, weakness,
dizziness, vertigo, headache, and sweating. Exposure to large
amounts can cause: Ataxia. Convulsions.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Harmful if absorbed through skin.
Eye Contact: Causes eye irritation.
Inhalation: Harmful if inhaled. Material is irritating to mucous
membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Central nervous system. Skeletal muscle. Cardiovascular system.
Liver. Kidneys. Peripheral nervous system.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be possibly carcinogenic based on its IARC, ACGIH,
NTP, or EPA classification.
CHRONIC EXPOSURE - MUTAGEN
Human
1 UMOL/L
Cell Type: fibroblast
Unscheduled DNA synthesis
Human
20 UG/L
Cell Type: lymphocyte
Cytogenetic analysis
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Human
10 MG/L
Cell Type: lymphocyte
Sister chromatid exchange
Rat
100 UG/KG
Intraperitoneal
Cytogenetic analysis
Mouse
200 MG/KG
Oral
DNA inhibition
Mouse
100 MG/KG
Oral
Cytogenetic analysis
Hamster
1 MMOL/L
Cell Type: ovary
DNA inhibition
Hamster
2400 MG/L
Cell Type: ovary
Cytogenetic analysis
Hamster
167 MG/L
Cell Type: ovary
Sister chromatid exchange
Hamster
10 UMOL/L
Cell Type: lung
Mutation in mammalian somatic cells.
Cattle, Horse
1 PPM
Cell Type: kidney
Cytogenetic analysis
Mammal
1 MMOL/L
Cell Type: lymphocyte
DNA damage
CHRONIC EXPOSURE - TERATOGEN
Result: Laboratory experiments have shown teratogenic effects.
Species: Rat
Dose: 220 UG/KG
Route of Application: Oral
Exposure Time: (1-22D PREG)
Result: Specific Developmental Abnormalities: Blood and
lymphatic system (including spleen and marrow).
Species: Rat
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Dose: 1 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death.
Species: Rat
Dose: 125 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 500 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Central nervous system. Specific Developmental Abnormalities:
Urogenital system.
Species: Rat
Dose: 80 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 707 MG/KG
Route of Application: Oral
Exposure Time: (11-14D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death.
Specific Developmental Abnormalities: Craniofacial (including
nose and tongue).
Species: Mouse
Dose: 882 MG/KG
Route of Application: Subcutaneous
Exposure Time: (6-14D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Specific
Developmental Abnormalities: Central nervous system. Effects on
Embryo or Fetus: Extra embryonic structures (e.g., placenta,
umbilical cord).
Species: Mouse
Dose: 900 MG/KG
Route of Application: Subcutaneous
Exposure Time: (6-14D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities: Eye,
ear. Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 1600 MG/KG
Route of Application: Intraperitoneal
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Exposure Time: (9-25D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Newborn: Biochemical and metabolic.
Species: Rat
Dose: 600 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (9-15D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Newborn: Biochemical and metabolic.
Species: Rat
Dose: 1 GM/KG
Route of Application: Intraperitoneal
Exposure Time: (15-24D PREG)
Result: Effects on Newborn: Biochemical and metabolic.
Species: Mouse
Dose: 900 MG/KG
Route of Application: Oral
Exposure Time: (6-14D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth). Effects on Embryo or Fetus:
Extra embryonic structures (e.g., placenta, umbilical cord).
Specific Developmental Abnormalities: Eye, ear.
Species: Mouse
Dose: 438 MG/KG
Route of Application: Oral
Exposure Time: (8-12D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Mouse
Dose: 900 MG/KG
Route of Application: Subcutaneous
Exposure Time: (6-14D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility: Litter size
(e.g.; # fetuses per litter; measured before birth).
Species: Hamster
Dose: 200 MG/KG
Route of Application: Oral
Exposure Time: (7-11D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth).
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Algae
Species: Selenastrum capricornutum resp.
Time: 96 h
Value: 0.024 - 0.026 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: > 100 mg/l
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Test Type: LC50 Fish
Species: Salmon
Time: 96 h
Value: 100 mg/l
Test Type: LC50 Fish
Species: Cyprinus carpio
Time: 96 h
Value: 20 - 96.5 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 180 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
IMDG
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
Marine Pollutant: Yes
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 607-039-00-8
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22 37 41 43 52/53
Harmful if swallowed. Irritating to respiratory system. Risk of
serious damage to eyes. May cause sensitization by skin
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contact. Harmful to aquatic organisms, may cause long-term
adverse effects in the aquatic environment.
S-PHRASES: 24/25 26 36/37/39 46 61
Avoid contact with skin and eyes. In case of contact with eyes,
rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves, and eye/face
protection. If swallowed, seek medical advice immediately and
show this container or label. Avoid release to the environment.
Refer to special instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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